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Role of transport polarization in electrocatalysis:A case study of the Ni-cluster/Graphene interface

Journal of Materials Science & Technology 2021年第33期92卷 120-128页

作者： fang Bian Xin Ge Wu Shan Shan Li Gao Wu Qin Xiang Ying Meng Yin Wang Hong Wei Yang School of Materials Science and Engineering Northeastern UniversityShenyang 110819China College of Sciences Northeastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China International Centre of Quantum and Molecular Structures and Department of Physics Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals Kunming Precious Metals New Materials Technology Co.Ltd.Kunming 650106China

As cathodes,iron-series(Fe,Co,Ni)clusters supported by carbon materials exhibit outstanding electrocatalytic reduction activities in many electrocatalytic *** date,this general characteristic of ironseries clusters that should be related to the inherent attributes of these electrodes has not been fully understood from the perspectives of thermodynamics and electronic structure *** transport is a necessary process in electrocatalysis,and therefore,the study of the change of the electronic state in electron transport is beneficial for understanding this general characteristic of iron-series cluster *** this work,the electron transport properties,including the conductivity and transport spin-polarization at the Ni-cluster/graphene interface are carefully investigated as an example of carbon-supported iron-series *** first-principles calculations within the framework of the nonequilibrium Green’s function density functional theory(NEGF-DFT),we reveal that the electronic transport states of the coupled Ni-cluster/graphene are strongly changed compared to those of their isolated Ni-cluster and graphene *** is found that graphene dominates the overall conductivity of the interface,while the morphology of Ni-clusters controls the spin polarization *** spin polarization can lead to the self-excitation effect of the electrons that raises the energy of the electronic system,improves the thermodynamics of the reduction reaction and promotes catalytic *** work hints that iron-series elements(Fe,Co,Ni)based electrodes may generally show transport polarization that is likely to give rise to a high electrocatalytic reduction activity and such transport polarizability can be used as a new factor in the further exploration and design for electrocatalytic materials.

关键词： First-principles calculations electrocatalysis non-equilibrium electron injection transport polarization Ni-cluster/graphene

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Rapid Detection of Fox-derived Components using Mitochondrial COI Gene Sequence

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Animal Husbandry and Feed Science 2014年第6期6卷 345-347,352页

作者： Sun Min Gao hongwei Gong fang Liu Caixia Shandong Entry-Exit Inspection and Quarantine Bureau

Fox is an important economic fur animal with a very promising prospect. The fox mitochondrial COl gene-specific primers and probes were used to opti- mize and develop a real time fluorescence PCR system for rapid detection of fox-derived components. The results showed that the real time fluorescence PCR gave a very high sensitivity, with the detection limit as low as 12 fg DNA, and it did not present any cross reaction with other common species like pig, cow, sheep, dog, soybean and maize. It could be concluded that this method can be used as an effective method for detecting the fox-derived components in food and feedstuff, and can also be applied for distinguishing the fox fur from adulterants.

关键词： Fox COI gene Real time fluorescence PCR

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GelNB molecular coating as a biophysical barrier to isolate intestinal irritating metabolites and regulate intestinal microbial homeostasis in the treatment of inflammatory bowel disease

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Bioactive Materials 2023年第1期19卷 251-267页

作者： Qijiang Mao Haoqi Pan Yiyin Zhang Yi Zhang Qiuwen Zhu Yi Hong Zhengze Huang Yang Li Xu Feng Yifeng fang WenChao Chen Pengfei Chen Bo Shen hongwei Ouyang Yuelong Liang Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016China Key Laboratory of Laparoscopic Technology of Zhejiang province Hangzhou310016China Zhejiang Province Medical Research Center of Minimally Invasive Diagnosis and Treatment of Abdominal Diseases Hangzhou310028China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine Department of Orthopedic Surgery of the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Zhejiang University-University of Edinburgh Institute Zhejiang University School of MedicineKey Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang ProvinceZhejiang University School of MedicineHangzhouChina The State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou310028China Department of Orthopaedic Surgery Sir Run Run Shaw HospitalMedical College of Zhejiang UniversityHangzhouZhejiang310016China

