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基于失巢凋亡相关基因构建膀胱癌预后模型及其免疫治疗意义

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广东药科大学学报 2025年第1期41卷 125-135页

作者：刘恒燊董娜邵红伟张文峰广东药科大学生命科学与生物制药学院广东广州510006

目的本研究旨在识别膀胱癌(bladder cancer,BLCA)中差异表达的失巢凋亡相关基因(ARGs),构建预后模型并开发免疫评分系统,以评估患者预后及治疗效果,为膀胱癌精准治疗提供理论依据。方法获取TCGA中膀胱癌患者的数据后识别ARGs,构建预... 详细信息

目的本研究旨在识别膀胱癌(bladder cancer,BLCA)中差异表达的失巢凋亡相关基因(ARGs),构建预后模型并开发免疫评分系统,以评估患者预后及治疗效果,为膀胱癌精准治疗提供理论依据。方法获取TCGA中膀胱癌患者的数据后识别ARGs,构建预后模型,基于预后基因开发膀胱癌免疫评分系统,分析不同组情况及探索对高风险组患者有增强治疗效果的药物。结果根据机器学习算法,用4个关键基因(CALR、CAV1、CSPG4和NTRK2)构建了膀胱癌预后模型,构建的风险模型可将BLCA分为高风险组和低风险组,低风险组生存率更高,且该模型可作为独立预后因子,还识别出几种对高风险组患者有增强治疗效果的药物。结论本研究提供了新的系统分析方法,用于评估膀胱癌患者的预后、临床特征、免疫细胞浸润、化疗反应和免疫治疗效果。

关键词：膀胱癌失巢凋亡免疫浸润分析预后模型

Improved osteointegration and angiogenesis of strontium-incorporated 3D-printed tantalum scaffold via bioinspired polydopamine coating

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Journal of Materials Science & Technology 2021年第10期69卷 106-118页

作者： Shi Cheng Jin Ke Mengyu Yao hongwei shao Jielong Zhou Ming Wang Xiongfa Ji Guoqing Zhong Feng Peng Limin Ma Yu Zhang Department of Orthopedics Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515China

Tantalum(Ta)is used in orthopedic implants because it has excellent ***,high elastic modulus,bio-inertness,and unsatisfactory osteointegration limits its wider use in clinical ***,a 3 D porous Ta scaffold with low elastic modulus was fabricated using selective laser melting(SLM).Strontium(Sr)was incorporated on the surface of the scaffold with the aid of polydopamine(PDA)to further improve its osteointegration *** prepared scaffolds exhibited a stable Sr ion release in 14 *** bone marrow stem cells(BMSCs)showed improved early adhesion and spreading after Sr was incorporated on the porous Ta *** osteogenic behavior,including extracellular matrix mineralization(ECM),alkaline phosphatase activity(ALP),and expression of bone-related RNA,were all ***,the Sr-incorporated porous Ta scaffolds exhibited better angiogenic behavior,such as promoting migration,tube formation,and angiogenesis-related RNA expression abilities of human vascular endothelial cells(HUVECs).Additionally,histological images(H&E,Masson and CD31 immunofluorescent staining)suggested that Sr-incorporated porous Ta scaffolds displayed enhanced osteointegration and angiogenesis after implantation in rat femur for 12 *** findings prove that the PDA-based Sr-incorporated porous Ta scaffolds show promising use in orthopedic implants.

关键词： 3D Ta scaffold Strontium Osteogenesis Angiogenesis Orthopedic implant

Enhanced osteogenesis of titanium with nano-Mg(OH)_(2) film and a mechanism study via whole genome expression analysis

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Bioactive Materials 2021年第9期6卷 2729-2741页

作者： Mengyu Yao Shi Cheng Guoqing Zhong Jielong Zhou hongwei shao Limin Ma Chang Du Feng Peng Yu Zhang Department of Biomedical Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou510641China Department of Orthopedics Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong510080China Shantou University Medical College Shantou515041GuangdongChina

Titanium(Ti)has been the most widely used orthopedic implant in the past ***,their inert surface often leads to insufficient osteointegration of Ti *** solve this issue,two bioactive Mg(OH)_(2) films were developed on Ti surfaces using hydrothermal treatment(Ti-M1#and Ti-M2#).The Mg(OH)_(2) films showed nano-flake structures:sheets on Ti-M1#with a thickness of 14.7±0.7 nm and a length of 131.5±2.9 nm,and on Ti-M2#with a thickness of 13.4±2.2 nm and a length of 56.9±5.6 *** films worked as Mg ions releasing *** the gradual degradation of Mg(OH)_(2) films,weakly alkaline microenvironments will be established surrounding the modified *** from the sustained release of Mg ions,nanostructures,and weakly alkaline microenvironments,the as-prepared nano-Mg(OH)_(2) coated Ti showed better in vitro and in vivo ***,Ti-M2#showed better osteogenesis than Ti-M1#,which can be ascribed to its smaller ***,whole genome expression analysis was applied to study the osteogenic mechanism of nano-Mg(OH)_(2) *** both coated samples,most of the genes related to ECM-receptor interaction,focal adhesion,and TGF-β pathways were upregulated,indicating that these signaling pathways were activated,leading to better ***,cells cultured on Ti-M2#showed markedly upregulated BMP-4 gene expression,suggesting that the nanostructure with Mg ion release ability can better activate BMP-4 related signaling pathways,resulting in better ***-Mg(OH)_(2) films demonstrated a superior osteogenesis and are promising surface modification strategy for orthopedic applications.

