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Mechanics of nonbuckling interconnects with prestrain for stretchable electronics

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Applied Mathematics and Mechanics(English Edition) 2021年第5期42卷 689-702页

作者： Zixuan LU Liang GUO hongyu zhao State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

The performance of the flexibility and stretchability of flexible electronics depends on the mechanical structure design,for which a great progress has been made in past *** use of prestrain in the substrate,causing the compression of the transferred interconnects,can provide high elastic ***,the nonbuckling interconnects have been designed,where thick bar replaces thin ribbon layout to yield scissor-like in-plane deformation instead of in-or out-of-plane buckling *** nonbuckling interconnect design achieves significantly enhanced ***,combined use of prestrain and nonbuckling interconnects has not been *** paper aims to study the mechanical behavior of nonbuckling interconnects bonded to the prestrained substrate analytically and *** is found that larger prestrain,longer straight segment,and smaller arc radius yield smaller strain in the *** the other hand,larger prestrain can also cause larger strain in the interconnects after releasing the ***,the optimization of the prestrain needs to be found to achieve favorable stretchability.

关键词： nonbuckling interconnect prestrain finite deformation stretchability stretchable electronics

Roles of statistical modeling in characterizing the genetic basis of human diseases and traits

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Quantitative Biology 2021年第4期9卷 371-377页

作者： hongyu zhao Department of Biostatistics Yale School of Public HealthNew HavenCT 06510USA

One major goal of human genetics is to identify variants,genes,and pathways causing diseases,both common and *** thinking and approaches have played a major role in advancing human genetics research both historically and in recent years after the completion of the Human Genome *** has been a paradigm shift from family-based linkage studies to population-based association studies in the past 15 years thanks to the Human Genome Project,and many genomic regions have been implicated for human diseases and *** first success of genome wide association study(GWAS)was published in 2005 by Josephine Hoh and her colleagues[1]who were able to use only 96 cases and 50 controls and a low-resolution array to identify complement factor H as a major gene for age related macular degeneration.

关键词： diseases degeneration linkage

Elucidating the enhancement of kaolinite flotation by iron content through density functional theory: A study on sodium oleate adsorption efficiency

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International Journal of Mining Science and Technology 2024年第6期34卷 855-866页

作者： Lingyun Liu Chuilei Kong hongyu zhao Fangqin Lu Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Huainan 232001China Department of Materials Science and Engineering Anhui University of Science and TechnologyHuainan 232001China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China

This study delves into the intricate relationship between iron(Fe)content in kaolinite and its impact on the adsorption behavior of sodium *** effects of different iron concentrations on adsorption energy,hydrogen bond kinetics and adsorption efficiency were studied through simulation and experimental *** results show that the presence of iron in the kaolinite structure significantly improves the adsorption capacity of sodium *** samples with high iron content have better adsorption properties,lower adsorption energy levels and shorter and stronger hydrogen bonds than pure *** optimal concentration of oleic acid ions for achieving maximum adsorption efficiency was identified as 1.2 mmol/L across different kaolinite *** this concentration,the adsorption rates and capacities reach their peak,with Fe-enriched kaolinite samples exhibiting notably higher flotation recovery *** optimal concentration represents a balance between sufficient oleic acid ion availability for surface interactions and the prevention of self-aggregation phenomena that could hinder *** study offers promising avenues for optimizing the flotation process in mineral processing applications.

关键词： Iron Influence Sodium Oleate Adsorption Kaolinite Surfaces Molecular Interaction Analysis Flotation Efficiency Optimization

High-Effi ciency Catalytic Interface IrO x/CeO_(2)with Adsorbate Evolution Mechanism Boosts Oxygen Evolution Reaction in Acid Media

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Transactions of Tianjin University 2023年第5期29卷 395-405页

作者： hongyu zhao Jie Yin Pinxian Xi State Key Laboratory of Applied Organic Chemistry Frontiers Science Center for Rare IsotopesKey Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China

