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基于网络药理学和分子对接技术探讨蟾酥治疗肺癌的作用机制

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西部中医药 2024年第5期37卷 110-118页

作者：秦欣欣张山于会勇周鸿威郭雨菲王成祥北京中医药大学第三附属医院北京100029

目的:采用网络药理学及分子对接技术探索蟾酥治疗肺癌的分子作用机制。方法:通过中药与化学成分数据库、BATMAN、SwissADME、SwissTargetPrediction数据库获取并筛选蟾酥的活性成分及作用靶点;通过人类基因数据库(the human gene databa... 详细信息

目的:采用网络药理学及分子对接技术探索蟾酥治疗肺癌的分子作用机制。方法:通过中药与化学成分数据库、BATMAN、SwissADME、SwissTargetPrediction数据库获取并筛选蟾酥的活性成分及作用靶点;通过人类基因数据库(the human gene database,GeneCards)、在线人类孟德尔遗传数据库(online mendelian inheritance in man,OMIM)、药物靶标数据库(therapeutic targetdatabase,TTD)获取肺癌主要靶点,利用STRING平台构建共同靶点蛋白-蛋白互作网络(protein-protein interactions,PPI);运用Cytoscape 3.7.1软件构建蟾酥活性成分-肺癌-靶点交集网络;通过R语言软件对共同靶点进行基因本体(gene ontology,GO)和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)通路富集分析;通过AutoDock Tools 1.5.6、AutoDock vina 1.1.2进行分子对接验证。结果:共筛选出蟾酥有效活性成分19个,蟾酥作用于肺癌的靶点94个,PPI网络显示表皮生长因子受体、丝裂原活化蛋白激酶3、丝裂原活化蛋白激酶1、白细胞介素6、类固醇受体辅激活因子等为核心靶点,主要涉及肽基-酪氨酸磷酸化及修饰、丝氨酸磷酸化及修饰等生物过程;蟾酥作用于肺癌的生物学通路主要富集在PI3K/Akt、癌症蛋白聚糖、癌症MicroRNAs等信号通路;分子对接结果证明蟾酥大部分有效活性成分与核心蛋白靶点有较好的结合活性。结论:蟾酥可通过多成分、多靶点、多通路治疗肺癌。

关键词：肺癌网络药理学分子对接作用机制蟾酥

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云南瑞丽黄胸鼠肥满度季节性差异及影响因素

山地农业生物学报 2024年第2期43卷 56-62页

作者：周宏伟任天广董文鸽郭宪国宋文宇大理大学病原与媒介生物研究所/云南省自然疫源性疾病防控技术重点实验室云南大理671003 大理大学护理学院云南大理671003

黄胸鼠Rattus tanezumi是中国南部常见的鼠疫传染源和农业害兽。为了解不同环境因素对黄胸鼠肥满度的影响及其个体差异程度,本研究对2009年8月—2010年5月在云南省瑞丽市捕获的819只黄胸鼠肥满度进行了分析。结果表明,黄胸鼠肥满度具有... 详细信息

黄胸鼠Rattus tanezumi是中国南部常见的鼠疫传染源和农业害兽。为了解不同环境因素对黄胸鼠肥满度的影响及其个体差异程度,本研究对2009年8月—2010年5月在云南省瑞丽市捕获的819只黄胸鼠肥满度进行了分析。结果表明,黄胸鼠肥满度具有明显的偏雄性二态现象:雄性的肥满度明显高于雌性;且在不同景观、不同生境、不同季节均有显著差异。在调查的10个月内,黄胸鼠的肥满度存在明显波动,其中雄性肥满度呈现出“三峰”:最高值(第一峰)出现在10月、第二高峰值出现在次年1月、第三高峰值在次年5月;雌性肥满度呈现为“双峰”:最高值(第一峰)出现在10月、第二高峰值在次年4月。这些结果提示应在1月、4月、5月、10月、12月等月份加强对黄胸鼠的防范。

关键词：肥满度害兽监测黄胸鼠季节变化性二态

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Multicolor emission from lanthanide ions doped lead-free Cs_(3)Sb_(2)Cl_(9) perovskite nanocrystals

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Journal of Rare Earths 2024年第5期42卷 940-946,I0005页

作者： He Shao Lifang Li Xiufeng Wu Lin Xu Biao Dong Donglei zhou Xue Bai hongwei Song State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials College of Materials Science and EngineeringNanjing University of Posts&TelecommunicationsNanjing210023China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin UniversityChangchun130012China