Inflammatory bowel disease(IBD)is a chronic,immune-mediated inflammatory disease characterized by the destruction of the structure and function of the intestinal epithelial *** to the poor remission effect and severe adverse events associated with current clinical medications,IBD remains an incurable ***,we demonstrated a novel treatment strategy with high safety and effective inflammation remission via tissue-adhesive molecular *** molecular coating is composed of o-nitrobenzaldehyde(NB)-modified Gelatin(GelNB),which can strongly bond with-NH_(2)on the intestinal surface of tissue to form a thin biophysical *** found that this molecular coating was able to stay on the surface of the intestine for long periods of time,effectively protecting the damaged intestinal epithelium from irritations of external intestinal metabolites and harmful *** addition,our results showed that this coating not only provided a beneficial environment for cell migration and proliferation to promote intestinal repair and regeneration,but also achieved a better outcome of IBD by reducing intestinal ***,the in vivo experiments showed that the GelNB was better than the classic clinical ***,our molecular coating showed potential as a promising strategy for the prevention and treatment of IBD.

关键词： Inflammatory bowel GelNB Molecular coating Biophysical barrier

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Correction of β-thalassemia mutant by base editor in human embryos

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Protein & Cell 2017年第11期8卷 811-822页

作者： Puping Liang Chenhui Ding hongwei Sun Xiaowei Xie Yanwen Xu Xiya Zhang Ying Sun Yuanyan Xiong Wenbin Ma Yongxiang Liu Yali Wang Jianpei fang Dan Liu Zhou Songyang Canquan Zhou Junjiu Huang Key Laboratory of Gene Engineering of the Ministry of Education Guangzhou Key Laboratory of Healthy Aging Research and State Key Laboratory of Biocontrol SYSU-BCM Joint Research Center School of Life Sciences Sun Yat-sen University Guangzhou 510275 China Key Laboratory of Reproductive Medicine of Guangdong Province School of Life Sciences and the First Affiliated Hospital Sun Yat-sen University Guangzhou 510275 China Department of Pediatrics Second Affiliated Hospital Sun Yat-sen University Guangzhou 510120 China Verna and Marrs Mclean Department of Biochemistry and Molecular Biology Baylor College of Medicine One Baylor Plaza Houston. TX 77030. USA

β-Thalassemia is a global health issue, caused by mutations in the HBB gene. Among these mutations, HBB -28 （A〉G） mutations is one of the three most common mutations in China and Southeast Asia patients with β-thalassemia. Correcting this mutation in human embryos may prevent the disease being passed onto future generations and cure anemia. Here we report the first study using base editor （BE） system to correct disease mutant in human embryos. Firstly, we produced a 293T cell line with an exogenous HBB -28 （A〉G） mutant fragment for gRNAs and targeting efficiency evaluation. Then we collected primary skin fibroblast cells from a β-thalassemia patient with HBB -28 （A〉G） homozygous mutation. Data showed that base editor could precisely correct HBB -28 （A〉G） mutation in the patient＇s primary cells. To model homozygous mutation disease embryos, we consb＇ucted nuclear transfer embryos by fusing the lymphocyte or skin fibroblast cells with enucleated in vitro matured （IVM） ***, the gene correction efficiency was over 23.0% in these embryos by base editor. Although these embryos were still mosaic, the percentage of repaired blastomeres was over 20.0%. In addition, we found that base editor variants, with narrowed deamination window, could promote G-to-A conversion at HBB -28 site precisely in human embryos. Collectively, this study demonstrated the feasibility of curing genetic disease in human somatic cells and embryos by base editor system.

关键词： β-thalassemia HBB -28 (A〉G) baseeditor human embryo

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Correction To:Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3969-3972页

作者： Xiaojuan Han Congzhu Ding Dandan Wang Genhong Yao hongwei Chen Lingyun Sun Tianshu Xu Qijun fang Gang Hu Department of Rheumatology and Immunology Department of Traditional Chinese Medicine Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School Nanjing China Department of Traditional Chinese Medicine Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School Nanjing China Department of Rheumatology and Immunology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School Nanjing China Department of Pharmacology Nanjing University of Chinese Medicine Nanjing Jiangsu China

In the process of collating the raw data,the authors noticed two inadvertent mistakes occurred in Fig.4b and Fig.6g(and the corresponding uncropped images in“Supplementary Data 2-Figure 6g”)that need to be corrected after online publication of the *** correct data are provided as *** key findings of the article are not affected by these *** original article has been corrected.

