检索结果-南通市图书馆

The application and perspective of NMR and MS based strategies for functional compounds mining in medicinal and dietary plants

引用

Food Science and Human Wellness 2024年

作者： Bodou Zhang Sheng Li Zhenzhen Liang Yinling Wei Jing Dong hongyan wen Lingli Guo Xiaojiang Hao Yu Zhang University of Chinese Academy of Sciences State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Medicinal and dietary plants provide numerous nutritional and functional compounds and also have various potential health benefits to humanity. The specific and efficient techniques for accurate identification of nutritional compounds and functional metabolites is crucial for the development of functional foods from medicinal and dietary plants. Nuclear magnetic resonance (NMR) and mass spectrometry (MS) are indispensable and essential technologies that provide an unsurpassed wealth of untargeted identification， quantitative and qualitative analysis， and structural information in the study of food and plant products. In the past decade， the rapid development of modern analytical technology has led to the emergence of new approaches and strategies for natural products discovery. Especially the application of novel NMR- and MS-based identification and dereplication strategies aided by artificial intelligence and machine learning algorithms have brought about a significant shift in the natural products discovery process. These developments and changes in the natural products filed have given us insights into how to accurately target and mining nutritional， functional， and bioactive compounds. Thus， we have summarized recent research on novel NMR and MS based strategies and methods focusing on functional compounds， accurate identification and efficient discovery mainly in medicinal and dietary plants. This review could provide a comprehensive perspective for a better understanding of novel strategies and methods based on NMR and MS technologies， which could provide valuable insights and ideas for functional compounds mining.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protein crystallization with DNA templates

引用

Particuology 2024年第3期86卷 262-268页

作者： Bo Zhang Jia Yu Zhe Pu wenhui Guo Ruoqi Yang Yu wen Zhijiang Rong Hui Wang Xiaoli Wu Bo Wang hongyan Sun School of Environment and Resources Taiyuan University of Science and TechnologyTaiyuan030024China School of Chemical Engineering and Technology Taiyuan University of Science and TechnologyTaiyuan030024China

Protein crystallization plays a significant role in three-dimensional structural analysis and protein pu-rification.It is important to increase the crystallization efficiency,which is possible by adding hetero-geneous templates in crystallization systems.DNA is biologically compatible and artificially designable polymer,which is easy to extract.In this study,single-and double-stranded DNA of precise sequences were designed and used as templates to promote protein crystallization of lysozyme and catalase.In-fluence of DNA,single-stranded DNA with 10,20,40 bases and double-stranded DNA with 10,20,40 base pairs,were investigated.The success rate of obtaining crystals of lysozyme and catalase in equal period was significantly improved with the addition of DNA comparing without templates added.Double-stranded DNA led to higher nucleation rate than that with single-stranded DNA.The promotion of nucleation was more obvious at low concentration of protein solution and with longer chain DNA templates.Crystal number and crystallization rate was enhanced with addition of long double-stranded DNA templates.All the results confirm that DNA is an effective polymer additive to enhance protein crystallization,especially for the application of the scarce protein crystallization.

关键词： DNA Polymer Additive Protein Crystallization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

细胞凋亡在纤维化疾病中调控作用的研究进展

引用

中华内科杂志 2024年第7期63卷 716-719页

作者：张少晨郭容宏张婷婷温鸿雁山西医科大学第二医院风湿免疫科太原

纤维化疾病是由于机体受到多种刺激因子的作用, 肌成纤维细胞活化或发生表型转化, 使胶原蛋白表达增加及细胞外基质过度沉积, 最终导致器官结构和功能受损的一类疾病。目前国内外的研究已证明, 细胞凋亡在纤维化疾病的发病机制中发挥至... 详细信息

纤维化疾病是由于机体受到多种刺激因子的作用, 肌成纤维细胞活化或发生表型转化, 使胶原蛋白表达增加及细胞外基质过度沉积, 最终导致器官结构和功能受损的一类疾病。目前国内外的研究已证明, 细胞凋亡在纤维化疾病的发病机制中发挥至关重要的作用。本文对细胞凋亡在心、肝、肺、肾、皮肤和骨髓等纤维化疾病中的作用进行综述, 有助于揭示纤维化疾病的发病机制, 并为寻求新的诊断和治疗方法提供理论依据。

