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Correlation analysis of intestinal flora and pathological process of type 2 diabetes mellitus

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Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 166-180页

作者： Yongcheng An Yuhui Duan hongyu dai Chen Wang Lu Shi Changhao He Yinglan Lv Huimin Li Shuhang dai Baosheng Zhao School of Life Sciences Beijing University of Chinese MedicineBeijing102488China Department of Pharmacology School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing102488China Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical SciencesState University of New YorkBuffaloNew YorkNYUSA Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing100029China

Objective: To observe the relationship between the different stages of type 2 diabetes mellitus(T2DM)and the intestinal flora and verify its underlying mechanism.Methods: T2DM rats were generated by high-fat diet(HFD) combined with intraperitoneal streptozotocin(STZ) injection. The rats were divided into four groups: the control group(fed with normal feed for1 month), the HFD group(fed with HFD for 1 month), the T2DM group(HFD combined with STZ and blood glucose ≥11.1 m M), and the unformed T2DM model(Un-mod) group(HFD combined with STZ and blood glucose <11.1 m M). Feces were collected, and bacterial communities in the fecal samples were analyzed by 16S r RNA gene sequencing. The content of short-chain fatty acids(SCFAs) in feces was measured by gas chromatography. Western blot and quantitative real-time polymerase chain reaction were used to detect the expression of G protein-coupled receptor 41(GPR41) and GPR43.Results: At different stages of T2DM, the intestinal flora and SCFAs content of rats were significantly decreased(all P <.05). Our results indicated that g__Prevotella had a significant negative correlation, and g__Ruminococcus_torques_group and g__lachnoclastic had a significant positive correlation with blood glucose. The content of SCFAs, in particular acetate and butyrate, in rat feces of different stages of T2DM were significantly reduced, as well as GPR41 and GPR43 expression. The results in the Un-mod group were similar to the T2DM group, and the expression of GPR41 and GPR43 proteins were significantly higher than those in the T2DM group(both P <.001).Conclusion: The intestinal flora-SCFAs-GPR41/GPR43 network may be important in the development of T2DM. Decreasing blood glucose levels by regulating the intestinal flora may become a new therapeutic strategy for T2DM, which has very important clinical and social values.

关键词： Type 2 diabetes mellitus Intestinal flora 16S rRNA gene sequencing Analysis of correlation High-fat diet Insulin resistance

适用于时速200 km架空刚性接触网的受电弓关键参数分析

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城市轨道交通研究 2024年第7期27卷 55-64页

作者：田彩冯超代洪宇广州地铁设计研究院股份有限公司 510010广州

[目的]接触网与受电弓的匹配性直接影响弓网系统的受流性能,随着架空刚性接触网适用的列车运行速度等级逐渐提高,有必要开展与架空刚性接触网匹配的高速受电弓选型研究。[方法]基于有限元分析法建立了架空刚性接触网-受电弓耦合仿真模型... 详细信息

[目的]接触网与受电弓的匹配性直接影响弓网系统的受流性能,随着架空刚性接触网适用的列车运行速度等级逐渐提高,有必要开展与架空刚性接触网匹配的高速受电弓选型研究。[方法]基于有限元分析法建立了架空刚性接触网-受电弓耦合仿真模型,对适用于列车运行速度为200 km/h架空刚性接触网的受电弓关键参数进行分析;利用正交试验设计法,研究了受电弓多结构参数同时变化对弓网动态性能的影响。[结果及结论]单一参数变化的相对最优取值为:弓头等效质量为6.4 kg,下框架等效质量为6.6 kg,下臂杆等效刚度为10 N/m,弓头等效阻尼为40~60 N s/m,下臂杆等效阻尼为130 N s/m。弓头等效质量变化对弓网动态响应的影响最大,弓头等效刚度、弓头及上框架等效阻尼次之,下臂杆等效质量的影响最小。所获得的适用于列车运行速度为200 km/h架空刚性接触网的受电弓优组合参数为:弓头等效质量为5.7 kg,下臂杆等效质量为4.6 kg,弓头等效刚度为10373 N/m、弓头等效阻尼为60 N s/m,上框架等效阻尼为40 N s/m。

关键词：地铁刚性接触网受电弓

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用户对无人物流配送的使用意愿分析

物流科技 2024年第8期47卷 51-54页

作者：戴红玉杭州电子科技大学浙江杭州310018

近年来,B2C电子商务迅猛发展,包裹递送量正在快速增长,特殊事件激发了无人化配送的需求,多数知名物流企业在一英里物流中开发新的交付实践。以可持续发展和客户为中心的无人配送汽车正在改变传统配送方式,如果公众不接受该技术,无人物... 详细信息

