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Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis

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Bioactive Materials 2021年第4期6卷 905-915页

作者： Zhen Geng Luli Ji Zhaoyang Li Jing Wang hongyan he Zhenduo Cui Xianjin Yang Changsheng Liu Key Laboratory for Ultrafine Materials of Ministry of Education East China University of Science and TechnologyShanghai200237China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350China Engineering Research Center for Biomedical Materials of the Ministry of Education East China University of Science and TechnologyShanghai200237China The State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237China

Implant loosening remains a major clinical challenge for osteoporotic *** is because osteoclastic bone resorption rate is higher than osteoblastic bone formation rate in the case of osteoporosis,which results in poor bone ***(Sr)has been widely accepted as an anti-osteoporosis *** this study,we fabricated a series of apatite and Sr-substituted apatite coatings via electrochemical deposition under different acidic *** results showed that Ca and Sr exhibited different mineralization *** main mineralization products for Ca were CaHPO4⋅2H2O and Ca3(PO4)2 with the structure changed from porous to spherical as the pH values *** main mineralization products for Sr were SrHPO4 and Sr5(PO4)3OH with the structure changed from flake to needle as the pH values *** in vitro experiment demonstrated that coatings fabricated at high pH condition with the presence of Sr were favorable to MSCs adhesion,spreading,proliferation,and osteogenic *** addition,Sr-substituted apatite coatings could evidently inhibit osteoclast differentiation and ***,the in vivo study indicated that nano-needle like Sr-substituted apatite coating could suppress osteoclastic activity,improve new bone formation,and enhance bone-implant *** study provided a new theoretical guidance for implant coating design and the fabricated Sr-substituted coating might have potential applications for osteoporotic patients.

关键词： Calcium Strontium Mineralization Osteoclast activity Osseointegration

TWIST1通过激活自噬促进肺动脉高压大鼠模型肺血管重塑作用及机制的实验研究

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现代检验医学杂志 2024年第4期39卷 45-49页

作者：贺红艳晁满香翟翠张晴李海燕西安医学院医学技术学院西安710021 西安医学院基础与转化医学研究所、陕西省脑疾病防治重点实验室西安710021 空军军医大学空军第九八六医院神经内科西安710000

目的探讨Twist相关蛋白1(Twist-related protein 1,TWIST1)对野百合碱(Monocrotaline,MCT)诱导的肺动脉高压(pulmonary arterial hypertension,PAH)大鼠肺血管重塑的影响及机制。方法将50只健康雄性SD大鼠,随机分为5组,即对照组、模型组、二甲基亚砜(Dimethyl sulfoxide,DMSO)溶剂处理的模型组、TWIST1抑制剂Harmine组、自噬抑制剂羟氯喹组。检测右心室收缩压(RVSP),右心室肥厚指数(RVHI)和内膜厚度百分比(MT%)以评估大鼠PAH的发展。采用免疫印迹法检测TWIST1,自噬相关蛋白LC3B以及RND3的蛋白质水平。结果与对照组比较,MCT诱导的PAH大鼠中TWIST1和LC3B表达增加,分别为对照组的2.32±0.22倍和0.87±0.19倍,差异具有统计学意义(t=15.812,11.227,均P<0.001);同时RND3表达下调,为对照组的0.32±0.07倍,差异具有统计学意义(t=-13.003,P<0.001)。给与TWIST1抑制剂Harmine或自噬抑制剂羟氯喹可显著抑制MCT诱导的自噬激活和RND3表达下调,同时降低了MCT诱导的PAH大鼠的RVSP,RVHI和MT%,差异具有统计学意义(t=-24.277~16.636,均P<0.001)。结论TWIST1通过诱导自噬激活促进肺血管重塑,促进PAH的发生发展。

关键词：肺动脉高压血管重塑 Twist相关蛋白1

军队医院护理人员前沿外科手术队护理技术现况研究

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联勤军事医学 2024年第5期38卷 419-424页

作者：李景芳何晓庆雷璐敏邱晨何红艳周体陈巧灵曾登芬解放军医学院研究生院北京100853 解放军总医院第四医学中心眼科解放军总医院第四医学中心麻醉科解放军总医院第四医学中心骨科解放军总医院第四医学中心关节运动医学科解放军总医院第四医学中心护理部

目的探索军队护理人员前沿外科手术队(forward surgical team, FST)护理技术的掌握现况,为制定FST护理核心技术培训体系提供参考。方法 2023-02/2023-05月采用整群抽样法选取14所军队三甲医院718名护理人员作为调查对象,采用一般资料... 详细信息

