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α-Synuclein aggregation and transmission in Parkinson’s disease: a link to mitochondria and lysosome

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Science China(Life Sciences) 2020年第12期63卷 1850-1859页

作者： Rui Wang hongyang sun Haigang Ren Guanghui Wang Laboratory of Molecular Neuropathology Jiangsu Key Laboratory of Neuropsychiatric Diseases&Department of PharmacologyCollege of Pharmaceutical SciencesSoochow UniversitySuzhou 215123China

The presence of intraneuronal Lewy bodies(LBs) and Lewy neurites(LNs) in the substantia nigra(SN) composed of aggregatedα-synuclein(α-syn) has been recognized as a hallmark of pathological changes in Parkinson’s disease(PD). Numerous studies have shown that aggregated α-syn is necessary for neurotoxicity. Meanwhile, the mitochondrial and lysosomal dysfunctions are associated with α-syn pathogenicity. The hypothesis that α-syn transmission in the human brain contributes to the instigation and progression of PD has provided insights into PD pathology. This review will provide a brief overview of increasing researches that shed light on the relationship of α-syn aggregation with mitochondrial and lysosomal dysfunctions, and highlight recent understanding of α-syn transmission in PD pathology.

关键词： α-synuclein Lewy pathology mitochondria lysosome aggregation transmission

Incubation experiment demonstrates effects of carbon and nitrogen on microbial phosphate-solubilizing function

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Science China(Life Sciences) 2017年第4期60卷 436-438页

作者： hongyang sun Yanhong Wu Jun Zhou Haijian Bing Key Laboratory of Mountain Surface Process and Ecological Regulation Institute of Mountain Hazards and Environment Chinese Academy of Sciences

Dear Editor,Phosphorus(P)ultimately comes from rock weathering in natural ecosystems(Porder et al.,2007),and thus solubilization of rock phosphate plays a crucial ecological role in P supply for the ecosystems.Especially,microbial solubilization of rock phosphate is a vital process for the replenishment of available P in alpine ecosystems where the weathering degree of soil is low.The phosphate solubilizing microorganisms(PSM),major participants in the process,are directly

关键词： Figure PSE

Poly-PR in C9ORF72-Related Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Causes Neurotoxicity by Clathrin-Dependent Endocytosis

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Neuroscience Bulletin 2019年第5期35卷 889-900页

作者： Rui Wang Xingyun Xu Zongbing Hao Shun Zhang Dan Wu hongyang sun Chenchen Mu Haigang Ren Guanghui Wang Laboratory of Molecular Neuropathology Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology College of Pharmaceutical SciencesSoochow University

GGGGCC repeat expansions in the C9 ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia(c9 ALS/FTD). It has been reported that hexanucleotide repeat expansions in C9 ORF72 produce five dipeptide repeat(DPR) proteins by an unconventional repeat-associated non-ATG(RAN)translation. Within the five DPR proteins, poly-PR and poly-GR that contain arginine are more toxic than the other DPRs(poly-GA, poly-GP, and poly-PA). Here, we demonstrated that poly-PR peptides transferred into cells by endocytosis in a clathrin-dependent manner, leading to endoplasmic reticulum stress and cell death. In SH-SY5 Y cells and primary cortical neurons, poly-PR activated JUN amino-terminal kinase(JNK) and increased the levels of p53 and Bax. The uptake of poly-PR peptides by cells was significantly inhibited by knockdown of clathrin or by chlorpromazine, an inhibitor that blocks clathrin-mediated endocytosis. Inhibition of clathrin-dependent endocytosis by chlorpromazine significantly blocked the transfer of poly-PR peptides into cells, and attenuated poly-PRinduced JNK activation and cell death. Our data revealed that the uptake of poly-PR undergoes clathrin-dependentendocytosis and blockade of this process prevents the toxic effects of synthetic poly-PR peptides.