The toxicity of lead ions has become the severe challenge for the all-inorganic lead halide p erovskite materials,although some works have rep orted the lead-free perovskite nanocrystals(NCs),the photoluminescence quantum yield(PLQY)of these materials is still ***,because the halogen ions can be easily exchanged,the controllable multicolor emission in perovskite NCs is difficult to realize in current *** this work,we introduced lanthanide ions into lead-free Cs_(3)Sb_(2)Cl_(9) perovskite *** from the energy transfer between Cs_(3)Sb_(2)Cl_(9) perovskite NC host and lanthanide ions,the multicolor emission was *** on controlling the doping concentration of Tb^(3+)and Eu^(3+)ions,the white light emission under UV excitation would be turned easily in the Tb^(3+)/Eu^(3+)codoped *** addition,efficient energy transfer from perovskite NCs to Tb^(3+)or Eu^(3+)ions is beneficial to improving the optical properties of lead-free perovskite NCs,resulting in maximum PLQYs of red,green and white light emission of 22.6%,19.7%and 28.5%,***,a white light emitting device(WLED)was fabricated with a power efficiency of 18.5 lm/W,which presents the Commission Internationale de l'Eclairage(CIE)of(0.33,0.35).

关键词： Perovskite nanocrystals Lead free Lanthanide ions Energy transfer White light emitting device Rare earths

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专科层次药学专业多学科融合综合性实验探索

中国中医药现代远程教育 2024年第18期22卷 43-46页

作者：杜珊姗赵梦杜鑫杜林林宋丽丽周宏伟承德护理职业学院医学技术系河北承德067000 张家口市崇礼区石嘴子乡卫生院五十家分院内科河北张家口076350 平泉市医院普外科河北平泉067500 承德护理职业学院医学系河北承德067000

目的探索开展药学专业多学科融合综合性实验打破学科界限,节约教育成本,帮助学生系统地掌握专业知识和实践技能,培养学生综合考虑问题的思维方式和运用综合的技术、方法、手段分析问题、解决问题的能力和创新能力,实现对其能力、素质的... 详细信息

目的探索开展药学专业多学科融合综合性实验打破学科界限,节约教育成本,帮助学生系统地掌握专业知识和实践技能,培养学生综合考虑问题的思维方式和运用综合的技术、方法、手段分析问题、解决问题的能力和创新能力,实现对其能力、素质的全面培养。方法选取2021级药学专业三年制学生79人,5人一小组,共计16组进行实验。结果此次药学专业多学科融合综合性实验探索中,各科教师积极协调组织,学生积极参与且学习兴趣浓厚。综合性实验顺利进行,取得了预期效果,学生也对此满意度较高。结论此次综合性实验探索打破了学科界限,节约了教育成本,在进行实验的同时提升了学生分析问题解决问题的能力,实现了能力素质的综合提升,帮助学生提升了职业适应能力,为其以后的实习和工作打下了坚实基础,同时也为以后开展更多的多学科融合综合性实验积累了宝贵经验。

关键词：药学多学科融合综合性实验

Identification of key species in gut microbiome for metabolic diseases

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Identification of key species in gut microbiome for metaboli...

Comprehensive eco-environmental effects of the shelter-forest ecological engineering along the Tarim Desert Highway

第三届中国生物物理学会代谢生物学分会学术研讨会

作者： hongwei zhou Zhujiang Hospital Southern Medical University

＜正＞Gut mirobiome is associated with many chronic metabolic diseases,therefore gut microbiome check has a potential for disease diagnosis and risk ***,gut microbial composition is highly complex and could be affected by many host factors and become highly variable among *** studies have reported inconsistent dysbiosis patterns for the same disease but the underlying reason remained unclear and this phenomenon hindered the

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Chinese Science Bulletin 2008年第S2期53卷 190-202页

作者： LEI JiaQiang LI ShengYu JIN ZhengZhong FAN JingLong WANG HaiFeng FAN DongDong zhou hongwei GU Feng QIU YongZhi XU Bo Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830011China Graduate University of the Chinese Academy of Sciences Beijing 100049China Tarim Branch PetroChina Company LimitedKorla 841000China

