检索结果-南通市图书馆

Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin

引用

Science China(Life Sciences) 2024年第6期67卷 1226-1241页

作者： Zhengyang Guo Jiaqi Huang Xiao Huo Chen Huang Xiaotong Yu Yan Sun Yanfang Li Tianhui he hongyan Guo Jianling Yang Lixiang Xue Cancer Center of Peking University Third Hospital Beijing 100191China Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third HospitalBeijing 100191China Peking University Third Hospital Cancer Center Department of Radiation OncologyPeking University Third HospitalBeijing 100191China Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Ovarian cancer is the most lethal and aggressive gynecological cancer with a high recurrence rate and is often diagnosed *** ovarian cancer,multiple metabolic enzymes of lipid metabolism are abnormally expressed,resulting in metabolism *** a characteristic pathway in polyunsaturated fatty acid(PUFA)metabolism,arachidonic acid(AA)metabolism is disturbed in ovarian ***,we established a 10-gene signature model to evaluate the prognostic risk of PUFA-related *** 10-gene signature has strong robustness and can play a stable predictive role in datasets of various platforms(TCGA,ICGC,and GSE17260).The high association between the risk subgroups and clinical characteristics indicated a good performance of the *** data further indicated that the high expression of LTA4H was positively correlated with poor prognosis in ovarian *** of LTA4H enhanced sensitivity to Cisplatin and modified the characteristics of immune cell infiltration in ovarian ***,our results indicate that CCL5 was involved in the aberrant metabolism of the AA/LTA4H axis,which contributes to the reduction of tumor-infiltrating CD8+T cells and immune escape in ovarian *** findings provide new insights into the prognosis and potential target of LTA4H/CCL5 in treating ovarian cancer.

关键词： ovarian cancer polyunsaturated fatty acids prognostic risk model LTA4H tumor immunity CCL5

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Therapeutic strategies against bacterial biofilms

引用

Fundamental Research 2021年第2期1卷 193-212页

作者： Yufang Bi Guixue Xia Chao Shi Jianglin Wan Longqiang Liu Yuan Chen Yueming Wu Wenjing Zhang Min Zhou hongyan he Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Frontiers Science Center for Materiobiology and Dynamic Chemistry Key Laboratory o f Specially Functional Polymeric Materials and Related Technology(ECUST)Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

The emergence of multi-drug resistance makes bacterial infection a major threat to public health and *** formation of bacterial biofilms is one of the main reasons of bacterial *** complexity of chemical composition and physical structure makes the elimination of mature biofilms a difficult *** highly antibiotic resistant property of biofilms urgently calls for potent antimicrobial agents and novel antibiofilm *** have made a lot of efforts in this *** we review the current strategies to eliminate mature biofilms and progress in related drug delivery nanosystems,with the aim of inspiring researchers to design new antibiofilm systems.

关键词： Antimicrobial resistance Biofilm Persister cell Nanomaterials Drug delivery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

矿产资源开发“强区与富民”悖论研究——以新疆煤炭资源开发为例

引用

财经科学 2010年第7期 87-94页

作者：贺红艳新疆财经大学会计学院

煤炭资源开发是新疆发展“大轻工”战略的基础。为避免在新疆矿产资源开发中重蹈采掘企业超额利润、资源地GDP快速上升但居民收入增加缓慢的“强区富民”的悖论现象的覆辙，必须改变以单纯追求GDP增长为目标的经济发展思路和官员考核模... 详细信息

煤炭资源开发是新疆发展“大轻工”战略的基础。为避免在新疆矿产资源开发中重蹈采掘企业超额利润、资源地GDP快速上升但居民收入增加缓慢的“强区富民”的悖论现象的覆辙，必须改变以单纯追求GDP增长为目标的经济发展思路和官员考核模式。本文以煤炭资源开发为例，使用省际面板数据分别对资源开发与地区人均GDP和城镇居民人均可支配收入增长之间的关系进行了实证检验。结果显示煤炭资源开发与人均GDP增长正相关，与城镇居民人均可支配收入增长负相关。煤炭资源开发中“强区富民”的财富悖论效应在我国的地区层面成立。

