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养心氏联合曲美他嗪对5-氟尿嘧啶化疗后病人心肌损伤的保护作用及机制探讨

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中西医结合心脑血管病杂志 2019年第24期17卷 4000-4004页

作者：柴苗苗曹月娟迟红玉谢清清天津中医药大学研究生院天津300193 天津市人民医院

目的探讨养心氏联合曲美他嗪对接受5-氟尿嘧啶(5-FU)化疗方案的结直肠癌病人心肌损伤的保护作用及可能机制。方法选取2017年12月-2018年12月拟行mFOLFOX6化疗方进行辅助化疗的结直肠癌病人80例,随机分为3组,分别为单纯化疗组(对照组,24... 详细信息

目的探讨养心氏联合曲美他嗪对接受5-氟尿嘧啶(5-FU)化疗方案的结直肠癌病人心肌损伤的保护作用及可能机制。方法选取2017年12月-2018年12月拟行mFOLFOX6化疗方进行辅助化疗的结直肠癌病人80例,随机分为3组,分别为单纯化疗组(对照组,24例)、曲美他嗪组(单药组,28例)、养心氏联合曲美他嗪组(双药组,28例),对照组给予安慰剂,单药组和双药组初次接受化疗时开始加用药物干预,每2周化疗1次,观察4个周期。比较3组病人化疗前、化疗4周期后临床症状、心电图改善情况,测定血清脑利钠肽(BNP)、肌钙蛋白T(cTnT)、超敏C反应蛋白(hsCRP)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)以及乳酸脱氢酶(LDH)指标,分别于化疗前、化疗第2周期、化疗第3周期、化疗第4周期测定人血清超氧化物歧化酶(SOD)、丙二醛(MDA)、白介素-6(IL-6)指标。结果治疗4周后,双药组病人临床症状、心电图较对照组改善明显,差异有统计学意义(P<0.05);养心氏和曲美他嗪能降低血清BNP、cTnT、hsCRP、CK-MB水平,还能降低MDA、IL-6,升高SOD含量水平,且两药联用具有协同作用。结论养心氏和曲美他嗪对5-FU产生的心肌损伤具有一定的心肌保护作用,其作用机制可能与抑制氧化应激及炎症反应有关。

关键词：心肌损伤养心氏曲美他嗪 5-氟尿嘧啶作用机制

基于数据挖掘探析针刺治疗支气管哮喘的选穴规律

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湖南中医杂志 2024年第1期40卷 39-42,47页

作者：刘志艳李梦光杨涛姚蓥迟红玉天津市北辰区中医医院天津300193

目的:通过数据挖掘分析针刺治疗支气管哮喘的选穴规律。方法:检索中国知网(CNKI)、维普中文科技期刊数据库(VIP)、万方数据(WANFANG DATA)、中国生物医学文献服务系统(SinoMed)自建库至2022年9月20日收录的针刺治疗支气管哮喘的临床研... 详细信息

目的:通过数据挖掘分析针刺治疗支气管哮喘的选穴规律。方法:检索中国知网(CNKI)、维普中文科技期刊数据库(VIP)、万方数据(WANFANG DATA)、中国生物医学文献服务系统(SinoMed)自建库至2022年9月20日收录的针刺治疗支气管哮喘的临床研究文献,通过中医传承辅助平台系统V2.5进行频次、关联规则、聚类、核心处方分析。结果:共纳入42篇文献,包含52个腧穴,总使用频次为272次,使用频次排前10位的腧穴依次为:肺俞、定喘、足三里、丰隆、膻中、尺泽、列缺、天突、风门、大椎;常用腧穴主要分布于足太阳膀胱经、手太阴肺经、任脉。特定穴多选用背俞穴、交会穴及五输穴。腧穴配伍以肺俞-定喘最为常见。核心腧穴处方:肺俞、定喘、足三里、丰隆、膻中、风门。结论:特定穴的选用是针刺治疗哮喘组方的重要组成部分,临床应重视“治脏者,治其俞”之选穴思想,突出“局部配穴”“远近配穴”“前后配穴”之配穴特点,从而体现“扶正祛邪,标本兼顾”之治疗原则。

关键词：支气管哮喘针刺疗法数据挖掘选穴规律

手术联合电子束放射治疗瘢痕疙瘩后的复发及并发症分析

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中国美容整形外科杂志 2022年第11期33卷 654-658页

作者：阿力亚·阿布都拉迟宏羽董祥林新疆医科大学第一附属医院整形外科新疆乌鲁木齐830011

目的探讨瘢痕疙瘩患者手术联合电子束放射治疗后复发的影响因素以及并发症发生情况。方法回顾性分析自2017年1月至2021年5月,新疆医科大学第一附属医院整形外科采用手术联合电子束放射治疗200例瘢痕疙瘩患者的临床资料,统计治疗后的复... 详细信息