关键词： Titanium Surface modification Osteogenesis Whole genome analysis

A pH-response chemotherapy synergistic photothermal therapy for tumor suppression and bone regeneration by mussel-inspired Mg implant

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Regenerative Biomaterials 2021年第6期8卷 69-79页

作者： hongwei shao Shi Cheng Mengyu Yao Xiongfa Ji Hua Zhong DonghuiWang Xiujuan Fan Qian Li Jielong Zhou Yu Zhang Feng Peng Department of Orthopedics Research Center of Medical SciencesGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesNo.106Zhongshan 2nd RoadYuexiu DistrictGuangzhouGuangdong 510080China School of Medicine South China University of TechnologyGuangzhou University TownPanyu DistrictGuangzhouGuangdong 510006China Department of Orthopedics The Fifth Affiliated Hospital of Southern Medical UniversityNo.566 Congcheng AvenueConghua DistrictGuangzhouGuangdong 510900China School of Materials Science and Engineering Hebei University of TechnologyNo.5340 Xiping RoadBeichen DistrictTianjin 300130China Department of Orthopedics The Second School of Clinical MedicineSouthern Medical UniversityNo.111 Liuhua RoadYuexiu DistrictGuangzhouGuangdong 510515China Institute of New Materials Guangdong Academy of SciencesNo.363 Changxing RoadTianhe DistrictGuangzhouGuangdong 510651China

Primary malignant bone tumors can be *** resection of tumor plus chemotherapy is the standard clinical ***,postoperative recovery is hindered due to tumor recurrence caused by residual tumor cells and bone defect caused by resection of tumor ***,a multifunctional mussel-inspired film was fabricated on Mg alloy,that is,an inner hydrothermal-treated layer,a middle layer of polydopamine,and an outer layer of *** modified Mg alloy showed excellent photothermal effect and thermal/pH-controlled release of *** synergistic effect of chemotherapy and photothermal therapy enabled the modified Mg alloy to kill bone tumor in vitro and inhibit tumor growth in nude ***,because of the controlled release of Mg ions and biocompatibility of polydopamine,the modified Mg alloy supported extracellular matrix mineralization,alkaline phosphatase activity,and bone-related gene expression in C3H10T1/*** implantation model in rats verified that the modified Mg showed excellent *** findings prove that the use of mussel-inspired multifunction film on Mg alloy offers a promising strategy for the therapy of primary malignant bone tumor.

关键词： magnesium alloy bone tumor bone regeneration surface modification

Artificial sensory neurons and their applications

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Journal of Semiconductors 2025年第1期46卷 108-128页

作者： Jiale shao hongwei Ying Peihong Cheng Lingxiang Hu Xianhua Wei Zongxiao Li Huanming Lu Zhizhen Ye Fei Zhuge Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China School of Electronic and Information Engineering Ningbo University of TechnologyNingbo 315211China State Key Laboratory of Environment-friendly Energy Materials Southwest University of Science and TechnologyMianyang 621010China Institute of Wenzhou Zhejiang UniversityWenzhou 325006China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200072China

With the rapid development of artificial intelligence(AI)technology,the demand for high-performance and energyefficient computing is increasingly *** limitations of the traditional von Neumann computing architecture have prompted researchers to explore neuromorphic computing as a *** computing mimics the working principles of the human brain,characterized by high efficiency,low energy consumption,and strong fault tolerance,providing a hardware foundation for the development of new generation AI *** neurons and synapses are the two core components of neuromorphic computing *** perception is a crucial aspect of neuromorphic computing,where artificial sensory neurons play an irreplaceable role thus becoming a frontier and hot topic of *** work reviews recent advances in artificial sensory neurons and their ***,biological sensory neurons are briefly ***,different types of artificial neurons,such as transistor neurons and memristive neurons,are discussed in detail,focusing on their device structures and working ***,the research progress of artificial sensory neurons and their applications in artificial perception systems is systematically elaborated,covering various sensory types,including vision,touch,hearing,taste,and ***,challenges faced by artificial sensory neurons at both device and system levels are summarized.