关键词： stripping Figure correction

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Highly efficient and stable planar perovskite solar cells with large-scale manufacture and low-cost SnO2 layer towards commercialization viable

Highly efficient and stable planar perovskite solar cells wi...

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第四届新型太阳能电池学术研讨会

作者： Junjie Ma Xiaolu Zheng hongwei Lei Guojia fang School of Physics and Technology Wuhan University

The past five years have seen the remarkable rise of a new type of hybrid perovskite solar cells(PSCs).However, there still remain challenges for PSCs towards large-scale application and *** main reasons are the instability of the perovskite film and the lack of large-scale and low-cost manufacture techniques for electron transfer layer(ETL).Tin oxide(SnO) has emerged as a promising candidate for ETL, however, systematic exploration of its commercialized application in PSCs is still ***, we prepared SnO ETL through the electron beam evaporation(e-beam) technology,realizing large-scale,low-cost and uniform manufacture which would be available for industrial deployment.A Cs-containing blended perovskite absorber layer was introduced into the PSCs to effectively enhance the ambient *** a result, PSCs exhibit a high efficiency of 18.2% without any interface modification, and remarkable long-term stability, which remained 97% of its initial PCE after being stored over 34 *** result demonstrated the great potential of the PSCs based on SnO ETL towards commercially viable.

关键词： perovskite solar cells electron beam evaporation SnO2 commercialization

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一种AMR磁罗盘的误差建模与校准方法

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北京航空航天大学学报 2009年第1期35卷 104-107页

作者：孙宏伟房建成北京航空航天大学仪器科学与光电工程学院北京100191

针对传统磁罗盘硬磁校准时容易受到外界干扰,标定校准为相对值的问题,详细分析了AMR(Anisotropic Magneto Resistance,各向异性磁阻效应)磁罗盘的系统误差并建立其误差模型,提出了标量校准方法用于磁罗盘的硬磁标定校准.与传统方法相比... 详细信息

针对传统磁罗盘硬磁校准时容易受到外界干扰,标定校准为相对值的问题,详细分析了AMR(Anisotropic Magneto Resistance,各向异性磁阻效应)磁罗盘的系统误差并建立其误差模型,提出了标量校准方法用于磁罗盘的硬磁标定校准.与传统方法相比,该方法不需要确切的航向参考值,利用任意多位置下的大量测试数据通过迭代求取校准参数的最优解,通过施加约束避免校准过程中磁干扰的影响,并且校准值为绝对矢量.经过硬磁校准,磁罗盘航向精度提高7倍.实验结果验证了该方法的有效性和实用性.

关键词：磁罗盘标量校准硬磁误差

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Research on the Method of Calculating Node Injected Reactive Power Based on L Indicator

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Journal of Power and Energy Engineering 2014年第4期2卷 361-367页

作者： Xue Gong Bingcheng Zhang Bing Kong Anan Zhang hongwei Li Wei fang School of Electrical Engineering and Information Southwest Petroleum University Chengdu China Baikouquan Oil Production Plant Petro China Xinjiang Oilfield Company Karamay China

With the power grid load increasing, the problem of grid voltage stability is increasingly prominent, and the possibility of voltage instability is also growing. In order to improve the voltage stability, this paper analyzed how the voltage stability was influenced by different reactive power injection based on the simplified L-indicator of on-line voltage stability monitoring. According to the basic differential property of the simplified L-indicator, a general and normative analytical algorithm about reactive power optimization was deduced. The analytical algorithm can calculate the load node injected reactive power, and then the network can run in the optimal steady state on the basis of the calculation results. According to the simulation results of IEEE-14, IEEE-30, IEEE-57 and IEEE-118, the feasibility and effectiveness of the proposed algorithm to improve voltage stability and reduce the risk of grid collapse were verified.

