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Near-infrared light triggered multi-hit therapeutic nanosystem for tumor specific photothermal effect amplified signal pathway regulation and ferroptosis

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Bioactive Materials 2022年第3期7卷 63-76页

作者： He Lian Ping Guan hongyan tan Xiaoshu Zhang Zhaoxu Meng Department of Biomedical Engineering School of Medical InstrumentationShenyang Pharmaceutical UniversityShenyang110016China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang110016China School of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang110016China

The high therapeutic resistance of tumor is the primary cause behind tumor recurrence and incurability.In recent years,scientists have devoted themselves to find a variety of treatments to solve this problem.Herein,we propose a multi-hit strategy that is based on the biodegradable hollow mesoporous Prussian blue(HMPB)-based nanosystem for tumor-specific therapy that encapsulated the critical heat shock protein 90(HSP90)inhibitor 17-dimethylamino-ethylamino-17-demethoxydeldanamycin(17-DMAG).The nanosystem was further modified using thermotropic phase transition material star-PEG-PCL(sPP)and hyaluronic acid(HA),which offers near infrared light(NIR)responsive release characteristic,as well as enhanced tumor cell endocytosis.Upon cell internalization of 17-DMAG-HMPB@sPP@HA and under 808 nm laser irradiation,photothermal-conversion effect of HMPB directly kills cells using hyperthermia,which further causes phase transition of sPP to trigger release of 17-DMAG,inhibits HSP90 activity and blocks multiple signaling pathways,including cell cycle,Akt and HIF pathways.Additionally,the down-regulation of GPX4 protein expression by 17-DMAG and the release of ferric and ferrous ions from gradual degradation of HMPB in the endogenous mild acidic microenvironment in tumors promoted the occurrence of ferroptosis.Importantly,the antitumor effect of 17-DMAG and ferroptosis damage were amplified using photothermal effect of HMPB by accelerating release of ferric and ferrous ions,and reducing HSP90 expression in cells,which induced powerful antitumor effect in vitro and in vivo.This multi-hit therapeutic nanosystem helps provide a novel perspective for solving the predicament of cancer treatment,as well as a promising strategy for design of a novel cancer treatment nanoplatform.

关键词： Multi-hit therapy HSP90 Ferroptosis Photothermal effect

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The crucial role of soil moisture in the evolution of forest cover in Asia since the Last Glacial Maximum

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The Innovation 2024年第3期5卷 9-10页

作者： Ying Cheng hongyan Liu School of Geography and Tourism Shaanxi Normal UniversityXi’an 710119China College of Urban and Environmental Sciences and MOE Laboratory for Earth Surface Processes Peking UniversityBeijing 100871China

Forest cover plays a pivotal role in facilitating ecosystem services and climate regulation.In recent decades,much concern has been raised regarding the extent to which forest cover tracks past climate change.Studies at different spatiotemporal scales have revealed significant temporal lags,ranging from decades to millennia,with no consensus reached on this issue.

关键词： forest soil Forest

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The clinical characteristics and risk factors for necrotizing soft tissue infection in children

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儿科学研究(英文) 2024年第1期8卷 21-26页

作者： Liu Jing Chen Jigang Wang Yanni Qi hongyan Yu Jing Department of Burn and Plastic Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing China

Importance: Necrotizing soft tissue infection (NSTI) is a serious infectious disease. However, the early clinical manifestations and indicators of NSTI in children are still unclear.Objective: The purpose of this study was to analyze the clinical characteristics and risk factors of NSTI in pediatric patients.Methods: A total of 127 children with skin and soft tissue infection (SSTI) were treated at our hospital and divided into two groups: the NSTI group and the non-NSTI group, based on their discharge diagnosis from January 2011 to December 2022. Then, we collected and analyzed the clinical characteristics and risk factors of all patients, including sex and age, disease inducement, admission temperature, local skin manifestations, infection site, the presence of sepsis, bacterial culture, and laboratory indicators.Results: In our study, there was a statistical difference in the age distribution and disease inducement between NSTI and non-NSTI groups. The occurrence of local skin manifestations (blisters/bullae and ecchymosis) and the presence of sepsis significantly increased in the NSTI group compared to the non-NSTI group. Additionally, only the platelet count on laboratory tests was statistically different between the NSTI and non-NSTI groups. Finally, the logistic regression analysis suggested that local skin manifestations such as blisters/bullae, and ecchymosis, as well as the presence of sepsis, were identified as risk factors for NSTI.Interpretation: Children with SSTI and skin manifestations such as blisters/bullae, ecchymosis, and the presence of sepsis are at a higher risk of developing NSTI. These symptoms serve as useful indicators for early detection of NSTI.

