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化皮刺参组织中盾纤毛虫的分离与鉴定

养殖与饲料 2024年第8期23卷 57-61页

作者：邓鸿圣张荣伟陈毅赵小然大连海洋大学水生动物医院辽宁大连116023 大连海洋大学水产动物营养与饲料实验室辽宁大连116023

[目的]对化皮刺参(Apostichopus japonicus)病例中的寄生虫进行分离鉴定,分析其致病因素,为刺参盾纤毛虫病诊断和防控提供参考依据。[方法]对辽宁某养殖场送检的化皮刺参表皮、体壁、肌肉、体腔液、呼吸树、肠道进行镜检,将观察到的纤... 详细信息

[目的]对化皮刺参(Apostichopus japonicus)病例中的寄生虫进行分离鉴定,分析其致病因素,为刺参盾纤毛虫病诊断和防控提供参考依据。[方法]对辽宁某养殖场送检的化皮刺参表皮、体壁、肌肉、体腔液、呼吸树、肠道进行镜检,将观察到的纤毛虫离体培养,并进行18S rDNA测序。[结果]病参各组织器官观察到纤毛虫H-1、H-2、H-3和H-4,H-4通过形态学判断为后口虫,成功离体培养出H-3与镜检未观察到的H-5。纤毛虫H-3与H-5的18S rDNA序列比对结果显示为海洋尾丝虫(Uronema marinum)。[结论]本病例中刺参各组织寄生多种纤毛虫,体腔液中寄生海洋尾丝虫,呼吸树中寄生后口虫和海洋尾丝虫。

关键词：化皮刺参盾纤毛虫 18S rDNA 离体培养后口虫海洋尾丝虫

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N6-methyladenosine facilitates mitochondrial fusion of colorectal cancer cells via induction of GSH synthesis and stabilization of OPA1 mRNA

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National Science Review 2024年第3期11卷 72-91页

作者： Jiawang Zhou Haisheng Zhang Ke Zhong Lijun Tao Yu Lin Guoyou Xie Yonghuang Tan You Wu Yunqing Lu Zhuojia Chen Jiexin Li Xin deng Qin Peng Zigang Li hongsheng Wang Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical Sciences Sun Yat-sen University Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Department of Biomedical Sciences City University of Hong Kong Institute of Systems and Physical Biology Shenzhen Bay Laboratory

Mitochondria undergo fission and fusion that are critical for cell survival and cancer development, while the regulatory factors for mitochondrial dynamics remain elusive. Herein we found that RNA m6A accelerated mitochondria fusion of colorectal cancer（CRC） cells. Metabolomics analysis and function studies indicated that m6A triggered the generation of glutathione（GSH） via the upregulation of RRM2B——a p53-inducible ribonucleotide reductase subunit with anti-reactive oxygen species potential. This in turn resulted in the mitochondria fusion of CRC cells. Mechanistically, m6A methylation of A1240 at 3 UTR of RRM2B increased its m RNA stability via binding with IGF2BP2. Similarly, m6A methylation of A2212 at the coding sequence（CDS） of OPA1——an essential GTPase protein for mitochondrial inner membrane fusion——also increased m RNA stability and triggered mitochondria fusion. Targeting m6A through the methyltransferase inhibitor STM2457 or the dm6ACRISPR system significantly suppressed mitochondria fusion. In vivo and clinical data confirmed the positive roles of the m6A/mitochondrial dynamics in tumor growth and CRC progression. Collectively, m6A promoted mitochondria fusion via induction of GSH synthesis and OPA1 expression, which facilitated cancer cell growth and CRC development.

关键词： m6A mitochondrial fusion glutathione OPA1 colorectal cancer

Oriented mesoporous nanofibers show nature's wisdom

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National Science Review 2024年第6期11卷 90-91页

作者： Yonghui deng Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Collaborative Innovation Center of Chemistry for Energy Material (iChEM) Fudan University State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences

Electrodes assembled with conventional nanoparticulate materials in electrochemical energy devices usually have a random and torturous porous system. To meet ever-increasing demands for higher volumetric energy density at packagelevel, packing more active materials in a limited volume becomes increasingly difficult since transportation of reactants(e.g. electrolyte) and charges through high-tortuosity channels/pathways in thick electrodes meets large impedance[1].

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Deterministic and Robust Volt-var Control Methods of Power System Based on Convex Deep Learning

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 719-729页

作者： Qing Ma Changhong deng the School of Electrical Engineering and Automation Wuhan UniversityWuhanChina

Volt-var control(VVC)is essentially a non-convex optimization problem due to the non-convexity of power flow(PF)constraints,resulting in the difficulty in obtaining the optimum without convexity *** existing second-order cone method for the convexity conversion often leads to a sharp increase in PF constraints and optimization variables,which in turn increases the optimization difficulty or even leads to optimization *** paper first proposes a deterministic VVC method based on convex deep learning power flow(DLPF).This method uses the input convex neural network(ICNN)to establish a single convex mapping between state parameters and node voltage to complete the convexity conversion while the optimization variables only correspond to reactive power equipment,which can ensure the global optimum with extremely fast computation *** cope with the impact brought by the uncertainty of distributed energy and omit the additional worst scenario search of traditional robust VVC,this paper proposes robust VVC method based on convex deep learning interval power flow(DLIPF),which continues to adopt ICNN to establish another convex mapping between state parameters and node voltage *** DLIPF with DLPF,this method decreases the modeling and optimization difficulty of robust VVC *** results on 30-bus,118-bus,and 200-bus systems prove the correctness and rapidity of the proposed methods.

