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Science China Chemistry 2024年第7期67卷 2199-2205页

作者： hongyan long Sha Zhao Chunyan Jian Xiuli Wu Fengfei Lu Minghong Liao Fengrui Che Xingxing Wu Yonggui Robin Chi State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore

Organoseleniums exhibit a diverse set of biological activities that are pivotal for drug discovery and are widely explored in synthetic chemistry and material *** many transformations have been developed for non-enantioselective C–Se bond formations,the catalyst-controlled stereoselective preparation of chiral organoseleniums continues to be of considerable *** particular,there are limited studies on the enantioselective seleno-Michael addition reactions to access chiral selenium functional ***,we disclose a carbene-catalyzed highly enantioselective nucleophilic C–Se bond construction through formal[3+3]annulations between selenocarboxamides and bromoenals,affording seleno-thiazinone products with good yields and excellent *** choice of a weak inorganic base was pivotal to suppressing the unproductive racemization and decomposition of the selenium ***,the catalytically generated chiral selenium-containing heterocyclic products feature remarkable antimicrobial activities that could serve as promising lead scaffolds for further agrochemical development.

关键词： seleno-Michael addition organocatalysis N-heterocyclic carbene seleno-heterocycles antimicrobial activity

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隆红艳教授辨证治疗儿童抽动障碍经验介绍

中医儿科杂志 2024年第3期20卷 15-17页

作者：杨凡梁朝祺隆红艳(指导) 南京中医药大学研究生院江苏南京210000 不详

隆红艳教授认为儿童抽动障碍病位在肝肾,与心脾关系密切,若小儿肝肾阴虚,肝阳上亢,肝风内动,则抽动频作。故隆教授在脏腑辨证基础上,首重肝肾,兼顾心脾,谨守“肝风内动”病机,形神同治,辨证选药,使肝气调达,肝风得息,肝体得养,则抽动之... 详细信息

隆红艳教授认为儿童抽动障碍病位在肝肾,与心脾关系密切,若小儿肝肾阴虚,肝阳上亢,肝风内动,则抽动频作。故隆教授在脏腑辨证基础上,首重肝肾,兼顾心脾,谨守“肝风内动”病机,形神同治,辨证选药,使肝气调达,肝风得息,肝体得养,则抽动之症痊愈。附案例1则,以资验证。

关键词：儿童抽动障碍肝风内动脏腑辨证形神并治临床经验隆红艳

基于网络药理学研究黄龙合剂治疗小儿咳嗽变异性哮喘的机制及实验验证

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国际中医中药杂志 2024年第2期46卷 196-202页

作者：纪茜茜王爱华隆红艳南京中医药大学南京210046 南京中医药大学附属南京中医院儿科南京210001 南京中医药大学附属南京中医院中心实验室南京210001

目的利用网络药理学方法、分子对接技术及体外细胞实验研究黄龙合剂基于IL-4/信号转导和转录激活因子6(STAT6)信号通路治疗小儿咳嗽变异性哮喘(CVA)的作用机制。方法通过TCMSP、HERB数据库及文献检索获得黄龙合剂组方中药的活性成分及... 详细信息

目的利用网络药理学方法、分子对接技术及体外细胞实验研究黄龙合剂基于IL-4/信号转导和转录激活因子6(STAT6)信号通路治疗小儿咳嗽变异性哮喘(CVA)的作用机制。方法通过TCMSP、HERB数据库及文献检索获得黄龙合剂组方中药的活性成分及作用靶点,检索GeneCards数据库、OMIM数据库、DrugBank数据库、PharmGKB数据库中CVA相关靶点。对药物-疾病靶点取交集,使用STRING数据库构建交集靶点PPI网络,采用Cytoscape 3.9.1进行网络拓扑分析,筛选核心靶点,并构建“疾病-药物-成分-靶点”网络,筛选核心成分。使用Metascape数据库对交集靶点进行GO功能和KEGG通路富集分析。使用PDB蛋白数据库、PubChem、AutoDock及R语言对核心靶点及核心成分进行分子对接验证。培养大鼠原代气道平滑肌细胞,采用Western blot检测细胞质和细胞核中p-STAT6表达。结果得到黄龙合剂治疗CVA的活性成分122个,核心成分包括槲皮素、山柰酚、木犀草素等,核心靶点有JUN、ESR1、TP53、MYC、HIF1α等。GO功能富集分析涉及对外来刺激的反应、对氧气水平的反应、蛋白质磷酸化的正向调控、细胞应激反应的调节等生物过程。KEGG通路富集分析显示,黄龙合剂治疗CVA靶点主要富集于AGE-RAGE信号通路、PI3K-Akt信号通路、TNF信号通路、JAK-STAT信号通路等。分子对接结果显示,核心靶点及药物核心成分有较好的结合活性。细胞实验表明,黄龙合剂可抑制IL-4介导的p-STAT6进入细胞核。结论预测了黄龙合剂治疗CVA的有效成分及靶点,其治疗小儿CVA的作用机制可能与抑制IL-4/STAT6信号通路有关。

