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药学实践与服务 2024年第3期42卷 101-107页

作者：曾棋平刘建清杨丽娜刘志宏宋洪涛福建医科大学附属漳州市医院药学部福建漳州363000 泉州医学高等专科学校福建泉州362000 联勤保障部队第九〇九医院药剂科福建漳州363000 联勤保障部队第九〇〇医院药剂科福建福州350025

目的将水飞蓟素和磷脂复合以研制水飞蓟素磷脂复合物(silymarin phospholipids complex,SM-PC),并考察其基本理化性质。方法采用溶剂挥发法制备SM-PC。通过前期的单因素考察,选择脂药比、药物浓度以及反应温度作为星点设计-效应面法的... 详细信息

目的将水飞蓟素和磷脂复合以研制水飞蓟素磷脂复合物(silymarin phospholipids complex,SM-PC),并考察其基本理化性质。方法采用溶剂挥发法制备SM-PC。通过前期的单因素考察,选择脂药比、药物浓度以及反应温度作为星点设计-效应面法的考察因素,以SM-PC的复合率为衡量指标筛选最佳研制工艺,并测定SM-PC的体外溶出度。结果SM-PC的最优制备条件如下:以丙酮为反应溶剂,水飞蓟素与大豆卵磷脂的比例为1∶1.8,反应温度56℃,反应物的浓度8.0 mg/ml。在此条件下制备3批样品得到SM-PC的复合率为(95.15±1.55)%,偏差<3%。体外溶出试验表明,SM-PC各组分在60 min的溶出接近90%,主要成分水飞蓟宾的溶出行为与市售水飞蓟素胶囊相似,远高于原料药。结论采用星点设计-效应面法成功制备SM-PC,明显提高了溶出度,为后续制剂的研究奠定基础。

关键词：水飞蓟素磷脂复合物溶剂挥发法星点设计-效应面法溶出

BRAF基因V600E突变的软组织透明细胞肉瘤1例

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中华皮肤科杂志 2024年第6期57卷 557-558页

作者：姜北雪郭晓静金红涛姜阳阳刘礼雄董文武周优优黄家敏阳芳深圳市人民医院、暨南大学第二临床医学院、南方科技大学第一附属医院皮肤科深圳518020 深圳市人民医院、暨南大学第二临床医学院、南方科技大学第一附属医院病理科深圳518020 深圳市人民医院、暨南大学第二临床医学院、南方科技大学第一附属医院风湿免疫科深圳518020

患者女,36岁,因左上臂肿物伴疼痛6个月就诊。患者6个月前无明显诱因左上臂出现一突出肿物,时有压痛,曾在外院诊断为寻常疣并多次行激光及冷冻治疗,无明显好转。近期自觉肿物增大明显而就诊。既往体健,家族中无类似疾病史。体检:各系统... 详细信息

患者女,36岁,因左上臂肿物伴疼痛6个月就诊。患者6个月前无明显诱因左上臂出现一突出肿物,时有压痛,曾在外院诊断为寻常疣并多次行激光及冷冻治疗,无明显好转。近期自觉肿物增大明显而就诊。既往体健,家族中无类似疾病史。体检:各系统检查无明显异常。皮肤科检查:左上臂可触及皮下肿物,边界尚清楚,大小约2.m×2.m,质硬,有压痛,表面见色素减退性瘢痕,中央一针头大小黑褐色斑点(图1A)。

关键词：左上臂 BRAF基因寻常疣冷冻治疗疾病史皮下肿物

Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis

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molecular Plant 2020年第9期13卷 1284-1297页

作者： Zhijuan Wang Ziyin Ren Chunhong Cheng Tao Wang hongtao Ji Yang Zhao Zhiping Deng Liya Zhi Jingjing Lu Xinying Wu Shimin Xu Mengmeng cao hongtao Zhao {2. {2. Jiankang Zhu Xia Li National Key Laboratory of Crop Genetic Improvement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhanHubei 430070P.R.China Center of Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuangHebei 050021P.R.China university of Chinese Academy of Sciences Beijing 100049P.R.China Shanghai Center for Plant Stress biology Chinese Academy of SciencesShanghai Institutes for Biological SciencesShanghai 200032P.R.China department of Horticulture and Landscape Architecture Purdue UniversityWest LafayetteIN 47907USA State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of Virology and BiotechnologyZhejiang Academy of Agricultural SciencesHangzhouZhejiang 3210021P.R.China College of Life Science and Technology Yangtze Normal UniversityChongqingP.R.China Key Laboratory of Mental Health Institute of PsychologyChinese Academy of SciencesBeijingP.R.China College of Life Sciences in Hebei Normal university ShijiazhuangHebei 050024P.R.China