关键词：矿产资源强区富民收益分配超额利润

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42 and inhibiting STAT1 activation

引用

Acta Pharmaceutica Sinica B 2024年第7期14卷 2942-2958页

作者： Shishi he Guowei Huang Rong Lei Rurong Jia Zhanghai he Jiewen Chen hongyan Huang Zixian Huang Ailifeire Yilihamu Xun Li Zilin Zhuang Mengjia Han Xueman Chen Di Huang Yan Nie Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Pathology Shantou University Medical CollegeShantou 515041China School of Basic Medical Science Southern Medical UniversityGuangzhou 510515China Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Breast Medicine Affiliated Foshan Maternity and Child Healthcare HospitalSouthern Medical UniversityFoshan 528000China Department of Breast Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Department of Oral and Maxillofacial Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Breast phyllodes tumor(PT)is a rare fibroepithelial neoplasm with potential malignant *** non-coding RNAs(lncRNAs)play multifaceted roles in various cancers,but their involvement in breast PT remains largely *** this study,microarray was leveraged for the first time to investigate the role of lncRNA in *** identified lncRNA ZFPM2-AS1 was significantly upregulated in malignant PT,and its overexpression endowed PT with high tumor grade and adverse ***,we elucidated that ZFPM2-AS1 promotes the proliferation,migration,and invasion of malignant PT in *** ZFPM2-AS1 through nanomaterial-mediated siRNA delivery in patient-derived xenograft(PDX)model could effectively inhibit tumor progression in ***,our findings showed that ZFPM2-AS1 is competitively bound to CDC42,inhibiting ACK1 and STAT1 activation,thereby launching the transcription of *** conclusion,our study provides evidence that ZFPM2-AS1 plays a pivotal role in the pathogenesis of breast PT,and suggests that ZFPM2-AS1 could serve as a prognostic indicator for patients with PT as well as a promising novel therapeutic target.

关键词： LncRNA Phyllodes tumor ZFPM2-AS1 Cell division cycle 42 Activated cdc42 kinase 1 Signal transducer and activator of transcription 1 TNF receptor superfamily member 19 Nano particles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于全球专利信息的离子液体领域发展态势分析

引用

过程工程学报 2021年第4期21卷 383-393页

作者：郑征何宏艳北京科技大学图书馆北京100083 中国科学院过程工程研究所离子液体清洁过程北京市重点实验室北京100190

当前世界各国对环境保护和绿色发展的重视程度日益提升,离子液体因其优良的理化性能和可设计性,在能源、材料以及环境等众多领域展现出广阔的应用前景。基于全球专利信息,对离子液体领域三类热点应用,包括CO_(2)捕集及利用、电化学储能... 详细信息

当前世界各国对环境保护和绿色发展的重视程度日益提升,离子液体因其优良的理化性能和可设计性,在能源、材料以及环境等众多领域展现出广阔的应用前景。基于全球专利信息,对离子液体领域三类热点应用,包括CO_(2)捕集及利用、电化学储能和生物质转化利用的全球专利申请趋势、申请地域、重要专利权人、重点技术等情况进行国内外的比较研究。研究结果表明,离子液体技术分类布局广泛,尤其是催化分离的相关专利充足。中国在离子液体领域的专利申请量多,但专利权人以高校或科研机构为主,专利转化应用和保护力度不足。因此建议中国离子液体领域加强科研机构与新型能源/环保科技公司合作,向动力电池、碳捕集、生物基材料、废水处理、空气净化等方面开展转化和深度应用。要点:(1)离子液体领域专利整体概况。介绍离子液体领域整体专利申请趋势、申请地域分布以及专利技术地图。(2)离子液体热点技术的专利分类分析。对三类热点技术CO_(2)捕集及利用、电化学储能和生物质转化利用的全球专利申请趋势、申请地域、重要专利权人、重点技术等情况进行国内外比较研究。(3)揭示了离子液体专利的技术特点及中国在离子液体领域的专利特点。离子液体技术分类布局广泛,尤其是催化分离的相关专利充足;中国在离子液体领域的专利申请量多,但专利权人以高校或科研机构为主,专利转化应用和保护力度不足。

