检索结果-南通市图书馆

Preparation and Properties of Bio-Based Flame Retardant Polyvinyl Alcohol

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2021年第5期9卷 909-921页

作者： You Shu Qionglin Luo hongwei Lin Yuejun ouyang Xiaomin Zhang Liping Sheng Shengpei Su Country National and Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources Hunan Normal UniversityChangsha410081China Hunan Engineering Laboratory for Preparation Technology of Polyvinyl Alcohol Fiber Material Huaihua UniversityHuaihua418000China

Polyvinyl alcohol (PVA) has been widely used in the fields of medical, food and packaging due to its excellentbiocompatibility, good fiber-forming and film-forming properties. However, the high flammability of PVA hasgreatly limited its wider applications. The flame-retardant PVA was prepared by melt blending of a bio-basedflame retardant (prepared from lignin, phosphoric acid and carbamide) with thermoplastic PVA (TPVA). Thechemical structure, morphology, thermal properties, mechanical properties, fire property and fluidity of thisflame retardant PVA were investigated by Fourier transform infrared spectrometer(FTIR), field emission scanning electron microscope(SEM), thermogravimetric analyzer(TGA), impact tester, universal testing machine,horizontal-vertical burning tester, limiting oxygen indexer(LOI) and melt flow rate meter(MFR). The resultsshowed that the prepared flame retardant had good compatibility with the PVA substrate;The impact strength,melt flow rate, fire property and char residue of this PVA material increased with the content of bio-based flameretardant. When the content of flame retardant was of 20%, the five indices including impact strength, meltflow rate, UL-94 level, LOI and char residual were 11.3 KJ/m^(2), 21.2 g/10 min, V-0 UL-94 level, 33.1%, and19.2%, respectively. This research can promote the high-value utilization of lignin and the application ofPVA in the fields of fire protection.

关键词： Bio-based flame retardant lignin ammonium polyphosphate polyvinyl alcohol

Apoptosis-enhanced ferroptosis therapy of pancreatic carcinoma through PAMAM dendrimer-iron(Ⅲ)complex-based plasmid delivery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2022年第4期65卷 778-788页

作者： Wenjing Ma Yue Gao Zhijun ouyang Yu Fan hongwei Yu Mengsi Zhan Han Wang Xiangyang Shi Mingwu Shen State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

The development of promising strategies to improve the treatment efficacy of pancreatic carcinoma still remains to be a challenging *** report here the development of a new dendrimer-based nanomedicine formulation to tackle pancreatic carcinoma through apoptosis-enhanced ferroptosis *** this article,G5 dendrimers were partially modified with a Fe(Ⅲ)chelator hydroxyquinoline-2-carboxylic acid(8-HQC)on their periphery,entrapped with gold nanoparticles(Au NPs)within their internal cavities,and chelated with Fe(Ⅲ).The thus created dendrimer-entrapped Au NPs(Fe-Au DENP-HQC)with an Au core size of 1.9 nm and 20.0 Fe(Ⅲ)ions complexed per dendrimer are stable,have a pH-dependent Fe(Ⅲ)release profile,and can generate reactive oxygen species under the tumor microenvironment(TME)and effectively compact plasmid DNA encoding p53 protein to form polyplexes with a hydrodynamic size of 143.9 nm and a surface potential of 33.6 *** show that cancer cells treated with the created Fe-Au DENP-HQC/p53 polyplexes can be more significantly inhibited through vector-mediated chemodynamic therapy(CDT)effect via Fe(Ⅲ)-induced Fenton reaction and the p53 gene delivery-boosted cell apoptosis and oxidative stress in the TME than single-mode CDT and gene *** investigations using a xenografted tumor model validated the effectiveness of apoptosis-enhanced ferropotosis therapy through the downregulation of GPX-4 and SLC7A11proteins,upregulation of p53 and PTEN proteins,as well as histological ***,the dendrimer nanoplatform enabled tumor fluorescence imaging through gene delivery-mediated enhanced green fluorescent protein *** Fe(Ⅲ)-complexed dendrimer vector system may be developed as a promising theranostic nanoplatform for ferroptosis or ferroptosis-based combination therapy of other cancer types.

