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Journal of Bionic Engineering 2023年第5期20卷 2179-2193页

作者： Yongwei Yan Fa song Nuo Xu Haochen Zhu hongxu Xing Shujun Zhang Jiyu Sun Key Laboratory of Bionic Engineering(Ministry of Education China)Jilin UniversityChangchun130022China School of Computing and Engineering Gloucestershire UniversityCheltenhamGL502HRUK

Using the method of structural finite element topology optimization and analysis of the hindwings of Trypoxylus dichotomus,this work identified the main loading force transmission path and designed the initial structure of a bionic flexible wing.A structural design scheme of the vibration damping unit was proposed,and the structural mechanics and modal vibration characteristics were simulated and analyzed.3D printing technology was used to manufacture the designed bionic wing skeleton,which was combined with two kinds of wing membrane *** Flapping Wing Micro-aerial Vehicle(FWMAV)transmission mechanism vibration characteristics were observed and analyzed by a high-speed digital camera.A triaxial force transducer was used to record the force vibration of the flexible bionic wing flapping in a wind tunnel.A wavelet processing method was used to process and analyze the force *** results showed that the force amplitude was more stable,the waveform roughness was the lowest,and the peak shaving phenomenon at the z-axis was the least obvious for the bionic flexible wing model that combined the topology-optimized bionic wing skeleton with a polyamide elastic *** was determined to be the most suitable design scheme for the wings of FWMAVs.

关键词： Vibration reduction characteristics Bionic wings Flapping-wing micro-aerial vehicle(FWMAV) Beetle hindwings

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公安智库报告的制度化与规范化研究

智库理论与实践 2023年第1期8卷 194-204页

作者：宋鸿绪包涵中国人民公安大学北京100038 中国人民公安大学侦查学院北京100038

[目的/意义]公安智库报告是我国新型公安智库成果产出的主要形式。开展公安智库报告的制度化研究,能够有效促进党政机关与公安智库之间良性互动,发挥公安智库报告在党政决策咨询中的积极作用。[方法/过程]采用文献综述、案例分析等研究... 详细信息

[目的/意义]公安智库报告是我国新型公安智库成果产出的主要形式。开展公安智库报告的制度化研究,能够有效促进党政机关与公安智库之间良性互动,发挥公安智库报告在党政决策咨询中的积极作用。[方法/过程]采用文献综述、案例分析等研究方法,概述公安智库报告的特点、研究范畴和生成环节,分析公安智库报告制度化的必要性,并提出公安智库报告的制度化和规范化发展路径。[结果/结论]公安智库报告的制度化与规范化进一步规范新型公安智库研究活动,保障公安智库与决策部门的有效互动,制约人为随意性。未来,建议我国新型公安智库与国家有关部门设立公安智库项目管理制度,规范报送流程,完善评价机制;基于“智库研究的双螺旋结构”建构新型公安智库研究的基本范式,规范公安智库报告的内容与格式。

关键词：公安智库报告新型公安智库制度化规范化

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Lung carcinoma with spindle and/or giant cell： a clinicopathological analysis of 17 cases

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The Chinese-German Journal of Clinical Oncology 2009年第1期8卷 1-6页

作者： Zhilong Zhao hongxu Liu Huiru Zhao Na song Yunpeng Liu Department of Thoracic Surgery Zhongshan Hospital Dalian University Dalian 116001 China Department of Thoracic Surgery The First Hospital China Medical University Shenyang 110001 Ghina Department of Oncology The First hospital China Medical University Shenyang 110001 China

