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宫腔镜黏膜下子宫肌瘤电切除术对黏膜下子宫肌瘤患者生殖预后及卵巢功能恢复的影响

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实用妇科内分泌电子杂志 2024年第6期11卷 7-9页

作者：赵洪霞张新艳中国人民解放军联勤保障部队第九七〇医院妇产科山东烟台264000

目的探究黏膜下子宫肌瘤患者行宫腔镜黏膜下子宫肌瘤电切术对其生殖预后、卵巢功能恢复的影响。方法选取80例黏膜下子宫肌瘤患者,按照随机数字表法分为对照组及研究组,每组40例。对照组行腹腔镜子宫肌瘤剔除术(LM),研究组行宫腔镜子宫... 详细信息

目的探究黏膜下子宫肌瘤患者行宫腔镜黏膜下子宫肌瘤电切术对其生殖预后、卵巢功能恢复的影响。方法选取80例黏膜下子宫肌瘤患者,按照随机数字表法分为对照组及研究组,每组40例。对照组行腹腔镜子宫肌瘤剔除术(LM),研究组行宫腔镜子宫肌瘤电切术(TCRM)。比较两组手术效果。结果两组手术时间、妊娠率比较(P>0.05)。研究组术中出血量为(35.29±6.30)ml,少于对照组的(38.80±6.21)ml,术后肛门首次排气、下床活动及住院时间均短于对照组,首次妊娠距手术时间短于对照组(P0.05)。结论TCRM、LM治疗黏膜下子宫肌瘤对患者卵巢功能的影响均较小,但TCRM在促进术后恢复、缩短首次妊娠时间方面更为有利。

关键词：子宫肌瘤宫腔镜电切除术卵巢功能生殖预后

Investigation on the Performance of the Pump-Free Double Heat Source Ejector Refrigeration System with R1234yf

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Journal of Thermal Science 2022年第5期31卷 1452-1464页

作者： YU Meihong zhao hongxia WANG Xinli HAN Jitian LAI Yanhua School of Energy and Power Engineering Shandong UniversityJi’nan250061China School of Control Science and Engineering Shandong UniversityJi’nan250061China

A pump is needed in an ejector refrigeration system,which makes the system high cost and complicated and hinders its application.A pump-free double heat source ejector refrigeration system using R1234yf as working fluid is proposed in which an injector driven by another heat source replaces the liquid circulating pump,making the system more affordable,simpler and more *** effect of different operation conditions on entrainment ratios and the influence of different factors on system performance are analyzed on the basis of mass,momentum and energy conservation *** influence degree of each factor on system performance is investigated by the orthogonal test *** condenser temperature has the largest effect on system *** pressure drop in the suction chamber of gas-liquid injector has the least impact on system *** COP can reach about 0.35 under a certain working *** system can be driven by two different temperature heat sources with no electricity needed,and it is a good choice for places with abundant heat resources or lack of electricity.

关键词： ejector refrigeration system injector entrainment ratio coefficient of performance(COP)

基于地域文化的乡村景观改造设计——以呼和浩特市东坡村为例

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广东蚕业 2024年第2期58卷 148-150页

作者：王佳慧赵红霞内蒙古农业大学内蒙古呼和浩特010018

建设宜居宜业和美乡村,是农业强国的题中应有之义,也是实现中国式现代化的重要举措。文章以呼和浩特市东坡村为例,结合地域文化,以红色文化为核心,以“科学规划、因地制宜、节约资源、保护环境”为原则,以延续红色脉络、激发红色活力、... 详细信息

建设宜居宜业和美乡村,是农业强国的题中应有之义,也是实现中国式现代化的重要举措。文章以呼和浩特市东坡村为例,结合地域文化,以红色文化为核心,以“科学规划、因地制宜、节约资源、保护环境”为原则,以延续红色脉络、激发红色活力、增强红色体魄为主题,以期打造充满活力并可持续发展的特色乡村景观。

关键词：乡村景观景观改造地域文化红色文化呼和浩特市

基于SPO语义三元组的自闭症谱系障碍药物知识发现

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护理研究 2024年第5期38卷 796-804页

作者：吕艳华赵宏霞李琦梁傲雪于琦山西医科大学管理学院山西030001

目的:运用语义挖掘技术抽取自闭症相关文献中的三元组并构建自闭症药物实体知识图谱,深层次开展自闭症治疗的潜力药物知识发现,同时也为其他疾病发现有价值的潜在治疗药物提供新思路。方法:采用基于统一医学语言系统(ULMS)的工具SemRep... 详细信息

目的:运用语义挖掘技术抽取自闭症相关文献中的三元组并构建自闭症药物实体知识图谱,深层次开展自闭症治疗的潜力药物知识发现,同时也为其他疾病发现有价值的潜在治疗药物提供新思路。方法:采用基于统一医学语言系统(ULMS)的工具SemRep、Metamap对自闭症文献记录进行处理并获得自闭症药物实体三元组,使用Neo4j数据库进行知识存储,构建自闭症药物实体知识图谱。基于该知识图谱,采用3种语义路径开展自闭症药物知识发现,并使用临床实验数据库(https://***)对结果进行有效性验证与分析。结果:获得的实体三元组包括1262个头实体、687个尾实体和18种实体关系;3种语义路径共发现32种药物,筛选出27种自闭症潜力药物,并且19种药物可以在临床实验数据库中验证。结论:基于语义三元组知识图谱开展自闭症药物知识发现可为药物重定位提供一定的理论和方法基础,为传统药物发现提供新的思路,以期为临床实验及其科学研究提供决策支持。

