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Algebraic form and analysis of SIR epidemic dynamics over probabilistic dynamic networks

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Control Theory and Technology 2023年第4期21卷 602-611页

作者： hongxing yuan Zengqiang Chen Zhipeng Zhang Rui Zhu Zhongxin Liu College of Artificial Intelligence Nankai UniversityTianjin300350China School of Artificial Intelligence Tiangong UniversityTianjin300387China

The outbreak of corona virus disease 2019 has profoundly affected people’s way of life.It is increasingly necessary to investigate epidemics over social networks.This paper studies susceptible-infected-removed(SIR)epidemics via the semi-tensor product.First,a formal susceptible-infected-removed epidemic dynamic model over probabilistic dynamic networks(SIRED-PDN)is given.Based on an evolutionary rule,the algebraic form for the dynamics of individual states and network topologies is given,respectively.Second,the SIRED-PDN can be described by a probabilistic mix-valued logical network.After providing an algorithm,all possible final spreading equilibria can be obtained for any given initial epidemic state and network topology by seeking attractors of the network.And the shortest time for all possible initial epidemic state and network topology profiles to evolve to the final spreading equilibria can be obtained by seeking the transient time of the network.Finally,an illustrative example is given to show the effectiveness of our model.

关键词： SIR epidemic Probabilistic dynamic networks Final spreading equilibria Semi-tensor product of matrices Algebraic form

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盐霉素体外对猪流行性腹泻病毒的抑制效果

畜牧兽医学报 2024年第4期55卷 1661-1671页

作者：马亚娟苏恺林依丹王亚文张亚楠袁洪兴袁晨宋勤叶河北农业大学动物医学院保定071000 馆陶县农业农村局邯郸057750

猪流行性腹泻(porcine epidemic diarrhea, PED)是由猪流行性腹泻病毒(porcine epidemic diarrhea virus, PEDV)引起的一种以水样腹泻、呕吐和脱水为主要特征的猪肠道传染病,给全球养猪业造成巨大的经济损失,但目前仍无有效的疫苗和治... 详细信息

猪流行性腹泻(porcine epidemic diarrhea, PED)是由猪流行性腹泻病毒(porcine epidemic diarrhea virus, PEDV)引起的一种以水样腹泻、呕吐和脱水为主要特征的猪肠道传染病,给全球养猪业造成巨大的经济损失,但目前仍无有效的疫苗和治疗药物。盐霉素(salinomycin, SLM)是一种常用的抗生素,具有不易产生耐药性、排泄迅速、残留量极低的优点。为明确SLM对PEDV的抑制作用,首先通过TCID_(50)(tissue culture infective dose)检测PEDV在Vero细胞上的增殖规律,进一步经CCK-8试验和细胞病变效应(cytopathic effect, CPE)测定SLM的半数细胞毒性浓度(half-cytotoxic concentration, CC_(50))和其对PEDV的半数抑制浓度(median inhibition concentration, IC_(50)),最后建立SLM、PEDV和Vero细胞的作用模型,利用RT-qPCR、免疫印迹(Western blot)和间接免疫荧光(indirect immunofluorescent assay, IFA)技术检测SLM对PEDV复制周期的影响。结果表明PEDV感染Vero细胞后24 h病毒滴度最高(10^(7.7)·0.1 mL^(-1));SLM对Vero细胞的CC_(50)为7.698μmol·L^(-1),对PEDV的IC_(50)为1.617μmol·L^(-1);随着SLM浓度的增加,PEDV滴度、N蛋白和N基因mRNA的表达量逐渐下降;SLM抑制PEDV的复制阶段,对病毒的吸附、入侵和释放阶段无明显影响。该研究结果可以为进一步挖掘PEDV抑制药物提供新思路。

关键词： PEDV CV777毒株 Vero细胞盐霉素复制周期

Paper-based biosensors based on multiple recognition modes for visual detection of microbially contaminated food

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未来食品学报(英文) 2024年第1期4卷 61-70页

作者： Jie Li Keren Chen yuan Su Longjiao Zhu hongxing Zhang Wentao Xu Xiangyang Li Beijing Laboratory of Food Quality and Safety Beijing Key Laboratory of Agriculraral Product Detection and Control of Spoilage Organisms and Pesticide ResidueFaculty of Food Science and EngineeringBeijing University of AgricultureBeijing 102206China Department of Munition and Health Instirure of Munition and HealthChina Agricultural UniversityBeijing 100191China

Microbially contaminated food can cause serious health hazards and economic losses,therefore sensitive,rapid,and highly specific visual detection is called for.Traditional detection of microorganisms is complex and time-consuming,which cannot meet current testing demands.The emergence of paper-based biosensors provided an effective method for efficient and visual detection of microorganisms,due to its high speed,all-in-one device,low cost,and convenience.This review focused on 5 biomarkers,namely nucleic acids,proteins,lipopolysaccharides.metabolites,and the whole microorganism of microorganisms.Besides,the recognition methods were summed up in 5 forms,including immunological recognition,aptamer recognition,nucleic acid amplification-mediated recognition.DNAzyme recognition and clustered regularly interspaced short palindromic repeats mediated recognition.In addition,we summarized the applications of paper-based biosensors in the detection of microorganisms thoroughly.Through the exploration of different biomarkers,identification methods,and applications,we hope to provide a reference for the development of paper-based biosensors and their application in safeguarding the food chain.