Oxygen evolution reaction(OER)in acid media has been intensively studied recently for its important role in proton exchange membrane ***_(2)-based nanomaterials have been widely used in various applications for their redox properties,oxygen vacancy,and surface ***_(2)-based nanocatalysts also exhibit superior catalytic performance in OER in acid ***,we fabricated a highly effi cient catalytic interface between IrO x and CeO_(2)(IrO x/CeO_(2)),which showed a boosting OER activity with an overpotential of 217 mV at the current density of 10 mA/cm 2 and long-term stability for 10 h in 0.5 mol/L H_(2)SO_(4),which were better than those of many reported *** in situ diff erential electrochemical mass spectrometry results demonstrated that IrO x/CeO_(2)and the commercial IrO 2(IrO 2-com)followed the adsorbate evolution mechanism,whereas the pure CeO_(2)surface followed the lattice oxygen oxidation mechanism under the same conditions for *** indicated that the interface of IrO x and CeO_(2)improved mass transfer effi ciency and reactivity,which also prevented the lattice oxygen evolution in the CeO_(2)structure and protected the whole *** work fi nds a new way for OER in acid media catalyzed by CeO_(2)-based nanocatalysts and promotes the design strategy for other CeO_(2)-based nanostructures.

关键词： OER Rare-earth oxide Ir-O cluster Acid electrolyte

Variable importance-weighted Random Forests

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Frontiers of Electrical and Electronic Engineering in China 2017年第4期5卷 338-351页

作者： Yiyi Liu hongyu zhao Department of Biostatistics School of Public Health Yale University New Haven CT 06511 USA Program of Computational Biology and Bioinformatics Yale University New Haven CT 06511 USA

Background： Random Forests is a popular classification and regression method that has proven powerful for various prediction problems in biological studies. However, its performance often deteriorates when the number of features increases. To address this limitation, feature elimination Random Forests was proposed that only uses features with the largest variable importance scores. Yet the performance of this method is not satisfying, possibly due to its rigid feature selection, and increased correlations between trees of forest. Methods： We propose variable importance-weighted Random Forests, which instead of sampling features with equal probability at each node to build up trees, samples features according to their variable importance scores, and then select the best split from the randomly selected features. Results： We evaluate the performance of our method through comprehensive simulation and real data analyses, for both regression and classification. Compared to the standard Random Forests and the feature elimination Random Forests methods, our proposed method has improved performance in most cases. Conclusions： By incorporating the variable importance scores into the random feature selection step, our method can better utilize more informative features without completely ignoring less informative ones, hence has improved prediction accuracy in the presence of weak signals and large noises. We have implemented an R package ＂viRandomForests＂ based on the original R package ＂randomForest＂ and it can be freely downloaded from http：// ***/software.

关键词： Random Forests variable importance score classification regression

Incorporating functional annotation information in prioritizing disease associated SNPs from genome wide association studies

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Science China(Life Sciences) 2014年第11期57卷 1072-1079页

作者： HOU Lin MA TianZhou zhao hongyu Department of Biostatistics Yale School of Public Health VA Cooperative Studies Program Coordinating Center Department of Biostatistics University of Pittsburgh

With recent advances in genotyping and sequencing technologies,many disease susceptibility loci have been ***,much of the genetic heritability remains unexplained and the replication rate between independent studies is still ***,there have been increasing efforts on functional annotations of the entire human genome,such as the Encyclopedia of DNA Elements(ENCODE)project and other similar *** has been shown that incorporating these functional annotations to prioritize genome wide association signals may help identify true association ***,to our knowledge,the extent of the improvement when functional annotation data are considered has not been studied in the *** this article,we propose a statistical framework to estimate the improvement in replication rate with annotation data,and apply it to Crohn’s disease and DNase I hypersensitive *** results show that with cell line specific functional annotations,the expected replication rate is improved,but only at modest level.

