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Climate change in the Hongliujing area of Lop Nur over the past 200 years revealed by the stable oxygen isotopes of Tamarix cones

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Frontiers of Earth Science 2023年第4期17卷 970-980页

作者： Zhiguang LI Yaqing DONG Haoyu ZHANG hongxiao sun Danyang JIA Shikai SONG Yuanjie ZHAO Hebei Key Laboratory of Environmental Change and Ecological Construction College of Geographical SciencesHebei Normal UniversityShijiazhuang 050024China Hebei Center for Ecological and Environmental Geology Research Hebei GEO UniversityShijiazhuang 050031China

The layers of Tamarix cones within sedimentary deposits in arid regions have significant chronological and paleoenvironmental ***,we compare the δ^(18)O values of Tamarix cones in the Hongliujing area of Lop Nur with meteorological data for the Ruoqiang meteorological station for 1960-2019 *** regression analysis was used to reconstruct the average temperature for April and the precipitation for November in the Hongliujing area over the past 200 *** results showed that the δ^(18)O values were significantly negatively correlated with the temperature for February,April,May,August,December,and with the annual mean temperature;significantly negatively correlated with the precipitation for February and April;significantly negatively correlated with the sunshine hours for March and May;significantly positively correlated with the sunshine hours for February,July,August,October,and December,and with the annual mean values;and significantly correlated with the relative humidity for April,July,August,September,October,and November,and with the annual mean *** on the δ^(18)O record of the past 200 years,the Hongliujing area experienced two warm-wet periods(1874-1932 and 2004-2019 AD)and two cold-dry periods(1832–1873 and 1933-2003 AD).Thus,the climate was characterized by alternating warm-wet and cold-dry *** analysis revealed three main cycles:45 years,29 years,and 14 years.

关键词： Tamarix cones climate change δ^(18)O Lop Nur

Screening for lipophilic marine toxins and their potential producers in coastal waters of Weihai in autumn,2020

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Journal of Oceanology and Limnology 2022年第6期40卷 2218-2230页

作者： Huixia GENG hongxiao sun Chao LIU Fanzhou KONG Qingchun ZHANG Tian YAN Rencheng YU CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Ecology and Environmental Science Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Lipophilic marine toxins(LMTs)produced by some microalgae in the sea could accumulate in shellfish and pose potential threats to the health of seafood *** and shellfish samples were collected from coastal waters of Weihai in Shandong Peninsula,China in autumn,2020,and screened for lipophilic marine toxins and their potential producers using liquid chromatography-tandem mass spectrometry(LC-MS/MS)analysis and high throughput sequencing of partial DNA(V4 region of the 18S rRNA gene)extracted from ***-2(PTX2),trace amounts of azaspiracid(AZA1 or AZA40),and 13-desmethyl spirolide C(13-DesMe-C)were detected in phytoplankton samples,while PTX2 and gymnodimine(GYM)were detected in shellfish *** toxin content in shellfish samples was much lower than the regulatory limit or values reported *** suggest that lipophilic marine toxins should have low risk in coastal waters of Weihai in *** on the data of high throughput sequencing,the OTUs were assigned to 5 identified species of Alexandrium,including *** capable of producing 13-DesMe-C and *** OTUs were found closely related to the toxic species in genus Dinophysis,but it is impossible to assign them to any identified species due to the low resolving power of the V4 region for *** OTUs could not be assigned to any identified species in the genus Azadinium,suggesting the existence of unidentified species in this region.

