检索结果-南通市图书馆

Journal of Genetics and Genomics 2008年第8期35卷 491-497页

作者： hongshan chen Kan Zhai Jialin chen Yulong chen Haijun Wen Sufang chen Yuping Wu State Key Laboratory of Biocontrol Department of Biochemistry School of Life Sciences Sun Yat-Sen University Guangzhou 510275 China National Nature Preserve Administration Bureau on Sousa chinensis of Pearl River Estuary Zhuhai 519000 China The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510000 China

In this study, the mitochondrial DNA （mtDNA） control region and the mitochondrial cytochrome b gene of stranded Indo-Pacific humpback dolphin （Sousa chinensis） samples from the Pearl River Estuary and Xiamen waters were sequenced and analyzed. The result of mtDNA control region revealed 34 variable sites and four unique haplotypes （named as A, B, C and D） identified among the total samples from these two water areas, and the most common haplotype （A） was shared by 75% of the dolphins sampled from the two water areas. The haplotypic diversity （h） was 0.455 and the nucleodde diversity （π） was 0.0088. The phylogenetic analysis showed that the haplotype A, C, and D were closely related, but the haplotype B （unique for XM01 from Xiamen） was far from the other three. By scanning cytochrome b fragments, two haplotypes （A and B） were identified in these two water areas, and the most common haplotype （A） was shared by 91.67% individuals, while XM01 from Xiamen as the only exception. The data suggest that there is a possibility of gene exchange between the two populations in the Pearl River Estuary and Xiamen waters, and there possibly exists a unique maternal lineage in Xiamen waters.

关键词： Sousa chinensis mitochondrial DNA control region cytochrome b genetic diversity

Hydrogenation of CO_(2) to p-xylene over ZnZrO_(x)/hollow tubular HZSM-5 tandem catalyst

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第12期99卷 725-737页

作者： Haifeng Tian Zhiyu chen Haowei Huang Fei Zha Yue Chang hongshan chen College of Chemistry&Chemical Engineering Northwest Normal UniversityLanzhou 730070GansuChina Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Lanzhou 730070GansuChina College of Physics and Electronic Engineering Northwest Normal UniversityLanzhou 730070GansuChina

The conversion of CO_(2) into specific aromatics by modulating the morphology of zeolites is a promising ***-5 zeolite with hollow tubular morphology is *** morphology of zeolite was precisely controlled,and the acid sites on its outer surface were passivated by steam-assisted crystallization method,so that the zeolite exhibits higher aromatic selectivity than sheet HZSM-5 zeolite and greater p-xylene selectivity than chain HZSM-5 *** tandem catalyst was formed by combining hollow tubular HZSM-5 zeolites with ZnZrO_(x)metal *** para-selectivity of p-xylene reached 76.2%at reaction temperature of 320℃,pressure of 3.0 MPa,and a flow rate of 2400 mL g^(-1)h^(-1)with an H_(2)/CO_(2) molar ratio of 3/*** research indicates that the high selectivity of p-xylene is due to the pore structure of hollow tubular HZSM-5 zeolite,which is conducive to the formation of ***,the passivation of the acid site located on the outer surface of zeolite effectively prevents the isomerization of *** reaction mechanism of CO_(2) hydrogenation over the tandem catalyst was investigated using in-situ diffuse reflectance Fourier transform infrared spectroscopy and density functional *** results showed that the CO_(2) to p-xylene followed a methanol-mediated route over ZnZrO_(x)/hollow tubular HZSM-5 tandem *** addition,the catalyst showed no significant deactivation in the 100 h stability *** present study provides an effective strategy for the design of catalysts aimed at selectively preparing aromatics through CO_(2)hydrogenation.