Objective： Lung carcinoma with spindle and （or） giant cell （LCSG） is a rare epithelial malignant tumor. The aim of our study is to investigate the clinicopathological and prognostic characteristics of 17 cases of LCSGs. Methods： Among 421 patients underwent resection of lung carcinomas, 17 cases of LCSG were studied for clinical, gross and histological parameters. Follow-up information was obtained and analyzed to clarify prognostically significant parameters. Results： The LCSG patients consisted of 15 males and 2 females, with the age ranging from 45 to 78 years （median, 58 years）; 5 cases of stage Ⅰ, 3 of stage Ⅱ, 9 of stage Ⅲ by pathological TNM staging; 2 cases of exclusively spindle cell carcinoma, 5 cases of lung carcinoma with spindle cell, 10 cases of lung carcinoma with giant-cell carcinoma. Cough, chest distress, or chest pain were the most common presenting symptoms, occurring in 15 patients （88.2%）. Of 5 patients in stage Ⅰ, 4 were alive and free of relapse for more than 5 years. The difference in survival was statistically significant between LCSG and squamous cell carcinoma patients （median survival, 36 vs. 61 months; P = 0.027）. Lymph node metastasis and carcinoma with giant cell were the hazardous factors impacting postoperative prognosis of LCSG patients. Conclusion： LCSG patients in early stage may have an optimistic outcome. Lung carcinomas with giant cell displayed multiple cell components in histopathology, and poor outcome due to more lymph node involved.

关键词： pleomorphic carcinoma spindle cell carcinoma (SCC) lung carcinomas with giant cell lung carcinoma with spindle cell sarcomatous carcinoma

Dynamic analysis of heat extraction rate by supercritical carbon dioxide in fractured rock mass based on a thermal-hydraulic-mechanics coupled model

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International Journal of Mining Science and Technology 2022年第2期32卷 225-236页

作者： Chunguang Wang Xingkai Shi Wei Zhang Derek Elsworth Guanglei Cui Shuqing Liu hongxu Wang Weiqiang song songtao Hu Peng Zheng College of Energy and Mining Engineering Shandong University of Science and TechnologyQingdao 266590China New-energy Development Center of Sinopec Shengli Oilfield Dongying 257001China Energy and Mineral Engineering and G3 Center Penn State UniversityUniversity ParkPA 16802USA Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110004China Shandong Provincial Geo-Mineral Engineering Co. LtdJinan 250013China Qingdao Wofu New Energy Science and Technology Co. LtdQingdao 266010China

Heat production from geothermal reservoirs is a typical heat transfer process involving a cold working fluid contacting a hot rock *** to the thermal-physical characteristics of water,supercritical CO_(2)(scCO_(2))has a higher heat storage capacity over a wide temperature-pressure range and may be favored as a heat transfer *** characteristic of scCO_(2)-based heat extraction is that the hydraulic-thermal properties of the scCO_(2) vary dramatically and dynamically with the spatial pressure gradient during unsteady-state flow along *** highly nonlinear behavior presents a challenge in the accurate estimation of heat extraction efficiency in scCO_(2)-based *** this paper,a thermal-h ydraulic-mechanical(THM)coupled model is developed by considering deformation of the fractured reservoir,non-Darcy flow and the varying thermal-physical properties of scCO_(2).The proposed model is validated by matching the modeling temperature distribution with published *** results show that during continuous injection of scCO_(2),the fracture first widens and then narrows,ultimately reopening over the long *** sequential fracture deformation behaviors are in response to the combined impacts of mechanical compression and thermally-induced *** controlling the injection parameters of the scCO_(2),it is found that the heat extraction rate is positively correlated to its pore pressure or mass flow *** heat extraction rate can be significantly enhanced,when the inlet temperature of scCO_(2) is below its critical *** a result,the heat increment recovered per unit mass of scCO_(2) decreases as the hot rock is gradually ***,the heat increment recovered per unit mass of scCO_(2) decreases by increasing the inlet temperature of scCO_(2) or its mass flow rate,but increases as the outlet pressure ***,multi-linear regression indicates that controlling the inlet temperature of the scCO_(2) can sig

关键词： Supercritical CO_(2) Heat extraction Hot rock Geothermal energy Fracture-matrix interaction

