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万古霉素药物浓度监测在治疗严重脓毒症中的临床应用

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武警医学 2024年第6期35卷 516-519页

作者：王晓红斯日古楞贾志新尹红霞武警内蒙古总队医院药剂科内蒙古自治区人民医院药学处武警内蒙古总队医院内二科北京武警特色医学中心研究部突发公共卫生事件医学防治研究所

目的评估万古霉素药物浓度监测(TDM)治疗严重脓毒症的临床应用效果。方法收集2018-06至2021-12内蒙古自治区人民医院ICU收治的脓毒症患者为研究对象。按是否应用TDM分为TDM组和非TDM组。计录两组患者治疗后白细胞计数、降钙素原、C反... 详细信息

目的评估万古霉素药物浓度监测(TDM)治疗严重脓毒症的临床应用效果。方法收集2018-06至2021-12内蒙古自治区人民医院ICU收治的脓毒症患者为研究对象。按是否应用TDM分为TDM组和非TDM组。计录两组患者治疗后白细胞计数、降钙素原、C反应蛋白、中性粒细胞率、血清肌酐、住院时间和万古霉素持续使用时间，评估两组的临床疗效。结果两组患者治疗后，白细胞计数、降钙素原、C反应蛋白、中性粒细胞率、住院时间、万古霉素使用时间对比，差异均无统计学意义。但TDM组血清肌酐(139.99±84.80)μmol/L、中性粒细胞率(79.94±7.89)%和降钙素原(3.72±5.73) ng/ml的平均值明显低于非TDM组，差异有统计学意义(P<0.05)。结论万古霉素TDM在对严重脓毒症患者的治疗中具有较好的指导作用，维持了有效的药物浓度，又可降低肾毒性发生风险，建议临床推广。

关键词：药物浓度监测万古霉素严重脓毒症临床疗效

CONVERGENCE PROPERTIES OF CONJUGATEGRADIENT METHODS WITH STRONG WOLFE LINESEARCH

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Systems Science and Mathematical Sciences 1998年第2期11卷 112-116页

作者： HAN Jiye LIU Guanghui yin hongxia(Institute of Applied Mathematics, Academia Silica, Beijing 100080, China)

In this paper, we investigate the convergence property of the conjugate gradientalgorithms which depend on the search directionsby using different choices for the scalar oh, where 9k is the gradient of f at ac. Undersome assumptions which are slightly weaker than those in [1], we prove a global convergenceresult which allows ac to be set in a wider range than that in [1].

关键词： Conjugate gradient algorithms global convergence) unconstrained optimization.

Application of synchrotron source based DEI method in guinea pig cochleae imaging

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Progress in Natural Science:Materials International 2007年第1期17卷 59-67页

作者： yin hongxia, LIU Bo, GAO Xin, GAO Xiulai and LUO Shuqian ( College of Biomedical Engineering, Capital University of Medical Sciences, Beijing 100069, China Department of Anatomy, Capital University of Medical Sciences, Beijing 100069, China) College of Biomedical Engineering Capital University of Medical Sciences Beijing 100069 China Department of Anatomy Capital University of Medical Sciences Beijing 100069 China

Hard X-ray diffraction enhanced imaging (DEI), which is based on a synchrotron source and monochromator-analyzer-crystal system, is an effective method for imaging X-ray phase shift. Utilizing an analyzer crystal with high angular sensitivity of micro-radian, DEI can measure the transmitted, refracted and scattered X-rays when projecting onto a sample. It dramatically improves the contrast and spatial resolution of the resultant images. At the topography station of Beijing Synchrotron Radiation Facilities (BSRF), we implemented DEI method in guinea pig cochleae imaging and acquired a series of DEI images. Based on these images, the apparent absorption and refraction images were calculated. The DEI images revealed the holistic spiral structures and inner details of guinea pig cochleae clearly, even including the structures at the cellular level, such as the static cilia of hairy cells and the limbus of Hansen cell. Due to the advantages of high contrast, high spatial resolution and distinct edge-enhanced effect, DEI method promises extensive applications in biology, medicine and clinic in the near future.

关键词： diffraction enhanced imaging hard X-ray imaging phase-contrast imaging cochlea micro-structure synchrotron source.