关键词： Amyotrophic lateral sclerosis C9ORF72 Poly-PR Clathrin ER stress

Air-drying changes the distribution of Hedley phosphorus pools in forest soils

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Pedosphere 2020年第2期30卷 272-284页

作者： Jipeng WANG Yanhong WU Jun ZHOU Haijian BING hongyang sun Ji LUO Shengyan PU Key Laboratory of Mountain Surface Processes and Ecological Regulation Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China

Hedley labile phosphorus(P)pools in soil tend to be several times larger than annual forest requirements,even in highly weathered soils characterized by P limitation.The discrepancy between plant and soil P status could be partly attributable to the frequently adopted air-drying pretreatment that tends to increase soil P solubility.In this study,the effects of air-drying on the distribution of Hedley P fractions were examined using soils collected under 4 forest types at Gongga Mountain,southwestern China.The results showed that the microbial biomass P(Pmic)in the organic horizon decreased markedly after air-drying.The concentrations of Hedley labile P in the air-dried samples were 31%–73%more than those in the field-moist samples.Consequently,the air-drying-induced increments of Hedley labile P pools in the surface soil horizons were 0.8–3.8 times the annual plant P requirements.The organic horizon was more susceptible to the air-drying-induced increases in Hedley labile P than the mineral horizon,probably because of the stronger release of Pmicand disruption of soil organic matter.The quality of P,indexed by the ratio of Hedley labile P to slowly cycling P,shifted in favor of the Hedley labile fractions after air-drying,further revealing that air-drying changed the distribution of Hedley P pools in forest soils.These indicated that the effects of air-drying could not be ignored when interpreting the discrepancy between the P status of plants and the Hedley labile P pools in forest soils.To more efficiently evaluate the P status in forest soils via the Hedley fractionation procedure,the use of field-moist soils is recommended.

关键词： Hedley fractionation labile phosphorus microbial biomass phosphorus phosphorous limitation slowly cycling phosphorus soil pretreatment

Range of applicability of real mode superposition approximation method for seismic response calculation of non-classically damped industrial buildings

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Earthquake Engineering and Engineering Vibration 2022年第2期21卷 475-488页

作者： Li Xiaodong sun hongyang Ji Xiaodong Sanjukta Chakraborty Wang Lijun Department of Civil Engineering Key Laboratory of Civil Engineering Safety and Durability of China Education MinistryTsinghua UniversityBeijing 100084China Central Research Institute of Building and Construction Co.Ltd Beijing 100088China Department of Civil Engineering Indian Institute of Technology PalakkadKerala 678557India Huachengboyuan Engineering Technology Group Beijing 100052China

An industrial building is a non-classically damped system due to the different damping properties of the primary structure and equipment.The objective of this paper is to quantify the range of applicability of the real model superposition approximation method to the seismic response calculation of industrial buildings.The analysis using lumped mass-and-shear spring models indicates that for the equipment-to-structure frequency ratiosγf>1.1 orγf0.07.Furthermore,extensive parametric analyses are conducted,where both steel structures and reinforced concrete structures with equipment with various damping ratios are considered.Finally,the finite element analysis of a five-story industrial building is adopted to validate the proposed range of applicability.

关键词： non-classical damping structure-equipment interaction real mode superposition approximation method complex mode superposition method seismic response calculation

饶河县森林和草原火灾风险普查结果分析及工作改善建议

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林业勘查设计 2024年第3期53卷 55-58页

作者：于鹏孙洪洋刘晓东黑龙江省自然资源权益调查监测院哈尔滨150080

根据黑龙江省饶河县第一次全国自然灾害综合风险普查工作的成果,全面掌握森林和草原火灾风险隐患,及重点区域抗灾能力等情况。结合饶河县森林和草原火灾风险的实际情况,给出提高自然灾害综合防治能力、做好森林和草原防火工作的建议。

关键词：森林火灾自然灾害风险隐患饶河县

Strongly coupled Te-SnS_(2)/MXene superstructure with self-autoadjustable function for fast and stable potassium ion storage

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Journal of Energy Chemistry 2021年第10期30卷 416-424,I0011页

