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Predictive value of bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome

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World Journal of Diabetes 2024年第1期15卷 34-42页

作者： Jie chen Wan-Chao Zhang Xiao-Qiang Tang Ruo-Han Yin Tao Wang Xiao-Yu Wei Chang-Jie Pan Radiology Department The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Radiology Department The People’s Hospital of WuQia CountyWuqia 845450Xinjiang Uygur Autonomous RegionChina

BACKGROUND Cardiovascular disease is a major complication of diabetes mellitus(DM).Type-2 DM(T2DM)is associated with an increased risk of cardiovascular events and mortality,while serum biomarkers may facilitate the prediction of these *** differential diagnosis of T2DM complicated with acute coronary syndrome(ACS)plays an important role in controlling disease progression and improving *** To investigate the correlation of serum bilirubin andγ-glutamyltranspeptidase(γ-GGT)with major adverse cardiovascular events(MACEs)in T2DM patients with *** The clinical data of inpatients from January 2022 to December 2022 were analyzed *** to different conditions,they were divided into the T2DM complicated with ACS group(T2DM+ACS,n=96),simple T2DM group(T2DM,n=85),and simple ACS group(ACS,n=90).The clinical data and laboratory indices were compared among the three groups,and the correlations of serum total bilirubin(TBIL)levels and serumγ-GGT levels with other indices were discussed.T2DM+ACS patients received a 90-day follow-up after discharge and were divided into event(n=15)and nonevent(n=81)groups according to the occurrence of MACEs;Univariate and multivariate analyses were further used to screen the independent influencing factors of MACEs in *** The T2DM+ACS group showed higherγ-GGT,total cholesterol,low-density lipoprotein cholesterol(LDL-C)and glycosylated hemoglobin(HbA1c)and lower TBIL and high-density lipoprotein cholesterol levels than the T2DM and ACS groups(P<0.05).Based on univariate analysis,the event and nonevent groups were significantly different in age(t=3.3612,P=0.0011),TBIL level(t=3.0742,P=0.0028),γ-GGT level(t=2.6887,P=0.0085),LDL-C level(t=2.0816,P=0.0401),HbA1c level(t=2.7862,P=0.0065)and left ventricular ejection fraction(LEVF)levels(t=3.2047,P=0.0018).Multivariate logistic regression analysis further identified that TBIL level and LEVF level were protective factor for MACEs,and age andγ-GGT

关键词： Acute coronary syndrome Type-2 diabetes mellitus Total bilirubin Major adverse cardiovascular events

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DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis

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Genes & Diseases 2024年第1期11卷 91-94页

作者： Qiuxia Cui Jian Sun Jingping Yuan Juanjuan Li Chuanyu Yang Guangshi Du chengang Zhou Pu Qiu Jidong Gao Yuanqi Zhang Dewei Jiang Ceshi chen Affiliated Hospital of Guangdong Medical University Science&Technology of China ZhanjiangGuangdong 524000China Department of Breast Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenGuangdong 518116China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Department of Pathology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Breast and Thyroid Surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Translational Medicine Research Center of Guizhou Medical University GuiyangGuizhou 550025China Department of Breast Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Yunnan Cancer Hospital and the Third Affiliated Hospital of Kunming Medical University and Yunnan Cancer Center KunmingYunnan 650500China Academy of Biomedical Engineering Kunming Medical UniversityKunmingYunnan 650500China

Most basal-like breast cancers(BLBCs)have a poor prognosis and high crossover with triple-negative breast cancers(TNBCs).However,approximately 50%of TNBC patients develop chemoresistance.^(1) Dexamethasone reportedly induces Krüppel-like factor 5(KLF5)and can cause docetaxel and cisplatin resistance in TNBC.A super-enhancer can maintain the transcription of KLF5.