关键词：细胞凋亡纤维化疾病细胞因子

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

多任务推荐算法研究综述

引用

计算机科学与探索 2024年第2期18卷 363-377页

作者：温民伟梅红岩袁凤源张晓宇张兴辽宁工业大学电子与信息工程学院辽宁锦州121001

单任务推荐算法存在数据稀疏、冷启动和推荐效果不稳定等问题。多任务推荐算法可以将多种类型的用户行为数据和额外信息进行联合建模,从而更好地挖掘用户的兴趣和需求,以提高推荐效果和用户满意度,为解决单任务推荐算法存在的一系列问... 详细信息

单任务推荐算法存在数据稀疏、冷启动和推荐效果不稳定等问题。多任务推荐算法可以将多种类型的用户行为数据和额外信息进行联合建模,从而更好地挖掘用户的兴趣和需求,以提高推荐效果和用户满意度,为解决单任务推荐算法存在的一系列问题提供了新思路。首先,梳理了多任务推荐算法的发展背景与趋势。其次,介绍了多任务推荐算法的实现步骤以及构建原则,并阐述了多任务学习具有数据增强、特征识别、特征互补和正则化效应等优势。然后,对不同共享模式的多任务学习方法在推荐算法中的应用进行了介绍,并对部分经典模型的优缺点及任务之间的关系进行了归纳总结。接着,介绍了多任务推荐算法常用的数据集和评估指标,并阐述了与其他推荐算法在数据集合评估指标方面的区别和联系。最后,指出多任务学习存在负迁移、参数优化冲突、可解释性差等不足,对多任务推荐算法与强化学习、凸函数优化方法、异构信息网络相结合进行了展望。

关键词：推荐系统多任务学习多任务推荐

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

盐津乌骨鸡与瓢鸡屠宰性能与肉品质的比较

引用

食品工业科技 2024年第12期45卷 241-247页

作者：杨源荀文廖国周杨春芳吴红艳葛长荣王桂瑛云南农业大学食品科学技术学院云南昆明650201 云南农业大学云南省畜产品加工工程技术研究中心云南昆明650201

为探讨盐津乌骨鸡与瓢鸡屠宰性能及肉质理化特性差异,以300日龄盐津乌骨鸡与瓢鸡为对象,对两个品种间的屠宰性能、感官与常规理化指标进行测定与比较分析。结果表明:盐津乌骨鸡与瓢鸡均具有良好肉用性能,雌性盐津乌骨鸡的胸肌率显著高... 详细信息

为探讨盐津乌骨鸡与瓢鸡屠宰性能及肉质理化特性差异,以300日龄盐津乌骨鸡与瓢鸡为对象,对两个品种间的屠宰性能、感官与常规理化指标进行测定与比较分析。结果表明:盐津乌骨鸡与瓢鸡均具有良好肉用性能,雌性盐津乌骨鸡的胸肌率显著高于雄性盐津乌骨鸡和瓢鸡(P<0.05);同一品种雄鸡的宰前体重、屠体重、全净膛重、胸肌重、腿肌重和腿肌率高于雌鸡(P<0.05),屠宰性能更好。两个品种鸡肉的外观评分均较高(6.30~7.30分),腿肉较胸肉有更高的香味、质地、滋味和总体接受性评分。两个品种鸡宰后pH均在优质鸡范围内,瓢鸡腿肉的蒸煮损失率、水分含量、粗灰分、粗脂肪均显著高于盐津乌骨鸡(P<0.05)。同一品种不同部位组间,腿肉的蒸煮损失(P<0.05)和粗蛋白含量(P<0.05)低于胸肉;而水分(P<0.05)和粗脂肪(P<0.05)含量高于胸肉。本研究为两种优良地方鸡种的深度开发利用提供科学理论依据,也为云南优质地方鸡品质评价标准的建立奠定基础。

关键词：盐津乌骨鸡瓢鸡屠宰性能肉品质

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于多光谱图像的小麦种子形态和成分性状的自动化检测算法开发

引用

植物生理学报 2024年第4期60卷 739-752页

作者：李鸿岩戴杰周洁闻桢杰 Phil Howell 周济南京农业大学前沿交叉研究院/工学院/作物表型组学交叉研究中心南京210095 英国国立农业植物研究所/剑桥作物研究中心英国剑桥CB3OLE

在全球气候变化加剧的背景下,小麦(Triticum aestivum)产量与中国粮食安全密切相关,因此,基于小麦种子外部形态与内部成分的快速、无损检测对高通量鉴定其品质和活力意义重大。针对当前种子检测通量及准确性的限制,本研究通过多学科融合... 详细信息