关键词： harmful algal blooms phytoplankton shellfish lipophilic marine toxins(LMTs) Yellow Sea liquid chromatography-tandem mass spectrometry

A microRNA-21-responsive doxorubicin-releasing sticky-flare for synergistic anticancer with silencing of microRNA and chemotherapy

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Science China Chemistry 2021年第6期64卷 1009-1019页

作者： Min Hong hongxiao sun Qiangqiang Yang Shuang Cheng Shuxian Yu Shuhua Fan Chuan Li Cheng Cui Weihong Tan School of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng 252059China School of Agriculture Liaocheng UniversityLiaocheng 252059China Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of Life SciencesCollaborative Innovation Center for Chemistry and Molecular MedicineHunan UniversityChangsha 410082China Department of Pharmacy Tai’an Municipal HospitalTai’an 271000China

A sticky-flare gold nanoparticle probe(AuNP-probe)is designed by the combination of locked nucleic acid functionalized silencing of microRNA technology for intracellular microRNA-21(miRNA-21)sensitively detecting,fluorescence imaging,localizing and *** limit of detection is as low as 0.01 n *** miRNA-21 in cancer cells serves as endogenous drug release stimuli to trigger the release of probe-loaded doxorubicin(Dox),which soon translocates into cell *** multifunctional Dox-loaded AuNP-probe(Dox-AuNP-probe)could induce cancer cell apoptosis effectively through the synergistic effect of gene silencing and *** Dox-AuNP-probe exhibits superior drug potency compared to free Dox molecules,with a cell inhibition rate of 57%(but only 20%for Dox)to wild-type cancer cells and 30%(but 0%for Dox)to drug-resistent cancer cells after 72 h,and this strategy not only has the function of sensing,but also can effectively bypass drug *** MCF-7 xenograft tumor-bearing mice,the Dox-AuNP-probes show greater inhibition for tumor tissues than miRNA-21 targeted AuNP-probes(Targeting-AuNP-probe)or free Dox ***,the Dox-AuNP-probe represents a promising nanotheranostic platform for future applications in cancer molecular imaging and therapy,especially providing a potential strategy to treat resistant cancers.

关键词： gold nanoparticle probe silencing microRNA-21 doxorubicin controlled-release synergistic anticancer

Valvuloplasty of fetal pulmonary atresia with intact ventricular septum and hypoplastic right heart: Mid-term follow-up results

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Journal of Interventional Medicine 2022年第4期5卷 196-199页

作者： Gang Luo Shuai Gao hongxiao sun Zhixian Ji Dunliang Wang Yue sun Silin Pan Heart Center Women and Children’s HospitalQingdao UniversityQingdao266034PR China Department of Anesthesiology Women and Children’s HospitalQingdao UniversityQingdao266034PR China Department of Obstetrics Women and Children’s HospitalQingdao UniversityQingdao266034PR China

Objective:This study aimed to analyze and evaluate the results of mid-term follow-up after fetal pulmonary valvuloplasty(FPV)in fetuses with pulmonary atresia with intact ventricular septum(PA/IVS).Methods:From August 31,2018,to May 31,2019,seven fetuses with PA/IVS and hypoplastic right heart were included in this *** underwent echocardiography by the same specialist and were operated on by the same *** and echocardiography data were collected,and changes in the associated indices noted during follow-up were ***:All seven fetuses successfully underwent *** median gestational age at FPV was 27.54 *** average FPV procedural time was 6 *** bradycardia requiring treatment occurred in 4/7 ***,five pregnancies were successfully delivered,and the other two were *** to data before fetal cardiac interventions(FCI),tricuspid valve annulus diameter/mitral valve annulus diameter(TV/MV)and right ventricle diameter/left ventricle diameter(RV/LV)of all fetuses had progressively *** maximum tricuspid regurgitation velocity decreased from 4.60 m/s to 3.64 m/*** average follow-up time was 30.40±2.05 *** the follow-up period,the diameter of the tricuspid valve ring in five children continued to improve,and the development rate of the tricuspid valve was relatively obvious from 6 months to 1 year after ***,the development of the right ventricle after birth was relatively *** was discovered that there were individual variations in the development of the right ventricle during ***:The findings support the potential for the development of the right ventricle and tricuspid valve in fetuses with PA/IVS who underwent *** of the right ventricle and tricuspid valve does not occur synchronously during *** right ventricle develops rapidly in utero,but the development of tricuspid valve is more apparent after birth than in utero.