Seed germination and seedling establishment are important for the reproductive success of plants,but seeds and seedlings typically encounter constantly changing environmental *** inhibiting seed germination and post-germinative growth through the PYR1/PYL/RcaR ABA receptors and PP2. co-receptors,the phytohormone abscisic acid(ABA)prevents premature germination and seedling growth under unfavorable ***,little is known about how the ABA-mediated inhibition of seed germination and seedling establishment is ***,we report that ABA Signaling Terminator(ABT),a WD40 protein,efficiently switches off ABA signaling and is critical for seed germination and seedling *** is induced by ABA in a PYR1/PYL/RcaR-PP2.-dependent *** of ABT promotes seed germination and seedling greening in the presence of ABA,whereas knockout of ABT has the opposite *** found that ABT interacts with the PYR1/PYL/RcaR and PP2. proteins,interferes with the interaction between PYR1/PYL4 and ABI1/ABI2.and hampers the inhibition of ABI1/ABI2.by ABA-bound PYR1/PYL4,thereby terminating ABA *** together,our results reveal a core mechanism of ABA signaling termination that is critical for seed germination and seedling establishment in Arabidopsis.

关键词： ABA ABT ABA signaling PYR1/PYL7RcaR-ABA-PP2.s complex seed germination post-germinative development

Synaptic function required the interaction between Dneurexin and caKI/CMG in Drosophila

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Synaptic function required the interaction between Dneurexin...

Effect of mesopores on solidification of sirolimus self-microemulsifying drug delivery system

江苏省遗传学会第七届二次代表大会暨学术研讨会

作者： Mingkuan Sun, Lijuan liu Xiankun Zeng, Li liu, Ming fang, Wei Xie* {2. of Genetics and developmental biology, Genetics Research Center, Southeast university Medical School, the Key Laboratory of developmental Genes and Human Disease, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 2.0009, Jiangsu Province, China

Neurexins are neuron-specific cell surface molecules thought to localized at presynaptic membrane region. In vitro studies have shown that vertebrate Neureinxs may be sufficient for the induction of the postsynaptic differentiation. Genetic experiments also implicate an essential role of Neureinxs in the proper synaptic function in vivo. However, the precise mechanism underlie these actions is not fully understood. In this study, we show that the intracellular fragment of the fly neurexin （Dneurexin） interacts directly with caKI/CMG, the Drosophila homolog of vertebrate caSK, via a conserved PDZ binding motif. Such interactions appear not to be necessary for the synaptic targeting of Dneurexin molecules presynaptically, but could be a requirement for the proper synaptic function.

关键词： Dneurexin caKI/CMG protein interaction PDZ binding motif Drosophila

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Chinese Chemical Letters 2018年第12期29卷 1849-1852页

作者： Chun Tao Yue Yu Zhenzhen Chen Minxin Zhang linlin {2. Zhihong {2. Jialiang Zhang Qian Zhang hongtao Song department of Pharmacy Fuzong Clinical Medical College of Fujian Medical University (Fuzhou General Hospital) College of Pharmacy Fujian Medical University

To investigate the influence of mesopores towards the solidification of self-microemulsifying drug delivery system(SMEDDS), mesoporous silica nanospheres(MSNs) and Santa Barbara Amorphous-15(SBA-15) were compared. The MSNs had hydrodynamic size of 195.35 ± 5.82.nm, and pore diameter of 2.70 nm. The SBA-15 had hydrodynamic size of 2.12.19 ± 106.93 nm, and pore diameter of 10.91 nm. The MSNs and SBA-15 showed similar loading efficiency of SMEDDS containing sirolimus(SRL). However,MSNs had higher drug dissolution and in vivo absorption, with relative bioavailability of 174.62.. Thus,the length of mesopores played a more important role in solidification of SMEDDS as compared with the pore diameter. This study suggests that the SMEDDS-MSNs can be a potential candidate for oral administration of hydrophobic drugs.