关键词：药理作用分子作用机制(中药) 咳嗽变异性哮喘黄龙合剂网络药理学分子对接模拟 IL-4/STAT6信号通路

略论运脾学说的建立与发展及其对儿科临床的指导意义

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江苏中医药 2008年第11期40卷 28-31页

作者：张骠隆红艳南京市中医医院江苏南京210001

简要回顾运脾学说的渊源与沿革,总结其确立与发展的历程,系统阐述该学说的理论基础和临床应用范围。在此基础上,就该学说对儿科临床的指导意义与价值、运脾方药的现代作用机制和运脾学说研究的发展趋势进行了较为深入的探讨。

关键词：运脾学说历史渊源中医儿科学

Mercury Speciation of Flue Gas Desulphurization By-Products in Coal-Fired Power Plants in China

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Journal of Power and Energy Engineering 2020年第11期8卷 1-11页

作者： Gang Tian hongyan long Yu Liu Chen Zhang Fan Zhang Hongchang Wang Jinwei Zhu Yanping Zhang Hongmei Wang Fan Wang Chinese Research Academy of Environmental Sciences Beijing China

The aim of this study was to develop and examine the morphology and distribution of mercury (Hg) in flue gas desulfurization (FGD) by-product. Mercury in the coal of coal-fired power plants is concentrated in the by-products of desulfurization process, and it is widely used as an additive in cement, building materials and other industries. Due to the different stability of various forms of mercury in the environment, subsequent use of products containing desulfurization by-product additives will continue to be released into the environment, endangering human health. Therefore, it is very necessary to study the form and distribution of mercury in the by-products of desulfurization in coal-fired power plants to provide a theoretical basis for subsequent harmless treatment. For content and morphology of mercury analysis, 1 sample of dry FGD ash and 6 samples of wet FGD gypsum were analyzed. The total 7 samples were extracted using a modification of sequential chemical extractions (SCE) method, which was employed for the partitioning Hg into four fractions: water soluble, acid soluble, H2O2 soluble, and residual. The Hg analysis was done with United States Environmental Protection Agency (USEPA) method 7471B. Comparing with the wet FGD gypsums of coal-fired boilers, the total Hg content in the dry FGD by-product was as high as

关键词： Mercury Mercury Speciation Flue Gas Desulphurization By-Product Sequential Chemical Extractions Morphology and Distribution Gypsum

Electrode particulate materials for advanced rechargeable batteries:A review

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Particuology 2024年第3期86卷 160-181页

作者： Mingyang Ma Miao Du Yan Liu hongyan Lü Jialin Yang Zelin Hao Jinzhi Guo Xinglong Wu MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityChangchunJilin130024China Department of Chemistry Northeast Normal UniversityChangchunJilin130024China

The demand for large-scale energy storage is increasing due to the decreasing non-renewable resources and deteriorating environmental *** rechargeable batteries with high energy density and long cycle performance is an ideal choice to meet the demand of energy storage *** development of excellent electrode particles is of great significance in the commercialization of nextgeneration *** ideal electrode particles should balance raw material reserves,electrochemical performance,price and environmental *** them,the development of electrode particulate materials with excellent electrochemical properties is the top priority at *** this review,the typical researches of electrode materials are summarized in terms of crystal structure,morphology,pore structure,surface and interface ***,the structural characteristics and improvement methods of transition metal oxides,polyanionic compounds,Prussian blue and their analogues are ***,the different effects of particulate morphology,pore,surface and interface structure on the performance of electrode materials are *** designing high-performance electrode materials,preparation route should be set according to the particle properties of the materials and the synergistic effect of various optimization methods should be *** the same time,in addition to the electrode materials,other components of the rechargeable batteries,such as current collector,separator and electrolytes,should be optimized to improve the overall performance of the *** review would provide important guiding principle for designing high-performance electrode particulate materials.

关键词： Particulate properties Electrode materials Rechargeable batteries

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生物质基活性炭负载金属催化还原NO_x

环境科学研究 2018年第9期31卷 1588-1596页

作者：束韫龙红艳张凡王洪昌许超中国环境科学研究院北京100012

为研究生物质材料的脱硝性能,利用木质素与纤维素2种生物质基活性炭作为还原剂,用碱金属与过渡金属作为催化活性相,制备了一系列生物质基活性炭负载金属催化剂用于富氧环境中催化还原NO_x,考察了生物质原料种类、炭化温度以及催化剂组... 详细信息