关键词：离子液体专利分析发展态势

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Carbonation of Pure Minerals in Portland Cement:Evolution in Products as a Function of Water-to-solid Ratio

引用

Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1214-1222页

作者： XIONG Kun SHANG Xiaopeng LI hongyan WANG Dan Zhengzhou Lutong Highway Construction Co. Ltd.Zhengzhou 450052China (Special Glass Key Lab of Hainan Province)&(State Key Laboratory of Marine Resource Utilization in South China Sea) Hainan UniversityHaikou 570228China Department of Architectural Engineering Shandong Urban Construction Vocational CollegeJinan 250103China (State Key Laboratory of High Performance Civil Engineering Materials Jiangsu Sobute New Materials Co.Ltd.)&(School of Material Science and EngineeringSoutheast UniversityNanjing 211189China)

Minerals in Portland cement including tricalcium silicate(C_(3)S),β-dicalcium silicate(β-C_(2)S),tricalcium aluminate(C_(3)A),and tetracalcium ferroaluminate(C_(4)AF),show a significantly different activity and product evolution for CO_(2)curing at various water-to-solid *** pure minerals were synthesized and subject to CO_(2)curing in this study to make an in-depth understanding for the carbonation properties of cement-based *** showed that the optimum water-to-solid ratios of C_(3)S,β-C_(2)S,C_(3)A and C_(4)AF were 0.25,0.15,0.30 and 0.40 for carbonation,corresponding to 2 h carbonation degree of 38.5%,38.5%,24.2%,and 21.9%,*** produced calcite duringβ-C_(2)S carbonation decreased as the water-to-solid ratio increased,with an increase in content of metastable CaCO_(3)of vaterite and *** thermodynamic stability of CaCO_(3)produced during carbonation was C_(3)A>C_(4)AF>β-C_(2)S>C_(3)*** carbonation degree of Portland cement was predicted based on the results of pure minerals and the composition of cement,and the error of predicted production of CaCO_(3)was only 1.1%,which provides a potential method to predict carbonation properties of systems with a complex mineral composition.

关键词： accelerated carbonation portland cement calcium carbonate water-to-solid ratio

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

建立非营利性医院财务分析体系的探讨

引用

中国医院管理 2005年第6期25卷 52-54页

作者：何宏岩安宜城医院财务部安徽安庆246001

文章就非营利性医院财务分析系统建立的前提和目标进行了研究。对如何建立财务效益分析、发展能力分析等一般财务分析指标提出观点,并提出建立医院运营能力、药品、人才等方面专项财务分析指标的设想,以建立非营利性医院财务分析的指标... 详细信息

文章就非营利性医院财务分析系统建立的前提和目标进行了研究。对如何建立财务效益分析、发展能力分析等一般财务分析指标提出观点,并提出建立医院运营能力、药品、人才等方面专项财务分析指标的设想,以建立非营利性医院财务分析的指标体系。

关键词：医院财务分析财务指标

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Improved STNModels and heuristic Rules for Cooperative Scheduling in Automated Container Terminals

引用

Computer Modeling in Engineering & Sciences 2024年第2期138卷 1637-1661页

作者： hongyan Xia Jin Zhu Institute of Logistics Science and Engineering Shanghai Maritime UniversityShanghai201306China