目的探讨瘢痕疙瘩患者手术联合电子束放射治疗后复发的影响因素以及并发症发生情况。方法回顾性分析自2017年1月至2021年5月,新疆医科大学第一附属医院整形外科采用手术联合电子束放射治疗200例瘢痕疙瘩患者的临床资料,统计治疗后的复发及并发症发生情况,通过组间比较以及多因素分析得出复发的显著性影响因素;同时分析并发症发生情况。结果200例患者中,29例患者在随访截止前复发,总复发率为14.5%。二元Logistic回归分析结果显示:家族易感人群(P=0.026,OR=3.074)、治疗前病灶严重程度(P<0.05,OR=1.100)以及总放射剂量(P=0.016,OR=0.875)是治疗后复发的显著影响因素。在随访过程中,红斑作为19.0%患者的早期并发症出现;作为远期并发症,3.5%的患者出现切口延迟愈合,26.0%的患者出现不同程度的放射性色素沉着。结论家族易感人群以及较严重的病灶是瘢痕疙瘩复发的独立危险因素。在安全剂量范围内(12~30 Gy),较高的放射剂量为保护因素,总放射剂量越高,越不容易复发。放射治疗后放射性色素沉着最常见。

关键词：瘢痕疙瘩电子束放射复发并发症影响因素

Effect of Replacing Fish Meal with Extruded Soybean Meal on Growth, Feed Utilization and Apparent Nutrient Digestibility of Juvenile White Shrimp(Litopenaeus vannamei)

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Journal of Ocean University of china 2015年第5期14卷 865-872页

作者： YANG Qihui TAN Beiping DONG Xiaohui chi Shuyan LIU hongyu Laboratory of Aquatic Animal Nutrition and Feed College of Fisheries Guangdong Ocean University

Extruded soybean meal （ESBM） was evaluated as a protein source for partial replacement of fish meal （FM） in diets of juvenile Litopenaeus vannarnei. In the control diet （Diet 1）, FM protein was replaced with increasing dietary levels of ESBM （4.28%, 8.40%, 12.62%, 16.82%, and 25.26%） at 10%, 20%, 30%, 40%, and 60% levels （Diets 2 to 6, respectively）. An eight-week feeding trial was conducted on 720 juvenile shrimp （0.67 g ± 0.01 g mean initial Weight）, and nutrient digestibility of the six diets was determined. ESBM could replace 20% of FM without causing a significant reduction in growth of shrimp, but other dietary treatments strongly affected whole body composition. Crude protein content of the whole body fed Diet 6 was significantly lower than that fed Diet 2 （P〈0.05）, while crude lipid content of the whole body fed Diet 5 or 6 was significantly higher than that fed Diet 2 （P〈0,05）. Protein digestibilities of Diets 5 and 6 were significantly lower than that of Diet 1 （P〈0.05）. Digestibility of lipids ranged from 96.97% in Diet 6 to 98.34% in Diet 3, whereas dry matter digestibility decreased with increasing replacement level. This study indicates that 20% FM replacement with ESBM in the basic diet containing 40% protein and 30% FM is optimal for juvenile L. vannamei.

关键词： Litopenaeus vannamei fish meal extruded soybean meal growth performance feed ttilization nutrient digestibility

曲美他嗪联合养心氏片防治放疗相关心脏损伤的临床疗效观察及作用机制研究

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世界中医药 2020年第2期15卷 266-269页

作者：迟红玉柴苗苗崔丽郭兆增妥少勇曹月娟天津中医药大学研究生院天津300193 天津市人民医院心内二科天津300192

目的:观察曲美他嗪联合养心氏片防治放疗相关心脏损伤的临床疗效,并探讨其可能的作用机制。方法:选取2017年8月至2018年11月天津市人民医院收治的接受胸部放疗患者72例作为研究对象,按随机数字表法随机分为对照组、单药组和双药组,每组2... 详细信息