关键词： FOXO1 drugs damage

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乌克兰卡霍夫卡大坝损毁的多维度影响评估

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Science Bulletin 2024年第11期69卷 1642-1646页

作者：陈斌安佳夫黄玉飞陈曦东吴胜标林晨宫鹏 Future Urbanity&Sustainable Environment(FUSE)Lab Division of Landscape ArchitectureDepartment of ArchitectureFaculty of ArchitectureThe University of Hong KongHong Kong 999077China Department of Real Estate and Construction Faculty of ArchitectureThe University of Hong KongHong Kong 999077China Faculty of Business and Economics The University of Hong KongHong Kong 999077China Department of Geography and Department of Earth SciencesThe University of Hong KongHong Kong 999077China

Water plays a central role in sustaining a thriving human society. Given its immense importance, safeguarding the related water infrastructure such as dams and reservoirs, which ensures the proper functioning of water... 详细信息

关键词：影响评估 reservoirs immense

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家校社协同育人再研究——基于责任边界的视角

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教育科学研究 2024年第3期 35-42页

作者：陈辉陈虹中华女子学院儿童发展与教育学院(家庭建设研究院) 100101

家庭、学校和社会合作共育长期以来受到国家和社会的普遍重视,但仍存在诸多问题,其中一个重要原因就在于对于三个主体的教育责任和边界缺乏更为客观、全面和深入的认识与分析。从责任边界的视角分析各主体的教育责任,发现在个体因素和... 详细信息

家庭、学校和社会合作共育长期以来受到国家和社会的普遍重视,但仍存在诸多问题,其中一个重要原因就在于对于三个主体的教育责任和边界缺乏更为客观、全面和深入的认识与分析。从责任边界的视角分析各主体的教育责任,发现在个体因素和社会因素的影响下,各主体的教育责任有时代差异和“应然-实然”之分,责任边界存在弹性;各主体教育责任的差别主要表现在优势领域和对象范围上,而不在大小多少上;协同的实现需要共识达成和制度建设,以保障各主体责任结构合理、运行有序,从而实现最优育人这一系统整体同一的目的。

关键词：责任边界家校社协同育人

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平台质量管理门槛、双侧用户效用与平台收益——网络外部性与价格敏感性视角

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华东经济管理 2024年第8期38卷 26-39页

作者：陈晨谢果伊犁师范大学霍尔果斯商学院新疆伊宁835000 伊犁师范大学新疆口岸经济发展与管理中心新疆伊宁835000 东北大学工商管理学院辽宁沈阳110167 都柏林大学经济学院爱尔兰都柏林Dublin4

消费者对商品质量的担忧已成为电商增长的障碍,天猫和京东等电商平台通过提高质量管理来增强消费者信任,而拼多多利用低价和宽松的质量门槛快速提升市场份额。文章构建了一个双寡头垄断模型,分析电商质量管理门槛异质性对用户效用和平... 详细信息

消费者对商品质量的担忧已成为电商增长的障碍,天猫和京东等电商平台通过提高质量管理来增强消费者信任,而拼多多利用低价和宽松的质量门槛快速提升市场份额。文章构建了一个双寡头垄断模型,分析电商质量管理门槛异质性对用户效用和平台利润的影响。研究发现:质量管理的差异直接影响平台竞争力和用户效用,高网络外部性的平台在质量管理门槛下能获得更大的利润;质量管理门槛的不同,可能会提高消费者价格敏感度,降低用户效用,但网络外部性高、收费低的平台和商家会受益更多;质量管理门槛对网络外部性和价格敏感度产生影响,平台在调整质量管理门槛时需关注其对市场策略和盈利的影响。

关键词：质量管理门槛异质性用户效用平台收益网络外部性消费者价格敏感度

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LA-D-B1,a novel Abemaciclib derivative,exerts anti-breast cancer effects through CDK4/6

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BIOCELL 2024年第5期48卷 847-860页

作者： LING MA ZIRUI JIANG XIAO HOU YUTING XU ZIYUN chen SIYI ZHANG HANXUE LI SHAOJIE MA GENG ZHANG XIUJUN WANG JING JI Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening College of PharmacyJiangsu Ocean UniversityLianyungang222000China School of Medicine Xiamen UniversityXiamen361102China