关键词： Mesopores Mesoporous silica nanospheres SBA-15 Self-microemulsifying drug delivery system Sirolimus Bioavailability

Neuregulinl represses limbic epileptogenesis via activation of ErbB4 signaling in parvalbumin-positive interneurons

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Neuregulinl represses limbic epileptogenesis via activation ...

Changes in hippocampal neurons and memory function during the developmental stage of newborn rats with hypoxic-ischemic encephalopathy

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Guo-He TAN~(1,★),Yuan-Yuan liu~(1,★),Xiao-ling HU~1,Dong-Min YIN~2.lin MEI~(2.*),Zhi-Qi XIONG~(1,*) 1 Institute of Neuroscience and State Key Laboratory of Neuroscience,Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,Shanghai 2.0031,China 2.Program of developmental Neurobiology and department of Neurology,Institute of molecular Medicine and Genetics,Georgia’s Health Sciences university,Augusta,GA 30912.usa

Objective Epilepsy is a common and refractory neurological disorder that affects l%-2.worldwide people,but the neuronal regulatory mechanisms of epileptogenesis remain largely ***-dependent expression of polypeptide growth factors has been implicated in epileptogenesis;however,little is known about factors that may act as intrinsic,homeostatic or counter-balancing *** this study,we investigated the role of a growth factor neuregulin 1(NRG1) and its ErbB4 receptor in limbic *** Two classical models of limbic epilepsy,kindling and pilocarpine models,were used to investigate the expression pattern of NRG1 and ErbB4. Using {2.e- and gain- of- function strategies,we determined the role of NRG1/ErbB4 signaling in epileptogenesis pharmacologically and ***/loxP-mediated cell-specific mutation was employed to identify the specific cellular mechanism underlying the effect of this signaling in limbic ***(1) Limbic seizure activity increased the expression of Nrg1 and phosphorylation of ErbB4 receptor in the brain.(2. In kindling model, epileptogenesis was inhibited by intracerebral infusion of recombinant NRG1,but exacerbated by neutralizing endogenous NRG1 with soluble ecto-ErbB4.(3) Pharmacologically,inhibition of ErbB4 activity with PD158780 greatly promoted kindling-induced epileptogenesis.(4) Genetically,heart-rescued ErbB4 knockout mice exhibited accelerated progression of the kindling effect.(5) Specific depletion of ErbB4 in parvalbumin(PV)-positive GABAergic interneurons resulted in accelerated kindling ***,NRG1 infusion failed to suppress kindling development in PV-Cre;ErbB4 mice.(6) Deletion of ErbB4 in caMKIIα-positive pyramidal neurons was ineffective for epileptogenesis,as evidenced by normal kindling progression of both caMKIIα-iCre;ErbB4 and caMKIIα-CreER;ErbB4 mice.(7) Ablation of ErbB4 in PV-positive neurons increased kindling-induced brain hyperexcitability and spo

关键词： limbic epilepsy epileptogenesis neuregulin 1 ErbB4 parvalbumin-positive interneurons

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Neural Regeneration Research 2006年第8期1卷 681-684页

作者： Chuanjun liu1, Yue Li2. Huiying Gao3 1department of Pediatric Internal Medicine, Taian Health Center for Women and Children,Taian 2.1000, Shandong Province, China 2.1} of Anatomy, 3department of Histology and Embryology, Taishan Medical College, Taian 2.1000, Shandong Province, China department of Pediatric Internal Medicine Taian Health Center for Women and Children Taian 271000 Shandong Province China department of Anatomy Taishan Medical College Taian 271000 Shandong Province China department of Histology and Embryology Taishan Medical College Taian 271000 Shandong Province China