作者： hongyang sun Yelong Zhang Xiaodan Xu Jianwen Zhou Fan Yang Hao Li Hao Chen Yucheng Chen Zheng Liu Zhenping Qiu Da Wang Lipo Ma Jiawei Wang Qingguang Zeng Zhangquan Peng School of Applied Physics and Materials Wuyi UniversityJiangmen 529020GuangdongChina Jiangmen Advanced Battery Material Engineering and Technology Research Center Jiangmen 529020GuangdongChina Laboratory of Advanced Spectro-Electrochemistry and Lithium-Ion Batteries Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Potassium-ion batteries(PIBs)are a promising candidate for next-generation electric energy storage applications because of the abundance and low cost of potassium.However,the development of PIBs is limited by sluggish kinetics and huge volume expansion of anodes,leading to poor rate capability and cycling stability.Herein,an advanced superstructure anode,including Te-doped SnS_(2) nanosheets uniformly anchored on MXene surface(Te-SnS_(2)/MXene),is rationally designed for the first time to boost K^(+)storage performance.Featuring with strong interface interaction and self-autoadjustable interlayer spacings,the Te-SnS_(2)/MXene can efficiently accelerate electron/ion transfer,accommodate volume expansion,inhibit crack formation,and improve pseudocapacitive contribution during cycling.Thus,the novel Te-SnS_(2)/MXene anode delivers a high reversible capacity(343.2 mAh g^(-1) after 50 cycles at0.2 A g^(-1)),outstanding rate capability(186.4 mAh g^(-1) at 20 A g^(-1)),long cycle stability(165.8 mAh g^(-1)after 5000 cycles at 10 A g^(-1) with a low electrode swelling rate of only 15.4%),and reliable operation in flexible full battery.The present Te-SnS_(2)/MXene becomes among the best transition metal-based anode materials for PIBs reported to date.

关键词： Tin disulfide MXene Tellurium doping Potassium-ion battery

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艺术设计的人性化特征再探究

鞋类工艺与设计 2024年第5期4卷 94-96页

作者：刘濠妮邓莹慧孙红阳东华理工大学江西南昌330013

随着设计渗透到日常生活的各个方面,人们审美观念的转变和市场对设计的需求变化,使得设计师们越来越注重将“以人为本”的设计理念融入艺术设计中,以更好地满足人们对设计的追求和需求。本文将从“以人为本”的设计理念出发,通过借助优... 详细信息

随着设计渗透到日常生活的各个方面,人们审美观念的转变和市场对设计的需求变化,使得设计师们越来越注重将“以人为本”的设计理念融入艺术设计中,以更好地满足人们对设计的追求和需求。本文将从“以人为本”的设计理念出发,通过借助优秀的艺术设计案例,阐述其中人性化设计的特点及表现,并对未来人性化设计的发展趋势进行展望。

关键词：艺术设计以人为本人性化

浅析02版和03版UN R117法规关于轮胎湿地抓着性能试验方法的差异

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中国汽车 2024年第1期 54-58页

作者：郭东东孙鸿洋王文军沙雷中汽研汽车检验中心(天津)有限公司天津300300

本文详细比较了UN R117《关于滚动噪声和/或湿路面抓地力和/或滚动阻力方面批准轮胎的统一规定》03版新内容与02版旧内容关于轮胎湿地抓着性能试验方法的差异。对于新旧版法规的路面条件、试验环境条件、车辆要求、试验胎压及载荷、试... 详细信息

本文详细比较了UN R117《关于滚动噪声和/或湿路面抓地力和/或滚动阻力方面批准轮胎的统一规定》03版新内容与02版旧内容关于轮胎湿地抓着性能试验方法的差异。对于新旧版法规的路面条件、试验环境条件、车辆要求、试验胎压及载荷、试验数据约束和试验数据计算方法等做了详细对比分析,并对比新旧版法规下不同类型轮胎使用拖车法试验的计算结果的差异。

关键词：轮胎湿地抓着性能新旧版标准差异