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颈髓血管母细胞瘤一例

中华病理学杂志 2018年第1期47卷 65-66页

作者：卜虹妍李晓菊王康敏魏亚权常文民周晓军西安金域医学检验所有限公司 710018 西安市红会医院病理科解放军南京总医院病理科

患者女,54岁.因左肩部酸痛1个月,加重伴右肘部麻木疼痛半个月于2017年2月6日入院.患者于1个月前无明显诱因出现左肩部酸胀、疼痛,给予贴敷膏药后好转.半个月前左肩部酸胀加重,同时出现右肘部麻木、疼痛,疼痛呈夜间痛、咳嗽痛,白天活动... 详细信息

患者女,54岁.因左肩部酸痛1个月,加重伴右肘部麻木疼痛半个月于2017年2月6日入院.患者于1个月前无明显诱因出现左肩部酸胀、疼痛,给予贴敷膏药后好转.半个月前左肩部酸胀加重,同时出现右肘部麻木、疼痛,疼痛呈夜间痛、咳嗽痛,白天活动后缓解.体检：四肢活动可,肌力、肌张力无异常,左肩部压痛,右肘部压痛明显.

关键词：血管母细胞瘤颈髓肩部酸痛左肩部四肢活动疼痛肘部夜间痛

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远程病理诊断的应用进展

临床与病理杂志 2019年第1期39卷 198-202页

作者：卜虹妍韩晓锐魏亚权王康敏西安金域医学检验所有限公司西安710018

远程病理会诊已成为现代医学不可缺少的一个平台,其发展主要历经了3种模式:静态图像、遥控自动化显微镜及数字化病理切片。数字化病理切片的出现,实现可视化数据的永久储存和不受时空限制的同步浏览处理,已广泛应用于病理学的各个领域。

关键词：远程病理远程医学静态图像遥控自动化显微镜数字化病理切片

COPD合并焦虑、抑郁的血清生物标志物研究

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国际呼吸杂志 2017年第12期37卷 926-932页

作者：窦静波庞红燕李云芳卜小宁杨媛华杨汀北京市普仁医院呼吸内科 100062 首都医科大学附属北京朝阳医院呼吸与危重症医学科 100020 中日友好医院呼吸与危重症医学科北京100029

目的寻找 COPD 患者合并焦虑抑郁可能的生物标记物。分析生物标志物在鉴别 COPD患者是否合并焦虑抑郁状态的应用价值,多指标联合检测是否能提高其诊断价值。方法选取 2015年1月1日至8月31日在北京朝阳医院呼吸... 详细信息

目的寻找 COPD 患者合并焦虑抑郁可能的生物标记物。分析生物标志物在鉴别 COPD患者是否合并焦虑抑郁状态的应用价值,多指标联合检测是否能提高其诊断价值。方法选取 2015年1月1日至8月31日在北京朝阳医院呼吸与危重症医学科门诊就诊以及住院的 COPD 患者, 应用医院焦虑抑郁量表筛选出存在焦虑抑郁状态 COPD 患者37例作为 COPD 合并焦虑抑郁组,另选取不合并焦虑抑郁的 COPD患者40例作为对照组。检测目前国内外报道过的焦虑抑郁患者及健康对照人群间差异有统计学意义的指标：IL-6、肿瘤坏死因子α （TNF-α）、纤维蛋白原（FIB）和表皮生长因子（EGF）,对结果进行统计学分析。结果 COPD 合并焦虑抑郁组和对照组间 FIB、EGF、IL-6和 TNF-α差异有统计学意义（P ＜0.05）,FIB在 COPD 合并焦虑抑郁组显著低于对照组,EGF、IL-6 和 TNF-α在 COPD合并焦虑抑郁组显著高于对照组。FIB、TNF-α、IL-6和 EGF的 ROC曲线下面积（AUC）分别为0.715、0.688、0.681和0.633,单项指标中以 FIB的 AUC最大,多指标联合应用诊断合并焦虑抑郁的价值优于单项指标。结论 FIB、TNF-α、IL-6和 EGF可作为 COPD 患者合并焦虑抑郁的生物标记物,应用多指标联合检验可提高诊断价值。