关键词： Congenital heart disease fetal cardiac intervention fetal pulmonary valvuloplasty hypoplastic right heart syndrome pulmonary atresia with intact septum

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永磁直线伺服系统终端互补滑模位置控制

电机与控制学报 2023年第6期27卷 182-190页

作者：赵希梅孙洪潇金鸿雁沈阳工业大学电气工程学院辽宁沈阳110870

为了解决永磁直线同步电机(PMLSM)直驱伺服系统易受端部效应、非线性摩擦以及外部扰动等不确定因素影响的问题,提出一种将互补滑模控制(CSMC)与终端滑模控制(TSMC)相结合的终端互补滑模控制(TCSMC)方法。首先,建立具有不确定因素的PMLS... 详细信息

为了解决永磁直线同步电机(PMLSM)直驱伺服系统易受端部效应、非线性摩擦以及外部扰动等不确定因素影响的问题,提出一种将互补滑模控制(CSMC)与终端滑模控制(TSMC)相结合的终端互补滑模控制(TCSMC)方法。首先,建立具有不确定因素的PMLSM动态模型。其次,将广义滑模面与互补滑模面相结合,同时利用饱和函数替换切换函数设计CSMC,与传统的滑模控制相比,其跟踪误差减半,能有效削弱抖振。为了进一步提高系统的收敛速度,在互补滑模面中引入终端项,设计TCSMC,使得系统在CMSC减少系统误差的基础上,进一步提高控制性能。最后,通过理论分析,证明控制器的稳定性,系统实验表明,与CSMC和TSMC相比,TCSMC不但提高了系统收敛速度和控制精度,削弱了抖振现象,而且明显增强了系统的鲁棒性。

关键词：永磁直线同步电机不确定因素终端互补滑模控制器收敛速度控制精度鲁棒性

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利用专用工装实现球面光楔加工

电光与控制 2012年第8期19卷 93-96页

作者：庄纪纲孙红晓中国航空工业洛阳电光设备研究所河南洛阳471009

楔形的球面透镜是头盔瞄准/显示器的光学系统中消除大离轴角产生的较大畸变、视差的光学零件,几何中心与原始光轴既偏心又倾斜,采用传统的加工方法无法实现双球心位置与旋转轴线关系的建立。通过设计专用工装解决了工件定位问题,实现了... 详细信息

楔形的球面透镜是头盔瞄准/显示器的光学系统中消除大离轴角产生的较大畸变、视差的光学零件,几何中心与原始光轴既偏心又倾斜,采用传统的加工方法无法实现双球心位置与旋转轴线关系的建立。通过设计专用工装解决了工件定位问题,实现了准确的外圆及缺口加工。

关键词：头盔显示器畸变校正球面光楔工装磨边

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电力系统中的谐波分析与抑制技术研究

电力设备管理 2024年第6期 29-31页

作者：孙红晓国网浙江省电力有限公司淳安县供电公司

本文结合本厂实际情况详细分析了谐波对电网的影响,包括增加电力系统内损耗、谐波增加设备损坏风险等,并详细说明谐波产生的原因。同时针对电力系统中的谐波抑制技术展开分析,并基于有源滤波器抑制功率提出了相应的干预措施,通过仿真分... 详细信息

本文结合本厂实际情况详细分析了谐波对电网的影响,包括增加电力系统内损耗、谐波增加设备损坏风险等,并详细说明谐波产生的原因。同时针对电力系统中的谐波抑制技术展开分析,并基于有源滤波器抑制功率提出了相应的干预措施,通过仿真分析判断了上述相关措施的可行性。根据本文的仿真结果可知,在采取上述谐波抑制措施后,谐波的总畸变率下降至1.43%,达到了预期标准。

关键词：电力系统谐波抑制技术有源滤波器

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低压配电台区柔性互联关键技术应用探析

电力设备管理 2024年第8期 23-25页

作者：孙红晓国网浙江省电力有限公司淳安县供电公司

本文提出区域配网的台区柔性互联规划方法,用以优化配网负荷结构、均衡负荷,并结合电网工程案例,站在供电公司角度上聚焦能源互联,从项目规划建设、网架结构、关键设备、控制及保护等方面梳理低压配电台区柔性互联关键技术,并展望现代... 详细信息