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动脉导管未闭的外科治疗

深圳中西医结合杂志 2003年第3期13卷 156-157页

作者：姜亦忠符韶鹏张秀和张柏民赵洪序宋翔翎吉林大学中日联谊医院心血管外科吉林长春130031

目的　探讨动脉导管未闭的外科治疗。方法　常规或微创入路非体外循环下结扎或切断缝合动脉导管 ,体外循环下经肺动脉直接缝合动脉导管 ,同时治疗并发症。结果　全组病例无一死亡 ,痊愈出院。结论　外科手术治疗动脉导管未闭是不可替代... 详细信息

目的　探讨动脉导管未闭的外科治疗。方法　常规或微创入路非体外循环下结扎或切断缝合动脉导管 ,体外循环下经肺动脉直接缝合动脉导管 ,同时治疗并发症。结果　全组病例无一死亡 ,痊愈出院。结论　外科手术治疗动脉导管未闭是不可替代的治疗方法。

关键词：动脉导管未闭微创术式胸膜外手术

波形钢腹板连续刚构桥剪力滞效应的翼缘有效宽度法研究

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公路工程 2020年第6期45卷 8-14,58页

作者：熊绍伟吴国松冉志红宋红旭张静隆凯云南大学建筑与规划学院云南昆明650500 重庆交通大学工程设计有限公司重庆400074

为了研究波形钢腹板连续刚构桥剪力滞效应的翼缘有效宽度法,以一座悬臂施工的连续刚构桥为例,分别建立杆系有限元模型和实体有限元模型,由此得到初等梁理论下的正应力和实际正应力。采用剪力滞效应的翼缘有效宽度法对初等梁理论下的正... 详细信息

为了研究波形钢腹板连续刚构桥剪力滞效应的翼缘有效宽度法,以一座悬臂施工的连续刚构桥为例,分别建立杆系有限元模型和实体有限元模型,由此得到初等梁理论下的正应力和实际正应力。采用剪力滞效应的翼缘有效宽度法对初等梁理论下的正应力进行修正,将修正的正应力与实际正应力进行对比,对翼缘有效宽度法的适用性进行评估。结果表明:悬臂施工阶段,随着悬臂长度的增加,顶板的适用性降低,底板反之,顶板的适用性优于底板;成桥阶段,顶板的适用性优于底板;整体上看,成桥阶段的适用性优于悬臂施工阶段;翼缘有效宽度法的适用性与翼缘实际宽度和理论计算跨径的比值有关。

关键词：桥梁工程剪力滞效应翼缘有效宽度连续刚构桥波形钢腹板

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8种中药对猪源大肠杆菌的体外抑菌效果

贵州农业科学 2018年第4期46卷 94-97页

作者：王帅兵王婧陈海峰陈晓兰张龙王妲妲宋宏旭吉梦凡江苏农牧科技职业学院江苏泰州225300

为筛选出抗猪源大肠杆菌的中药,选取板蓝根、五倍子、鱼腥草、穿心莲、黄连、黄芩、连翘和金银花等8种中药进行煎液(相当于1g/mL生药),采用纸片法和牛津杯法测定中药对猪源大肠杆菌的体外抗菌活性,对具抑菌作用的中药采用试管二倍稀释... 详细信息

为筛选出抗猪源大肠杆菌的中药,选取板蓝根、五倍子、鱼腥草、穿心莲、黄连、黄芩、连翘和金银花等8种中药进行煎液(相当于1g/mL生药),采用纸片法和牛津杯法测定中药对猪源大肠杆菌的体外抗菌活性,对具抑菌作用的中药采用试管二倍稀释法测定最低抑菌浓度(MIC)和最低杀菌浓度(MBC)。结果表明:板蓝根、五倍子、穿心莲、黄连和黄芩等5种中药对猪源大肠杆菌(TXH11-1)具抑制作用,五倍子的作用最强,对3株菌(TXH11-1、TXH5-2和MAZW7-3)的MIC均为31.25 mg/mL,MBC为62.50~125.00mg/mL;其次是黄连,平均MIC、MBC分别为62.50mg/mL和208.33mg/mL;穿心莲平均MIC为104.17mg/mL,MBC为125.00~500.00 mg/mL;黄芩抑菌效果稍弱,平均MIC为208.33 mg/mL,仅对TXH11-1和MAZW7-3有杀菌作用,MBC≥250.00mg/mL;板蓝根的作用最弱,仅对TXH11-1和TXH5-2具抑制作用,MIC≥250.00mg/mL,对TXH11-1有杀菌作用,MBC为500.00mg/mL;金银花、连翘和鱼腥草对3株试验菌均无抑制作用。