关键词： Hollow tubular HZSM-5 zeolite Tandem catalyst CO_(2)hydrogenation P-xylene Reaction mechanism

High-order femtosecond vortices up to the 30th order generated from a powerful mode-locked Hermite-Gaussian laser

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2023年第10期12卷 2084-2096页

作者： Hongyu Liu Lisong Yan hongshan chen Xin Liu Heyan Liu Soo Hoon Chew Alexander Gliserin Qing Wang Jinwei Zhang School of Optical and Electronic Information and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Department of Optics and Mechatronics Engineering College of Nanoscience and NanotechnologyPusan National UniversityBusan 46241South Korea Max Planck Center for Attosecond Science Max Planck POSTECH/Korea Research InitiativePohang 37673South Korea School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China

Femtosecond vortex beams are of great scientific and practical interest because of their unique phase properties in both the longitudinal and transverse modes,enabling multi-dimensional quantum control of light *** now,generating femtosecond vortex beams for applications that simultaneously require ultrashort pulse duration,high power,high vortex order,and a low cost and compact laser source has been very challenging due to the limitations of available generation ***,we present a compact apparatus that generates powerful high-order femtosecond vortex pulses via astigmatic mode conversion from a mode-locked Hermite-Gaussian Yb:KGW laser oscillator in a hybrid scheme using both the translation-based off-axis pumping and the angle-based non-collinear pumping *** hybrid scheme enables the generation of femtosecond vortices with a continuously tunable vortex order from the 1st up to the 30th order,which is the highest order obtained from any femtosecond vortex laser source based on a mode-locked *** average powers and pulse durations of all resulting vortex pulses are several hundred milliwatts and<650 fs,*** particular,424-fs 11th-order vortex pulses have been achieved with an average power of 1.6 W,several times more powerful than state-of-the-art oscillator-based femtosecond vortex sources.

关键词： pumping laser mode

ASF1A-dependent P300-mediated histone H3 lysine 18 lactylation promotes atherosclerosis by regulating EndMT

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第7期14卷 3027-3048页

作者： Mengdie Dong Yunjia Zhang Minghong chen Yongkang Tan Jiao Min Xian He Fuhao Liu Jiaming Gu Hong Jiang Longbin Zheng Jiajing chen Quanwen Yin Xuesong Li Xiang chen Yongfeng Shao Yong Ji hongshan chen Department of Cardiovascular Surgery the First Affiliated Hospital of Nanjing Medical Universityand Key Laboratory of Cardiovascular and Cerebrovascular MedicineSchool of PharmacyNational Vaccine Innovation PlatformNanjing Medical UniversityNanjing 211166China Key Laboratory of Cardiovascular and Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China Department of Clinical Medicine Nanjing Medical University TIANYUAN Honors SchoolNanjing Medical UniversityNanjing 211166China Department of Anesthesiology Sir Run Run HospitalNanjing Medical UniversityNanjing 211166China Department of Cardiovascular Surgery the First Affiliated Hospital of Nanjing Medical UniversityNanjing 211166China Key Laboratory of Cardiovascular and Cerebrovascular Medicine Key Laboratory of Targeted Intervention of Cardiovascular DiseaseCollaborative Innovation Center for Cardiovascular Disease Translational MedicineState Key Laboratory of Reproductive MedicineSchool of Pharmacythe Affiliated Suzhou Hospital of Nanjing Medical UniversityGusu SchoolNanjing Medical UniversityNanjing 211166China National Key Laboratory of Frigid Zone Cardiovascular Diseases(NKLFZCD) Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China)College of PharmacyKey Laboratory of Cardiovascular Medicine Research and Key Laboratory of Myocardial IschemiaChinese Ministry of EducationNHC Key Laboratory of Cell Transplantationthe Central Laboratory of the First Affiliated HospitalHarbin Medical UniversityHarbin 150081China Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjing 211166China Department of Cardiology Huai’an First People’s Hospital Affiliated with Nanjing Medical UniversityHuai’an 223399China