关键词： dendrimers ferroptosis gene delivery pancreatic carcinoma fluorescence imaging

3D Artificial Array Interface Engineering Enabling Dendrite-Free Stable Zn Metal Anode

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2023年第3期15卷 112-128页

作者： Jianbin Ruan Dingtao Ma Kefeng ouyang Sicheng Shen Ming Yang Yanyi Wang Jinlai Zhao hongwei Mi Peixin Zhang College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen 518060People’s Republic of China College of of Materials Science and Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Guangdong Flexible Wearable Energy and Tools Engineering Technology Research Center Shenzhen 518060People’s Republic of China

The ripple effect induced by uncontrollable Zn deposition is considered as the Achilles heel for developing high-performance aqueous Zn-ion *** this problem,this work reports a design concept of 3D artificial array interface engineering to achieve volume stress elimination,preferred orientation growth and dendrite-free stable Zn metal *** mechanism of MXene array interface on modulating the growth kinetics and deposition behavior of Zn atoms were firstly disclosed on the multi-scale level,including the in-situ optical microscopy and transient simulation at the mesoscopic scale,in-situ Raman spectroscopy and in-situ X-ray diffraction at the microscopic scale,as well as density functional theory calculation at the atomic *** indicated by the electrochemical performance tests,such engineered electrode exhibits the comprehensive enhancements not only in the resistance of corrosion and hydrogen evolution,but also the rate capability and cyclic ***-rate performance(20 mA cm^(-2))and durable cycle lifespan(1350 h at 0.5 mA cm^(-2),1500 h at 1 mA cm^(-2)and 800 h at 5 mA cm^(-2))can be ***,the improvement of rate capability(214.1 mAh g^(-1)obtained at 10 A g^(-1))and cyclic stability also can be demonstrated in the case of 3D MXene array@Zn/*** the previous 2D closed interface engineering,this research offers a unique 3D open array interface engineering to stabilize Zn metal anode,the controllable Zn deposition mechanism revealed is also expected to deepen the fundamental of rechargeable batteries including but not limited to aqueous Zn metal batteries.

关键词： Aqueous Zn-ion batteries Volume stress 3D artificial array interface Controllable deposition Zn metal anode

Tumor‑Anchoring Drug‑Loaded Fibrous Microspheres for MR Imaging‑Guided Local Chemotherapy and Metastasis Inhibition

在线全文

学校读者我要写书评

暂无评论

Advanced Fiber Materials 2022年第4期4卷 807-819页

作者： Beilei Zhang Yue Gao Rui Yang Zhijun ouyang hongwei Yu Han Wang Xiangyang Shi Mingwu Shen State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China CQM-Centro de Quimica da Madeira Universidade da Madeira9020‑105 FunchalPortugal Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

Unobtrusive metastasis and invasion of malignant tumors are major causes for the death of cancer patients,and unfortunately the lack of specificity and abrupt release of anticancer drugs applied to the primary tumors are causing serious side effects in cancer ***,the development of controlled local drug delivery systems that can effectively treat primary tumors and inhibit tumor metastasis is of critical importance for improved cancer ***,we developed hyaluronic acid(HA)-modified porous fibrous microspheres as a drug delivery system with the functions of long-acting local chemotherapy,tumor metastasis inhibition and magnetic resonance(MR)***(lactic-co-glycolic acid)(PLGA)short fibers obtained by combined electrospinning and homogenization techniques were successfully modified with gadolinium(Gd^(3+))chelates and HA,which were subsequently mixed with doxorubicin(DOX)to obtain the multifunctional drug-loaded fibrous microspheres of DOX-PLGA-PEI-DTPA-Gd/HA(DOX−PGH)by electrospray and further *** developed DOX−PGH microspheres with an average diameter of 118.8μm possess good structural stability and a high r1 relaxivity,and can achieve long-term DOX *** cellular and animal experiments demonstrated that the DOX−PGH microspheres could facilitate targeted delivery of DOX to accelerate 4T1 cell death while reducing cancer cell metastasis due to the cooperative actions of long-term DOX-mediated chemotherapy and the fibrous microsphere-induced tumor anchoring to likely avoid primary tumor cell shedding,and render MR imaging of tumors during the *** developed DOX−PGH microspheres may represent one of the updated local tumor chemotherapy formulations for improved tumor therapy with justified antitumor and anti-metastasis efficacy.