本文提出区域配网的台区柔性互联规划方法,用以优化配网负荷结构、均衡负荷,并结合电网工程案例,站在供电公司角度上聚焦能源互联,从项目规划建设、网架结构、关键设备、控制及保护等方面梳理低压配电台区柔性互联关键技术,并展望现代化发展背景下台区柔性互联系统高级应用的发展方向。

关键词：柔性互联配电台区网架结构互联拓扑运行调控

过表达线粒体融合蛋白2对阿霉素诱导下血管内皮祖细胞衰老及凋亡的影响

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中华实验外科杂志 2021年第5期38卷 810-813页

作者：高帅泮思林罗刚纪志娴孙宏晓青岛大学附属妇女儿童医院青岛市妇女儿童医院心脏中心266034

目的探讨过表达线粒体融合蛋白2(Mfn2)对阿霉素(Dox)诱导下血管内皮祖细胞(EPCs)衰老及凋亡的影响。方法抽取SD雄性大鼠外周动脉血,分离培养EPCs,进一步分为,正常EPCs组、空载体组、Mfn2过表达组,经0.2μmol/L和2.0μmol/L Dox诱导,通... 详细信息

目的探讨过表达线粒体融合蛋白2(Mfn2)对阿霉素(Dox)诱导下血管内皮祖细胞(EPCs)衰老及凋亡的影响。方法抽取SD雄性大鼠外周动脉血,分离培养EPCs,进一步分为,正常EPCs组、空载体组、Mfn2过表达组,经0.2μmol/L和2.0μmol/L Dox诱导,通过激光共聚焦显微镜观察线粒体分裂情况;通过β-半乳糖苷酶活性检测、原位末端标记法(TUNEL)染色,检测细胞衰老和凋亡情况;蛋白印迹法检测细胞衰老标志蛋白多肿瘤抑制基因1(p16INK4A)的表达;实时荧光定量聚合酶链反应检测内皮型一氧化氮合酶(eNOS)及血管性血友病因子(vWF)的表达。多组间均数比较采用单因素方差分析。结果在0.2μmol/L和2.0μmol/L Dox处理下,Mfn2过表达组[(5.83±1.71)%、(6.72±0.57)%]线粒体分裂的细胞比例低于正常EPCs组[(19.16±0.82)%、(68.56±5.31)%]和空载体组[(17.53±2.86)%、(66.54±2.86)%,F=40.403、302.725,P<0.05],差异均有统计学意义;在0.2μmol/L Dox处理下,Mfn2过表达组[(15.0±0.33)%]β-半乳糖苷酶活性升高的细胞比例低于正常EPCs组[(35.0±0.61)%]和空载体组[(36.0±1.23)%,F=637.291,P<0.05],差异均有统计学意义;在2μmol/L Dox处理下,Mfn2过表达组[(11.90±0.50)%]TUNEL+细胞的比例低于正常EPCs组[(34.50±0.80)%]和空载体组[(35.20±1.60)%,F=458.327,P<0.05],差异均有统计学意义;在0.2μmol/L Dox处理条件下,Mfn2过表达组eNOS mRNA(0.65±0.02)和vWF mRNA(0.65±0.01)的相对表达高于正常EPCs组(0.43±0.03、0.50±0.02)以及空载体组(0.34±0.02、0.48±0.02,F=134.643、71.646,P<0.05),差异均有统计学意义;在2.0μmol/L Dox处理条件下,Mfn2过表达组eNOS mRNA(0.71±0.02)和vWF mRNA(0.66±0.03)的表达高于正常EPCs组(0.33±0.02、0.28±0.02)以及空载体组(0.38±0.03、0.35±0.01,F=225.712、262.934,P<0.05),差异均有统计学意义。结论过表达Mfn2可以抑制线粒体分裂,拮抗Dox诱导下EPCs的衰老及凋亡,恢复EPCs的功能。

关键词：线粒体融合蛋白2 内皮祖细胞基因转染阿霉素线粒体分裂