为研究生物质材料的脱硝性能,利用木质素与纤维素2种生物质基活性炭作为还原剂,用碱金属与过渡金属作为催化活性相,制备了一系列生物质基活性炭负载金属催化剂用于富氧环境中催化还原NO_x,考察了生物质原料种类、炭化温度以及催化剂组分对脱硝效率的影响.结果表明:(1)当反应温度低于250℃时,炭表面主要是NO_x的吸附过程;而当反应温度高于250℃时,炭还原NO_x行为占主导,并伴随N2、CO_2与CO的生成.炭化温度对炭反应活性的影响主要依赖于炭化温度对炭材料表面含氧官能团、比表面积以及炭表面金属还原性的影响.(2)研究中考察的金属(K、Cu、Fe、Ni)均对还原NO_x与O_2有催化作用,其中,K对C-NO_x反应具有明显促进作用,但对C-O_2反应并无明显促进作用,所有样品中SAC-K的选择性因子为0.56,对还原NO_x的选择性最高,且恒温反应过程NO_x还原量(以C计)达到了1 293μmol/g.(3)与传统煤基活性炭催化剂相比,木屑基活性炭负载钾催化剂表现出了优良的NO_x还原选择性;X-射线光电子表征结果显示,木屑基活性炭负载钾催化剂优良的性能与其表面钾活性相的高度分散有关.研究显示,相比于煤基炭材料,生物质基炭材料具有更加优异的选择性还原NO_x性能.

关键词：生物质氮氧化物还原活性炭选择性

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张骠教授诊治小儿咳嗽变异性哮喘经验

长春中医药大学学报 2015年第1期31卷 53-55页

作者：李红燕隆红艳南京中医药大学南京210029 南京市中医院南京210001

张骠教授认为,小儿咳嗽变异性哮喘多为"风""热""痰"相兼为患,以"风痰痹阻,肺热气逆"为多。治以"祛风解痉,宣肺化痰,清肺降逆"为要,自拟黄龙止咳方。药用炙麻黄、桑白皮、杏仁、苏子、前胡、地龙、蝉蜕、旋覆花等。现代药理研究表明,自... 详细信息

张骠教授认为,小儿咳嗽变异性哮喘多为"风""热""痰"相兼为患,以"风痰痹阻,肺热气逆"为多。治以"祛风解痉,宣肺化痰,清肺降逆"为要,自拟黄龙止咳方。药用炙麻黄、桑白皮、杏仁、苏子、前胡、地龙、蝉蜕、旋覆花等。现代药理研究表明,自拟黄龙止咳方具有不同程度平喘、消痰、抗病毒、抗过敏等作用,可使风祛热消,气顺痰消,咳嗽自愈。

关键词：小儿咳嗽变异性哮喘(CVA) 风痰痹阻肺热气道张骠

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儿童咳嗽变异性哮喘气道炎症研究

长春中医药大学学报 2015年第2期31卷 414-417页

作者：李红燕隆红艳南京中医药大学南京210029 南京市中医院南京210001

咳嗽变异性哮喘的发病机制及病理生理与典型哮喘相似,均以持续气道炎症、气道高反应性和气道重构为特点,平均约有30%的患儿最终发展为典型哮喘。近年来随着病理学的发展,发现哮喘患者发作期和缓解期均存在气道内炎症细胞浸润和炎性介质... 详细信息

咳嗽变异性哮喘的发病机制及病理生理与典型哮喘相似,均以持续气道炎症、气道高反应性和气道重构为特点,平均约有30%的患儿最终发展为典型哮喘。近年来随着病理学的发展,发现哮喘患者发作期和缓解期均存在气道内炎症细胞浸润和炎性介质增多,提出了哮喘是一种气道慢性炎症性疾病的概念。气道炎症是气道重塑等病理发展的关键,现代医学研究认为,咳嗽变异性哮喘气道炎症机制复杂。明确有关炎症细胞及炎性介质在气道炎症机制中所起的作用或影响,可提高对本病的认识,及早干预,阻止病情进一步发展。

关键词：儿童咳嗽变异性哮喘气道炎症气道重塑

Protein crystallization with DNA templates

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Particuology 2024年第3期86卷 262-268页

作者： Bo Zhang Jia Yu Zhe Pu Wenhui Guo Ruoqi Yang Yu Wen Zhijiang Rong Hui Wang Xiaoli Wu Bo Wang hongyan Sun School of Environment and Resources Taiyuan University of Science and TechnologyTaiyuan030024China School of Chemical Engineering and Technology Taiyuan University of Science and TechnologyTaiyuan030024China

Protein crystallization plays a significant role in three-dimensional structural analysis and protein *** is important to increase the crystallization efficiency,which is possible by adding hetero-geneous templates in crystallization *** is biologically compatible and artificially designable polymer,which is easy to *** this study,single-and double-stranded DNA of precise sequences were designed and used as templates to promote protein crystallization of lysozyme and ***-fluence of DNA,single-stranded DNA with 10,20,40 bases and double-stranded DNA with 10,20,40 base pairs,were *** success rate of obtaining crystals of lysozyme and catalase in equal period was significantly improved with the addition of DNA comparing without templates ***-stranded DNA led to higher nucleation rate than that with single-stranded *** promotion of nucleation was more obvious at low concentration of protein solution and with longer chain DNA *** number and crystallization rate was enhanced with addition of long double-stranded DNA *** the results confirm that DNA is an effective polymer additive to enhance protein crystallization,especially for the application of the scarce protein crystallization.

关键词： DNA Polymer Additive Protein Crystallization