目的:观察曲美他嗪联合养心氏片防治放疗相关心脏损伤的临床疗效,并探讨其可能的作用机制。方法:选取2017年8月至2018年11月天津市人民医院收治的接受胸部放疗患者72例作为研究对象,按随机数字表法随机分为对照组、单药组和双药组,每组24例。对照组采用常规放射治疗,单药组于放疗首日开始服用曲美他嗪20 mg/次,3次/d,服用至放疗结束;双药组于放疗首日开始服用曲美他嗪20 mg/次,3次/d,联合养心氏片3片/次,3次/d,服用至放疗结束,分别于放疗前、放疗剂量达到30 Gy、40 Gy及放疗结束时观察是否出现心脏损伤相关的临床表现,检测心电图、心肌标志物(cTnT、BNP、心肌酶谱)、丙二醛(MDA)、超氧化物歧化酶(SOD)及白细胞介素-6(IL-6)等指标,观察其变化。结果:与对照组相比,用药组在临床症状改善、心电图、超声心动图、心肌标志物等临床指标变化差异有统计学意义,在SOD、MDA、IL-6等分子机制上看变化差异有统计学意义。结论:曲美他嗪联合养心氏片能在一定程度上有效防治放疗期间发生的心脏损伤,安全性好,值得在临床上推广应用,养心氏片联合曲美他嗪对于放射性心脏损伤的保护作用机制可能是减轻辐射导致的氧化应激及炎性反应。

关键词：放疗心脏损伤曲美他嗪养心氏片作用机制心肌标志物氧化应激炎性反应

Soybeanβ-conglycinin and glycinin reduced growth performance and the intestinal immune defense and altered microbiome in juvenile pearl gentian groupers Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂

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Animal Nutrition 2022年第2期9卷 193-203页

作者： Yuanfa He Jinfang Liang Xiaohui Dong hongyu Liu Qihui Yang Shuang Zhang Shuyan chi Beiping Tan Laboratory of Aquatic Animal Nutrition and Feed Fisheries CollegeGuangdong Ocean UniversityZhanjiang 524088China Aquatic Animals Precision Nutrition and High-Efficiency Feed Engineering Research Center of Guangdong Province Zhanjiang 524088China Key Laboratory of Aquatic Livestock and Poultry Feed Science and Technology in South ChinaMinistry of AgricultureZhanjiang 524088China

The utilization efficiency of soy protein is affected by its 2 anti-nutritional substancesdthe antigens bconglycinin and *** study investigated their effects on the growth performance,intestinal immune defense,andmicrobiome in juvenile pearl gentian groupers(Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂).Three isonitrogenous and isolipidic diets were formulated containing fishmeal supplemented with 70 g/kgβ-conglycinin or 100 g/kg glycinin,or no supplementation(control).Each experimental diet was fed to quadruplicate groups with 30 fish in each tank for 8 *** inclusion of eitherβ-conglycinin or glycinin significantly reduced weight gain and specific growth rates,and cell proliferation of the distal *** evaluation of the intestine tract revealed the inflammation signs,characterized by reducing of plica height and width as well as the number of the goblet cells,and widening of the lamina *** group fed theβ-conglycinin diet had reduced lysozyme activity,contents of immunoglobulin M and complements 3 and *** activities of caspase-3 and-9 were observed in the group fed the bconglycinin diet compared to the other 2 *** the intestinal microbiota,the relative abundances of the potentially pathogenic genera Photobacterium and Vibrio were significantly higher in the glycinin group than those in ***,the existence of soybean antigens(β-conglycinin or glycinin)could damage the structural integrity of the intestine,reduce immune defense,reshape the intestinal microbiome and,ultimately,impair growth in fish.

关键词： β-Conglycinin Glycinin Pearl gentian groupers Immune response Intestinal microbiota

Effects of adding bulking agents on the biodrying of kitchen waste and the odor emissions produced

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Journal of Environmental Sciences 2018年第5期30卷 344-355页

作者： Jing Yuan Yun Li hongyu Zhang Difang Zhang David Chadwick Guoxue Li Guoying Wang Menghao chi Fan Yang Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation College of Resources and Environmental ScienceChina Agricultural UniversityBeijing 100193China Beijing Building Materials Academy of Science Research/State Key Laboratory of Solid Waste Reuse for Building Material Beijing 100041China Bangor University Deiniol Rd.BangorUnited Kingdom College of Resources and Environmental Science Jilin Agricultural UniversityJilin 130118China Beijing Municipal Research Institute of Environmental Protection Beijing 100037China

The effects of adding a bulking agent on the performance and odor emissions（ammonia and eight sulfur-containing odorous compounds） when biodrying kitchen waste were investigated. Three treatments were considered： the addition of either cornstalks（CS） or wood peat（WP） to kitchen waste as a bulking agent before biodrying, and a control treatment（CK）. The water-removal rates for CK, CS, and WP treatments were 0.35, 0.56, and0.43 kg/kg, respectively. Addition of bulking agents to kitchen waste produced less leachate,higher moisture-removal rates, and lower consumption of volatile solids. The CS treatment had the highest biodrying index（4.07）, and those for the WP and CK treatments were 3.67 and 1.97, respectively. Adding cornstalks or wood peat decreased NH3 emissions by 55.8%and 71.7%, respectively. Total sulfur losses were 3.6%–21.6% after 21 days biodrying, and H2 S and Me2 SS were the main（〉 95%） sulfur compounds released. The smallest amounts of sulfur-containing odorous compounds were emitted when cornstalks were added, and adding cornstalks and wood peat decreased total sulfur losses by 50.6%–64.8%.