关键词： Volt-var control convexity conversion convex deep learning power flow

Brillouin Klein space and half-turn space in three-dimensional acoustic crystals

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Science Bulletin 2024年第13期69卷 2050-2058页

作者： Zhenxiao Zhu Linyun Yang Jien Wu Yan Meng Xiang Xi Bei Yan Jingming Chen Jiuyang Lu Xueqin Huang Weiyin deng Ce Shang Perry Ping Shum Yihao Yang hongsheng Chen Kexin Xiang Gui-Geng Liu Zhengyou Liu Zhen Gao State Key Laboratory of Optical Fiber and Cable Manufacture Technology Department of Electronic and Electrical EngineeringSouthern University of Science and TechnologyShenzhen 518055China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China Key Laboratory of Artificial Micro-and Nanostructures of Ministry of Education and School of Physics and Technology Wuhan UniversityWuhan 430072China King Abdullah University of Science and Technology(KAUST) Physical Science and Engineering Division(PSE)Thuwal 23955-6900Saudi Arabia Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical InstrumentationZJU-Hangzhou Global Science and Technology Innovation CenterCollege of Information Science and Electronic EngineeringZJU-UIUC InstituteZhejiang UniversityHangzhou 310027China Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Institute for Advanced Studies Wuhan UniversityWuhan 430072China

The Bloch band theory and Brillouin zone(BZ)that characterize wave-like behaviors in periodic mediums are two cornerstones of contemporary physics,ranging from condensed matter to topological *** theoretical breakthrough revealed that,under the projective symmetry algebra enforced by artificial gauge fields,the usual two-dimensional(2D)BZ(orientable Brillouin two-torus)can be fundamentally modified to a non-orientable Brillouin Klein bottle with radically distinct manifold ***,the physical consequence of artificial gauge fields on the more general three-dimensional(3D)BZ(orientable Brillouin three-torus)was so far ***,we theoretically discovered and experimentally observed that the fundamental domain and topology of the usual 3D BZ can be reduced to a non-orientable Brillouin Klein space or an orientable Brillouin half-turn space in a 3D acoustic crystal with artificial gauge *** experimentally identify peculiar 3D momentum-space non-symmorphic screw rotation and glide reflection symmetries in the measured band ***,we experimentally demonstrate a novel stacked weak Klein bottle insulator featuring a nonzero Z2 topological invariant and self-collimated topological surface states at two opposite surfaces related by a nonlocal twist,radically distinct from all previous 3D topological *** discovery not only fundamentally modifies the fundamental domain and topology of 3D BZ,but also opens the door towards a wealth of previously overlooked momentum-space multidimensional manifold topologies and novel gaugesymmetry-enriched topological physics and robust acoustic wave manipulations beyond the existing paradigms.

关键词： Momentum-space non-symmorphic symmetry Brillouin Klein space and half-turn space Acoustic Klein bottle insulator Self-collimated topological surface states

Non-intrusive Load Monitoring Based on Graph Total Variation for Residential Appliances

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 947-957页

作者： Xiaoyang Ma Diwen Zheng Xiaoyong deng Ying Wang Dawei deng Wei Li the College of Electrical Engineering Sichuan UniversityChengdu 610065China State Grid Chongqing Electric Power Company Chongqing 400014China State Grid Sichuan Electric Power Company Chengdu 610095China State Grid Hubei Electric Power Company Limited Research Institute Wuhan 430077China

Non-intrusive load monitoring is a technique for monitoring the operating conditions of electrical appliances by collecting the aggregated electrical information at the household power *** several studies on the mining of unique load characteristics,few studies have extensively considered the high computational burden and sample *** on lowfrequency sampling data,a non-intrusive load monitoring algorithm utilizing the graph total variation(GTV)is proposed in this *** algorithm can effectively depict the load state without the need for prior ***,the combined Kmeans clustering algorithm and graph signals are used to build concise and accurate graph structures as load *** GTV representing the internal structure of the graph signal is introduced as the optimization model and solved using the augmented Lagrangian iterative *** introduction of the difference operator reduces the computing cost and addresses the inaccurate reconstruction of the graph *** low-frequency sampling data,the algorithm only requires a little prior data and no training,thereby reducing the computing *** conducted using the reference energy disaggregation dataset and almanac of minutely power dataset demonstrated the stable superiority of the algorithm and its low computational burden.

