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3D RNA nanocage for encapsulation and shielding of hydrophobic biomolecules to improve the in vivo biodistribution

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Nano Research 2020年第12期13卷 3241-3247页

作者： Congcong Xu Kaiming Zhang hongran yin Zhefeng Li Alexey Krasnoslobodtsev Zhen Zheng Zhouxiang Ji Sijin Guo Shanshan Li Wah Chiu Peixuan Guo Center for RNA Nanobiotechnology and Nanomedicine College of PharmacyDivision of Pharmaceutics and Pharmaceutical ChemistryCollege of MedicineDorothy M.Davis Heart and Lung Research InstituteJames Comprehensive Cancer CenterThe Ohio State UniversityColumbusOH43210USA Department of Bioengineering James H.Clark CenterStanford UniversityStanfordCA94305USA Department of Physics University of Nebraska at OmahaOmahaNE68182USA Nanoimaging Core Facility Office of Vice-Chancellor for ResearchUniversity of Nebraska Medical CenterOmahaNE68198USA SLAC National Accelerator Laboratory Stanford UniversityMenlo ParkCA94025USA

Ribonucleic acid(RNA)nanotechnology platforms have the potential of harboring therapeutics for in vivo delivery in disease ***,the nonspecific interaction between the harbored hydrophobic drugs and cells or other components before reaching the diseased site has been an obstacle in drug *** we report an encapsulation strategy to prevent such nonspecific hydrophobic interactions in vitro and in vivo based on a self-assembled three-dimensional(3D)RNA *** placing an RNA three-way junction(3WJ)in the cavity of the nanocage,the conjugated hydrophobic molecules were specifically positioned within the nanocage,preventing their exposure to the biological *** assembly of the nanocages was characterized by native polyacrylamide gel electrophoresis(PAGE),atomic force microscopy(AFM),and cryogenic electron microscopy(cryo-EM)*** stealth effect of the nanocage for hydrophobic molecules in vitro was evaluated by gel electrophoresis,flow cytometry,and confocal *** in vivo sheathing effect of the nanocage for hydrophobic molecules was assessed by biodistribution profiling in *** RNA nanocages with hydrophobic biomolecules underwent faster clearance in liver and spleen in comparison to their ***,this encapsulation strategy holds promise for in vivo delivery of hydrophobic drugs for disease treatment.

关键词： ribonucleic acid(RNA)nanocage three-way junction(3WJ) encapsulation hydrophobic biomolecule RNA nanotechnology

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行列式课堂教学设计及应用

科技风 2022年第8期 120-122页

作者：尹红然天津天狮学院数理教学部天津301700

行列式是线性代数课程中基本而重要的内容之一,是为了求解线性方程组而引入的,在线性代数和其他数学领域以及工程技术中有着广泛的应用.对二阶和三阶行列式的课堂进行了教学设计,并举例说明三阶行列式的计算和应用。

关键词：行列式方程组对角线

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某老城区木结构房屋安全性与抗震性能评价

工程质量 2024年第S1期42卷 190-193页

作者：邱金凯尹洪冉中冶检测认证有限公司北京100088 中冶建筑研究总院有限公司北京100088 德州市陵城区政务服务中心山东德州253500

在城市更新项目中,关于木结构房屋安全性和抗震性能评价的研究鲜有报道。为了保证木结构房屋的安全使用,论文以某老城区木结构房屋为例,运用现场调查、检测等方式,评价木结构房屋的安全性和抗震性能,为同类木结构房屋的安全性与抗震性... 详细信息

在城市更新项目中,关于木结构房屋安全性和抗震性能评价的研究鲜有报道。为了保证木结构房屋的安全使用,论文以某老城区木结构房屋为例,运用现场调查、检测等方式,评价木结构房屋的安全性和抗震性能,为同类木结构房屋的安全性与抗震性能评价提供方法参考。