Background:Regulatory proteins involved in human cellular division and proliferation,cyclin-dependent kinases 4 and 6(CDK4/6)are overexpressed in numerous cancers,including triple-negative breast cancer(TNBC).TNBC is a common pathological subtype of breast cancer that is prone to recurrence and metastasis,and has a single treatment *** one of the CDK4/6 inhibitors,abemaciclib can effectively inhibit the growth of breast *** this study,we synthesized LA-D-B1,a derivative of Abemaciclib,and investigated its anti-tumor effects in breast ***:Cellular viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** cloning and migration abilities were determined by colony formation assay and wound healing *** invasion abilities and adhesion were determined by cell invasion assay and cell adhesion *** impact of compound LA-D-B1 on cell proliferation and the cell cycle was analyzed through Western blotting,which quantified the levels of proteins associated with the cyclin-dependent kinase(CDK)4/6-cyclin D-Rb-E2F *** in vivo anti-tumor activity of compound LA-D-B1 was investigated using a chick chorioallantoic membrane(CAM)***:The study demonstrated that LA-D-B1 effectively suppressed breast cancer cell proliferation,induced apoptosis,and caused cell cycle ***,LA-D-B1 reduced the expression of key proteins in the CDK4/6-cyclin D-Rb-E2F pathway,including CDK4,CDK6 and *** results also indicated significant antitumor activity of LA-D-B1 in a transplanted tumor ***:In this study,LA-D-B1 demonstrated a potent anti-tumor effect by effectively suppressing cell proliferation and inhibiting cell cycle progression in breast *** findings highlight the potential of LA-D-B1 as a valuable compound for enhancing therapeutic outcomes and controlling the progression of breast cancer.

关键词： CDK4/6 inhibitor Breast cancer Antitumor activity Cell cycle

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Retrospective analysis based on a clinical grading system for patients with hepatic hemangioma:A single center experience

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2047-2053页

作者： cheng-Ming Zhou Jun Cao Shao-Ke chen Tuerhongjiang Tuxun Shadike Apaer Jing Wu Jin-Ming Zhao Hao Wen Department of Liver and Laparoscopic Surgery Digestive and Vascular Surgery CenterThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Operation Management The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of General Surgery The First Teaching CollegeXinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina

BACKGROUND The optimal approach for managing hepatic hemangioma is *** To evaluate a clinical grading system for management of hepatic hemangioma based on our 17-year of single institution *** A clinical grading system was retrospectively applied to 1171 patients with hepatic hemangioma from January 2002 to December *** were classified into four groups based on the clinical grading system and treatment:(1)Observation group with score0.05;χ^(2)=1.68,P>0.05).CONCLUSION This clinical grading system appeared as a practical tool for hepatic *** can be suggested for patients with a score≥*** those with<4,follow-up should be proposed.

关键词： Hepatic hemangioma Clinical grading system Surgical indication Outcome Postoperative complications

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Highly efficient 1D p-Te/2D n-Bi_(2)Te_(3) heterojunction self-driven broadband photodetector

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Nano Research 2024年第3期17卷 1864-1874页

作者： chenchen Zhao Dongbo Wang Jiamu Cao Zhi Zeng Bingke Zhang Jingwen Pan Donghao Liu Sihang Liu Shujie Jiao Tianyuan chen Gang Liu Xuan Fang Liancheng Zhao Jinzhong Wang School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China State Key Laboratory of High Power Semiconductor Lasers Changchun University of Science and TechnologyChangchun 130022China

Broadband photodetectors with self-driven functions have attracted intensive scientific interest due to their low energy consumption and high optical ***,high-performance broadband self-driven photodetectors are still a significant challenge due to the complex fabrication processes,environmental toxicity,high production costs of traditional 3D semiconductor materials and sharply raised contact resistance,severe interfacial recombination of 2D materials and 2D/3D mixed dimension ***,1D p-Te/2D n-Bi_(2)Te_(3) heterojunctions are constructed by the simple and low-cost hydrothermal method.1D p-Te/2D n-Bi_(2)Te_(3) devices are applied in photoelectrochemical(PEC)photodetectors,with their high performance attributed to the good interfacial contacts reducing interface *** device demonstrated a broad wavelength range(365–850 nm)with an Iph/Idark as high as *** R_(i),D^(*),and external quantum efficiency(EQE)values of the device were as high as 12.07 mA/W,5.87×10^(10) Jones,and 41.05%,respectively,which were significantly better than the performance of the prepared Bi_(2)Te_(3) and Te devices.A comparison of the freshly fabricated device and the device after 30 days showed that 1D p-Te/2D n-Bi_(2)Te_(3) had excellent stability with only 18.08%decay of *** is anticipated that this work will provide new emerging material for future design and preparation of a high-performance self-driven broadband photodetector.

