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大型原发性颅内孤立性纤维瘤的显微手术治疗效果及预后影响因素分析

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中华神经医学杂志 2024年第7期23卷 698-704页

作者：程立冬潘启航刘魏华黄伟朱洪涛马艺璇李俊华中科技大学同济医学院附属武汉市中心医院神经外科武汉430014 华中科技大学同济医学院附属同济医院神经外科武汉430010

目的探讨大型原发性颅内孤立性纤维瘤(SFT)的手术治疗效果及预后影响因素。方法回顾性纳入华中科技大学同济医学院附属武汉市中心医院及同济医院神经外科自2.10年1月至2.2.年12.采用显微手术治疗的47例大型原发性颅内SFT患者,分析患者... 详细信息

目的探讨大型原发性颅内孤立性纤维瘤(SFT)的手术治疗效果及预后影响因素。方法回顾性纳入华中科技大学同济医学院附属武汉市中心医院及同济医院神经外科自2.10年1月至2.2.年12.采用显微手术治疗的47例大型原发性颅内SFT患者,分析患者的临床资料、手术治疗效果及随访结果,明确肿瘤全切及患者预后的影响因素。结果肿瘤位于幕上32.,幕下15例,其中累及窦旁2.例。病理分级依据WHO分级分为:1级5例(10.6%),2.32.(68.1%),3级10例(2..3%)。31例(66.0%)患者实现肿瘤全切,16例(34.0%)为次全切除。7例(14.9%)患者术后出现术腔出血、远隔部位硬膜外血肿、皮下积液等手术并发症,均经二次手术或保守治疗后治愈。另有3例患者遗留肢体活动障碍,3例患者遗留视力障碍,2.术后合并癫痫发作。13例(2..7%)患者术后进行了辅助放疗。47例患者术后随访(69.1±2..6)个月,2.例(61.7%)患者肿瘤复发,其中6例出现颅内及颅外转移,4例患者死亡。47例患者无进展生存时间为(57.5±2..1)个月,术后1年、3年、5年无进展生存率分别为95.7%、87.2.、59.6%。病变是否累及窦旁是影响肿瘤全切的重要因素,手术全切是大型原发性颅内SFT患者无进展生存时间的独立保护因素(HR=4.2.1,95%CI:1.555~11.839,P=0.005)。结论大型原发性颅内SFT患者术后复发风险较高,肿瘤全切可有效预防肿瘤复发。

关键词：孤立性纤维瘤大型肿瘤手术全切除肿瘤复发

N9 microglial cells polarized by LPS and IL4 show differential responses to secondary environmental stimuli

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N9 microglial cells polarized by LPS and IL4 show differenti...

近表面疲劳裂纹的水浸式非共线横波混频检测方法研究

2.12.海内外华人神经科学会议

作者： Min-Hua Zheng Hong-Cui liu Yan-ling Du Hua Han~* {2. of Medical Genetics and developmental biology Fourth Military Medical university Xi’an China

＜正＞Microglia participates in the regulation of many inflammation-related pathological processes in the central nervous system, but how microglial activation is regulated has not been fully ***,by using a microglial cell line,we show that microglia, like other macrophages,are activated by inflammatory stimuli in a polarized *** LPS-polarized Ml microglia appeared to be unable to respond to a secondary TT4 stimulation,while TT4-polarized M2.microglia could respond to secondary LPS *** also show that Notch signaling is involved in microglial *** Notch signaling was blocked,the Ml polarization was suppressed,while the M2.polarization was *** of the Notch signal inhibitor did not permit M2.N9 cells to re-polarize to Ml upon LPS stimulation,suggesting that the effects of Notch blockade on microglial polarization could be "memorized" by cells. Lhese results suggest complicated mechanisms including epigenetic programs in the regulation of macrophage polarization.

