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Function investigation of p1..5 in ASFV infection

Virologica Sinica 2024年第3期39卷 469-477页

作者： Dan Yin Bin Shi Renhao Geng Yingnan Liu Lang Gong hongxia Shao Kun Qian Hongjun Chen Aijian Qin Ministry of Education Key Laboratory for Avian Preventive Medicine Yangzhou UniversityJiangsu 225009China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Jiangsu 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China Jiangsu 225009China Shanghai Veterinary Research Institute CAASShanghai200241China South China Agricultural University Guangzhou 510642China

Virus replication relies on complex interactions between viral *** the case of African swine fever virus(ASFV),only a few such interactions have been identified so *** this study,we demonstrate that ASFV protein p72 interacts with p1..5 using co-immunoprecipitation and liquid chromatography-mass spectrometry(LC-MS).It was found that protein p72 interacts specifically with p1..5 at sites amino acids(aa)1.21. of p72 and aa 1.68 of *** assess the importance of p1..5 in ASFV infection,we developed a recombinant virus(ASFVGZΔA1.7R)by deleting the A1.7R gene from the ASFVGZ *** with ASFVGZ,the infectious progeny virus titers of ASFVGZΔA1.7R were reduced by approximately 1.0 *** addition,we demonstrated that the growth defect was partially attributable to a higher genome copies-to-infectious virus titer ratios produced in ASFVGZΔA1.7R-infected MA1.4 cells than in those infected with *** finding suggests that MA1.4 cells infected with ASFVGZΔA1.7R may generate larger quantities of noninfectious ***,we found that p1..5 did not affect virus-cell binding or ***,we show for the first time the interaction between ASFV p72 and *** results effectively provide the relevant information of the p1..5 *** results extend our understanding of complex interactions between viral proteins,paving the way for further studies of the potential mechanisms and pathogenesis of ASFV infection.

关键词： African swine fever virus p72 protein p1..5 protein Protein interactions

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ATP homeostasis and signaling in plants

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Plant Communications 2024年第4期5卷 52-66页

作者： Jiaqi Xiao Yijie Zhou Yunyun Xie Taotao Li Xinguo Su Junxian He Yueming Jiang Hong Zhu hongxia Qu Guangdong Provincial Key Laboratory of Applied Botany South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China University of Chinese Academy of Sciences Beijing 100049China Guangdong AIB Polytechnic Guangzhou 510507China School of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongShatinNew TerritoriesHong KongChina

ATP is the primary form of energy for plants,and a shortage of cellular ATP is generally acknowledged to pose a threat to plant growth and development,stress resistance,and crop *** overall metabolic processes that contribute to the ATP pool,from production,dissipation,and transport to elimination,have been studied *** evidence has revealed that in addition to its role in energy supply,ATP also acts as a regulatory signaling molecule to activate global metabolic *** of the eATP receptor DORN1.contributed to a better understanding of how plants cope with disruption of ATP homeostasis and of the key points at which ATP signaling pathways intersect in cells or whole *** functions of SnRK1.,the master regulator of the energy management network,in restoring the equi-librium of the ATP pool have been demonstrated,and the vast and complex metabolic network mediated by SnRK1. to adapt tofluctuating environments has been *** paper reviews recent advances in understanding the regulatory control of the cellular ATP pool and discusses possible interactions among key regulators of ATP-pool homeostasis and crosstalk between iATP/eATP signaling *** of ATP deficit and modulation of cellular ATP homeostasis mediated by SnRK1. in plants are discussed at the physiological and molecular ***,we suggest future research directions for modulation of plant cellular ATP homeostasis.

关键词： ATP DORN1 SnRK1. ATP homeostasis and signaling

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Research progress of heterogeneous structure magnesium alloys:A review

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Journal of Magnesium and Alloys 2024年第6期12卷 2147-2181页

作者： Xiang Chen Junlei Zhang Min Wang Weizhang Wang Di Zhao Haiming Huang Qi Zhao Xiaofei Xu hongxia Zhang Guangsheng Huang Hubei Longzhong Laboratory Wuhan University of Technology Xiangyang Demonstration ZoneXiangyang 441000China College of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002China College of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China Hubei Key Laboratory of Energy Storage and Power Battery(Hubei University of Automotive Technology) Shiyan 442002China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China School of Mechanical Engineering Suzhou University of Science and TechnologySuzhou 215009China

In recent years,a new class of metallic materials featuring heterogeneous structures has *** materials consist of distinct soft and hard domains with significant differences in mechanical properties,allowing them to maintain high strength while offering superior ***(Mg)alloys,renowned for their low density,high specific strength,exceptional vibration damping,and electromagnetic shielding properties,exhibit tremendous potential as lightweight and functional *** their advantageous properties,high-strength Mg alloys often suffer from limited ***,the emergence of heterogeneous materials provides a fresh perspective for the development of Mg alloys with both high strength and *** article provided a fundamental overview of heterostructured materials and systematically reviewed the recent research progress in the design of Mg alloys with strength-ductility balance based on heterostructure *** review encompassed various aspects,including preparation methods,formation mechanisms of diverse heterostructures,and mechanical properties,both within domestic and international *** this basis,the article discussed the challenges encountered in the design and fabrication of heterostructured Mg alloys,as well as the urgent issues that require attention and resolution in the future.