In this work, we report a comprehensive study about the eco-environmental effects of the shelter forest along the Tarim Desert Highway, including the effects on aeolian environment, soil, micro-climate, biodiversity, and groundwater. The results show that: (1) The movement of windblown sand near the ground surface was affected by the shelter forest. The wind speed and sediment transport rate in the shelter forest decreased by 64%―80% and 87.45%―99.02%, respectively. In addition, there were also significant changes in the sand flux structure, the sand grain size, and the deflation and deposition on the ground surface. (2) Compared to the natural mobile sand, the soil bulk density in the forest area decreased while the total salt content, the total porosity, and the water content increased. In addition, the soil fertility was significantly improved in the forest area, and showed the "first rapid, then slow" variation pattern. (3) The shelter forest showed positive effects on the micro-climate. Within the 6 m height above the ground, the air temperature in the shelter forest at different heights was lower than that in the mobile sand, while the air humidity was higher, while, the soil temperature was also lower in the shelter forest than mobile sand. (4) The number of soil microbial species increased significantly with the improvement of habitat in the shelterbelt. However, the population of different species was not distributed evenly across the surveyed area. (5) Currently, no significant effects of groundwater-pumping and forest-irrigation water have been found on the groundwater level and its salinity. The variation amplitude of both groundwater level and salinity was at the level of centimeters and 1g/L, respectively. No obvious variation trend has been observed.

关键词： desert shelter-forest engineering environmental effect aeolian environment biodiversity

Spatial correlations in ground motion intensity measuring from the 2023 Türkiye earthquake

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Earthquake Research Advances 2024年第1期4卷 14-22页

作者： Guoliang Shao Ruizhi Wen hongwei Wang Yeifei Ren Baofeng zhou Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin150080 China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin150080 China

When evaluating an area's seismic risk or resilience,it is necessary to use the spatial correlation to analyze the ground motion parameters of multiple sites together in an *** two large earthquakes in Türkiye provided the possibility for spatial correlation analysis of ground motion intensity measurements in this *** on the strong motion records provided by The Disaster and Emergency Management Authority of Türkiye(AFAD),this study uses the local ground motion prediction equation in Türkiye to give spatial correlation analysis of Intensity *** study gives an exponential model based on a semivariogram and compares it with the correlation model obtained from previous studies.

关键词： Spatial correlation Semi-variance Türkiye GMPE

Automatically identifying imperfections and attacks in practical quantum key distribution systems via machine learning

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Science China(Information Sciences) 2024年第10期67卷 359-372页

作者： Jiaxin XU Xiao MA Jingyang LIU Chunhui ZHANG hongwei LI Xingyu zhou Qin WANG Institute of Quantum Information and Technology Nanjing University of Posts and Telecommunications Telecommunication and Networks National Engineering Research CenterNanjing University of Posts and Telecommunications Henan Key Laboratory of Quantum Information and Cryptography Strategic Support Force Information Engineering University

The realistic security of quantum key distribution(QKD) systems is currently a hot research topic in the field of quantum communications. There are always defects in practical devices, and eavesdroppers can make use of the security risk points of various devices to obtain key information. To date, current types of security analysis tend to analyze each security risk point individually, thereby posing great challenges for the overall security evaluation of QKD systems. In this paper, for the first time, we employ machine learning algorithms to identify the defects of different devices and certain attacks in real time, with an accuracy of 98%. It provides a novel solution for the practical security evaluation of QKD systems, thereby addressing the bottleneck problem of multiple risk points being difficult to address simultaneously in QKD systems,thus paving the way for the future large-scale application of quantum communication networks.

关键词： quantum key distribution device imperfections eavasdropping attacks real-time detection machine learning algorithms

Control of Virtual Synchronous Generator for Frequency Regulation Using a Coordinated Self-adaptive Method

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 175-184页

作者： hongwei Fang Zhiwei Yu School of Electrical and Information Engineering and Key Laboratory of Tianjin Electric Power System Simulation and Control Tianjin UniversityTianjin 300072China

Power inverter adopting virtual synchronous generator(VSG)control can provide inertia support for distributed generation ***,it cannot take into account the dynamic regulation characteristics of ***,when the system encounters a sudden change in load or disturbance,the dynamic process of frequency regulation will be greatly *** view of this issue,an improved VSG control strategy based on a coordinated self-adaptive(CSA)method is *** time domain analysis method is used to study the influences of virtual inertia and damping parameter perturbation on the system steady and dynamic ***,in order to make the control strategy suitable for large load changes and suppress frequency variations beyond the limit,the secondary frequency modulation is introduced into the control *** the coordinated adaptive control of virtual inertia,virtual damping and frequency modulation,the dynamic performance of vSG frequency regulation can be obviously *** and experiment results have verified the effectiveness of the proposed CSA control strategy.

关键词： Coordinated self-adaptive method frequency regulation time domain analysis virtual synchronous generator