目的探索军队护理人员前沿外科手术队(forward surgical team, FST)护理技术的掌握现况,为制定FST护理核心技术培训体系提供参考。方法 2023-02/2023-05月采用整群抽样法选取14所军队三甲医院718名护理人员作为调查对象,采用一般资料调查表与护理技术测评表对其进行调查。结果军队医院护理人员卫勤训练方式以线下理论培训最多(71.73%),卫勤任务类型以单位组织卫勤演练为主(72.14%),参加过的机动卫勤力量类型以野战医疗所(30.08%)、野战医疗队(29.53%)为主,卫勤任务中组室训练类型以其他组室(32.45%)、重伤救治组(26.46%)为主,94.57%的人员希望增加卫勤方面的培训。718名军队护理人员对FST护理技术中的通用技术模块掌握程度条目均分、培训需求条目均分最高,特殊技术模块掌握程度条目均分、培训需求条目均分最低。不同年龄、工作年限、职称的军队医院护理人员对通用技术和急救技术的掌握程度评分差异具有统计学意义(P均<0.05);不同工作年限、人员类别的军队医院护理人员对损伤控制技术和特殊技术的培训需求评分差异具有统计学意义(P均<0.05)。FST护理技术掌握程度与培训需求呈正相关关系。结论军队护理人员对FST护理技术整体掌握程度属于中等偏上水平,对技术条目的培训需求意愿强烈,应构建完善的FST护理技术培训体系,着重加强损伤控制技术和特殊技术模块知识的培训,为培训一专多能的FST护理队员提供重要参考。

关键词：外科手术队护理人员护理技术掌握程度培训需求

聚乙二醇6000模拟干旱胁迫下药物浸种对2种绿肥种子萌发的影响

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热带农业科学 2024年第6期44卷 48-54页

作者：武瑞瑞程金焕李亚男娄予强何红艳杨旸云南省农业科学院热带亚热带经济作物研究所云南保山678000

为寻找在干旱胁迫下促进硬皮豆和箭舌豌豆萌发的最佳浸种药物及浓度。以箭舌豌豆和硬皮豆种子为试验材料,浓度2%、5%和10%聚乙二醇6000(PEG-6000)模拟干旱处理,用壳聚糖、水杨酸、氯化钙和乙烯利对种子进行引发处理,蒸馏水浸种作对照,... 详细信息

为寻找在干旱胁迫下促进硬皮豆和箭舌豌豆萌发的最佳浸种药物及浓度。以箭舌豌豆和硬皮豆种子为试验材料,浓度2%、5%和10%聚乙二醇6000(PEG-6000)模拟干旱处理,用壳聚糖、水杨酸、氯化钙和乙烯利对种子进行引发处理,蒸馏水浸种作对照,测量发芽率、发芽指数、根鲜重、根长、根体积和根表面积等指标。结果表明,PEG-6000浓度为2%时,硬皮豆和箭舌豌豆萌发效果较好;PEG-6000浓度为5%和10%时,硬皮豆和箭舌豌豆种子萌发受抑制。2%PEG-6000溶液培养下,箭舌豌豆用药物引发后,测量指标随药物浓度升高而降低,分别在壳聚糖、水杨酸、氯化钙和乙烯利浓度为50、50、500、700 mg/L时达到最高值;硬皮豆在水杨酸50、200 mg/L和氯化钙1000 mg/L处理无萌发现象;在壳聚糖和乙烯利处理下,呈现先降低后升高变化趋势。用隶属函数法对绿肥种子发芽过程的6个生理生化指标进行综合评价,发现药物引发可缓解轻微干旱胁迫对种子萌发的影响,药物浸种24 h时,促进硬皮豆和箭舌豌豆种子萌发最佳处理方法分别是1 400 mg/L的乙烯利溶液和浓度为50 mg/L的壳聚糖溶液。

关键词：硬皮豆箭舌豌豆聚乙二醇6000 药物浸种隶属函数法

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Highly dispersed MgInCe-mixed metal oxides catalyzed direct carbonylation of glycerol and CO_(2)into glycerol carbonate

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Chinese Journal of Chemical Engineering 2024年第8期72卷 153-163页

作者： Xufang Chen Xin Shu Yanru Zhu Jian Zhang Zhigang Chai hongyan Song Zhe An Jing he State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou 324000China

Glycerol carbonate,an important glycerol value-added product,has been widely used as an active intermediate and inert solvent in the synthesis of cosmetics,detergents,chemical intermediates,polymers,and so *** direct carbonylation from glycerol with CO_(2)is considered a promising route,but still tough work due to the thermodynamic stability and the kinetic inertness of CO_(2).In this work,highlyselective direct carbonylation of glycerol and CO_(2)into glycerol carbonate has been achieved over highly dispersed MgInCe-mixed metal oxides(MgInCe-MMO),which were prepared through the topological transformation derived from the MgInCe-layered double hydroxides(MgInCe-LDHs).By precisely modulating the surface basic-acidic properties and the oxygen vacancies,an efficient carbonylation of glycerol with CO_(2)has been achieved with a selectivity of up to>99%to glycerol *** investigation into the synergistic catalysis of base-acid sites and oxygen vacancies has been clarified.

关键词： Catalytic reaction engineering Glycerol carbonate Direct carbonylation from glycerol Carbon dioxide Mixed metal oxides Synergistic catalysis

The New Development of International Arbitration Law: Emergency Arbitrator System

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The New Development of International Arbitration Law: Emerge...