关键词： Mg alloys Heterogeneous structure Processing techniques Strength and ductility Hetero-deformation induced stress Strain gradient

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Energy Blockchain in Smart Communities: Towards Affordable Clean Energy Supply for the Built Environment

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Energy Engineering 2024年第8期121卷 2313-2330页

作者： Mingguan Zhao Lida Liao Penglong Liang Meng Li Xinsheng Dong Yang Yang hongxia Wang Zhenhao Zhang Electric Power Research Institute State Grid Xinjiang Electric Power Co.Ltd.Urumqi830013China School of Energy and Power Engineering Changsha University of Science&TechnologyChangsha410114China Kumul Power Supply Company State Grid Xinjiang Electric Power Co.Ltd.Urumqi830013China Xinjiang Key Laboratory of Extreme Environment Operation and Detection Technology of Power Transmission&Transformation Equipment Urumqi830013China

The rapid growth of distributed renewable energy penetration is promoting the evolution of the energy system toward decentralization and decentralized and digitized smart *** study was based on energy blockchain,and developed a dual-biding mechanism based on the real-time energy surplus and demand in the local smart grid,which is expected to enable reliable,affordable,and clean energy supply in smart *** the proposed system,economic benefits could be achieved by replacing fossil-fuel-based electricity with the high penetration of affordable solar PV *** reduction of energy surplus realized by distributed energy production and P2P energy trading,within the smart grid results in less transmission loss and lower requirements for costly upgrading of existing *** adopting energy blockchain and smart contract technologies,energy secure trading with a low risk of privacy leakage could be *** prototype is examined through a case study,and the feasibility and efficiency of the proposed mechanism are further validated by scenario analysis.

关键词： Solar PV smart community energy blockchain P2P energy trading smart grid affordable energy supply

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Dynamic aggregation of carbon dots self-stabilizes symmetry breaking for exceptional hydrogen production with near-infrared light

Aggregate

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Aggregate 2024年第1期5卷 385-397页

作者： Qi Zhang Ya Zhang Hu Shi hongxia Zhang Jianghong Zhao Zhanfeng Zheng Hengquan Yang Pengju Yang School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuanChina Engineering Research Center of Ministry of Education for Fine Chemicals Shanxi UniversityTaiyuanChina Institute of Molecular Science Shanxi UniversityTaiyuanChina State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuanChina

Developing new photosystems that integrate broad-band near-infrared(NIR)light harvesting and efficient charge separation is a long-sought goal in the photocatalytic *** this work,we develop a novel photochemical strategy to prepare light-active carbon dots(CDs)under room temperature and discover that the aggregation of CDs can broaden the light absorption to the NIR region due to the electronic couplings between neighboring ***,the dynamic noncovalent interactions within CD aggregates can stabilize symmetry breaking and thus induce large dipole moments for charge separation and ***,the weak non-covalent interactions allow for flexible design of the aggregated degrees and the local electronic structures of CD aggregates,further strengthening NIR-light harvesting and charge separation *** a result,the CD aggregates achieve a record apparent quantum yield of 1..5%at 800 nm,which is one of the best-reported values for NIR-light-driven hydrogen photosynthesis to ***,we have prepared a series of different CDs and also observed that these CDs after aggregation all exhibit outstanding NIR-responsive photocatalytic hydrogen production activity,suggesting the universality of aggregation-enhanced *** discovery opens a new promising platform for using CD aggregates as efficient light absorbers for solar conversion.

关键词： aggregation charge separation hydrogen production near-infrared light photocatalysis

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RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations

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Genes & Diseases 2024年第1期11卷 87-90页

作者： hongxia Zhang Yueya Zhong Yuanming He Yujia Xu Ying Ren Haixia Zhuang Tong Sun Zhigang Zhu Xinliang Mao Institute of Clinical Pharmacology Science and Technology Innovation CenterGuangzhou University of Chinese MedicineGuangzhouGuangdong 510403China Guangdong Provincial Key Laboratory of Protein Modification and Degradation School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouGuangdong 511436China Department of Pharmacology College of Pharmaceutical SciencesSoochow UniversitySuzhouJiangsu 215123China Division of Hematology&Oncology Department of GeriatricsGuangzhou First People's HospitalCollege of MedicineSouth China University of TechnologyGuangzhouGuangdong 510180China

Chronic myelogenous leukemia(CML)is a malignancy from bone marrow myeloid stem cells mainly driven by the fusion gene *** addition to BCR-ABL,other genes including RNF6 are also dysregulated in CML cells.1.RNF6,a ubiquitin ligase of the RING family,promotes various cancer cell proliferation,chemoresistance,and tumor growth in vivo by targeting various proteins for ubiquitination and degradation,including SHP1.TLE3,FOXA1.and MAD1.^(2) However,its specific mechanism in CML is not known.