关键词： Clinical characteristics Risk factors Necrotizing soft tissue infection Skin and soft tissue infection

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Improved STNModels and Heuristic Rules for Cooperative Scheduling in Automated Container Terminals

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1637-1661页

作者： hongyan Xia Jin Zhu Institute of Logistics Science and Engineering Shanghai Maritime UniversityShanghai201306China

Improving the cooperative scheduling efficiency of equipment is the key for automated container terminals to copewith the development trend of large-scale ships. In order to improve the solution efficiency of the existing spacetimenetwork (STN) model for the cooperative scheduling problem of yard cranes (YCs) and automated guidedvehicles (AGVs) and extend its application scenarios, two improved STN models are proposed. The flow balanceconstraints in the original model are decomposed, and the trajectory constraints of YCs and AGVs are added toacquire the model STN_A. The coupling constraint in STN_A is updated, and buffer constraints are added toSTN_A so that themodel STN_B is built.As the size of the problem increases, the solution speed of CPLEX becomesthe bottleneck. So a heuristic method containing three groups of heuristic rules is designed to obtain a near-optimalsolution quickly. Experimental results showthat the computation time of STN_A is shortened by 49.47% on averageand the gap is reduced by 1.69% on average compared with the original model. The gap between the solution ofthe heuristic rules and the solution of CPLEX is less than 3.50%, and the solution time of the heuristic rules is onaverage 99.85% less than the solution time of CPLEX. Compared with STN_A, the computation time for solvingSTN_B increases by 58.93% on average.

关键词： Automated container terminal buffer cooperative scheduling heuristic rules space-time network

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Dynamics and vibration reduction performance of asymmetric tristable nonlinear energy sink

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 389-406页

作者： hongyan CHEN Youcheng ZENG Hu DING Siukai LAI Liqun CHEN School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechanoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina

With its complex nonlinear dynamic behavior,the tristable system has shown excellent performance in areas such as energy harvesting and vibration suppression,and has attracted a lot of attention.In this paper,an asymmetric tristable design is proposed to improve the vibration suppression efficiency of nonlinear energy sinks(NESs)for the first time.The proposed asymmetric tristable NES(ATNES)is composed of a pair of oblique springs and a vertical spring.Then,the three stable states,symmetric and asymmetric,can be achieved by the adjustment of the distance and stiffness asymmetry of the oblique springs.The governing equations of a linear oscillator(LO)coupled with the ATNES are derived.The approximate analytical solution to the coupled system is obtained by the harmonic balance method(HBM)and verified numerically.The vibration suppression efficiency of three types of ATNES is compared.The results show that the asymmetric design can improve the efficiency of vibration reduction through comparing the chaotic motion of the NES oscillator between asymmetric steady states.In addition,compared with the symmetrical tristable NES(TNES),the ATNES can effectively control smaller structural vibrations.In other words,the ATNES can effectively solve the threshold problem of TNES failure to weak excitation.Therefore,this paper reveals the vibration reduction mechanism of the ATNES,and provides a pathway to expand the effective excitation amplitude range of the NES.

关键词： asymmetric nonlinear energy sink(NES) tristable vibration control po-tential barrier

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Color Image Compression and Encryption Algorithm Based on 2D Compressed Sensing and Hyperchaotic System

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Computers, Materials & Continua 2024年第2期78卷 1977-1993页

作者： Zhiqing Dong Zhao Zhang hongyan Zhou Xuebo Chen School of Computer Science and Software Engineering University of Science and Technology LiaoningAnshan114051China School of Electronic and Information Engineering University of Science and Technology LiaoningAnshan114051China

With the advent of the information security era,it is necessary to guarantee the privacy,accuracy,and dependable transfer of pictures.This study presents a new approach to the encryption and compression of color images.It is predicated on 2D compressed sensing(CS)and the hyperchaotic system.First,an optimized Arnold scrambling algorithm is applied to the initial color images to ensure strong security.Then,the processed images are con-currently encrypted and compressed using 2D CS.Among them,chaotic sequences replace traditional random measurement matrices to increase the system’s security.Third,the processed images are re-encrypted using a combination of permutation and diffusion algorithms.In addition,the 2D projected gradient with an embedding decryption(2DPG-ED)algorithm is used to reconstruct images.Compared with the traditional reconstruction algorithm,the 2DPG-ED algorithm can improve security and reduce computational complexity.Furthermore,it has better robustness.The experimental outcome and the performance analysis indicate that this algorithm can withstand malicious attacks and prove the method is effective.