近年来,B2C电子商务迅猛发展,包裹递送量正在快速增长,特殊事件激发了无人化配送的需求,多数知名物流企业在一英里物流中开发新的交付实践。以可持续发展和客户为中心的无人配送汽车正在改变传统配送方式,如果公众不接受该技术,无人物流配送的交付方式将浪费巨大的资源。目前国内关于用户对无人物流配送的使用意愿研究较少,研究结合技术接受理论,通过LDA主题模型收集在线文本数据,发现无人物流配送的安全性、责任划分、数据泄露等问题对用户的使用意愿造成影响。

关键词：无人化配送物流 LDA主题模型使用意愿

Green tea polyphenols supplementation alters immunometabolism and oxidative stress in dairy cows with hyperketonemia

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Animal Nutrition 2021年第1期7卷 206-215页

作者： Yanfen Ma Ying Feng Liwen Song Muyang Li hongyu dai Hua Bao Guijie Zhang Lei Zhao Chunhua Zhang Jing Yi Yusheng Liang School of Agriculture Ningxia UniversityYinchuan 750021China Institute of Animal Nutrition and Feed Inner Mongolia Academy of Agriculture and Animal Husbandry SciencesHohhot 010031China College of Food Engineering&Biotechnology Tianjin University of Science&TechnologyTianjin 300457China College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural UniversityDaqing 163316China College of Veterinary Medicine Nanjing Agricultural UniversityNanjing 210095China Department of Animal Sciences and Division of Nutritional Sciences University of IllinoisUrbana 61801USA

Peripartal cows often experience negative energy balance,and are therefore prone to suffering from metabolic diseases such as hyperketonemia,which causes financial losses in dairy farms.This study aimed to investigate the effect of green tea polyphenol(GTP)supplementation during the periparturient period on production performance,oxidative stress and immunometabolism in dairy cows with hyperketonemia.One hundred Holstein cows were assigned to GTP(0.2 g/kg DM;n=50)or control(without GTP;n=50)group based on body weight,previous milk yield,and parity on d 15 before expected parturition.Subsequently,10 cows with hyperketonemia were selected from each group,according to bloodβ-hydroxybutyric acid(BHBA)concentration between 1.2 and 2.9 mmol/L from 2 to 3 d postpartum.All cows were fed a close-up diet and a lactation diet with or without GTP supply from 15 d prepartum until 30 d postpartum.Milk and blood samples were obtained from 20 cows selected with hyperketonemia on 10,20,and 30 d postpartum.Compared with control cows,greater milk yield and lower somatic cell count were observed in GTP cows.The GTP group had lower concentrations of BHBA,free fatty acids,cholesterol,triglyceride,reactive oxygen species,malondialdehyde,and hydrogen peroxide,greater concentrations of glucose,lower activities of aspartate aminotransferase,alanine aminotransferase,and glutamyl transpeptidase,alongside greater ac-tivities of superoxide dismutase,glutathione peroxidase,and total antioxidant capacity.Additionally,GTP supplementation up-regulated concentrations of interleukin-6 and interleukin-10,but down-regulated concentrations of tumor necrosis factor-α,interleukin-1β,interleukin-2,interleukin-8,and interferon-γin plasma.Greater concentrations of plasma immunoglobulin G were also detected in the GTP group.Overall,the data suggested that GTP supplementation from 15 d prepartum to 30 d postpartum improved the milk yield and health status in cows with hvoerketonemia during early lactation.

关键词： Green tea polyphenol Hyperketonemia Peripartal period dairy cow

多频复合超声真空煮制对卤牛肉肌纤维结构及保水性的影响

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食品科学 2024年第4期45卷 264-270页

作者：蔡华珍戴泓宇陈建功陆楷懿冯腾迅周頔陈杨滁州学院生物与食品工程学院安徽滁州239000

以牛腱子肉为研究对象,对比不同复合超声频数(40/52/68、40/52、40/68、52/68、40、52、68、0 kHz)处理后卤牛肉纤维结构、质构特性和水分变化,探讨多频复合超声真空煮制对卤牛肉纤维结构以及保水性的影响。结果表明,随着复合超声频数... 详细信息