BACKGROUND: Under the normal circumstance, there exist some synapses with inactive functions in central nervous system (CNS), but these functions are activated following nerve injury. At the early stage of brain injury, the abnormal functions of brain are varied, and they have very strong plasticity and are corrected easily. OBJECTIVE: To observe the changes of neuronal morphology in hippocampal ca1 region and memory function in newborn rats with hypoxic-ischemic encephalopathy(HIE) from ischemia 6 hours to adult. DESIGN: Completely randomized grouping, controlled experiment. SETTING: Taian Health Center for Women and Children; Taishan Medical College. MATERIALS: Altogether 12. seven-day-old Wistar rats, of clean grade, were provided by the Experimental Animal Center, Shandong university of Traditional Chinese Medicine. Synaptophysin (SYN) polyclonal antibody was provided by Maixin Biological Company, Fuzhou. METHODS: This experiment was carried out in the Laboratory of Morphology, Taishan Medical College between October 2.00 and December 2.03. ① The newborn rats were randomly divided into 2.groups: model group and control group, 60 rats in each group. Five rats were chosen from each group at postoperative 6 hours, 2. hours, 72.hours, 7 days, 2.weeks and 3 weeks separately for immunohistochemical staining. Fifteen newborn rats were chosen from each group at postoperative 4 weeks and 2.months separately for testing memory ability (After test, 5 rats from each group were sacrificed and used for immunohistochemical staining)② The right common carotid artery of newborn rats of model group was ligated under the anesthetized status. After two hours of incubation, the rats were placed for 2.hours in a container filled with nitrogen oxygen atmosphere containing 0.08 volume fraction of oxygen, thus, HIE models were created; As for the newborn rats in the control group, only blood vessels were isolated, and they were not ligated and hypoxia-treated. ③ Thalamencephal tissue se

关键词： Changes in hippocampal neurons and memory function during the developmental stage of newborn rats with hypoxic-ischemic encephalopathy

Photooligomerization Determines Photosensitivity and Photoreactivity of Plant Cryptochromes

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molecular Plant 2020年第3期13卷 398-413页

作者： Qing liu Tiantian Su Wenjin He Huibo Ren Siyuan liu Yadi Chen {2. Gao Xiaohua Hu Haoyue Lu Shijiang cao Ying Huang Xu Wang Qin Wang chentao {2. Basic Forestry and Proteomics Research Center UCLA-FAFU Joint Research Center on Plant ProteomicsCollege of Life SciencesFujian Agriculture and Forestry UniversityFuzhou 350002China department of molecular Cell&Developmental BiologyUniversity of CaliforniaLos AngelesCA 90095USA College of Life Sciences Fujian Normal UniversityFuzhou 350108China College of Forestry Fujian Agriculture and Forestry UniversityFuzhou 350002China These authors contributed equally to this article.

Plant and non-plant species possess cryptochrome(CRY)photoreceptors to mediate blue light regulation of development or the circadian *** blue light-dependent homooligomerization of Arabidopsis CRY2.is a known early photoreaction necessary for its functions,but the photobiochemistry and function of light-dependent homooligomerization and heterooligomerization of cryptochromes,collectively referred to as CRY photooligomerization,have not been well ***,we show that photooligomerization is an evolutionarily conserved photoreaction characteristic of CRY photoreceptors in plants and some non-plant *** analyses of the kinetics of the forward and reverse reactions of photooligomerization of Arabidopsis CRY1 and CRY2.provide a previously unrecognized mechanism underlying the different photosensitivity and photoreactivity of these two closely related *** found that photooligomerization is necessary but not sufficient for the functions of CRY2.implying that CRY photooligomerization is presumably accompanied by additional function-empowering conformational *** further demonstrated that the CRY2.CRY1 heterooligomerization plays roles in regulating functions of Arabidopsis CRYs in *** together,these results suggest that photooligomerization is an evolutionarily conserved mechanism determining the photosensitivity and photoreactivity of plant CRYs.

关键词： light signaling photomorphogenesis cryptochrome,oligomerization

Energy loss and Stopping Power of ^(4)He Ions in mylar Foils

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Chinese Physics Letters 1994年第4期11卷 200-202页

作者： JIN Changwen LU Xiting HUANG Xiaojing YE Yanlin XIA Zonghuang liu {2. JIANG Dongxing department of Technical Physics Peking UniversityBeijing 100871

The energy loss and stopping power of ^(4)He ions in mylar foils were determined in a transmission *** experimental stopping power data were compared to the previous measurements at higher *** lower energies,no previous measurements *** present results were also compared to the commonly used semiempirically theoretical predictions by Ziegler and Manoyan,and significant deviations were observed.

关键词： geometry Stopping semiempirical