关键词： Image encryption image compression hyperchaotic system compressed sensing

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An Adaptive User Service Deployment Strategy for Mobile Edge Computing

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China Communications 2022年第10期19卷 238-249页

作者： Gang Li Jingbo Miao Zihou Wang Yanni Han hongyan tan Yanwei Liu Kun Zhai Institute of Information Engineering Chinese Academy of SciencesBeijing 100093China School of Cyber Security University of Chinese Academy of SciencesBeijing 101408China National Computer Network Emergency Response Technical Team/Coordination Center of China Beijing 100029China Sunwise Intelligent Technology Company Beijing 100190China

Mobile edge computing(MEC) is a cloud server running at the edge of a mobile network, which can effectively reduce network communication delay. However, due to the numerous edge servers and devices in the MEC, there may be multiple servers and devices that can provide services to the same user simultaneously. This paper proposes a userside adaptive user service deployment algorithm ASD(Adaptive Service Deployment) based on reinforcement learning algorithms. Without relying on complex system information, it can master only a few tasks and users. In the case of attributes, perform effective service deployment decisions, analyze and redefine the key parameters of existing algorithms, and dynamically adjust strategies according to task types and available node types to optimize user experience delay. Experiments show that the ASD algorithm can implement user-side decision-making for service deployment. While effectively improving parameter settings in the traditional Multi-Armed Bandit algorithm,it can reduce user-perceived delay and enhance service quality compared with other strategies.

关键词： edge computing adaptive algorithm reinforcement learning computing unloading service deployment

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Dynamic Coupling Analysis of Semisubmersible Platform Float-over Method for Docking Case

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Journal of Ocean University of China 2024年第2期23卷 345-357页

作者： DING hongyan QIN Licheng ZHANG Puyang SONG Zhengrong XIE Weiwei State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China Offshore Oil Engineering Co. Ltd.Tianjin 300461China

In this paper,the multi-body coupled dynamic characteristics of a semisubmersible platform and an HYSY 229 barge were investigated.First,coupled hydrodynamic analysis of the HYSY 229 barge and the semisubmersible platform was performed.Relevant hydrodynamic parameters were obtained using the retardation function method of three-dimensional frequency-domain potential flow theory.The results of the hydrodynamic analysis were highly consistent with the test findings,verifying the accuracy of the multifloating hydrodynamic coupling analysis,and key hydrodynamic parameters were solved for different water depths and the coupling effect.According to the obtained results,the hydrodynamic influence was the largest in shallow waters when the coupling effect was considered.Furthermore,the coupled motion equation combined with viscous damping,fender system,and mooring system was established,and the hydrodynamics,floating body motion,and dynamic response of the fender system were analyzed.Motion analysis revealed good agreement among the surge,sway,and yaw motions of the two floating bodies.However,when the wave period reached 10 s,the motion of the two floating bodies showed severe shock,and a relative motion was also observed.Therefore,excessive constraints should be added between the two floating bodies during construction to ensure construction safety.The numerical analysis and model test results of the semisubmersible platform and HYSY 229 barge at a water depth of 42 m and sea conditions of 0°,45°,and 90° were in good agreement,and the error was less than 5%.The maximum movement of the HYSY 229 barge reached 2.61 m in the sway direction,whereas that of the semisubmersible platform was 2.11 m.During construction,excessive constraints should be added between the two floating bodies to limit their relative movement and ensure construction safety.

关键词： float-over method semisubmersible platform coupling hydrodynamic fender system time-domain analysis

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Role of methoxy and C_(α)-based substituents in electrochemical oxidation mechanisms and bond cleavage selectivity of β-O-4 lignin model compounds

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Green Energy & Environment 2024年第1期9卷 114-125页

作者： Yang Zhou Qiang Zeng hongyan He Kejia Wu Fuqiao Liu Xuehui Li School of Chemistry and Chemical Engineering The Guangdong Provincial Key Laboratory of Green Chemical Product TechnologyState Key Laboratory of Pulp and Paper EngineeringSouth China University of TechnologyGuangzhouGuangdong510640China CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China

In order to better understand the specific substituent effects on the electrochemical oxidation process of β-O-4 bond, a series of methoxyphenyl type β-O-4 dimer model compounds with different localized methoxyl groups, including 2-(2-methoxyphenoxy)-1-phenylethanone, 2-(2-methoxyphenoxy)-1-phenylethanol, 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethanone, 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethanol, 2-(2,6-dimethoxyphenoxy)-1-(4-methoxyphenyl)ethanone, 2-(2,6-dimethoxyphenoxy)-1-(4-methoxyphenyl)ethanol have been selected and their electrochemical properties have been studied experimentally by cyclic voltammetry, and FT-IR spectroelectrochemistry. Combining with electrolysis products distribution analysis and density functional theory calculations, oxidation mechanisms of all six model dimers have been explored. In particular, a total effect from substituents of both para-methoxy(on the aryl ring closing to Cα) and Cα-OH on the oxidation mechanisms has been clearly observed, showing a significant selectivity on the Cα-Cβbond cleavage induced by electrochemical oxidations.

关键词： Lignin model compounds β-O-4 dimers Electrochemical oxidation Oxidation mechanisms Substituent effect

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Highly-coherent second-harmonic generation in a chip-scale source

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Light(Science & Applications) 2024年第1期13卷 6-7页

作者： Xuanyi Liu hongyan Fu Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen518055China

A highly efficient second-harmonic source is integrated into a silicon nitride microring resonator,unlocking the potential for advanced chip-scale devices such as miniaturized atomic clocks and fully integrated self-r... 详细信息

关键词： resonator harmonic source

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