关键词：自闭症谱系障碍知识图谱语义挖掘药物重定位

Raman spectroscopic study of DNA photodamage sensitized by hypocrellin B and 5-brominated-hypocrellin B

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Chinese Science Bulletin 1998年第13期43卷 1128-1135页

作者： hongxia zhao Yiming Xu Zhiyi Zhang Chinese Acad Sci Inst Biophys Beijing 100101 Peoples R China

Hypocrellin B (HB) is a highly effective photosensitizer. One of its derivatives, 5_brominated_hypocrellin B (5_Br_HB) has better photosensitive characteristics than it. Using Raman spectroscopy, the microcosmic photodamage to DNA sensitized by HB and 5_Br_HB was studied at molecular level. The results showed that when HB and 5_Br_HB were added to the solution of DNA and irradiated, the characteristic Raman frequencies and intensities of DNA changed to various degrees. The photodamage occurred on the whole DNA molecule, including phosphate backbone,deoxyribose and four bases. Not only the conformation but also the configuration of DNA was photodamaged: breakage of some H_bonds, disappearance of B_form conformation , scission of double or single strand and serious damage of four bases. The damage to A_T pairs was stronger than that to C_G pairs and DNA became polynucleotides finally. The 5_Br_HB_photosensitized damage to DNA was stronger than HB , which suggested the better photosensitive characteristics of 5_Br_HB in bioactive environment. The molecular mechanisms of photodamage to DNA sensitized by 5_Br_HB and HB were also elucidated.

关键词： hypocrellin B 5_brominated hypocrellin B calf thymus DNA photodamage Raman spectroscopy.

Performance Study and Multi-Objective Optimization of a Two-Temperature CO_(2) Refrigeration System with Economizer Based on Energetic, Exergetic and Economic Analysis

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Journal of Thermal Science 2022年第5期31卷 1416-1433页

作者： LIU Guangdi zhao hongxia WANG Zheng ABDULWAHID Alhasan Ali HAN Jitian School of Energy and Power engineering Shandong UniversityJi’nan250061China

A two temperature CO_(2) refrigeration system with economizer is proposed and compared with the traditional dual-temperature CO_(2) refrigeration system based on energy consumption,exergy and economic *** genetic algorithm multi-objective optimization method,taking the COP,exergy loss and total economic cost as the objective functions to find the best design conditions of the two *** Pareto fronts are obtained at different ambient *** for order preference by similarity to an ideal solution decision-making method is adopted to determine the optimum state *** simulation results show that when operating at different ambient temperatures,the introduction of economizer can improve COP,reduce exergy loss and the overall economic cost rate of the two-temperature CO_(2) refrigeration *** addition,economic analyses take the impact of carbon dioxide emission cost and electricity price into *** results indicate that with the increase of CO_(2) emission cost and electricity price,the hourly economic cost of both systems increases,but the hourly economic cost of the two-temperature CO_(2) refrigeration system with economizer system is always lower than that of conventional two-temperature CO_(2) refrigeration system.

关键词： two-temperature refrigeration CO_(2) multi-objective optimization energy exergetic economic cost

Experimental study on freezing of liquids under static magnetic field

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Chinese Journal of Chemical Engineering 2017年第9期25卷 1288-1293页

作者： hongxia zhao Feng Zhang Hanqing Hu Sheng Liu Jitian Han School of Energy and Power Engineering Shandong University Vegetable Research Center Beijing Academy of Agriculture and Forestry Sciences National Engineering Research Center for Vegetables

Freezing processes of several liquids under static magnetic field(SMF) less than 50 mT were investigated. Central temperature of liquid samples held in glass test tubes immersed in a liquid bath was measured and collected. Nucleation temperature and phase transition time were obtained from freezing curves. Normality tests were performed for nucleation temperature of these liquids with/without magnetic field and normality distributions were justified. Analysis of variances was carried out for nucleation temperature of these liquids with magnetic field flux density as the influencing factor. Results showed that no significant difference was found for deionized water with or without SMF. However, differences exist in 0.9% NaCl solution and 5% ethylene glycol solution with and without SMF. Nucleation temperature of 0.9% NaCl with SMF is lower than that without SMF, while its phase transition time is shorter than that without SMF. Nucleation temperature of 5% ethylene glycol with SMF is higher than that without SMF, while its phase transition time is not modified with SMF.