关键词： Paper-based biosensor Microorganism Multiple recognition Biomarker Visual detection

Optimized Technology for Residuum Processing in the ARGG Unit

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China Petroleum Processing & Petrochemical Technology 2006年第2期8卷 25-31页

作者： Pan Luoqi yuan hongxing Nie Baiqiu Chemical Industry Academy of Sichuan University Chengdu 610065 Baling Petrochemical Company SINOPEC Yueyang 414014

The influence of feedstock property on operation in the FCC unit was studied to identify the cause leading to deteriorated products distribution related with increasingly heavier feedstock for the ARGG unit. In order to maximize the economic benefits of the ARGG unit a string of measures, including the modification of catalyst formulation, retention of high catalyst activity, application of mixed termina-tion agents to control the reaction temperature and once-through operation, and optimization of catalyst regeneration technique, were adopted to adapt the ARGG unit to processing of the heavy feedstock with its carbon residue equating to 7 % on an average. The heavy oil processing technology has brought about apparent economic benefits.

关键词：重油 ARGG 催化剂炭渣终止剂最优化技术石油炼制

Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty:a prospective,double-blind,pilot,randomised controlled trial

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General Psychiatry 2024年第2期37卷 224-233页

作者： Jie Yang Mingshu Tao Rongguang Liu Jiaxing Fang Chunyan Li Dexian Chen Qi Wei Xingyu Xiong Wenxin Zhao Wen Tan yuan Han hongxing Zhang He Liu Song Zhang Junli Cao Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Hospital of Chengdu University of Traditional Chinese Medicine&Traditional Chinese Medicine Hospital of Sichuan ProvinceChengduSichuanChina NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs&Jiangsu Province Key Laboratory of Anesthesiology&Jiangsu Key Laboratory of Applied Technology of Anesthesia and Analgesia Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Eye&ENT Hospital of Fudan UniversityShanghaiChina Department of Anesthesiology&Clinical Research Center for Anesthesia and Perioperative Medicine&Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University||Huzhou Central Hospital||The Affiliated Huzhou HospitalZhejiang University School of Medicine||Affiliated Central Hospital Huzhou UniversityHuzhouZhejiangChina Department of Anesthesiology Renji Hospital School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Postoperative sleep disturbance(PSD)is a common and serious postoperative complication and is associated with poor postoperative outcomes.Aims This study aimed to investigate the effect of transcranial direct current stimulation(tDCS)on PSD in older patients undergoing lower limb major arthroplasty.Methods In this prospective,double-blind,pilot,randomised,sham-controlled trial,patients 65 years and over undergoing lower limb major arthroplasty were randomly assigned to receive active tDCS(a-tDCS)or sham tDCS(s-tDCS).The primary outcomes were the objective sleep measures on postoperative nights(N)1 and N2.Results 116 inpatients were assessed for eligibility,and a total of 92 patients were enrolled;47 received a-tDCS and 45 received s-tDCS.tDCS improved PSD by altering the following sleep measures in the a-tDCS and s-tDCS groups;the respective comparisons were as follows:the promotion of rapid eye movement(REM)sleep time on N1(64.5(33.5-105.5)vs 19.0(0.0,45.0)min,F=20.10,p<0.001)and N2(75.0(36.0-120.8)vs 30.0(1.3-59.3)min,F=12.55,p<0.001);the total sleep time on N1(506.0(408.0-561.0)vs 392.0(243.0-483.5)min,F=14.13,p<0.001)and N2(488.5(455.5-548.5)vs 346.0(286.5-517.5)min,F=7.36,p=0.007);the deep sleep time on N1(130.0(103.3-177.0)vs 42.5(9.8-100.8)min,F=24.4,p<0.001)and N2(103.5(46.0-154.8)vs 57.5(23.3-106.5)min,F=8.4,p=0.004);and the percentages of light sleep and REM sleep on N1 and N2(p<0.05 for each).The postoperative depression and anxiety scores did not differ significantly between the two groups.No significant adverse events were reported.Conclusion In older patients undergoing lower limb major arthroplasty,a single session of anodal tDCS over the left dorsolateral prefrontal cortex showed a potentially prophylactic effect in improving postoperative short-term objective sleep measures.However,this benefit was temporary and was not maintained over time.