以牛腱子肉为研究对象,对比不同复合超声频数(40/52/68、40/52、40/68、52/68、40、52、68、0 kHz)处理后卤牛肉纤维结构、质构特性和水分变化,探讨多频复合超声真空煮制对卤牛肉纤维结构以及保水性的影响。结果表明,随着复合超声频数的增加,肌原纤维小片化指数、β-转角与无规卷曲结构含量均随之增加,质构特性中弹性有增大趋势,而α-螺旋和β-折叠结构的相对含量、卤牛肉的硬度、咀嚼性、内聚性则随之降低,肌纤维表面结缔组织的溶解性增加,肌纤维分离、断裂愈加明显;低场核磁共振分析结果表明,超声处理使横向弛豫时间T2向左迁移并缩短,改变了水分分布,左迁幅度随复合超声频数增加而增大,结合水和自由水含量亦随之增加,准结合水含量相应减少;三频组蒸煮损失率显著低于双频和单频组,出品率的趋势则相反,三频出品率最高。综上,超声处理对卤牛肉肌纤维结构的破坏和保水性改善具有明显的频率效应,复合超声频数越多,频率效应越显著。

关键词：卤牛肉多频复合超声真空煮制肌纤维结构保水性

Relationship between hyperlipidemia and the gut microbiome of rats, characterized using high-throughput sequencing

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Journal of Traditional Chinese Medical Sciences 2020年第2期7卷 154-161页

作者： Yaqi Li Quantao Ma Jingkang Wang Pengfei Li Long Cheng Yongcheng An Yuhui Duan hongyu dai Ting Wang Baosheng Zhao School of Chinese Materia Medica Beijing University of Chinese Medicine102488China School of Life Sciences Beijing University of Chinese Medicine102488China Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine100029China

Objective:To determine the effects of a high-fat diet(HFD)on the gut microbiome in rats,to explore the relationship between the intestinal flora and blood lipid profile.Methods:SpragueeDawley rats were fed an HFD for four weeks to induce hyperlipidemia,then 16S rRNA sequencing was used to compare the intestinal flora between hyperlipidemic and control diet-fed rats.Results:The microbiome of rats fed an HFD for four weeks differed from that of control diet-fed rats.Bacterial species that were less abundant were most affected by HFD feeding,among which were many pathogenic species,which became significantly more abundant.Eighteen genera were present in significantly different numbers in hyperlipidemic and control rats,more than half of which have been linked to infection and inflammation,or energy intake and obesity.The results indicated a type of stress response of the flora to a high-fat environment.In addition,the age of the rats tended to influence the gut microbial composition.Conclusion:These findings suggest that HFD may induce hyperlipidemia by affecting the gut microbial composition.Changes in the abundance of pro-inflammatory and pathogenic bacteria,and those that influence energy intake and obesity,may be important mediators of this.

关键词： Hyperlipidemia Gut microbiota 16S rRNA sequencing High-fat diet

Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway

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Chinese Journal of Natural Medicines 2023年第11期21卷 812-829页

作者： CHENG Long SHI Lu HE Changhao WANG Chen LV Yinglan LI Huimin AN Yongcheng DUAN Yuhui dai hongyu ZHANG Huilin HUANG Yan FU Wanxin SUN Weiguang ZHAO Baosheng School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Department of Pharmacognosy School of PharmacyChina Medical UniversityShenyang 110122China College of Life Sciences Beijing University of Chinese MedicineBeijing 102488China GuangZhou Baiyunshan Xingqun Pharmaceutical Co. Ltd.Guangzhou 510288China Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Mulberry (Morus alba L.) leaf is a well-established traditional Chinese botanical and culinary resource. It has found widespread application in the management of diabetes. The bioactive constituents of mulberry leaf, specifically mulberry leaf flavonoids (MLFs), exhibit pronounced potential in the amelioration of type 2 diabetes (T2D). This potential is attributed to their ability to safeguard pancreatic β cells, enhance insulin resistance, and inhibit α-glucosidase activity. Our antecedent research findings underscore the substantial therapeutic efficacy of MLFs in treating T2D. However, the precise mechanistic underpinnings of MLF’s anti-T2D effects remain the subject of inquiry. Activation of brown/beige adipocytes is a novel and promising strategy for T2D treatment. In the present study, our primary objective was to elucidate the impact of MLFs on adipose tissue browning in db/db mice and 3T3-L1 cells and elucidate its underlying mechanism. The results manifested that MLFs reduced body weight and food intake, alleviated hepatic steatosis, improved insulin sensitivity, and increased lipolysis and thermogenesis in db/db mice. Moreover, MLFs activated brown adipose tissue (BAT) and induced the browning of inguinal white adipose tissue (IWAT) and 3T3-L1 adipocytes by increasing the expressions of brown adipocyte marker genes and proteins such as uncoupling protein 1 (UCP1) and beige adipocyte marker genes such as transmembrane protein 26 (Tmem26), thereby promoting mitochondrial biogenesis. Mechanistically, MLFs facilitated the activation of BAT and the induction of WAT browning to ameliorate T2D primarily through the activation of AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) signaling pathway. These findings highlight the unique capacity of MLF to counteract T2D by enhancing BAT activation and inducing browning of IWAT, thereby ameliorating glucose and lipid metabolism disorders. As such, MLFs emerge as a prospective and innovative