在全球气候变化加剧的背景下,小麦(Triticum aestivum)产量与中国粮食安全密切相关,因此,基于小麦种子外部形态与内部成分的快速、无损检测对高通量鉴定其品质和活力意义重大。针对当前种子检测通量及准确性的限制,本研究通过多学科融合,结合多光谱成像、计算机视觉、自动化图像处理等技术,开发了一种通过多光谱图像从近百粒种子中快速提取单粒、并在单粒尺度完成外部形态(如种子面积、长度、宽度与圆度等)和内部物质成分(如植物色素、淀粉、植物油脂与水分含量等)量化分析的算法。针对所选的15个小麦品种,算法对1 347粒种子形态性状的分析结果与人工测量结果间的决定系数(R2)为面积0.900 (RMSE=1.504)、长度0.981 (RMSE=0.188)、宽度0.911 (RMSE=0.795);对513粒种子的六个关键光谱波段的R2为0.973、0.970、0.983、0.953、0.891、0.893;以上P值均小于0.005。在此基础上,通过形态与光谱性状的聚类和主成分分析,本研究还构建了区分不同品种小麦种子的分类方法,进而探索了重要种子农艺性状(如种子破损区域及种胚检测等)的自动鉴选算法,为种子活力和品质的高通量检测研究提供了新思路和新方法。

关键词：种子形态分析种子成分表征多光谱成像技术自动化图像处理小麦

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of chemical composition on the element distribution,phase composition and calcification roasting process of vanadium slag

引用

International Journal of Minerals,Metallurgy and Materials 2022年第12期29卷 2144-2151页

作者： Tangxia Yu Tao Jiang Jing wen hongyan Sun Ming Li Yi Peng State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization Panzhihua 617000China School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Mineral of Ministry of Education Northeastern UniversityShenyang 110819China Liaoning Key Laboratory for Metallurgical Sensor and Technology Shenyang 110819China

The chemical composition of vanadium slag significantly affects its element distribution and phase composition,which affect the subsequent calcification roasting process and vanadium recovery.In this work,seven kinds of vanadium slags derived from different regions in China were used as the raw materials to study the effects of different components on the vanadium slag’s elements distribution,phase composition,calcification roasting,and leaching rate of major elements using scanning electron microscope,X-ray diffraction analysis,and inductively coupled plasma-optical emission spectroscopy.The results show that the spinel phase is wrapped with silicate phase in all vanadium slag samples.The main elements in the spinel phase are Cr,V,and Ti from the interior to the exterior.The size of spinel phase in low chromium vanadium slag is larger than the other vanadium slags with higher chromium contents.The spinel phase of high-calcium and high-phosphorus vanadium slag is more dispersed.The strongest diffraction peak of vanadium spinel phase in the vanadium slag migrates to a higher diffraction angle,and(Fe_(0.6)Cr_(0.4))_(2)O_(3)is formed after calcification roasting as the chromium content increased.A large amount of Ca_(2)SiO_(4)is produced because excess Ca reacts with Si in high-calcium and high-phosphorus vanadium slag.The vanadium leaching rate reaches 88%in some vanadium slags.The chromium leaching rate is less than 5%in all vanadium slags.The silicon leaching rate of high-calcium and high-phosphorus vanadium slag is much higher than that of the other slags.The leaching rate of manganese is higher than 10%,and the leaching rates of iron and titanium are negligible.

关键词： vanadium slag calcification roasting element distribution phase composition leaching rate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of the interface reaction behaviors of CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) solid-state systems based on the diffusion couple method

引用

International Journal of Minerals,Metallurgy and Materials 2023年第5期30卷 834-843页

作者： Jing wen hongyan Sun Tao Jiang Bojian Chen Fangfang Li Mengxia Liu School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China Liaoning Key Laboratory for Metallurgical Sensor and Technology Shenyang 110819China

The formation mechanism of calcium vanadate and manganese vanadate and the difference between calcium and manganese in the reaction with vanadium are basic issues in the calcification roasting and manganese roasting process with vanadium slag.In this work,CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples were prepared and roasted for different time periods to illustrate and compare the diffusion reaction mechanisms.Then,the changes in the diffusion product and diffusion coefficient were investigated and calculated based on scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS) analysis.Results show that with the extension of the roasting time,the diffusion reaction gradually proceeds among the CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples.The regional boundaries of calcium and vanadium are easily identifiable for the CaO–V_(2)O_(5) diffusion couple.Meanwhile,for the MnO_(2)–V_(2)O_(5) diffusion couple,MnO_(2) gradually decomposes to form Mn_(2)O_(3),and vanadium diffuses into the interior of Mn_(2)O_(3).Only a part of vanadium combines with manganese to form the diffusion production layer.CaV_(2)O_(6) and MnV_(2)O_(6) are the interfacial reaction products of the CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples,respectively,whose thicknesses are 39.85 and 32.13μm when roasted for 16 h.After 16 h,both diffusion couples reach the reaction equilibrium due to the limitation of diffusion.The diffusion coefficient of the CaO–V_(2)O_(5) diffusion couple is higher than that of the MnO_(2)–V_(2)O_(5) diffusion couple for the same roasting time,and the diffusion reaction between vanadium and calcium is easier than that between vanadium and manganese.