关键词： microglia macrophage polarization LPS IL4 Notch signaling

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声学技术 2024年第2期43卷 234-240页

作者：吕洪涛王俊涛刘志毅石亮李锋焦敬品中国航空综合技术研究所北京100028 北京工业大学材料与制造学部北京100124

针对近表面疲劳裂纹检测问题,开展了水浸式非共线横波混频检测方法研究。在材料非线性、水/试件界面和疲劳裂纹不同非线性源情况下,分析相互作用角和频率比对混频非线性效应的影响规律。在此基础上,对有无近表面疲劳裂纹试件沿着深度方... 详细信息

针对近表面疲劳裂纹检测问题,开展了水浸式非共线横波混频检测方法研究。在材料非线性、水/试件界面和疲劳裂纹不同非线性源情况下,分析相互作用角和频率比对混频非线性效应的影响规律。在此基础上,对有无近表面疲劳裂纹试件沿着深度方向进行扫查检测。结果表明,在不同非线性源情况下,混频特征图具有显著差异,根据混频特征图中和频纵波峰值及其对应相互作用角可对试件近表面疲劳裂纹进行检测;水/试件界面对近表面疲劳裂纹非共线横波混频检测具有一定影响,去参考检测方法可显著降低水/试件界面的影响,实现对近表面疲劳裂纹的有效检测。

关键词：近表面缺陷疲劳裂纹非线性超声混频

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基于站间协同的智能调度系统设计及关键技术

中国铁路 2024年第7期 172-178,187页

作者：赵宏涛曹桢郑勇刘文顺张志强周晓昭中国铁道科学研究院集团有限公司通信信号研究所北京100081 中国铁道科学研究院集团有限公司北京华铁信息技术有限公司北京100081 中国铁路北京局集团有限公司计划统计部北京100860 中国铁路北京局集团有限公司电务部北京100860 中国铁路成都局集团有限公司成都电务维修段四川成都610000

围绕基于站间协同的智能调度系统开展研究,探讨调度系统在数据服务驱动下的安全与智能发展趋势。京张高铁等线路的开通运营,标志着智能调度系统夯实数据安全保障机制,形成统一数据平台,顺利完成第1阶段工作。智能调度系统下一阶段需在... 详细信息

围绕基于站间协同的智能调度系统开展研究,探讨调度系统在数据服务驱动下的安全与智能发展趋势。京张高铁等线路的开通运营,标志着智能调度系统夯实数据安全保障机制,形成统一数据平台,顺利完成第1阶段工作。智能调度系统下一阶段需在数据效力利用、跨站协同安全防护及迭代学习能力开发等方面持续增强。总结分析既有系统不足,立足实际需求,引入虚拟协同区域概念,依托中心功能服务器的数据、服务和资源支持,设计基于站间协同的行车安全卡控方案;系统运用大数据和智能技术,实现了安全策略和调优规则的动态管理,有效促进了信息共享下的数据挖掘和区域感知下的安全决策。该研究成果不仅丰富了相关理论,也为铁路运输的安全化和智能化发展提供有益参考。

关键词：智能高铁智能调度系统 CTC 站间协同虚拟协同区域车站自律机安全防护

A novel class of apical sodium–dependent bile salt transporter inhibitors:1-(2.4-bifluorophenyl)-7-dialkylamino-1,8-naphthyridine-3-carboxamides

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Acta Pharmaceutica Sinica B 2017年第2期7卷 223-229页

作者： hongtao liu Guoxun Pang Jinfeng Ren Yue Zhao Juxian Wang department of Pharmacy Hebei General HospitalShijiazhuang 050051China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

The apical sodium-dependent bile acid transporter(ASBT) is the main transporter to promote re-absorption of bile acids from the intestinal tract into the enterohepatic *** of ASBT could increase the excretion of bile acids,thus increasing bile acid synthesis and consequently cholesterol ***,ASBT is an attractive target for developing new cholesterol-lowering *** this report,a series of 1-(2.4-bifluorophenyl)-7-dialkylamino-1,8-naphthyridine-3-carboxamides were designed as inhibitors of *** of them demonstrated potency against ASBT transport of bile *** particular,compound 4a_1 was found to have the best activity,resulting in 80.1%inhibition of ASBT at10μmol/L.

关键词： ASBT inhibitors Bile acids 1-(2.4-Bifluorophenyl)-7dialkylamino-1,8-naphthyridine-3-carboxa mides Cholesterol-lowering drug NC-1

STRENGTH PROPERTIES OF JOINTED ROCK MASSES BASED ON THE HOMOGENIZATION METHOD

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Acta Mechanica Solida Sinica 2012年第2期25卷 177-185页

作者： hongtao Zhang Jianming Zhu Yinghua liu Bingye Xu Xiaochun Wang department of Civil Engineering North China University of TechnologyBeijing 100144China department of Engineering Mechanics Tsinghua UniversityBeijing 100084China

This paper aims to determine the strength properties of jointed rock masses by means of the homogenization method. To reflect the microstructure of jointed rock masses, a representative element volume （REV） is selected. Assuming being rigid and perfectly plastic and utilizing the Mohr-Coulomb yield criterion for rock and joints, an upper bound limit analysis method is proposed based on the homogenization theory. By using the finite element method and Goodman joint element, a nonlinear mathematical programming with equality constraints is formulated, which can be solved by a direct iterative algorithm. Numerical results show the strength of jointed rock masses behaves anisotropy with different joint directions. This method presents an effective tool for the strength analysis of jointed rock masses.