关键词： Mulberry leaf flavonoids Brown adipose tissue Browning of white adipose tissue Type 2 diabetes AMPK/SIRT1/PGC-1α

菱形肌-肋间肌-低位前锯肌平面阻滞改善胸腔镜下肺癌根治术后早期恢复质量的有效性

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中国现代医生 2024年第8期62卷 25-29页

作者：郝倩代红雨李春艳周红梅朱志鹏嘉兴市第二医院麻醉科浙江嘉兴314000

目的验证菱形肌-肋间肌-低位前锯肌平面阻滞对胸腔镜下肺癌根治术患者术后早期恢复质量的改善作用;比较不同阻滞时机改善术后早期恢复质量的差异性。方法选取2022年1月至2023年1月拟行胸腔镜下肺癌根治术患者共75例,年龄18~75岁,美国麻... 详细信息

目的验证菱形肌-肋间肌-低位前锯肌平面阻滞对胸腔镜下肺癌根治术患者术后早期恢复质量的改善作用;比较不同阻滞时机改善术后早期恢复质量的差异性。方法选取2022年1月至2023年1月拟行胸腔镜下肺癌根治术患者共75例,年龄18~75岁,美国麻醉医师协会(American Society of Anesthesiologists,ASA)Ⅰ~Ⅱ级。随机分为3组:空白对照组(C组)、术前阻滞组(PR组)、术后阻滞组(PO组)。PR组与PO组分别在术前及术后接受超声引导下菱形-肋间-低位前锯肌平面阻滞,药物为0.375%罗哌卡因共30ml。通过术后恢复质量评分量表(postoperative recovery quality rating scale,QoR-40)评价患者术后24h、48h恢复质量;记录术后0.5、1、2、4、8、12、24、48h静息及活动状态数字疼痛评分(numeric rating scale,NRS)疼痛评分;记录术中及术后阿片类药物的消耗量、术后自控静脉镇痛(patient-controlled intravenous analgesia,PCIA)有效按压次数及恶心、呕吐发生率。结果与C组比较,PR组术中阿片类药物消耗量明显减少,PR组及PO组术后24h QoR-40得分更高,术后1~8h静息状态与1~12h活动状态NRS评分明显降低,PCIA有效按压次数及阿片类药物消耗量明显减少(P0.05);3组术后恶心、呕吐发生率差异无统计学意义(P>0.05)。结论菱形肌-肋间肌-低位前锯肌平面阻滞能改善胸腔镜下肺癌根治术患者术后早期恢复质量,减轻患者术后疼痛程度,减少围术期阿片类药物用药量,且其有效性与阻滞时机无关。

关键词：区域平面阻滞菱形-肋间-低位前锯肌阻滞胸腔镜手术肺癌根治术

A Fibonacci View on the Galois NFSR Used in Trivium

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Journal of Systems Science & Complexity 2024年第3期37卷 1326-1350页

作者： WANG hongyu ZHENG Qunxiong QI Wenfeng PLA Strategic Support Force Information Engineering University Zhengzhou 450001China

Trivium is an international standard of lightweight stream ciphers(ISO/IEC 29192-3:2012).In this paper,the Trivium-like NFSRs,a class of Galois NFSRs generalized from the Galois NFSR of Trivium,are studied from the perspective of Fibonacci NFSRs.It is shown that an n-stage Trivium-like NFSR cannot be equivalent to an n-stage Fibonacci NFSR,which is proved by showing the existence of“collision initial states”.As an intermediate conclusion,a necessary and sufficient condition for a kind of linear degeneracy of a Trivium-like NFSR is obtained from the persepective of interleaved sequences.Moreover,the smallest stage number of a Fibonacci NFSR that can generate all the output sequences of an n-stage Trivium-like NFSR is shown to be greater than n-7 and this value is no less than 371=287+min{93,84,111}specifically for the 288-stage Galois NFSR used in Trivium.These results contradict the existence of a equivalent Fibonacci model of Trivium NFSR of small stage,which implies that Trivium algorithm possesses a fair degree of immunity against“structure attack”.

关键词： Fibonacci NFSR galois NFSR interleaved sequence linear degeneracy trivium