关键词： ubiquitin myelogenous leukemia

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Establishing and Validating Refractive Error Reference Values for Myopia Prediction Among Children Aged 6–1. Years-Jiangsu Province,China,201.-2023

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China CDC weekly 2024年第32期6卷 804-810页

作者： Xiyan Zhang Chen-Wei Pan Wei Du Yonglin Zhou Jie Yang Yan Wang Yiliang Xin Wei Lu hongxia Ma School of Public Health Nanjing Medical UniversityNanjing CityJiangsu ProvinceChina Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina School of Public Health Suzhou Medical College of Soochow UniversitySuzhou CityJiangsu ProvinceChina School of Public Health Southeast UniversityNanjing CityJiangsu ProvinceChina

Summary What is already known about this topic?Previously,it has been proved that a simplified model that uses refraction error value provides a robust and efficient means of predicting myopia for non-myopic *** targeting non-myopic children with alert refraction errors(or insufficient hyperopia reserve)holds significant importance in reducing the incidence rate of *** is added by this report?This study,comprising two phases(surveillance and cohort studies),was aiming to pinpoint the precise refractive error value for the onset of myopia prediction among non-myopic children in Jiangsu *** are the implications for public health practice?First,when conducting myopia screenings using pupil dilation for non-myopic populations:the cycloplegic 50th percentile refractive error emerges as a more precise predictive ***,when conducting myopia screenings without pupil dilation:this study advocates for the incorporation of axial length(AL)and corneal curvature(CC)values as supplementary indicators in screenings.

关键词： precise dating holds

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Observation of Arctic surface currents using data from a surface drifting buoy

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Acta Oceanologica Sinica 2024年第1期43卷 70-79页

作者： hongxia Chen Lina Lin Long Fan Wangxiao Yang Yinke Dou Bingrui Li Yan He Bin Kong Guangyu Zuo Na Liu First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Laboratory for Regional Oceanography and Numerical Modeling Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Key Laboratory of Marine Science and Numerical Modeling Ministry of Natural ResourcesQingdao 266061China Naval Research Academy Tianjin 300061China College of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuan 030024China Polar Research Institute of China Shanghai 443005China

During the 1.th Chinese Arctic scientific expedition carried out in the summer of 201.,the surface current in the high-latitude areas of the Arctic Ocean was observed using a self-developed surface drifting buoy,which was initially deployed in the Chukchi *** buoy traversed the Chukchi Sea,Chukchi Abyssal Plain,Mendeleev Ridge,Makarov Basin,and Canada Basin over a period of 632 *** returning to the Mendeleev Ridge,it continued to drift toward the ***,the track of the buoy reflected the characteristics of the transpolar drift and Chukchi Slope Current,as well as the inertial flow,cross-ridge surface flow,and even the surface disorganized flow for some time *** results showed that:(1.the transpolar drift mainly occurs in the Chukchi Abyssal Plain,Mendeleev Ridge,and western Canada Basin to the east of the ridge where sea ice concentration is high,and the average northward flow velocity in the region between 79.41.N and 86.32°N was 5.1.cm/s;(2)the average surface velocity of the Chukchi Slope Current was 1..5 cm/s,and while this current moves westward along the continental slope,it also extends northwestward across the continental slope and flows to the deep sea;and(3)when sea ice concentration was less than 50%,the inertial flow was more significant(the maximum observed inertial flow was 26 cm/s,and the radius of the inertia circle was 3.6 km).

关键词： Chinese National Arctic Research Expedition(CHINARE) surface drifting buoy transpolar drift Chukchi Slope Current inertial flow

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Protective eff ect and mechanism of nanoantimicrobial peptide ND-C1. against Streptococcus pneumoniae infection

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World Journal of Emergency Medicine 2024年第1期15卷 28-34页