Functional characteristic and application of omega-3

作者： Shiping Lu hongyan he School of Marxism Xi'an University School of Medical Technology Xi'an Medical University

The emergency arbitrator system is a procedural system in which the parties apply for emergency temporary relief to the arbitration institution to protect their legitimate rights and interests before the formation of arbitral tribunal, whose core is the decision on emergency temporary relief measures. This system can make up for the inadequacy of in traditional arbitration that arbitration institutions cannot provide relief for emergency situations before the arbitral tribunal is formed. Therefore, its creation has considerable legitimacy and has become the latest development phenomenon of international arbitration legislation.

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Oil Crop Science 2019年第4期4卷 237-243页

作者： Weiyi Wang Shuaiqiang Xu hongyan he Wei Wang College of Life Sciences Zhejiang UniversityHangzhouChina Zhongzhi(Zhejiang)Flax Technology Development Co. Ltd.HangzhouChina Huzhou Weiyi Biological Technology Co. Ltd.HuzhouChina

Omega-3 is a group of polyunsaturated fatty acids,which are important substances in human cells and cannot be synthesized in the human body which must be taken from the *** definition and physiological functions of omega-3 unsaturated fatty acids(UFAs)were simply introduced in this *** and significant development of omega-3 UFAs in domestic and foreign functional food were *** application prospect of omega-3 UFAs will be helpful to the development and utilization of omega-3.

关键词： omega-3 physiological function functional food

Expression Profile and Function Analysis of Long Non-coding RNAs in the Infection of Coxsackievirus B3

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Virologica Sinica 2019年第6期34卷 618-630页

作者： Lei Tong Ye Qiu Hui Wang Yunyue Qu Yuanbo Zhao Lexun Lin Yan Wang Weizhen Xu Wenran Zhao hongyan he Guangze Zhao Mary HZhang Decheng Yang Xingyi Ge Zhaohua Zhong Department of Microbiology Harbin Medical UniversityHarbin 150081China College of Biology Hunan UniversityChangsha 410012China Department of Cell Biology Harbin Medical UniversityHarbin 150081China Department of Pathology and Laboratory Medicine University of British ColumbiaVancouverBC V6Z 1Y6Canada

The roles of lnc RNAs in the infection of enteroviruses have been barely demonstrated. In this study, we used coxsackievirus B3(CVB3), a typical enterovirus, as a model to investigate the expression profiles and functional roles of lnc RNAs in enterovirus infection. We profiled lnc RNAs and m RNA expression in CVB3-infected he La cells by lnc RNA-m RNA integrated microarrays. As a result, 700 differentially expressed lnc RNAs(431 up-regulated and 269 down-regulated) and665 differentially expressed m RNAs(299 up-regulated and 366 down-regulated) were identified in CVB3 infection. Then we performed lnc RNA-m RNA integrated pathway analysis to identify potential functional impacts of the differentially expressed m RNAs, in which lnc RNA-m RNA correlation network was built. According to lnc RNA-m RNA correlation, we found that XLOC-001188, an lnc RNA down-regulated in CVB3 infection, was negatively correlated with NFAT5 m RNA,an anti-CVB3 gene reported previously. This interaction was supported by q PCR detection following si RNA-mediated knockdown of XLOC-001188, which showed an increase of NFAT5 m RNA and a reduction of CVB3 genomic RNA. In addition, we observed that four most significantly altered lnc RNAs, SNHG11, RP11-145 F16.2, RP11-1023 L17.1 and RP11-1021 N1.2 share several common correlated genes critical for CVB3 infection, such as BRE and IRF2 BP1. In all, our studies reveal the alteration of lnc RNA expression in CVB3 infection and its potential influence on CVB3 replication,providing useful information for future studies of enterovirus infection.

关键词： Coxsackievirus B3(CVB3) lncRNA-mRNA correlation network Long non-coding RNA(lncRNA) XLOC-001188 NFAT5

Interface structure of α-Mg/14H-LPSO:First-principles prediction and experimental study

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Journal of Rare Earths 2024年第9期42卷 1792-1799,I0006页

作者： Yuan Shi Xiaohua Zhang hongyan Yue Chao Li School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin150040China

The interfacial structure of the α-Mg/14H-LPSO phase in rare earth-including magnesium alloy was investigated via high-angle annular dark-field scanning transmission electron microscopy(HAADFSTEM) imaging and first-principles calculations of density-functional *** possible interfacial models were constructed according to the different terminations of the LPSO phase,and the corresponding interfacial energies were calculated,from which the four most stable structures(Terl-MgY-hollow,Ter2-Zn-hollow,Ter3-MgYII-hollow and Ter4-Mg-bridge) were *** interfacial phase diagrams related to the Y chemical potentials were obtained from the calculations,and the most stable interfacial structure was ***-MgY-hollow and Ter2-Zn-hollow have the lowest interfacial energies in the range of-0.7 eV here fluctuating change of state is the minimized and the interface is the most *** separation work of the two models was calculated to predict the bonding strength of the structures at both ends of the *** calculation results show that the maximum interfacial separation work is 1.45 J/m^(2) for the interface model of α-Mg and 14H-LPSO phase structure with Ter2-Zn-hollow termination.

关键词： Rare earths Magnesium alloy HAADF-STEM LPSO First-principles Interface