Endothelial-to-mesenchymal transition(EndMT)is a key driver of *** glycolysis is increased in the endothelium of atheroprone areas,accompanied by elevated lactate *** lactylation,mediated by lactate,can regulate gene expression and participate in disease ***,whether histone lactylation is involved in atherosclerosis remains ***,we report that lipid peroxidation could lead to EndMT-induced atherosclerosis by increasing lactatedependent histone H3 lysine 18 lactylation(H3K18la)in vitro and in vivo,as well as in atherosclerotic patients’***,the histone chaperone ASF1A was first identified as a cofactor of P300,which precisely regulated the enrichment of H3K18la at the promoter of SNAI1,thereby activating SNAI1 transcription and promoting *** found that deletion of ASF1A inhibited EndMT and improved endothelial *** analysis based on Apoe^(KO)Asf1a^(ECKO) mice in the atherosclerosis model confirmed the involvement of H3K18la in atherosclerosis and found that endotheliumspecific ASF1A deficiency inhibited EndMT and alleviated atherosclerosis *** of glycolysis by pharmacologic inhibition and advanced PROTAC attenuated H3K18la,SNAI1 transcription,and EndMT-induced *** study illustrates precise crosstalk between metabolism and epigenetics via H3K18la by the P300/ASF1A molecular complex during EndMT-induced atherogenesis,which provides emerging therapies for atherosclerosis.

关键词： Histone lactylation Atherosclerosis Endothelial-tomesenchymal transition ASF1A SNAI1 Endothelial dysfunction Lactate Epigenetic

Non-canonical STING-PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第12期13卷 4765-4784页

作者： Xuesong Li Xiang chen Longbin Zheng Minghong chen Yunjia Zhang Ruigong Zhu Jiajing chen Jiaming Gu Quanwen Yin Hong Jiang Xuan Wu Xian Ji Xin Tang Mengdie Dong Qingguo Li Yuanqing Gao hongshan chen Key Laboratory of Cardiovascular and Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China Department of Anesthesiology Sir Run Run HospitalNanjing Medical UniversityNanjing 211166China Department of Pharmacy Huashan HospitalFudan UniversityShanghai 200040China Department of Cardiothoracic Surgery the Second Affliated Hospital of Nanjing Medical UniversityNanjing 211166China Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjing 211166China Department of Cardiology Huai'an First People's Hospital Affliated with Nanjing Medical UniversityHuai'an 223399China

Inflammation-driven endothelial dysfunction is the major initiating factor in atherosclerosis,while the underlying mechanism remains ***,we report that the non-canonical stimulator of interferon genes(STING)-PKR-like ER kinase(PERK)pathway was significantly activated in both human and mice atherosclerotic ***,STING activation leads to the activation of interferon regulatory factor 3(IRF3)and nuclear factor-kappa B(NF-κB)/p65,thereby facilitating IFN signals and *** contrast,our study reveals the activated non-canonical STING-PERK pathway increases scaffold protein bromodomain protein 4(BRD4)expression,which encourages the formation of super-enhancers on the proximal promoter regions of the proinflammatory cytokines,thereby enabling the transactivation of these cytokines by integrating activated IRF3 and NF-κB via a condensation ***-specific STING and BRD4 deficiency significantly decreased the plaque area and ***,this pathway is triggered by leaked mitochondrial DNA(mtDNA)via mitochondrial permeability transition pore(mPTP),formed by voltage-dependent anion channel 1(VDAC1)oligomer interaction with oxidized mtDNA upon cholesterol oxidation ***,compared to macrophages,endothelial STING activation plays a more pronounced role in *** propose a non-canonical STING-PERK pathway-dependent epigenetic paradigm in atherosclerosis that integrates IRF3,NF-κB and BRD4 in inflammatory responses,which provides emerging therapeutic modalities for vascular endothelial dysfunction.