Improving the cooperative scheduling efficiency of equipment is the key for automated container terminals to copewith the development trend of large-scale ships. In order to improve the solution efficiency of the existing spacetimenetwork (STN) model for the cooperative scheduling problem of yard cranes (YCs) and automated guidedvehicles (AGVs) and extend its application scenarios, two improved STN models are proposed. The flow balanceconstraints in the original model are decomposed, and the trajectory constraints of YCs and AGVs are added toacquire the model STN_A. The coupling constraint in STN_A is updated, and buffer constraints are added toSTN_A so that themodel STN_B is *** the size of the problem increases, the solution speed of CPLEX becomesthe bottleneck. So a heuristic method containing three groups of heuristic rules is designed to obtain a near-optimalsolution quickly. Experimental results showthat the computation time of STN_A is shortened by 49.47% on averageand the gap is reduced by 1.69% on average compared with the original model. The gap between the solution ofthe heuristic rules and the solution of CPLEX is less than 3.50%, and the solution time of the heuristic rules is onaverage 99.85% less than the solution time of CPLEX. Compared with STN_A, the computation time for solvingSTN_B increases by 58.93% on average.

关键词： Automated container terminal buffer cooperative scheduling heuristic rules space-time network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamics and vibration reduction performance of asymmetric tristable nonlinear energy sink

引用

Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 389-406页

作者： hongyan CheN Youcheng ZENG Hu DING Siukai LAI Liqun CheN School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechanoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina

With its complex nonlinear dynamic behavior,the tristable system has shown excellent performance in areas such as energy harvesting and vibration suppression,and has attracted a lot of *** this paper,an asymmetric tristable design is proposed to improve the vibration suppression efficiency of nonlinear energy sinks(NESs)for the first *** proposed asymmetric tristable NES(ATNES)is composed of a pair of oblique springs and a vertical ***,the three stable states,symmetric and asymmetric,can be achieved by the adjustment of the distance and stiffness asymmetry of the oblique *** governing equations of a linear oscillator(LO)coupled with the ATNES are *** approximate analytical solution to the coupled system is obtained by the harmonic balance method(HBM)and verified *** vibration suppression efficiency of three types of ATNES is *** results show that the asymmetric design can improve the efficiency of vibration reduction through comparing the chaotic motion of the NES oscillator between asymmetric steady *** addition,compared with the symmetrical tristable NES(TNES),the ATNES can effectively control smaller structural *** other words,the ATNES can effectively solve the threshold problem of TNES failure to weak ***,this paper reveals the vibration reduction mechanism of the ATNES,and provides a pathway to expand the effective excitation amplitude range of the NES.

关键词： asymmetric nonlinear energy sink(NES) tristable vibration control po-tential barrier

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Color Image Compression and Encryption Algorithm Based on 2D Compressed Sensing and Hyperchaotic System

引用

Computers, Materials & Continua 2024年第2期78卷 1977-1993页

作者： Zhiqing Dong Zhao Zhang hongyan Zhou Xuebo Chen School of Computer Science and Software Engineering University of Science and Technology LiaoningAnshan114051China School of Electronic and Information Engineering University of Science and Technology LiaoningAnshan114051China

With the advent of the information security era,it is necessary to guarantee the privacy,accuracy,and dependable transfer of *** study presents a new approach to the encryption and compression of color *** is predicated on 2D compressed sensing(CS)and the hyperchaotic ***,an optimized Arnold scrambling algorithm is applied to the initial color images to ensure strong ***,the processed images are con-currently encrypted and compressed using 2D *** them,chaotic sequences replace traditional random measurement matrices to increase the system’s ***,the processed images are re-encrypted using a combination of permutation and diffusion *** addition,the 2D projected gradient with an embedding decryption(2DPG-ED)algorithm is used to reconstruct *** with the traditional reconstruction algorithm,the 2DPG-ED algorithm can improve security and reduce computational ***,it has better *** experimental outcome and the performance analysis indicate that this algorithm can withstand malicious attacks and prove the method is effective.

关键词： Image encryption image compression hyperchaotic system compressed sensing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：