关键词： Voltage Stability L-Indicator Injected Reactive Power Reactive Power Optimization Fast Calculation

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HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia

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Protein & Cell 2019年第7期10卷 538-542页

作者： Yan Huang Chenhui Ding Puping Liang Duanduan Li Yu Tang Wei Meng hongwei Sun Hongyu Lu Yu Chen Xueying Chen Qunshan Huang Jianpei fang Canquan Zhou Shihua Yang Junjiu Huang College of Veterinary Medicine Key Laboratory of Comprehensive Prevention and Control for Severe Clinical Animal Diseases of Guangdong Province South China Agricultural University Guangzhou 510642 China Key Laboratory of Reproductive Medicine of Guangdong Province The First Affiliated Hospital and School of Life Sciences Sun Yatsen University Guangzhou 510275 China MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of Biocontrol School of Life Sciences SunYat-sen University Guangzhou 510275 China Department of Pediatrics Second Affiliated Hospital Sun Yat-sen University Guangzhou 510120 China

Dear Editor,β-Thalassemia is a common severe genetic disease caused by mutations in HBB and affects approximately 1.5% of the global population (Origa, 2017). In southern China, the carrier rate of β-thalassemia is as high as 6.43%, creating a high socio-economic burden (Xiong et al., 2010). In adult humans, there are three types of hemoglobin: HbA1 (~97%), HbA2 (~2%) and HbF (~1%). HbA1 (α2β2) is composed of two a-globin and two β-globi n sub units en coded by HBA and HBB, respectively;HbF (α2β2)is made up of two α-globin subunits and two β-globin sub units en coded by HBG. Mutations in the coding region or regulatory region of HBB are involved in β-thalassemia pathogenesis. Except for some rare dominant mutations, most HBB mutations are recessive (Origa, 2017). Depending on the mutation type, the β-globin level will either be reduced or completely depleted, resulting in α-globin accumulation and precipitation. These α-globin precipitates lead to red blood cell death, resulting in anemia and tissue damage, and even death in thalassemia major patients. Blood transfusions can help slow disease progression but lead to iron overload, ultimately resulting in iron toxicity. Bone marrow transfer is the only cure in the clinic and is available only to a small percentage of patients with human leukocyte antigervmatched donors. Recently, gene therapy and gene editing therapy have shown great promise in curing β-thalassemia (Glaser et al., 2015;Thompson et al., 2018). However, no appropriate animal models are available for evaluating the safety and efficacy of such advanced therapeutic strategies in vivo.β-thalassemia mice are the sole animal model available for research. However, substantial differences have been reported between the types and expressi on patter ns of human and mouse globins (McColl and Vadolas, 2016). Moreover, mice contain no fetal globin gene equivalent, and homozygous mutations of HBB in mouse for early models of β-thalassemia major or Cooley anemia are

关键词： mutation mouse Editor mice most help null sub

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On the technologies of Hα imaging spectrograph for the CHASE mission

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Science China(Physics,Mechanics & Astronomy) 2022年第8期65卷 29-36页

作者： Qiang Liu Hongjiang Tao Changzheng Chen Chengshan Han Zhe Chen Gui Mei Liang Yang Qinglong Hu hongwei Xin Xiansheng Li Hongyu Guan Donglin Xue Mingchao Zhu Changhong Hu Qinghua Ha Yukun He Cheng fang Chuan Li Zhen Li Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory for Modern Astronomy and Astrophysics Ministry of EducationNanjing 210023China

The Hα imaging spectrograph(HIS) is the scientific payload of the first solar space mission, the Chinese Hα solar explorer(CHASE), supported by the China National Space Administration(CNSA). The CHASE/HIS achieves, for the first time in space, Hα spectroscopic observations with high spectral and temporal resolutions. Separate channels for the raster scanning mode(RSM) and continuum imaging mode(CIM) are integrated into one, and a highly integrated design is achieved through multiple folding of the optical path and ultra-light miniaturized components. The design of HIS implements a number of key technologies such as high-precision scanning of the optical field of view(FOV), high-precision integrated manufacturing inspection, a large-tolerance pre-filter window, and full-link solar radiation calibration. The HIS instrument has a pixel spectral resolution of 0.024 ? and can complete a full-Sun scanning within 46 s.

关键词： space-based telescope design and performance testing of optical systems scan imaging

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