关键词：慢性阻塞性肺疾病焦虑抑郁生物标志物炎症因子

异机融合^(18)F-FDG PET/MRI对肾透明细胞癌WHO/ISUP病理分级预测价值

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武汉大学学报(医学版) 2025年第1期46卷 41-47页

作者：姜双士刘烜利周莹冯洪燕王科涂宁谢新立韩芳卜丽红武汉大学人民医院PET中心湖北武汉430060 大连大学附属中山医院PET中心辽宁大连116001 郑州大学第一附属医院核医学科河南郑州450052

目的:探讨异机融合^(18)F-FDG PET/MRI对肾透明细胞癌(ccRCC)WHO/ISUP病理分级的预测价值。方法:回顾性分析2018年3月至2023年3月于武汉大学人民医院PET中心行异机融合^(18)F-FDG PET/MRI的57例经病理证实的ccRCC患者的临床及影像资料... 详细信息

目的:探讨异机融合^(18)F-FDG PET/MRI对肾透明细胞癌(ccRCC)WHO/ISUP病理分级的预测价值。方法:回顾性分析2018年3月至2023年3月于武汉大学人民医院PET中心行异机融合^(18)F-FDG PET/MRI的57例经病理证实的ccRCC患者的临床及影像资料并分为低级别组(WHO/ISUP分级Ⅰ~Ⅱ级,33例)及高级别组(WHO/ISUP分级Ⅲ~Ⅳ级,24例)。使用χ^(2)检验、两独立样本t检验或Mann-Whitney U检验分析两组间各参数差异。并采用二元logistic回归分析联合ROC曲线评价异机融合^(18)F-FDG PET/MRI术前预测WHO/ISUP病理分级的诊断效能。结果:低级别与高级别组患者间病灶出血坏死、静脉癌栓、MTV、TLG及TLR的差异具有统计学意义(均PTLR>TLG>MTV>出血坏死>静脉癌栓,其中联合诊断肾透明细胞癌WHO/ISUP病理分级价值最高,AUC值为0.817(95%CI:0.692~0.907),灵敏度为75.0%,特异度81.8%。结论:异机融合^(18)F-FDG PET/MRI在预测ccRCCWHO/ISUP病理分级中具有重要价值,且TLR的预测价值最高。同时联合PET参数(MTV、TLG)以及MRI特征(出血坏死、静脉癌栓)可大大提高ccRCC患者病理肿瘤分级预测价值,改善患者生存预后。

关键词：肾透明细胞癌病理分级氟脱氧葡萄糖F18 正电子发射断层显像磁共振成像

Integrating geographical data and phenological characteristics derived from MODIS data for improving land cover mapping

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Journal of Geographical Sciences 2011年第4期21卷 705-718页

作者： CAI hongyan ZHANG Shuwen bu Kun YANG Jiuchun CHANG Liping Northeast Institute of Geography and Agroecology CAS Changchun 130012 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