关键词： Liquid Freezing Static magnetic field Nucleation temperature Phase transition time

钩藤降压解郁方抑制TLR4/NF-кB信号通路对高血压并发抑郁症大鼠海马小胶质细胞极化的影响

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中药新药与临床药理 2024年第2期35卷 174-182页

作者：马丹凤张传香陈蕾沈程赵红霞任卫琼湖南省儿童医院湖南长沙410007 湖南中医药大学第一附属医院湖南长沙410007

目的探讨钩藤降压解郁方(钩藤、天麻、地龙、葛根等)调控TLR4/NF-кB信号通路对高血压并发抑郁症(HD)大鼠海马小胶质细胞极化的影响。方法将40只原发性高血压大鼠随机分为5组:模型组、阳性药组及中药(钩藤降压解郁方)高、中、低剂量组,... 详细信息

目的探讨钩藤降压解郁方(钩藤、天麻、地龙、葛根等)调控TLR4/NF-кB信号通路对高血压并发抑郁症(HD)大鼠海马小胶质细胞极化的影响。方法将40只原发性高血压大鼠随机分为5组:模型组、阳性药组及中药(钩藤降压解郁方)高、中、低剂量组,每组8只;另取8只SD大鼠作为对照组。采用连续42 d慢性应激(CUMS)结合孤养的方式复制HD模型。造模同时给药干预,中药高、中、低剂量组分别给予钩藤降压解郁方29.61、14.81、7.40 g·kg^(-1)灌胃给药;阳性药组给予左旋氨氯地平0.45 mg·kg^(-1)+氟西汀1.8 mg·kg^(-1)灌胃给药;灌胃体积10 mL·kg^(-1),每天1次,连续42 d。采用无创血压计于给药前及每周最末日上午测量大鼠尾动脉收缩压;造模开始后的第2周和最后1周各进行1次糖水偏好行为学检测;造模结束后进行水迷宫实验;ELISA法测定血清炎性因子肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、IL-10水平;HE染色法及尼氏染色法观察大鼠海马组织神经元病理变化;免疫荧光双染法检测海马区小胶质细胞M1(CD16)、M2(CD206)型表达情况;Western Blot法检测海马组织中TLR4、NF-κB p65蛋白的表达情况。结果与对照组比较,模型组大鼠第1~6周的尾动脉收缩压均显著升高(P<0.01);糖水偏好率显著下降(P<0.01);逃避潜伏期明显延长(P<0.05,P<0.01),穿越平台次数及目标象限停留时间占比显著降低(P<0.01);血清TNF-ɑ、IL-1β含量显著上升(P<0.01),IL-10含量显著下降(P<0.01);胞核深染,胞质固缩,细胞凋亡明显;海马小胶质细胞CD206/CD16荧光强度比明显降低(P<0.05);海马组织TLR4、NF-κB p65蛋白表达显著上调(P<0.01)。与模型组比较,给药组大鼠第1~6周的尾动脉收缩压均显著降低(P<0.01);糖水偏好率均明显上升(P<0.05);血清TNF-ɑ、IL-1β含量显著下降(P<0.01),IL-10含量显著上升(P<0.01);尼氏体丰富,细胞凋亡明显减少。阳性药组及钩藤降压解郁方高剂量组大鼠的逃避潜伏期明显缩短(P<0.05,P<0.01),穿越平台次数及目标象限停留时间占比明显增加(P<0.05);海马小胶质细胞CD206/CD16荧光强度比明显升高(P<0.05,P<0.01);海马组织TLR4、NF-κB p65蛋白表达明显下调(P<0.05,P<0.01)。结论钩藤降压解郁方可能通过抑制TLR4/NF-кB通路调节HD大鼠海马小胶质细胞极化状态,调控炎症因子分泌,减轻海马神经元损伤。

关键词：钩藤降压解郁方高血压并发抑郁症小胶质细胞炎症反应 TLR4/NF-κB通路大鼠

5-Fluorocytosine–Sugar Conjugates for Glucose Transporter-Mediated Tumor Targeting: Synthesis, Cytotoxicity, and Cellular Uptake Mechanism

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Transactions of Tianjin University 2019年第6期25卷 611-617页

作者： Yu Wang Xiaofei Cheng hongxia zhao Qingzhi Gao Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency School of Pharmaceutical Science and Technology Tianjin University

Two novel sugar-conjugated 5-fluorocytosine(5-FC)antineoplastic compounds were designed and synthesized to improve the selective drug uptake by targeting the tumor-specific glucose transporter(GLUT).The antitumor activity of these compounds was evaluated in four different human cancer cell lines:A549(human lung cancer cell line),HT29(human colorectal cancer cell line),H460(human lung cancer cell line),and PC3(human prostate cancer cell line).The sugar conjugates exhibited cytotoxicity similar to or higher than 5-FC and 1-hexylcarbamoyl-5-FC in A549,HT29,H460,and ***,GLUT-mediated transport of the glycoconjugate was investigated with GLUT inhibitor-mediated cytotoxicity analysis in a GLUT-overexpressing HT29 cell *** cell-killing potency of 5-FC glycoconjugate was found to depend significantly on the GLUT inhibitor,and the cellular uptake of molecules was regulated by GLUT-mediated *** the results demonstrate the potential advantages of glycoconjugation for Warburg effect-targeted drug design.

关键词： Warburg effect Glucose transporter overexpressed 5-Fluorocytosine glycoconjugate Tumor targeting