关键词： sleep stimulation postoperative

PARALLEL IMPLEMENTATION AND OPTIMIZATION OF THE SEBVHOS ALGORITHM

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Journal of Electronics(China) 2011年第3期28卷 277-283页

作者： Li Wen Guo Li yuan hongxing Wei Yifang Guan Hua Deptartmen of Electronic Science and Technology University of Science and Technology of China Hefei 230027 China

In this paper, a parallel Surface Extraction from Binary Volumes with Higher-Order Smoothness (SEBVHOS) algorithm is proposed to accelerate the SEBVHOS execution. The original SEBVHOS algorithm is parallelized first, and then several performance optimization techniques which are loop optimization, cache optimization, false sharing optimization, synchronization overhead op-timization, and thread affinity optimization, are used to improve the implementation's performance on multi-core systems. The performance of the parallel SEBVHOS algorithm is analyzed on a dual-core system. The experimental results show that the parallel SEBVHOS algorithm achieves an average of 1.86x speedup. More importantly, our method does not come with additional aliasing artifacts, com-paring to the original SEBVHOS algorithm.

关键词： Multi-core Parallel algorithm Performance optimization 3D reconstruction

Collective Molecular Machines: Multidimensionality and Reconfigurability

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Nano-Micro Letters 2024年第8期16卷 309-340页

作者： Bin Wang yuan Lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical work.During the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense research.Effective progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and informatics.However,individual molecular machines are only capable of producing nanometer work and generally have only a single functionality.In order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new paradigm.In this review,we comprehensively discuss recent developments in the collective behaviors of molecular machines.In particular,collective behavior is divided into two paradigms.One is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional materials.The other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale operations.We discuss design strategies for both modes and focus on the modulation of features and properties.Subsequently,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

Photonic neuromorphic architecture for tens-of-task lifelong learning

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Light(Science & Applications) 2024年第3期13卷 519-530页

作者： yuan Cheng Jianing Zhang Tiankuang Zhou Yuyan Wang Zhihao Xu Xiaoyun yuan Lu Fang Sigma Laboratory Department of Electronic EngineeringTsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology(BNRist) Beijing 100084China Institute for Brain and Cognitive Science Tsinghua University(THUIBCS)Beijing 100084China

Scalable,high-capacity,and low-power computing architecture is the primary assurance for increasingly manifold and large-scale machine learning tasks.Traditional electronic artificial agents by conventional power-hungry processors have faced the issues of energy and scaling walls,hindering them from the sustainable performance improvement and iterative multi-task learning.Referring to another modality of light,photonic computing has been progressively applied in high-efficient neuromorphic systems.Here,we innovate a reconfigurable lifelong-learning optical neural network(L2 ONN),for highly-integrated tens-of-task machine intelligence with elaborated algorithm-hardware codesign.Benefiting from the inherent sparsity and parallelism in massive photonic connections,L2 ONN learns each single task by adaptively activating sparse photonic neuron connections in the coherent light field,while incrementally acquiring expertise on various tasks by gradually enlarging the activation.The multi-task optical features are parallelly processed by multi-spectrum representations allocated with different wavelengths.Extensive evaluations on freespace and on-chip architectures confirm that for the first time,L2 ONN avoided the catastrophic forgetting issue of photonic computing,owning versatile skills on challenging tens-of-tasks(vision classification,voice recognition,medical diagnosis,etc.)with a single model.Particularly,L2 ONN achieves more than an order of magnitude higher efficiency than the representative electronic artificial neural networks,and 14×larger capacity than existing optical neural networks while maintaining competitive performance on each individual task.The proposed photonic neuromorphic architecture points out a new form of lifelong learning scheme,permitting terminal/edge AI systems with light-speed efficiency and unprecedented scalability.

关键词： life neural versatile

Lactate metabolism in neurodegenerative diseases

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Neural Regeneration Research 2024年第1期19卷 69-74页

作者： Chaoguang Yang Rui-yuan Pan Fangxia Guan Zengqiang yuan The Brain Science Center Beijing Institute of Basic Medical SciencesBeijingChina School of Life Sciences Zhengzhou UniversityZhengzhouHenan ProvinceChina

Lactate,a byproduct of glycolysis,was thought to be a metabolic waste until the discovery of the Warburg effect.Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological conditions.The Astrocyte-Neuron Lactate Shuttle has cla rified that lactate plays a pivotal role in the central nervous system.Moreover,protein lactylation highlights the novel role of lactate in regulating transcription,cellular functions,and disease development.This review summarizes the recent advances in lactate metabolism and its role in neurodegenerative diseases,thus providing optimal pers pectives for future research.

关键词： Alzheimer's disease Astrocyte-Neuron Lactate Shuttle brain central nervous system glucose metabolism glycolysis neuroinflammation Parkinson's disease protein lactylation signaling molecule