关键词： topological insulating states interfacial recombination self-driven 1D p-Te/2D n-Bi_(2)Te_(3) photodetector

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Endoscopic ultrasound-guided biliary drainage vs percutaneous transhepatic bile duct drainage in the management of malignant obstructive jaundice

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1592-1600页

作者： Qin-Qin Zhu Bing-Fang chen Yue Yang Xue-Yong Zuo Wen-Hui Liu Ting-Ting Wang Yin Zhang Department of Gastroenterology The Third Affiliated Hospital of Soochow University(The First People’s Hospital of Changzhou)Changzhou 213000Jiangsu ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The Third Affiliated Hospital of Soochow University(The First People’s Hospital of Changzhou)Changzhou 213000Jiangsu ProvinceChina

BACKGROUND Malignant obstructive jaundice(MOJ)is a condition characterized by varying degrees of bile duct stenosis and obstruction,accompanied by the progressive development of malignant tumors,leading to high morbidity and mortality ***,the two most commonly employed methods for its management are percutaneous transhepatic bile duct drainage(PTBD)and endoscopic ultrasound-guided biliary drainage(EUS-BD).While both methods have demonstrated favorable outcomes,additional research needs to be performed to determine their relative *** compare the therapeutic effectiveness of EUS-BD and PTBD in treating *** This retrospective analysis,conducted between September 2015 and April 2023 at The Third Affiliated Hospital of Soochow University(The First People’s Hospital of Changzhou),involved 68 patients with *** patients were divided into two groups on the basis of surgical procedure received:EUS-BD subgroup(n=33)and PTBD subgroup(n=35).Variables such as general data,preoperative and postoperative indices,blood routine,liver function indices,myocardial function indices,operative success rate,clinical effectiveness,and complication rate were analyzed and compared between the *** In the EUS-BD subgroup,hospital stay duration,bile drainage volume,effective catheter time,and clinical effect-iveness rate were superior to those in the PTBD subgroup,although the differences were not statistically significant(P>0.05).The puncture time for the EUS-BD subgroup was shorter than that for the PTBD subgroup(P<0.05).Postoperative blood routine,liver function index,and myocardial function index in the EUS-BD subgroup were significantly lower than those in the PTBD subgroup(P<0.05).Additionally,the complication rate in the EUS-BD subgroup was lower than in the PTBD subgroup(P<0.05).CONCLUSION EUS-BD may reduce the number of punctures,improve liver and myocardial functions,alleviate traumatic stress,and decrease complication rates in MOJ treatment

关键词： Percutaneous hepatic biliary drainage Endoscopic ultrasound-guided biliary drainage Malignant obstructive jaundice Clinical effect Liver function Postoperative complications

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Al-Zn体系高压扭转过程中的相变机理

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材料导报 2024年第9期38卷 200-205页

作者：陈琛陈昱林苏璇卢璟钰于俊杰张建吉卫喜江南大学机械工程学院江苏无锡214122 江南大学江苏省食品制造装备重点实验室江苏无锡214122 江苏大学材料科学与工程学院江苏镇江212013

本工作对常温不互溶的Al-Zn体系进行了高压扭转下的机械合金化研究。将0.03 mm厚的纯Al和纯Zn交替堆叠,在3 GPa的压力下进行50圈的高压扭转处理。结果表明,高压扭转处理的Al-Zn合金中产生两种类型的相变,即晶体到非晶的相变,以及密排六... 详细信息

本工作对常温不互溶的Al-Zn体系进行了高压扭转下的机械合金化研究。将0.03 mm厚的纯Al和纯Zn交替堆叠,在3 GPa的压力下进行50圈的高压扭转处理。结果表明,高压扭转处理的Al-Zn合金中产生两种类型的相变,即晶体到非晶的相变,以及密排六方到面心立方的相变。局部高密度位错可能是Al-Zn合金从晶态转变到非晶态的主要原因,而HCP→FCC相变则归因为密排面原子沿晶界产生的Shockley不全位错的滑动。此外,本工作为深入研究Al-Zn合金的固态相变提供了一种新的途径,为提高铝锌合金的力学性能提供了新的思路。

关键词：高压扭转机械合金化相变铝锌合金

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