关键词： jointed rock mass homogenization representative element volume (REV) upperbound limit analysis anisotropy

Holey graphene hydrogel with in-plane pores for high- performance capacitive desalination

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Nano Research 2016年第8期9卷 2458-2466页

作者： Weiqing Kong Xidong Duan Yongjie Ge hongtao liu Jiawen Hu Xiangfeng Duan State Key Laboratory for Chemo/Biosensing and Chemometrics department of Chemistry and Chemical Engineering Hunan University Changsha 410082 China College of Chemistry and Chemical Engineering Central South University Changsha 410083 China department of Chemistry and Biochemistry University of Califomia Los Angeles CA 90095 USA

capacitive deionization is an attractive approach to water desalination and treatment. To achieve efficient capacitative desalination, rationally designed electrodes with high specific capacitances, conductivities, and stabilities are necessary. Here we report the construction of a three-dimensional （3D） holey graphene hydrogel （HGH）. This material contains abundant in-plane pores, offering efficient ion transport pathways. Furthermore, it forms a highly interconnected network of graphene sheets, providing efficient electron transport pathways, and its 3D hierarchical porous structure can provide a large specific surface area for the adsorption and storage of ions. Consequently, HGH serves as a binder-free electrode material with ex{2.ent electrical conductivity. Cyclic voltammetry （CV） measurements indicate that the optimized HGH can achieve specific capacitances of 358.4 F.g 1 in 6 M KOH solution and 148 F.g-1 in 0.5 M NaCl solution. Because of these high capacitances, HGH has a desalination capadty as high as 2..8 mg.g-1 （applied potential： 1.2.V; initial NaCI concentration： -5,000 mg.L-l）.

关键词： capacitive deionization desalination electrochemical capacitor graphene hydrogel (GH) in-plane pore

The MADS-box gene RhAGL6 plays a master role in regulating the receptacle malformation in rose at low temperature

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Horticultural Plant Journal 2024年第5期10卷 1214-1229页

作者： Weikun Jing Shuai Zhang Qingcui Zhao Yang liu Liangjun Zhao Junping Gao Nan Ma Xiaofeng Zhou Yonghong Li School of Food and Drug Shenzhen PolytechnicShenzhen 518055China department of Ornamental Horticulture College of HorticultureChina Agricultural UniversityBeijing 100193China Postdoctoral Innovation Practice Base Shenzhen PolytechnicShenzhen 518055China Flower Research Institute of Yunnan Academy of Agricultural Sciences KunmingYunnan 650205China

Low temperature usually results in the developmental deformity of flower organs,immensely affecting the quality of rose ***,it's largely unknown about the regulatory mechanisms activated by low ***,we used a low temperature-sensitive Rosa hybrida cv.‘Peach Avalanche’to screen a MADS-box gene RhAGL6 via conjoint analysis between RNA sequencing(RNA-seq)and whole-genome bisulfite sequencing(WGBS).Furthermore,we found that low temperature induced the hypermethylation and elevated histone 3 lys-2. trimethylation(H3K2.me3)level on the RhAGL6 promoter,leading to decreased RhAGL6 *** addition,RhAGL6 silencing resulted in the formation of abnormal *** also found that the levels of gibberellins(GA3)and abscisic acid(ABA)in the receptacle under low temperature were lower and higher,respectively,than under normal *** activity analysis revealed that GA3 significantly activated RhAGL6 promoter activity,whereas ABA inhibited ***,we propose that RhAGL6 regulates rose receptacle development by integrating epigenetic regulation and phytohormones signaling at low temperature.

关键词： Rosa hybrida Low temperature RhAGL6 Receptacle development DNA methylation H3K2.me3 Phytohormone

The genome-wide analysis of intermediate-size ncRNAs in higher plants

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The genome-wide analysis of intermediate-size ncRNAs in high...