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Decreased expression of m6A demethylase ALKBH5 in decidua contributes to preeclampsia via m6A-CORIN-HuR pathway

Genes & Diseases 2023年第3期10卷 650-653页

作者： Jieqiong Yang Jing Tong hongwanyu li Shijian Lv Weiya li Cong Zhang Wen Di Department of Obstetrics and Gynecology Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Center for Reproductive Medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200135China Shanghai Key Laboratory of Gynecologic Oncology Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200135China Shandong Provincial Key Laboratory of Animal Resistance Biology College of Life SciencesShandong Normal UniversityShandong 250014China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Preeclampsia(PE)is a pregnancy-specific hypertensive disorder which poses a severe threat to maternal and fetal health.1 Defective decidualization may contribute to PE.^(2) N6-methyladenosine(m6A)is associated with various *** regulatory mechanism of m6A in PE is not well established to *** aimed to identify differentially expressed m6A and explore its regulatory role in the pathogenesis of PE.

关键词： hypertensive m6A pregnancy

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Decidualization and Related Pregnancy Complications

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Maternal-Fetal Medicine 2022年第1期4卷 24-35页

作者： Jing Tong Shijian Lv Jieqiong Yang hongwanyu li Weiya li Cong Zhang Center for Reproductive Medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200135China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai200135China Shandong Provincial Key Laboratory of Animal Resistance Biology College of Life SciencesShandong Normal UniversityJinanShandong 250014China

Decidualization is the differentiation of endometrial stromal cells into secretory decidual stromal *** decidualization involves some amount of signaling molecules and pathways as well as genetic reprogramming,which is driven by the postovulatory rise in progesterone levels and local cyclic adenosine monophosphate *** extends from the primary decidual zone to the secondary decidual zone,and then exits through *** support that decidual fibroblasts function as the pool of decidual stromal cells during *** undergoes an acute inflammatory phase,an anti-inflammatory secretory phase to the final recession *** decidualization of the inner layer of endometrium,termed decidua,is the most critical determinant of pregnancy success,which can promote placenta formation,modulate immune tolerance,foster resistance to oxidative stress,sense embryo quality,and control *** to adequate decidualization in terms of hormones,biochemistry,and immunology leads to adverse pregnancy outcomes,including diseases such as preeclampsia,miscarriage,premature labor,repeated implantation failures,and some age-related decline in reproductive *** development of animal models and in vitro culture systems combined with emerging technologies provides a powerful system to explore the mechanism of ***,decidualization is a dynamic,multi-step process,and translating of current research progress into disease predictions and interventions for pregnancy complications remains to be *** study of periodic regeneration and spontaneous decidualization of the endometrium will be beneficial to the diagnosis and treatment of pregnancy diseases.

关键词： Decidua Decidualization Decidual stromal cells Endometrial stromal cells Pregnancy complications

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