关键词： Biodrying Kitchen waste Bulking agent Water content Ammonia Volatile sulfur compounds (VSCs)

Effect of Dietary Potassium on Growth, Nitrogen Metabolism, Osmoregulation and Immunity of Pacific White Shrimp （Litopenaeus vannamel） Reared in Low Salinity Seawater

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Journal of Ocean University of china 2014年第2期13卷 311-320页

作者： hongyu Liu Xinjie Zhang Beiping Tan Yingbo Lin Shuyan chi Xiaohui Dong Qihui Yang Laboratory of Aquatic Animal Nutrition and Feed Fisheries College Guangdong Ocean University Zhanjiang P. R. China Department of Oncology and Pathology Cancer Center Karolinska R8:04 Karolinska Hospital Stockholm Sweden

An 8 weeks feeding experiment was conducted to determine the effect of dietary potassium on the growth and physio-logical acclimation of Pacific white shrimp （Litopenaeus vannamei） reared in diluted seawater （salinity 4）. Six semi-purified practical diets containing 0.59, 0.96, 1.26, 1.48, 1.74, and 2.17 g potassium K＋ per 100 g diet were formulated, respectively. The survival and feed conversion rate did not show significant difference among groups of shrimps given these diets （P〉0.05）. The shrimps fed the diets containing 0.96-1.48 g K＋ per 100g diet gained the highest weight, specific growth rate, and protein efficiency ratio. Their ammonium-N excretion rate as well as hemolymph concentration of Na＋ and C1- were significantly lower than those of the control （P〈0.05）, but a reverse trend was observed for their gill Na＋/K＋-ATPase. Moreover, the shrimps fed with 1.48 g K＋ per 100 g diet were the highest in hemolymph urea level, and the phenoloxidase and lysozyme activities were significantly higher than those of the control （P〈0.05）. The growth and physiological response of the test shrimps suggested that diet containing 1.48 g K＋ per 100 g diet improved the growth of L. vannamei in low-salinity seawater, and enhanced the physiological acclimation of the organism.

关键词： Litopenaeus vannamei potassium nitrogen metabolism osmoregulation immunity

Quasi-two-dimensionalβ-Ga2O3 field effect transistors with large drain current density and low contact resistance via controlled formation of interfacial oxygen vacancies

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Nano Research 2019年第1期12卷 143-148页

作者： Zhen Li Yihang Liu Anyi Zhang Qingzhou Liu Chenfei Shen Fanqi Wu chi Xu Mingrui Chen hongyu Fu Chongwu Zhou Ming Hsieh Department of Electrical Engineering Mork Family Department of Chemical Engineering and Material ScienceDepartment of Physics and AstronomyUniversity of Southern CalifomiOy Los AngelesCalifornia 90089USA

Quasi-two-dimensi on al(2D)β-Ga2O3 is a rediscovered metal-oxide semiconductor with an ultra-wide bandgap of *** has been reported to be a promising material for next-generation power and radio frequency *** effect transistors(FETs)that can switch at high voltage are key compone nts in power and radio frequency devices,and reliable Ohmic con tacts are essential for high FET ***,obtaining low contact resistance onβ-Ga2O3 FETs is difficult since reactions betweenβ-Ga2O3 and metal contacts are not fully ***,we experimentally demonstrate the importanee of reactions at the metal/β-Ga2O3 interface and the corresponding effects of these reactions on FET *** Ti is employed as the metal contact,annealing ofβ-Ga2O3 FETs in argon can effectively transform Schottky contacts into Ohmic contacts and permit a large drain current density of-3.1 mA//μ*** contact resistance(Rcontact)between the Ti electrodes andβ-Ga2O3 decreased from^430 to^0.387Ω·mm after annealing.X-ray photoelectron spectroscopy(XPS)confirmed the formation of oxygen vacancies at the Ti/β-Ga2O3 interface after annealing,which is believed to cause the improved FET *** results of this study pave the way for greater application ofβ-Ga2O3 in electronics.

关键词： quasi-two-dimensional material metal-oxides field effect transistor β-Ga2O3 contact resistanee