关键词：木结构房屋安全性抗震性能城市更新

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钢管桩施工对邻近既有隧道的动力响应分析

四川理工学院学报（自然科学版） 2016年第1期29卷 76-81页

作者：尹洪桦尹洪冉胡明华祝佳宇长安大学公路学院西安710064 德州市陵城区房产管理局山东德州253000 德州市陵城区住房和城乡建设局山东德州253000

为了分析在打桩振动作用下既有隧道的动力响应,在验证某工程实际的基础上,采用有限元软件基于桩–土–隧道动力相互作用模型,对打桩施工引起邻近既有隧道的响应问题进行数值计算,分析在不同打桩距离情况下既有隧道的振动速度、最大总位... 详细信息

为了分析在打桩振动作用下既有隧道的动力响应,在验证某工程实际的基础上,采用有限元软件基于桩–土–隧道动力相互作用模型,对打桩施工引起邻近既有隧道的响应问题进行数值计算,分析在不同打桩距离情况下既有隧道的振动速度、最大总位移和弯矩响应及规律。建议打桩施工过程中加强既有隧道打桩侧1/4拱的振动监测,加强既有隧道拱顶的总位移监测,打桩施工前判断是否对既有隧道打桩侧起拱线附近进行加固处理,为类似实际工程问题提供参考。

关键词：打桩振动既有隧道动力响应有限元桩-土-隧道动力模型

Universal precursor seismicity pattern before locked-segment rupture and evolutionary rule for landmark earthquakes

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Geoscience Frontiers 2022年第3期13卷 22-34页

作者： hongran Chen Siqing Qin Lei Xue Baicun Yang Ke Zhang Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesChina Innovation Academy for Earth Science CASChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesChina School of Resources and Civil Engineering Northeastern UniversityChina

Despite extensive investigations,no precursor patterns for reliably predicting major earthquakes have thus far been *** locked segments that can accumulate adequate strain energy to cause major earthquakes are highly heterogeneous and low *** progressive cracking of the locked segments with these properties can produce an interesting seismic phenomenon:a landmark earthquake and a sequence of smaller subsequent earthquakes(pre-shocks)always arise prior to another landmark earthquake within a well-defined seismic zone and its current seismic *** a mechanical model,magnitude constraint conditions,and case study data of 62 worldwide seismic zones,we show that two adjacent landmark earthquakes reliably occur at the volume-expansion point and peak-stress point(rupture)of a locked segment;thus,the former is an identified precursor for the *** a precursor seismicity pattern before the locked-segment rupture has definite physical meanings,and it is universal regardless of the focal *** the evolution of landmark earthquakes follows a deterministic rule described by the model,they are *** results of this study lay a firm physical foundation for reliably predicting the occurrence of future landmark earthquakes in a seismic zone and can greatly improve our understanding of earthquake generation mechanism.

关键词： Precursor Locked segment Volume-expansion point Peak-stress point Landmark earthquake

Thymic epithelial cell development and differentiation: cellular and molecular regulation

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Protein & Cell 2013年第5期4卷 342-355页

作者： Lina Sun Haiying Luo hongran Li Yong Zhao State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of ZoologyChinese Academy of SciencesBeijing 100101China

Thymic epithelial cells (TECs) are one of the most important components in thymic microenvironment supporting thymocyte development and maturation. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor, mediating thymocyte positive and negative selections. Multiple levels of signals including intracellular signaling networks and cell-cell interaction are required for TEC development and differentiation. Transcription factors Foxn1 and autoimmune regulator (Aire) are powerful regulators promoting TEC development and differentiation. Crosstalks with thymocytes and other stromal cells for extrinsic signals like RANKL, CD40L, lymphotoxin, fibroblast growth factor (FGF) and Wnt are also definitely required to establish a functional thymic microenvironment. In this review, we will summarize our current understanding about TEC development and differentiation, and its underlying multiple signal pathways.