关键词： artificial sensory neurons artificial perception systems neuromorphic computing artificial intelligence

Optimization and Upgrading of Marine Tourism Products in Yantai Based on Resource Value Evaluation

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Journal of Landscape Research 2021年第5期13卷 18-20,28页

作者： LIU Xiaomei WANG Hui ZHAO Weijun shao hongwei School of Tourism Taishan UniversityTai’anShandong 271000China School of Sports Taishan UniversityTai’anShandong 271000China

The 21st century is the era of marine *** Chinese government attaches great importance to the development and utilization of marine *** the support of national marine policies,the development of marine tourism industry in Yantai has changed with each passing day,and the content of tourism products developed by Yantai is also constantly *** this study,by using literature research,data analysis and other methods,the development of marine tourism resources in Yantai was *** results show that the marine tourism products in Yantai are not well-known,less competitive,and are difficult to form a scale ***,some measures to promote the development of tourism industry in Yantai were proposed,such as optimizing and upgrading marine tourism products in Yantai,strengthening regional cooperation to increase product awareness,improving the structure scale of products in scenic spots to enhance competitiveness,attaching importance to the application of science and technology and strengthening product innovation.

关键词： Marine tourism Yantai Tourism products Optimization and upgrading

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浅析日本新宗教中的民族主义倾向

日本学刊 2008年第6期 91-103页

作者：邵宏伟中国国际友好联络会亚洲部副主任

20世纪70年代日本新宗教的教势得到了巨大发展,在日本宗教史上又一次掀起热潮。日本新宗教教义中的民族主义倾向在战后民主主义与和平主义思潮占主流的社会中并没有消失,要求维护日本传统和尊皇复古的右翼宗教团体一直打着民族主义的旗... 详细信息

20世纪70年代日本新宗教的教势得到了巨大发展,在日本宗教史上又一次掀起热潮。日本新宗教教义中的民族主义倾向在战后民主主义与和平主义思潮占主流的社会中并没有消失,要求维护日本传统和尊皇复古的右翼宗教团体一直打着民族主义的旗帜扩大教势,并推动日本社会逐渐迈向保守化。随着日本经济的高速发展,世俗民族主义不断膨胀,而新宗教中的民族主义也越发活跃。本文通过对日本新宗教中民族主义倾向的研究与剖析,探讨新宗教在日本社会中的作用以及对日本和世界政治可能带来的影响。

关键词：新宗教民族主义神道教义互动关系

最优收入分配制度探析——收入分配对经济增长倒“U”形影响的启示

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数量经济技术经济研究 2016年第5期33卷 44-64页

作者：靳涛邵红伟厦门大学经济学院澳大利亚国立大学商学和经济学院

本文总结了收入分配影响经济增长的作用机制,区分了两极分化、平均主义和正态分布的收入分配结构各自对经济增长的影响,得出收入分配对经济增长的影响呈倒"U"形的假说,并且用近30多年的国际横截面和面板数据,用各种估计方法实证了这一... 详细信息

本文总结了收入分配影响经济增长的作用机制,区分了两极分化、平均主义和正态分布的收入分配结构各自对经济增长的影响,得出收入分配对经济增长的影响呈倒"U"形的假说,并且用近30多年的国际横截面和面板数据,用各种估计方法实证了这一理论假说。然后结合理论和实证分析结果,总结了最优的收入分配制度,最优的收入分配制度是由序列保证起点公平、过程公平和结果公平的制度组成的完整制度体系,其目标是实现收入分配的正态分布且具有完全流动性,这种收入分配结构不仅最有利于促进经济增长,而且符合人类天性,实现了效率与公平的统一。此外,本文考察了中国现当代以来的收入分配制度变迁和经济增长的关系,为中国收入分配制度改善提出了有益的政策建议。

关键词：最优分配收入分配经济增长倒“U”形

收入分配差距根源研究--基于三步法收入分配分析框架

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社会科学 2016年第11期 44-51页

作者：邵红伟靳涛厦门大学经济学院澳大利亚国立大学商学和经济学院厦门大学经济研究所

在总结收入分配思想史的基础上,提出了一个收入分配分析框架:第一步,起点分析,整个社会经济系统中的制度、技术和结构等是形成收入差距的间接原因;第二步,过程分析,资本和劳动等生产要素分别按照其对生产的贡献获得了财产收入和劳动收入... 详细信息

在总结收入分配思想史的基础上,提出了一个收入分配分析框架:第一步,起点分析,整个社会经济系统中的制度、技术和结构等是形成收入差距的间接原因;第二步,过程分析,资本和劳动等生产要素分别按照其对生产的贡献获得了财产收入和劳动收入,这是形成收入差距的直接原因;第三步,结果分析,各个家庭总收入的相对分布形成了一个经济体的整体收入差距,可以分解为自然性收入差距、制度性收入差距、结构性收入差距和其它收入差距。一个经济体应通过公平的制度建设尽量消除制度性收入差距和结构性收入差距,使收入差距主要由自然性收入差距形成,基本服从正态分布且具有完全流动性。

关键词：收入分配自然性收入差距制度性收入差距结构性收入差距