关键词： Electrospinning Porous fibrous microspheres Tumor anchoring Local chemotherapy Tumor metastasis

A Multifunctional Anti-Proton Electrolyte for High-Rate and Super-Stable Aqueous Zn-Vanadium Oxide Battery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2022年第9期14卷 272-289页

作者： Yangwu Chen Dingtao Ma Kefeng ouyang Ming Yang Sicheng Shen Yanyi Wang hongwei Mi Lingna Sun Chuanxin He Peixin Zhang College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen 518060People’s Republic of China

Large volumetric expansion of cathode hosts and sluggish transport kinetics in the cathode–electrolyte interface,as well as dendrite growth and hydrogen evolution at Zn anode side are considered as the system problems that cause the electrochemical failure of aqueous Zn-vanadium oxide *** this work,a multifunctional anti-proton electrolyte was proposed to synchronously solve all those *** and experimental studies confirm that PEG 400 additive can regulate the Zn^(2+) solvation structure and inhibit the ionization of free water molecules of the ***,smaller lattice expansion of vanadium oxide hosts and less associated by-product formation can be realized by using such ***,such electrolyte is also beneficial to guide the uniform Zn deposition and suppress the side reaction of hydrogen *** to the integrated synergetic modifica-tion,a high-rate and ultrastable aqueous Zn-V_(2)O_(3)/C battery can be constructed,which can remain a specific capacity of 222.8 m Ah g^(-1)after 6000 cycles at 5 A g^(-1),and 121.8 m Ah g^(-1) even after 18,000 cycles at 20 A g^(-1),***“all-in-one”solution based on the electrolyte design provides a new strategy for developing high-performance aqueous Zn-ion battery.

关键词： Zn-vanadium oxide battery Multifunctional anti-proton electrolyte Integrated synergetic modification “All-in-one”solution

Motivational interviewing to improve the self-care behaviors for patients with chronic heart failure: A randomized controlled trial

在线全文

学校读者我要写书评

暂无评论

International Journal of Nursing Sciences 2018年第3期5卷 213-217页

作者： Juan Chen hongwei Zhao Shumin Hao Jiajia Xie Yixue ouyang Shue Zhao Cardiology Department The Third Hospital of Hebei Medical UniversityShijiazhuangChina Educational Administration Department The Third Hospital of Hebei Medical UniversityShijiazhuangChina

Objectives:This study aimed to investigate the effect of motivational interviewing on the self-care behaviours in patients with chronic heart ***:Sixty-two hospitalized patients with chronic heart failure were recruited in this study from April 2014 to April 2015 from a ***-nine patients were in the intervention group,and 33 patients were in the control *** in the intervention group received four sessions of motivational interviewing,whereas those in the control group received traditional health *** 2,4,and 8 weeks post-discharge,the intervention group underwent telephone follow-up based on motivational interviewing,whereas the control group underwent routine telephone *** outcome was measured using the Self-care of Heart Failure Index at baseline and at 2 months ***:Before intervention,the self-care behaviours scores were 79.00±48.80 in the intervention group and 88.68±29.26in the control *** statistically significant differences were found between two groups in scores for each subscale and total scale(P>0.05).After intervention,the scores of self-care behaviours in the two groups were both improved at 155.13±35.65 for the intervention group and 115.44±22.82 for the control group with statistically significance(P<0.01).The score of self-care behaviours increased by 76.13 point in the intervention group on average,whereas 26.76 point in the control *** was significant difference between increases in scores of self-care behaviours in two groups(P<0.01).Conclusions:The self-care behaviours of patients with chronic heart failure could be improved effectively through motivational interviewing.

关键词： Heart failure Motivational interviewing Nursing care Patient education Self-care behaviours

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

智慧网络中用户数据隐私保护的策略研究

无线互联科技 2022年第8期19卷 20-22页

作者：邓佳燕欧阳红巍湖南现代物流职业技术学院湖南长沙410131

智慧网络的快速发展,虽给人们生活带来巨大便利,但用户隐私信息易被不法分子窃取和利用,导致不可估量的损失。为了让用户更好地了解当前智慧网络中隐私数据保护状况,文章从3个方面对当前现状进行研究分析:首先,分析当前智慧网络中用户... 详细信息

智慧网络的快速发展,虽给人们生活带来巨大便利,但用户隐私信息易被不法分子窃取和利用,导致不可估量的损失。为了让用户更好地了解当前智慧网络中隐私数据保护状况,文章从3个方面对当前现状进行研究分析:首先,分析当前智慧网络中用户数据存在形式和一些潜在的风险;其次,阐述当前保护用户隐私信息的方法;最后,从用户如何捍卫自身利益角度提出切实可行的策略,即如何减少智慧网络中用户隐私信息暴露的风险。