关键词： thymus thymic epithelial cells Aire Foxn1 TNFR NF-κB FGFs

Biocompatible Multifunctional E-Skins with Excellent Self-Healing Ability Enabled by Clean and Scalable Fabrication

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Nano-Micro Letters 2021年第12期13卷 221-234页

作者： Xiuzhu Lin Fan Li Yu Bing Teng Fei Sen Liu hongran Zhao Tong Zhang State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China

Electronic skins(e-skins) with an excellent sensing performance have been widely developed over the last few ***,wearability,biocompatibility,environmental friendliness and scalability have become new limitations. Self-healing ability can improve the long-term robustness and reliability of e-skins. However,self-healing ability and integration are hardly balanced in classical structures of self-healable devices. Here,cellulose nanofiber/poly(vinyl alcohol)(CNF/PVA),a biocompatible moisture-inspired self-healable composite,was applied both as the binder in functional layers and the substrate. Various functional layers comprising particular carbon materials and CNF/PVA were patterned on the substrate. A planar structure was beneficial for integration,and the active self-healing ability of the functional layers endowed self-healed e-skins with a higher toughness. Water served as both the only solvent throughout the fabrication process and the trigger of the self-healing process,which avoids the pollution and bioincompatibility caused by the application of noxious additives. Our e-skins could achieve real-time monitoring of whole-body physiological signals and environmental temperature and humidity. Cross-interference between di erent external stimuli was suppressed through reasonable material selection and structural design. Combined with conventional electronics,data could be transmitted to a nearby smartphone for post-processing. This work provides a previously unexplored strategy for multifunctional e-skins with an excellent practicality.

关键词： Self-healing electronics Strain sensors Environmental friendly method Multifunctional e-skins Scalability

Overcoming the Limits of Cross-Sensitivity:Pattern Recognition Methods for Chemiresistive Gas Sensor Array

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Nano-Micro Letters 2024年第12期16卷 285-341页

作者： Haixia Mei Jingyi Peng Tao Wang Tingting Zhou hongran Zhao Tong Zhang Zhi Yang Key Lab Intelligent Rehabil&Barrier Free Disable(Ministry of Education) Changchun UniversityChangchun 130022People’s Republic of China Shanghai Key Laboratory of Intelligent Sensing and Detection Technology School of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237People’s Republic of China National Key Laboratory of Advanced Micro and Nano Manufacture Technology Department of Micro/Nano ElectronicsSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China

As information acquisition terminals for artificial olfaction,chemiresistive gas sensors are often troubled by their cross-sensitivity,and reducing their cross-response to ambient gases has always been a difficult and important point in the gas sensing *** recognition based on sensor array is the most conspicuous way to overcome the cross-sensitivity of gas *** is crucial to choose an appropriate pattern recognition method for enhancing data analysis,reducing errors and improving system reliability,obtaining better classification or gas concentration prediction *** this review,we analyze the sensing mechanism of crosssensitivity for chemiresistive gas *** further examine the types,working principles,characteristics,and applicable gas detection range of pattern recognition algorithms utilized in gas-sensing ***,we report,summarize,and evaluate the outstanding and novel advancements in pattern recognition methods for gas *** the same time,this work showcases the recent advancements in utilizing these methods for gas identification,particularly within three crucial domains:ensuring food safety,monitoring the environment,and aiding in medical *** conclusion,this study anticipates future research prospects by considering the existing landscape and *** is hoped that this work will make a positive contribution towards mitigating cross-sensitivity in gas-sensitive devices and offer valuable insights for algorithm selection in gas recognition applications.

关键词： Pattern recognition Sensor array Chemiresistive gas sensor Cross-sensitivity Artificial olfactory

Primary Osteosarcoma of the Breast in Young Women: One Case Report and Literature Review

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Clinical oncology and cancer researeh 2009年第4期6卷 307-308页

作者： Xuefeng Bai hongran Cao Department of Pathology Baotou CancerHospital Baotou 014030 Inner MongoliaChina

Case Report A 21-year-old female with a breast tumor for over a month came to our hospital. The physical examinations on her breast showed a mammary neoplasm of about 4 cm, with a good range of motion and no abnormality seen in the skin. The patient remained single, and had no family history of breast cancer or ovarian carcinoma. CT and X-ray examinations on the osseous tissue of the whole body showed that no lesions were found. A glabrous tumor with peplos was seen during the surgery, and was completely excised.

关键词： breast primary tumor osteosarcoma.