关键词： Endothelial dysfunction Infiammation Mitochondrial DNA STING ROS PERK BRD4 Atherosclerosis

Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第5期12卷 2280-2299页

作者： Xuesong Li Ruigong Zhu Hong Jiang Quanwen Yin Jiaming Gu Jiajing chen Xian Ji Xuan Wu Haiping Fu Hui Wang Xin Tang Yuanqing Gao Bingjian Wang Yong Ji hongshan chen Key Laboratory of Cardiovascular and Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjing 211166China Department of Cardiothoracic Surgery the Second Affiliated Hospital of Nanjing Medical UniversityNanjing 211166China Department of Cardiology Huai’an First People’s Hospital Affiliated with Nanjing Medical UniversityHuai’an 223399China

Disturbance of macrophage-associated lipid metabolism plays a key role in *** between autophagy deficiency and inflammation response in foam cells(FCs) through epigenetic regulation is still poorly understood. Here, we demonstrate that in macrophages, oxidized lowdensity lipoprotein(ox-LDL) leads to abnormal crosstalk between autophagy and inflammation,thereby causing aberrant lipid metabolism mediated through a dysfunctional transcription factor EB (TFEB)-P300-bromodomain-containing protein 4(BRD4) axis. ox-LDL led to macrophage autophagy deficiency along with TFEB cytoplasmic accumulation and increased reactive oxygen species generation. This activated P300 promoted BRD4 binding on the promoter regions of inflammatory genes, consequently contributing to inflammation with atherogenesis. Particularly, ox-LDL activated BRD4-dependent super-enhancer associated with liquid-liquid phase separation(LLPS) on the regulatory regions of inflammatory genes. Curcumin(Cur) prominently restored FCs autophagy by promoting TFEB nuclear translocation, optimizing lipid catabolism, and reducing inflammation. The consequences of P300 and BRD4 on super-enhancer formation and inflammatory response in FCs could be prevented by Cur. Furthermore, the anti-atherogenesis effect of Cur was inhibited by macrophage-specific Brd4 overexpression or Tfeb knock-out in Apoe knock-out mice via bone marrow transplantation. The findings identify a novel TFEB-P300-BRD4 axis and establish a new epigenetic paradigm by which Cur regulates autophagy, inhibits inflammation, and decreases lipid content.

关键词： Macrophage Autophagy TFEB P300 BRD4 Inflammation Atherosclerosis Curcumin

100-W Yb:YAG thin-disk vortex laser oscillator

在线全文

学校读者我要写书评

暂无评论

Light(Advanced Manufacturing) 2023年第4期4卷 140-149页

作者： hongshan chen Qing Wang Xin Liu Heyan Liu Xinhua Guo Tingting Yang Lisong Yan Jinwei Zhang School of Optical and Electronic Information and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China

Optical vortices carrying orbital angular momentum and spiral wavefront phases have garnered increasing research interest owing to their numerous ***,we present a simple yet effective approach to generate powerful optical vortices directly from a thin-disk laser *** demonstrated source delivered Laguerre-Gaussian beams with an output power of up to 101 *** the best of our knowledge,this is the highest output power of all optical vortex laser *** high-power vortex output will have significant implications for laser ablation and micromachining at high throughput and for large-area ***,it serves as a new platform for the further development of more complex high-power optical-vortex beams.

关键词： Thin disk Vortex oscillator High power Transverse-mode control

Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2022年第2期9卷 494-509页

作者： Ruigong Zhu Xian Ji Xuan Wu Jiajing chen Xuesong Li Hong Jiang Haiping Fu Hui Wang Zhe Lin Xin Tang Shixiu Sun Qingguo Li Bingjian Wang hongshan chen Key Laboratory of Cardiovascular&Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166PR China Department of Cardiothoracic Surgery The Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210003PR China Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjingJiangsu 211166PR China Department of Cardiology Huai'an First People's Hospital Affiliated with Nanjing Medical UniversityHuai'anJiangsu 223399PR China