Function investigation of p11.5 in ASFV infection

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Virologica Sinica 2024年第3期39卷 469-477页

作者： Dan yin Bin Shi Renhao Geng yingnan Liu Lang Gong hongxia Shao Kun Qian Hongjun Chen Aijian Qin Ministry of Education Key Laboratory for Avian Preventive Medicine Yangzhou UniversityJiangsu 225009China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Jiangsu 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China Jiangsu 225009China Shanghai Veterinary Research Institute CAASShanghai200241China South China Agricultural University Guangzhou 510642China

Virus replication relies on complex interactions between viral *** the case of African swine fever virus(ASFV),only a few such interactions have been identified so *** this study,we demonstrate that ASFV protein p72 interacts with p11.5 using co-immunoprecipitation and liquid chromatography-mass spectrometry(LC-MS).It was found that protein p72 interacts specifically with p11.5 at sites amino acids(aa)1–216 of p72 and aa 1–68 of *** assess the importance of p11.5 in ASFV infection,we developed a recombinant virus(ASFVGZΔA137R)by deleting the A137R gene from the ASFVGZ *** with ASFVGZ,the infectious progeny virus titers of ASFVGZΔA137R were reduced by approximately 1.0 *** addition,we demonstrated that the growth defect was partially attributable to a higher genome copies-to-infectious virus titer ratios produced in ASFVGZΔA137R-infected MA104 cells than in those infected with *** finding suggests that MA104 cells infected with ASFVGZΔA137R may generate larger quantities of noninfectious ***,we found that p11.5 did not affect virus-cell binding or ***,we show for the first time the interaction between ASFV p72 and *** results effectively provide the relevant information of the p11.5 *** results extend our understanding of complex interactions between viral proteins,paving the way for further studies of the potential mechanisms and pathogenesis of ASFV infection.

关键词： African swine fever virus p72 protein p11.5 protein Protein interactions

Induced pluripotent stem cells(iPSCs):molecular mechanisms of induction and applications

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2065-2090页

作者： Jonas Cerneckis hongxia Cai Yanhong Shi Department of Neurodegenerative Diseases Beckman Research Institute of City of HopeDuarteCA 91010USA Irell&Manella Graduate School of Biological Sciences Beckman Research Institute of City of HopeDuarteCA 91010USA

The induced pluripotent stem cell(iPSC)technology has transformed in vitro research and holds great promise to advance regenerative *** have the capacity for an almost unlimited expansion,are amenable to genetic engineering,and can be differentiated into most somatic cell *** have been widely applied to model human development and diseases,perform drug screening,and develop cell *** this review,we outline key developments in the iPSC field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic *** begin by discussing the pivotal discoveries that revealed the potential of a somatic cell nucleus for reprogramming and led to successful generation of *** consider the molecular mechanisms and dynamics of somatic cell reprogramming as well as the numerous methods available to induce ***,we discuss various iPSC-based cellular models,from mono-cultures of a single cell type to complex three-dimensional organoids,and how these models can be applied to elucidate the mechanisms of human development and *** use examples of neurological disorders,coronavirus disease 2019(COVID-19),and cancer to highlight the diversity of disease-specific phenotypes that can be modeled using iPSC-derived *** also consider how iPSC-derived cellular models can be used in high-throughput drug screening and drug toxicity ***,we discuss the process of developing autologous and allogeneic iPSC-based cell therapies and their potential to alleviate human diseases.

关键词： mechanisms programming holds

Stochastic LQ Control with Extra Measurability Restriction

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Journal of Systems Science & Complexity 2024年第3期37卷 1003-1022页

作者： WANG hongxia HU Yuxi LI Zixing SONG Lianfeng College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

Different from the standard linear quadratic(LQ)problem for stochastic systems,the LQ problem considered in the paper has extra measurability *** problem also appears in the LQ control problem for stochastic systems with delays,rational expectations problems,asymmetric information control,and so *** essential difficulty lies in that one has to optimize the input and its conditional expectations *** stochastic maximum principle(SMP)and orthogonal decomposition technique are the key ***,the authors establish the SMP and convert the original problem into forward and backward stochastic difference equations(FBSDEs)with extra measurability ***,the authors resolve the FBSDEs by using the orthogonal decomposition technique and obtain the analytical solution to the underlying ***,the authors explore the essential distinction between the problem and the standard stochastic LQ control ***,numerical examples are given to illustrate the obtained results.

关键词： Multiplicative noise systems optimal control stochastic maximum principle stochastic systems

Preparation of K-doped g-C_(3)N_(4) composite loaded on magnetic attapulgite and its degradation performance for malachite green

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Chinese Journal of Chemical Engineering 2024年第7期71卷 110-121页

作者： Aishun Ma Hanlin Qian hongxia Liu Sili Ren Jiangxi Key Laboratory of Mining&Metallurgy Environmental Pollution Control Jiangxi University of Science and TechnologyGanzhou 341000China Jiangxi Provincial Key Laboratory of Low-Carbon Processing and Utilization of Strategic Metal Mineral Resources Jiangxi University of Science and TechnologyGanzhou 341000China