关键词： Non-intrusive load monitoring graph total variation augmented Lagrangian function smart grid

Scattering of Water Waves by Dual Symmetric Inclined Floating Porous Barriers Using the DBEM

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China Ocean Engineering 2024年第1期38卷 156-168页

作者： WANG Li-xian deng Yan-wen YE Yang-sha deng Zheng-zhi Key Laboratory of High Performance Ship Technology(Wuhan University of Technology) Ministry of EducationWuhan 430063China School of Naval Architecture Ocean and Energy Power EngineeringWuhan University of TechnologyWuhan 430063China Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province Changsha 410114China Institute of Port Coastal and Offshore EngineeringZhejiang UniversityZhoushan 316021China

The scattering of normally incident water waves by two surface-piercing inclined perforated barriers in water with a uniform finite depth is investigated within the framework of linear water wave *** that thin barriers are zero-thickness,a novel numerical method involving the the coupling of the dual boundary element method(DBEM)with damping layers is *** order to effectively damp out the reflected waves,two damping layers,instead of pseudoboundaries are implemented near the two side boundaries of the computational ***,the modified linearized free surface boundary conditions are formulated and used for solving both the ordinary boundary integral equation as well as the hypersingular boundary integral equation for degenerate *** newly developed numerical method is validated against analytical methods using the matched eigenfunction expansion method for the special case of two vertical barriers or the inclined angle to the vertical being *** influence of the length of the two damping layers has been ***,these findings are also validated against previous results for several *** validation,the numerical results for the reflection coefficient,transmission coefficient and dissipation coefficient are obtained by varying the inclination angle and porosity-effect *** effects of both the inclination angle and the porosity on the amplitudes of wave forces acting on both the front and rear barriers are also *** is found that the effect of the inclination angle mainly shifts the location of the extremal values of the reflection and the transmission ***,a moderate value of the porosity-parameter is quite effective at dissipating wave energy and mitigating the wave loads on dual barriers.

关键词： dual boundary element method inclined perforated floating breakwater reflection coefficient transmission coefficient damping layer

Mathematical framework of nonlinear elastic waves propagating in pre-stressed media

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Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1705-1716页

作者： Jiangcheng CAI Mingxi deng College of Aerospace Engineering Chongqing UniversityChongqing 400044China

Acoustic nonlinearity holds potential as a method for assessing material *** to the acoustoelastic effect,where the velocity of elastic waves is influenced by third-order elastic constants,the propagation of nonlinear acoustic waves in pre-stressed materials would be influenced by higher-order elastic *** this,there has been a notable absence of research exploring this ***,this paper aims to establish a theoretical framework for governing the propagation of nonlinear acoustic waves in pre-stressed *** delves into the impact of pre-stress on higher-order material parameters,and specifically examines the propagation of one-dimensional acoustic waves within the contexts of the uniaxial stress and the biaxial *** paper establishes a theoretical foundation for exploring the application of nonlinear ultrasonic techniques to measure pre-stress in materials.

关键词： acoustoelastic effect nonlinear elastic wave pre-stress medium higher-order elastic constant

INVARIANTS-PRESERVING DU FORT-FRANKEL SCHEMES AND THEIR ANALYSES FOR NONLINEAR SCHRÖDINGER EQUATIONS WITH WAVE OPERATOR

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Journal of Computational Mathematics 2024年第3期42卷 814-850页

作者： Dingwen deng Zhijun Li College of Mathematics and Information Science Nanchang Hangkong UniversityNanchang 330063China

Du Fort-Frankel finite difference method(FDM)was firstly proposed for linear diffusion equations with periodic boundary conditions by Du Fort and Frankel in *** is an explicit and unconditionally von Neumann stable ***,there has been no research work on numerical solutions of nonlinear Schrödinger equations with wave operator by using Du Fort-Frankel-type finite difference methods(FDMs).In this study,a class of invariants-preserving Du Fort-Frankel-type FDMs are firstly proposed for one-dimensional(1D)and two-dimensional(2D)nonlinear Schrödinger equations with wave *** using the discrete energy method,it is shown that their solutions possess the discrete energy and mass conservative laws,and conditionally converge to exact solutions with an order of for ofο(T^(2)+h_(x)^(2)+(T/h_(x))^(2))1D problem and an order ofο(T^(2)+h_(x)^(2)+h_(Y)^(2)+(T/h_(X))^(2)+(T/h_(y))^(2))for 2D problem in ***,τdenotes time-step size,while,hx and hy represent spatial meshsizes in x-and y-directions,***,by introducing a stabilized term,a type of stabilized invariants-preserving Du Fort-Frankel-type FDMs are *** not only preserve the discrete energies and masses,but also own much better stability than original ***,numerical results demonstrate the theoretical analyses.

关键词： Nonlinear Schrodinger equations with wave operator Du Fort-Frankel finite difference methods Discrete energy and mass conservative laws Numerical convergence