Cellular senescence is closely associated with age-related *** aging,a special type of organ senescence,is the pathophysiological foundation of the diseases of the reproductive *** is characterized by the loss of integrity of the surface epithelium and a gradual decrease in the number of human ovarian surface epithelial cells(HOSEpiCs).To contribute to the research on delaying ovarian aging,we aimed to investigate the novel epigenetic mechanism of melatonin in protecting *** discovered that melatonin has antagonistic effects against the oncogene-induced senescence(OIS)of ***,the oncogene Ras decreased the expression of YTHDF2,which is the reader of RNA-m6A,by stimulating the generation of reactive oxygen species(ROS).Moreover,we found that the suppression of YTHDF2 increased the expression of MAP2K4 and MAP4K4 by enhancing the stability of the transcription of their mRNAs,thereby upregulating the expression of the senescence-associated secretory phenotype(SASP)through the activation of the MAP2K4 and MAP4K4-dependent nuclear factor-κB(NF-κB)signaling *** further determined that melatonin has antagonistic effects against the OIS of HOSEpiCs by inhibiting the ROS-YTHDF2-MAPK-NF-κB *** findings provide key insights into the potential avenues for preventing and treating ovarian aging.

关键词： Gene expression Inflammation Melatonin Senescence YTHDF2

Al6ONa2组装Zintl相晶体的理论研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高等学校化学学报 2019年第11期40卷 2354-2359页

作者：张兆燕陈宏善西北师范大学物理与电子工程学院

结合遗传算法和从头算方法确定了Al6ONa2的低能异构体.揭示了以非金属为中心的Al-Na团簇的幻数行为.金属团簇离域的凝胶轨道和非金属原子的价轨道作用形成定域在O原子上的成键轨道和离域在整个团簇上的反键轨道,26个价电子形成s2p6S2P6... 详细信息

结合遗传算法和从头算方法确定了Al6ONa2的低能异构体.揭示了以非金属为中心的Al-Na团簇的幻数行为.金属团簇离域的凝胶轨道和非金属原子的价轨道作用形成定域在O原子上的成键轨道和离域在整个团簇上的反键轨道,26个价电子形成s2p6S2P6D10的闭合壳层强幻数电子结构.Al6O2-与Na+通过离子键结合,Al6O2-的电子结构符合Wade-Mingos规则.基于超原子阴离子Al6O2-具有较强的热稳定性和化学惰性,组装了具有Pn3m和Fd3m空间群的AB2型晶体结构,Al6ONa2团簇的结合能为-23.44eV,组装结构中团簇单元间的相互作用能分别为-1.19和-1.53eV.晶体结构的电子结构分析表明,2种组装晶体均为宽带隙半导体.声子色散曲线和弹性常数的计算表明组装晶体具有良好的动力学稳定性.

关键词：幻数团簇超原子阴离子电子结构团簇组装

在线全文

学校读者我要写书评

暂无评论

论《普宁》的生命政治叙事

当代外国文学 2024年第3期45卷 96-102页

作者：陈泓杉国防科技大学外国语学院

纳博科夫的《普宁》叙述俄国流亡知识分子在美国的求生绝境和荒诞遭遇,再现跨文化语境下流散主体的文化商讨和自我塑形,以小人物和碎片化小叙事所蕴含的生命政治记录其社会心理轨迹和文化震撼。本文拟从当代权力话语理论,特别是身体研... 详细信息

纳博科夫的《普宁》叙述俄国流亡知识分子在美国的求生绝境和荒诞遭遇,再现跨文化语境下流散主体的文化商讨和自我塑形,以小人物和碎片化小叙事所蕴含的生命政治记录其社会心理轨迹和文化震撼。本文拟从当代权力话语理论,特别是身体研究视野汲取批评活力,从主人公之身体表征、遮体政治及健康书写入手,解析跨文化语境下权力与规训之间的复杂关系,认为:普宁居无定所的游牧性生活是在追寻某种冲出文化囚牢的“无器官身体”文化反抗,其遮体政治凸显了服饰所赋值的权力博弈,其以牙齿为典型意象的健康书写折射出身体美学的权力操纵,此三者杂糅在于消解异域文化的身体表征与主体存在性困境,揭示了生命政治与文化权力之密切关系,共同构成小说一道独特的叙事艺术和深刻思想意蕴。

关键词：纳博科夫《普宁》生命政治叙事跨文化语境