Visible-light-driven photocatalysis is a promising technology for the treatment of dye *** this work,a novel photocatalyst of K-doped g-C_(3)N_(4) loaded on magnetic attapulgite(ATP)(Kω-g-C_(3)N_(4)@ATP-Fe_(3)O_(4))with excellent visible light photocatalytic properties and stability were successfully prepared and *** removal efficiency of Kω-g-C_(3)N_(4)@ATP-Fe_(3)O_(4) for malachite green(MG)was studied,and the degradation mechanism was analyzed and *** was found that the K_(5)-g-C_(3)N_(4)@ATP-Fe_(3)O_(4) photocatalyst possessed excellent degradation efficiency of over 98.0%for the MG dye wastewater under optimal ***,the K_(5)-g-C_(3)N_(4)@ATP-Fe_(3)O_(4) materials possessed good recyclability with a removal rate over 82%after 4 *** visible light condition,the K_(5)-g-C_(3)N_(4)@ATP-Fe_(3)O_(4) photocatalyst produce radicals of·OH and O_(2)^(-)to degrade the MG dyes,which was supported by electron paramagnetic resonance(EPR)and radical trapping *** addition,the LC-MS analysis interpreted the degradation pathways and intermediates of MG in the *** findings in this work indicate that the prepared photocatalytic material has excellent degradation efficiency for MG and can be applied in dye wastewater treatment.

关键词： Photocatalyst Malachite green K-doped g-C_(3)N_(4) Degradation

Bacterial persisters: molecular mechanisms and therapeutic development

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3305-3336页

作者： hongxia Niu Jiaying Gu ying Zhang School of Basic Medical Science and Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province Zhejiang Chinese Medical UniversityHangzhou 310053 ZhejiangChina State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003 ZhejiangChina Jinan Microecological Biomedicine Shandong Laboratory Jinan 250022 ShandongChina

Persisters refer to genetically drug susceptible quiescent(non-growing or slow growing)bacteria that survive in stress environments such as antibiotic exposure,acidic and starvation *** cells can regrow after stress removal and remain susceptible to the same *** are underlying the problems of treating chronic and persistent infections and relapse infections after treatment,drug resistance development,and biofilm infections,and pose significant challenges for effective *** the characteristics and the exact mechanisms of persister formation,especially the key molecules that affect the formation and survival of the persisters is critical to more effective treatment of chronic and persistent ***,genes related to persister formation and survival are being discovered and confirmed,but the mechanisms by which bacteria form persisters are very complex,and there are still many unanswered *** article comprehensively summarizes the historical background of bacterial persisters,details their complex characteristics and their relationship with antibiotic tolerant and resistant bacteria,systematically elucidates the interplay between various bacterial biological processes and the formation of persister cells,as well as consolidates the diverse anti-persister compounds and *** hope to provide theoretical background for in-depth research on mechanisms of persisters and suggest new ideas for choosing strategies for more effective treatmentofpersistent infections.

关键词： mechanisms treatment persist

Performance Improvement of Two-Phase Steam Ejector based on CFD Techniques,Response Surface Methodology and Genetic Algorithm

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Journal of Thermal Science 2024年第2期33卷 675-695页

作者： ZHANG Hao ZHAO hongxia ZHANG Xiuao ZENG Hongxuan DENG Jianqiang School of Energy and Power Engineering Shandong UniversityJi’nan250061China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an710049China

The steam ejector is a crucial component in the waste heat recovery *** performance determines the amount of recovered heat and system ***,poor ejector performance has always been the main bottleneck for system ***,this study proposes an optimization methodology to improve the steam ejector's performance by utilizing computational fluid dynamics(CFD) techniques,response surface methodology(RSM),and genetic algorithm(GA).Firstly,a homogeneous equilibrium model(HEM) was established to simulate the two-phase flow in the steam ***,the orthogonal test was presented to the screening of the key decision variables that have a significant impact on the entrainment ratio(ER).Next,the RSM was used to fit a response surface regression model(RSRM).Meanwhile,the effect of the interaction of geometric parameters on the performance of the steam ejector was ***,GA was employed to solve the RSRM's global optimal ER *** results show that the RSRM exhibits a good fit for ER(R^(2)=0.997).After RSM and GA optimization,the maximum ejector efficiency is 27.94%,which is 48.38% higher than the initial ejector of 18.83%.Furthermore,the optimized ejector efficiency is increased by 46.4% on average under off-design ***,the results reveal that the combination of CFD,RSM,and GA presents excellent reliability and feasibility in the optimization design of a two-phase steam ejector.

关键词： two-phase steam ejector optimization methodology CFD techniques response surface methodology genetic algorithm homogeneous equilibrium model