关键词：中药抑菌圈最小抑菌浓度最小杀菌浓度猪源大肠杆菌

基于蛋白质组学探讨电针治疗血管性痴呆的作用机制

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中国针灸 2024年第7期44卷 807-820页

作者：陈英华孙玮王浩宇秦瑞琦苏晓庆李俊峰吴彤赵红旭宋元毓杨建宇黑龙江中医药大学附属第一医院针灸五科哈尔滨150040 黑龙江中医药大学光明中医杂志社

目的:基于串联质谱标签(TMT)定量蛋白质组学技术,探讨电针治疗血管性痴呆(VD)的可能作用机制。方法:选用SPF级雄性SD大鼠80只,采用Morris水迷宫实验筛选出符合标准的78只SD大鼠,将其随机分为假手术组(18只)和手术组(60只)。手术组采用... 详细信息

目的:基于串联质谱标签(TMT)定量蛋白质组学技术,探讨电针治疗血管性痴呆(VD)的可能作用机制。方法:选用SPF级雄性SD大鼠80只,采用Morris水迷宫实验筛选出符合标准的78只SD大鼠,将其随机分为假手术组(18只)和手术组(60只)。手术组采用四血管阻断(4-VO)法复制VD模型,将造模成功的36只大鼠随机分为模型组(18只)和电针组(18只)。每组进一步按干预时间分为3个亚组,每亚组6只。造模后7 d对电针组大鼠行电针干预,穴取左右“四神聪”和双侧“风池”,予连续波,频率2 Hz,电流强度1 mA,每日1次,每次30 min,3个亚组分别干预7、14、21 d。采用Morris水迷宫实验于干预前后评估大鼠学习记忆能力,并选择干预后学习记忆能力最优的电针组亚组及相应假手术组、模型组亚组进行蛋白质组学检测,鉴定电针干预VD相关差异表达蛋白并进行生物信息学分析,采用平行反应监测(PRM)技术和Western blot法验证差异表达的目标蛋白。结果:与假手术组比较,模型组大鼠逃避潜伏期延长、穿越原平台次数减少(P<0.01);与模型组比较,电针组大鼠干预7、14、21d逃避潜伏期缩短、穿越原平台次数增加(P<0.01,P<0.05)。与干预7、14 d比较,电针组大鼠干预21 d逃避潜伏期缩短、穿越原平台次数增加(P<0.01,P<0.05),选择该亚组进行后续蛋白质组学检测、PRM分析及Western blot验证。与假手术组比较,模型组大鼠差异表达蛋白有71种,其中上调的有50种,下调的有21种;与模型组比较,电针组大鼠差异表达蛋白有54种,其中上调的有30种,下调的有24种。功能富集分析、聚类分析发现,差异表达蛋白主要与细胞过程、代谢过程、吞噬识别、免疫反应、细胞外基质组织的调节等生物过程有关。在哺乳动物雷帕霉素靶蛋白(mTOR)信号通路及神经营养因子信号通路中均富集到了糖原合成酶激酶3β(GSK3β)和丝裂原活化蛋白激酶激酶2(Map2k2)蛋白,PRM分析和Western blot验证与蛋白质组学分析结果一致,即与模型组比较,电针组大鼠海马GSK3β和Map2k2蛋白表达升高(P<0.01,P<0.05)。结论:电针“四神聪”“风池”可改善VD大鼠认知功能,其作用机制涉及多靶点、多通路,可能与GSK3β、Map2k2蛋白及mTOR、神经营养因子信号通路相关。

关键词：血管性痴呆电针串联质谱标签(TMT)定量蛋白质组学生物信息学分析作用机制

Primarily screening and analyzing ESTs differentially expressed in rats' primary liver cancer