The study developed a feasible method for large-area land cover mapping with combination of geographical data and phenological characteristics, taking Northeast China （NEC） as the study area. First, with the monthly average of precipitation and temperature datasets, the spatial clustering method was used to divide the NEC into four ecoclimate regions. For each ecoclimate region, geographical variables （annual mean precipitation and temperature, elevation, slope and aspect） were combined with phenological variables derived from the moderate resolution imaging spectroradiometer （MODIS） data （enhanced vegetation index （EVI） and land surface water index （LSWI））, which were taken as input variables of land cover classification. Decision Tree （DT） classifiers were then performed to produce land cover maps for each region. Finally, four resultant land cover maps were mosaicked for the entire NEC （NEC_MODIS）, and the land use and land cover data of NEC （NEC_LULC） interpreted from Landsat-TM images was used to evaluate the NEC_MODIS and MODIS land cover product （MODIS_IGBP） in terms of areal and spatial agreement. The results showed that the phenological information derived from EVI and LSWI time series well discriminated land cover classes in NEC, and the overall accuracy was significantly improved by 5.29% with addition of geographical variables. Compared with NEC_LULC for seven aggregation classes, the area errors of NEC_MODIS were much smaller and more stable than that of MODIS_IGBP for most of classes, and the wall-to-wall spatial comparisons at pixel level indicated that NEC_MODIS agreed with NEC_LULC for 71.26% of the NEC, whereas only 62.16% for MODIS_IGBP. The good performance of NEC_MODIS demonstrates that the methodology developed in the study has great potential for timely and detailed land cover mapping in temperate and boreal regions.

关键词： geographical data vegetation phenology MODIS land cover Northeast China

Acupuncture at Kǒngzuì (孔最LU 6) for 76 cases of hemorrhoids

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World Journal of Acupuncture-Moxibustion 2018年第1期28卷 68-69,I0010页

作者： Xiuye LI He bu Yao MA hongyan LV Acupuncture-moxibustion Department of The Second Affiliated Hospital of Baotou Medical College Baotou 014030 Inner Mongolia Province China

Objective： To observe the effect of acupuncture at Kǒngzuì（孔最LU 6） for ***： Seventy six cases of hemorrhoids patients, 19 cases were diagnosed with internal hemorrhoids,25 cases were diagnosed with external hemorrhoids, 32 cases were diagnosed with mixed hemorrhoids,they were treated with acupuncture. Kongzui（孔最LU 6） was perpendicular inserted bilaterally with a depth of 0.5-1 cun, and reducing manipulation was performed. Treatment of 24 days were given and the improvement of hemorrhage and pain, the reducement of size of hemorrhoids and the recurrence were compared before and after treatment to evaluate the clinical ***： Sixty eight cases were cured, which accounted for 86.5%, six cases were effective, which accounted for 7.9%, two cases were ineffective, which accounted for 2.6%.Conclusion： Acupuncture at Kǒngzui（孔最LU 6） bilaterally has sound effect for treatment of internal hemorrhoids, external hemorrhoids and mixed hemorrhoid.

关键词： Acupuncture Kǒngzuì(孔最LU 6) Hemorrhoids

Acupuncture-moxibustion therapy of "banking up original qi and consolidating the foundation" for prevention and treatment of seasonal allergic rhinitis:A randomized controlled trial

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World Journal of Acupuncture-Moxibustion 2018年第1期28卷 33-37,I0005,I0006页

作者： Yao MA He bu Xiuye LI hongyan L Xue ZHANG Acupuncture-Moxibustion Department The Second Affiliated Hospital of Baotou Medical College Baotou 014030 Inner Mongolia Province China