关键词： solid-state reaction reaction regularity of calcium and vanadium reaction regularity of manganese and vanadium diffusion couple method interface reaction behavior

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

晋陕峡谷苏家岭和清水川口旧石器地点黄土地层释光年代与古环境

引用

第四纪研究 2024年第2期44卷 453-465页

作者：文再忠鹿化煜王社江弋双文张改课石道明张红艳南京大学地理与海洋科学学院江苏南京210023 陕西省考古研究院陕西西安710054 中国科学院古脊椎动物与古人类研究所中国科学院脊椎动物演化与人类起源重点实验室北京100044

在黄河中游晋陕峡谷地区发现了多处旧石器遗存,但是,这些重要的遗址点大多缺乏年代约束。新发现的苏家岭和清水川口旧石器地点位于陕西一侧黄河二、三级阶地上,黄土堆积中出土的石器类型以“石核-石片技术”组合为主要特征。本研究采集... 详细信息

在黄河中游晋陕峡谷地区发现了多处旧石器遗存,但是,这些重要的遗址点大多缺乏年代约束。新发现的苏家岭和清水川口旧石器地点位于陕西一侧黄河二、三级阶地上,黄土堆积中出土的石器类型以“石核-石片技术”组合为主要特征。本研究采集了苏家岭(黄土堆积厚度17.1 m)和清水川口(黄土堆积厚度4.7 m)共14个光释光样品,采用石英单片再生剂量法(SAR-OSL)和钾长石红外后释光法(pIR200IR290)测定了两个遗址点黄土序列的年代,同时测试了沉积物样品的粒度和磁化率。结果表明,两处沉积物主体均为典型的风成黄土。石英SAR-OSL年龄与钾长石pIR200IR290年龄在25~50 ka有很好的对应关系,钾长石年龄与S1古土壤的预期年龄(MIS 5)相一致。苏家岭出土的石器所在地层年代范围为25~76 ka,洪积层的石核年代在76~95 ka间;清水川口出土的石器年代范围为31~42 ka。地层特征、磁化率和粒度证据表明,在晚更新世间冰阶和末次间冰期末期,晋陕峡谷地区相对暖湿的气候条件利于远古人类生存;同时,黄土高原南部苏家岭与北部清水川口的古环境存在区域的差异。苏家岭和清水川口地点出土的“石核-石片技术”组合表明,晚更新世古人类在中国北方广阔的区域活动,中国中部是晚更新世人类栖居的良好场所。

关键词：旧石器地点光释光测年黄土地层晚更新世古人类黄土高原

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of mitophagy in the hallmarks of aging

引用

The Journal of Biomedical Research 2023年第1期37卷 1-14页

作者： Jie wen Tingyu Pan hongyan Li Haixia Fan Jinhua Liu Zhiyou Cai Bin Zhao Department and Institute of Neurology Guangdong Medical UniversityZhanjiangGuangdong 524001China Guangdong Key Laboratory of Aging-related Cardiac and Cerebral Diseases ZhanjiangGuangdong 524001China Chongqing Key Laboratory of Neurodegenerative Diseases Chongqing 400013China Department of Neurology Chongqing General HospitalChongqing 400013China Department of Neurology the Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Chongqing Medical University Chongqing 400042China

Aging, subjected to scientific scrutiny, is extensively defined as a time-dependent decline in functions that involves the majority of organisms. The time-dependent accretion of cellular lesions is generally a universal trigger of aging, while mitochondrial dysfunction is a sign of aging. Dysfunctional mitochondria are identified and removed by mitophagy, a selective form of macroautophagy. Increased mitochondrial damage resulting from reduced biogenesis and clearance may promote the aging process. The primary purpose of this paper is to illustrate in detail the effects of mitophagy on aging and emphasize the associations between mitophagy and other signs of aging, including dietary restriction, telomere shortening, epigenetic alterations, and protein imbalance.The evidence regarding the effects of these elements on aging is still limited. And although the understanding of relationship between mitophagy and aging has been long-awaited, to analyze details of such a relationship remains the main challenge in aging studies.

关键词： mitophagy aging dietary restriction telomere shortening epigenetic alterations protein imbalance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：