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Chinese Journal of Cancer Research 2013年第1期25卷 71-78页

作者： Dandan Liu Lijuan Zhi Mingxia Ma Dan Qiao Meijuan Wang Yawei Wang Baijie Jin Anqi Li Guting Liu Yiqing Zhang Yanyan song hongxu Zhang College of Life Science Henan Normal University Xinxiang University

Objective： To screen and analyze key express sequence tags （ESTs） which were differentially displayed in every period of SD rats＇ primary hepatic carcinoma and reveal the molecular mechanism of carcinogenesis. Methods： Using diethylnitrosamine （DENA） as a cancerigenic agent, animal models with different phases of primary hepatic cancer were constructed in SD rats. Rats were respectively sacrificed at d 14, d 28, d 56, d 77, d 105 and d 112 after the rats received DENA by gavage, then the livers were harvested. One part of the livers was classified according to their pathological changes, while the other was reserved for molecular mechanism studies on hepatocarcinogenesis. The differentially expressed genes were isolated from both normal and morbid tissues by mRNA differential display technique （DDRT-PCR）. After the fragments were sequenced, bioinformatics were .used to analyze the results. Results： Twelve differentially expressed cDNA fragments were obtained. Nine fragments had the homology with known cDNA clones, especially EST-7 was similar to BN/SsNHsdMCW mitochondrion gene and the identity was 100% which suggested EST-7 may be the part of BN/SsNHsdMCW mitochondrion gene. In contrast, other three fragments （EST-1, EST-3 and EST-5） had extremely low identity to any genes registered in GENBANK databases. Conclusions： BN/SsNHsdMCW mitochondrion gene was expressed in different periods of hepatocarcinogenesis. Moreover, EST-I, EST-3 and EST-5 were suggested to contribute to the development of rat hepatocarcinogenesis, and thus may be candidates of new targets of oncogenes or cancer suppressor genes.

关键词： Animal models of primary liver cancer DDRT-PCR (differential display reverse transcription PCR) ESTs (express sequence tags) mitochondrion gene

CO_(2)-EOR过程中油藏储层构造封存能力的模拟

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非常规油气 2024年第2期11卷 99-107页

作者：王璐刘森姬泽敏廉黎明田茂章宋文枫岳孝昆房红旭鲁效庆中国石油勘探开发研究院北京100083 中国石油大学(华东)材料科学与工程学院山东青岛266580

为应对日益严峻的能源危机和温室效应,CO_(2)提高采收率技术脱颖而出,因此CO_(2)提高采收率后的地质封存安全性和相应的封存能力评估引起了广泛关注。借助数值模拟方法,基于吉林油田某区块油藏的实际储层条件,构建了注入CO_(2)含量为10%... 详细信息

为应对日益严峻的能源危机和温室效应,CO_(2)提高采收率技术脱颖而出,因此CO_(2)提高采收率后的地质封存安全性和相应的封存能力评估引起了广泛关注。借助数值模拟方法,基于吉林油田某区块油藏的实际储层条件,构建了注入CO_(2)含量为10%~90%的9个模型,分别探究了含水饱和度为30%,50%和90%以及储层压力为10 MPa,20 MPa和30 MPa时油藏各相组分的分布规律;基于前人对封存CO_(2)安全储存状态划分的研究,最终明确了CO_(2)的安全封存量。结果表明:1)当含水饱和度(30%)和压力(10 MPa)一定时,增加CO_(2)含量(10%~90%)可大幅提高CO_(2)的有效封存体积分数(26%~93%);2)压力的提升(10~30 MPa)促进了CO_(2)在油相中的溶解,从而略微降低了储层的封存能力(18%~7%);3)含水饱和度对储层封存CO_(2)的能力的影响微乎其微。该研究旨在阐明不同条件下CO_(2)的构造埋存量,为相关研究提供借鉴。

关键词： CO_(2)封存封存能力评估含水饱和度储层压力 CO_(2)含量数值模拟