作者： Yangyang Guo Yaqi Sun hongxia Wu Jian Lu Yuan Lin Jiaqing Zhu Meihong Lai Meiqi Zhang Jun Wang Jungang Zheng Department of Intensive Care Medicine Hangzhou Traditional Chinese Medicine Hospital Affi liated to Zhejiang Chinese Medical UniversityHangzhou 310021China National Children’s Regional Medical Center National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Spleen and Stomach Diseases Hangzhou Traditional Chinese Medicine Hospital Affi liated to Zhejiang Chinese Medical UniversityHangzhou 310021China Department of Ultrasonic Medicine the First Affi liated Hospital of Ningbo UniversityNingbo 315010China Department of Anesthesiology the First Affi liated Hospital of Ningbo UniversityNingbo 315010China Zhejiang University School of Medicine Hangzhou 310058China The First People’s Hospital of Yuexi County Yuexi 616650China

BACKGROUND:Streptococcus pneumoniae(***)is a common pathogen that causes bacterial ***,with increasing bacterial resistance,there is an urgent need to develop new drugs to treat *** *** with a 1.-carbon saturated fatty acid(ND-C1.)is a novel nanoantimicrobial peptide designed by modifying myristic acid at the C-terminus of humanα-defensin 5(HD5)via an amide ***,it is unclear whether ND-C1. is effective against lung infections caused by ***:In vitro,three groups were established,including the control group,and the HD5 and ND-C1. treatment groups.A virtual colony-count assay was used to evaluate the antibacterial activity of HD5 and ND-C1. against *** morphological changes of *** treated with HD5 or ND-C1. were observed by scanning electron *** vivo,mice were divided into sham,vehicle,and ND-C1. treatment *** in the sham group were treated with 25μL of phosphate-buffered saline(PBS).Mice in the vehicle and ND-C1. treatment groups were treated with intratracheal instillation of 25μL of bacterial suspension with 2×1.8 CFU/mL(total bacterial count:5×1.^(6) CFU),and then the mice were given 25μL PBS or intratracheally injected with 25μL of ND-C1.(including 20μg or 50μg),*** rates were evaluated in the vehicle and ND-C1. treatment *** burden in the blood and bronchoalveolar lavage fluid were *** lung histology of the mice was assessed.A propidium iodide uptake assay was used to clarify the destructive eff ect of ND-C1. against ***:Compared with HD5,ND-C1. had a better bactericidal eff ect against *** because of its stronger ability to destroy the membrane structure of *** in *** vivo,ND-C1. significantly delayed the death time and improved the survival rate of mice infected with ***-C1. reduced bacterial burden and lung tissue ***,ND-C1. had a membrane per

关键词： Streptococcus pneumoniae Antimicrobial peptides Humanα-defensin 5 Infection

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Ischemia-reperfusion injury:molecular mechanisms and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 558-596页

作者： Meng Zhang Qian Liu Hui Meng hongxia Duan Xin Liu Jian Wu Fei Gao Shijun Wang Rubin Tan Jinxiang Yuan The Collaborative Innovation Center Jining Medical UniversityJiningShandong 272067China Clinical Medical College Jining Medical UniversityJiningShandong 272067China Second Clinical Medical College Jining Medical UniversityJiningShandong 272067China Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital and Institutes of Biomedical SciencesFudan UniversityShanghaiChina Institute of Zoology Chinese Academy of SciencesBeijingChina Department of Physiology Basic medical schoolXuzhou Medical UniversityXuzhou 221004China

Ischemia-reperfusion(I/R)injury paradoxically occurs during reperfusion following ischemia,exacerbating the initial tissue *** limited understanding of the intricate mechanisms underlying I/R injury hinders the development of effective therapeutic *** Wnt signaling pathway exhibits extensive crosstalk with various other pathways,forming a network system of signaling pathways involved in I/R *** review article elucidates the underlying mechanisms involved in Wnt signaling,as well as the complex interplay between Wnt and other pathways,including Notch,phosphatidylinositol 3-kinase/protein kinase B,transforming growth factor-β,nuclear factor kappa,bone morphogenetic protein,N-methyl-D-aspartic acid receptor-Ca2+-Activin A,Hippo-Yes-associated protein,toll-like receptor 4/toll-interleukine-1.receptor domain-containing adapter-inducing interferon-β,and hepatocyte growth factor/mesenchymal-epithelial transition *** particular,we delve into their respective contributions to key pathological processes,including apoptosis,the inflammatory response,oxidative stress,extracellular matrix remodeling,angiogenesis,cell hypertrophy,fibrosis,ferroptosis,neurogenesis,and blood-brain barrier damage during I/R *** comprehensive analysis of the mechanisms involved in Wnt signaling during I/R reveals that activation of the canonical Wnt pathway promotes organ recovery,while activation of the non-canonical Wnt pathways exacerbates ***,we explore novel therapeutic approaches based on these mechanistic findings,incorporating evidence from animal experiments,current standards,and clinical *** objective of this review is to provide deeper insights into the roles of Wnt and its crosstalk signaling pathways in I/R-mediated processes and organ dysfunction,to facilitate the development of innovative therapeutic agents for I/R injury.

关键词： therapeutic reperfusion damage

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