关键词：智慧网络用户数据隐私数据

Spontaneous movement of a retrotransposon generated genic dominant male sterility providing a useful tool for rice breeding

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

National Science Review 2023年第9期10卷 204-213页

作者： Conghao Xu Yifeng Xu Zhengji Wang Xiaoyu Zhang Yuying Wu Xinyan Lu hongwei Sun Lei Wang Qinglu Zhang Qinghua Zhang Xianghua Li Jinghua Xiao Xu Li Mingfu Zhao Yidan ouyang Xianbo Huang Qifa Zhang National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research(Wuhan) Hubei Hongshan LaboratoryHuazhong Agricultural University Ningde Inspection and Testing Centre for Agricultural Product Quality and Safety Fujian Academy of Agricultural Sciences Sanming Institute of Agricultural Sciences

Male sterility in plants provides valuable breeding tools in germplasm innovation and hybrid crop ***,genetic resources for dominant genic male sterility,which hold great promise to facilitate breeding processes,are extremely rare in natural *** we characterized the Sanming Dominant Genic Male Sterility in rice and identified the gene SDGMS using a map-based cloning *** found that spontaneous movement of a 1978-bp long terminal repeat(LTR) retrotransposon into the promoter region of the SDGMS gene activates its expression in anther tapetum,which causes abnormal programmed cell death of tapetal cells resulting in dominant male *** encodes a ribosome inactivating protein showing N-glycosidase *** activation of SD GMS triggers transcription reprogramming of genes responsive to biotic stress leading to a hypersensitive response which causes *** results demonstrate that an ectopic gene activation by transposon movement can give birth to a novel trait which enriches phenotypic diversity with practical utility.

关键词： Oryza sativa dominant male sterility ribosome-inactivating protein retrotransposon

Effective and precise adenine base editing n mouse zygotes

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2018年第9期9卷 808-813页

作者： Puping Liang hongwei Sun Xiya Zhang Xiaowei Xie Jinran Zhang Yaofu Bai Xueling ouyang Shengyao Zhi Yuanyan Xiong Wenbin Ma Dan Liu Junjiu Huang Zhou Songyang Key Laboratory of Gene Engineering of the Ministry of Education Guangzhou Key Laboratory of Healthy Aging Research and SYSU-BCM Joint Research Center School of Life Sciences Sun Yat-sen University Guangzhou 510275 China Key Laboratory of Reproductive Medicine of Guangdong Province School of Life Sciences and the First Affiliated Hospital Sun Yatsen University Guangzhou 510275 China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Verna and Marrs Mclean Department of Biochemistry and Molecular Biology Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA

Dear Editor, Many human genetic diseases are caused by pathogenic single nucleotide mutations. Animal models are often used to study these diseases where the pathogenic point mutations are created and/or corrected through gene editing （e.g., the CRISPP-JCas9 system）（Komor et al., 2017; Liang et al., 2017）. CRISPR/Cas9-mediated gene editing depends on DNA double-strand breaks （DSBs）, which can be of low efficiency and lead to indels and off-target cleavage （Kim et al., 2016）. We and others have shown that base editors （BEs） may represent an attractive alternative for disease mouse model generation （Liang et al., 2017; Kim et al., 2017）. Compared to CRISPR/ Cas9, cytidine base editors （CBEs） can generate C·G to T·A mutations in mouse zygotes without activating DSB repair pathways （Liang et al., 2017; Kim et al., 2017; Komor et al., 2016）. In addition, CBEs showed much lower off-targets than CRISPR]Cas9 （Kim et al., 2017）, making the editing process potentially safer and more controllable. Recently, adenine base editors （ABEs） that were developed from the tRNA- specific adenosine deaminase （TADA） of Escherichia coli were also reported （Gaudelli et al., 2017）. As a RNA-guided programmable adenine deaminase, ABE can catalyze the conversion of A to I. Following DNA replication, base I is replaced by G, resulting in A·T to G·C conversion （Gaudelli et al., 2017; Hu et al., 2018）. The development of ABEs has clearly expanded the editing capacity and application of BEs. Here, we tested whether ABEs could effectively generate disease mouse models, and found high efficiency by ABEs in producing edited mouse zygotes and mice with single-nucleotide substitutions.

关键词： WIDE TARGET SPECIFICITIES DNA CLEAVAGE GENOMIC DNA EMBRYOS