Objective： To observe the clinical efficacy of acupuncture-moxibustion therapy of ＂banking up original qi and consolidating the foundation＂ for prevention and treatment of seasonal allergic ***： Sixty included patients were divided into two groups according to the random number table method with 30 patients in each group. In acupuncture group, warming-needle moxibustion was carried out at Zúsānlǐ（足三里ST 36）, and cone moxibustion on Fùzǐ（附子Radix Aconiti Lateralis Praeparata） cake was conducted at Guānyuán（关元CV 4）, Qìhǎi（气海CV 6） and Dàzhuī（大椎GV 14）. The treatment was conducted in May or June（2 months before the onset of rhinitis in this area）. The treatment was carried out for once every other day and three times per week. Treatment for 24 times was considered as 1 course of treatment. No intervention treatment was conducted in control group. The score of rhinitis symptom, the visual analogue scale（VAS） score changes of total nasal symptom score（TNSS） and total non-nasal symptom score（TNNSS） of patients in 2015 and in 2016 were observed, and the clinical efficacy of the two groups was ***：（1） The score of rhinitis symptom, the VAS score changes of TNSS and TNNSS in acupuncture group in 2016 declined when compared with the results in 2015, which were 4.57 ±0.82 vs 9.40 ± 1.89,13.37 ± 4.01 vs 30.80 ±4.77 and 15.93 ±6.30 vs 46.13 ± 9.79（P〈 0.001）, the results in acupuncture group after treatment were lower than that in control group at same time, which were 4.57 ±0.82 vs 7.53 ±2.06,13.37±4.01 vs 27.17±6.84,15.93±6.30 vs 35.53±11.69（all P〈0.001）. According to comparison, there was no obvious difference in the results in control group at the two time points, which were 8.60 ±2.39 vs7.53 ± 2.06, 29.63 ± 6.30 vs 27.17 ± 6.84 and 40.90 ±12.31 vs 35.53± 11.69（all P〉 0.05）.（2） The total effective rate was 96.7%（29/30） in acupuncture group and 10%（3/30） in control group, and the difference was statistically significant（P〈 0.001）.Conclusion： Acupuncture-m

关键词： Acupuncture-moxibustion Seasonal allergic rhinitis Prevent disease before it arises Bank up original qi and consolidate the foundation

1例自身免疫性郎飞结病MRI及^(18)F-FDG PET/CT表现

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中国医学影像技术 2024年第1期40卷 149-150页

作者：涂宁冯洪燕卜丽红武汉大学人民医院PET中心湖北武汉430060

患者男,42岁,18个月前因“双下肢酸胀乏力”于外院确诊“自身免疫性郎飞结病”并接受利妥昔单抗、醋酸泼尼松及免疫球蛋白治疗,近1个月症状加重;既往体健。查体:双下肢肌肉稍萎缩,肌力3级,左膝及以下、右侧大腿及以下感觉减退,双侧直腿... 详细信息

患者男,42岁,18个月前因“双下肢酸胀乏力”于外院确诊“自身免疫性郎飞结病”并接受利妥昔单抗、醋酸泼尼松及免疫球蛋白治疗,近1个月症状加重;既往体健。查体:双下肢肌肉稍萎缩,肌力3级,左膝及以下、右侧大腿及以下感觉减退,双侧直腿抬高试验阳性。

关键词：朗飞结自身免疫正电子发射断层显像

论《回到教育的未来》未来观与方法论——兼论“情景分析法”何以是理解国际未来教育的新思维

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比较教育研究 2024年第11期46卷 65-75页

作者：陈红燕卜玉华华东师范大学国际与比较教育研究所上海200062 华东师范大学基础教育改革与发展研究所上海200062

《回到教育的未来》是经济合作与发展组织发布的面向2040年未来教育发展的报告。已有研究聚焦于对其“四幅图景”的内容性描绘与批判,缺乏底层逻辑反思。通过分析报告中未来观与方法论的转变发现:西方未来教育观早已摆脱未来宿命论和不... 详细信息

《回到教育的未来》是经济合作与发展组织发布的面向2040年未来教育发展的报告。已有研究聚焦于对其“四幅图景”的内容性描绘与批判,缺乏底层逻辑反思。通过分析报告中未来观与方法论的转变发现:西方未来教育观早已摆脱未来宿命论和不可知论,转向前瞻性未来思维范式;报告使用的“情景分析法”是典型的前瞻性研究工具,其目的并非描绘静态的未来学校图景,而是以“未来图景”为对话对象与思维支架,以期更好地理解当下及变革的风险。因此,解读本报告时需要转换认识论范式,理解“四幅图景”的创制思路、了解图景背后的潜在驱动力、模型构建的内在逻辑、可能性风险与问题等。如此,才能真正把握其要义。

关键词：经济合作与发展组织未来教育前瞻性未来情景分析法