关键词： prioritization functional annotation genome wide association studies

Comprehensive Analysis of Ubiquitously Expressed Genes in Humans from A Data-driven Perspective

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Genomics, Proteomics & Bioinformatics 2023年第1期21卷 164-176页

作者： Jianlei Gu Jiawei Dai Hui Lu hongyu zhao SJTU-Yale Joint Center for Biostatistics and Data Science Department of Bioinformatics and BiostatisticsSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Center for Biomedical Informatics Shanghai Engineering Research Center for Big Data in Pediatric Precision MedicineShanghai Children’s HospitalShanghai 200040China Department of Biostatistics Yale UniversityNew HavenCT 06511USA

Comprehensive characterization of spatial and temporal gene expression patterns in humans is critical for uncovering the regulatory codes of the human genome and understanding the molecular mechanisms of human *** expressed genes(UEGs)refer to the genes expressed across a majority of,if not all,phenotypic and physiological conditions of an *** is known that many human genes are broadly expressed across ***,most previous UEG studies have only focused on providing a list of UEGs without capturing their global expression patterns,thus limiting the potential use of UEG *** this study,we proposed a novel data-driven framework to leverage the extensive collection of40,000 human transcriptomes to derive a list of UEGs and their corresponding global expression patterns,which offers a valuable resource to further characterize human *** results suggest that about half(12,234;49.01%)of the human genes are expressed in at least 80%of human transcriptomes,and the median size of the human transcriptome is 16,342 genes(65.44%).Through gene clustering,we identified a set of UEGs,named LoVarUEGs,which have stable expression across human transcriptomes and can be used as internal reference genes for expression *** further demonstrate the usefulness of this resource,we evaluated the global expression patterns for 16 previously predicted disallowed genes in islet beta cells and found that seven of these genes showed relatively more varied expression patterns,suggesting that the repression of these genes may not be unique to islet beta cells.

关键词： Ubiquitous expression Housekeeping gene Disallowed gene Expression specificity Expression variability

Magnetic Microrobots with Folate Targeting for Drug Delivery

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Cyborg and Bionic Systems 2023年第1期4卷 309-317页

作者： Min Ye Yan Zhou hongyu zhao Xiaopu Wang Shenzhen Institute of Artificial Intelligence and Robotics for Society(AIRS) The Chinese University of Hong KongShenzhenGuangdong 518129China

Untethered microrobots can be used for cargo delivery(e.g.,drug molecules,stem cells,and genes)targeting designated ***,it is not enough to just reach the lesion site,as some drugs can only play the best therapeutic effect within the *** this end,folic acid(FA)was introduced into microrobots in this work as a key to mediate endocytosis of drugs into *** microrobots here were fabricated with biodegradable gelatin methacryloyl(GelMA)and modified with magnetic metal-organic framework(MOF).The porous structure of MOF and the hydrogel network of polymerized GelMA were used for the loading of enough FA and anticancer drug doxorubicin(DOX)*** the magnetic property of magnetic MOF,these microrobots can gather around the lesion site with the navigation of magnetic *** combination effects of FA targeting and magnetic navigation substantially improve the anticancer efficiency of these *** result shows that the cancer cells inhibition rate of microrobots with FA can be up to 93%,while that of the ones without FA was only 78%.The introduction of FA is a useful method to improve the drug transportation ability of microrobots,providing a meaningful reference for further research.

关键词： drugs enough meaningful

Single Image Fog Removal Based on Local Extrema

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IEEE/CAA Journal of Automatica Sinica 2015年第2期2卷 158-165页

作者： hongyu zhao Chuangbai Xiao Jing Yu Xiujie Xu College of Computer Science and Technology Beijing University of Technology Department of Electronic Engineering Tsinghua University College of Computer Science and Technology Beijing University of Technology

Atmospheric conditions induced by suspended particles, such as fog and haze, severely alter the scene appearance. In this paper, we propose a novel defogging method based on the local extrema, aiming at improving the image visibility under foggy or hazy weather condition. The proposed method utilizes atmospheric scattering model to realize the fog removal. It applies the local extrema method to figure out three pyramid levels to estimate atmospheric veil, and manipulates the tone and contrast of details at different scales through multi-scale tone manipulation algorithm. The results on the experiments of comparison with traditional methods demonstrate that the proposed method can achieve more accurate restoration for the color and details, resulting in a great improvement in image visibility. © 2014 Chinese Association of Automation.

关键词： Visibility