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Integrated Gas Sensor Based on MEMS

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稀有金属材料与工程 2006年第A3期35卷 173-175页

Integrated gas sensor suspending bridge style micro-structure has been developed on Al_2O_3 new type membrane based on ***_4 gas sensing unit and CO gas sensing unit were fabricated separately on 4 unit array style suspending bridge *** have studied on time-sequence modulation form voltage pulse heating method which forms different work temperature

关键词： Al2O3 membrane micro-structure gas sensor

DNA methylation of SMPD3-based diagnostic biomarkers of NASH and mild fibrosis

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Genes & Diseases 2024年第1期11卷 99-102页

作者： Na Wu Mofan Feng Siran Yue Xinyu shi Nan Tang Yalan Xiong jianying Wang Lei zhang Hualing Song Yi shi Guang He Guang Ji Baocheng Liu Shanghai Innovation Center of Traditional Chinese Medicine Health Service School of Public HealthShanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Institute for Advancing Translational Medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 999077China

Non-alcoholic fatty liver disease(NAFLD)is a liver condition that is widely prevalent across the world.A considerable number of people with NAFLD have the potential to progress to a more severe form of the condition known as nonalcoholic steatohepatitis(NASH),accompanied by bridging *** advancement is more likely if the patient has metabolic risk factors such as obesity or type 2 diabetes that deteriorate over ***,even slight inflammation or fibrosis in NAFLD can significantly increase the likelihood of progression compared to steatosis *** underscores the importance of revising the present methods of monitoring NAFLD patients to ensure early detection and effective management of the disease.

关键词： NAFLD inflammation NASH

Central nervous system efficacy of aumolertinib versus gefitinib in patients with untreated,EGFR-mutated,advanced non-small cell lung cancer:data froma randomized phase III trial(AENEAS)

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Cancer Communications 2024年第9期44卷 1005-1017页

作者： Shun Lu Xiaorong Dong Hong Jian Jianhua Chen Gongyan Chen Yuping sun Yinghua Ji ZipingWang Jianhua shi Junguo Lu Shaoshui Chen Dongqing Lv guojun zhang Chunling Liu Juan Li Xinmin Yu Zhong Lin Zhuang Yu ZhehaiWang Jiuwei Cui Xingxiang Xu Jian Fang Jifeng Feng Zhi Xu RuiMa Jie Hu Nong Yang Xiangdong Zhou XiaohongWu Chengping Hu Zhihong zhang You Lu Yanping Hu Liyan Jiang Qiming wang Renhua guo jianying Zhou Baolan Li Chunhong Hu Wancheng tong Helong zhang LinMa Yuan Chen Zhijun Jie Yu Yao Longzhen zhang JieWeng Weidong Li Jianping Xiong Xianwei Ye Jianchun Duan Haihua Yang Meili sun HongyingWei JiaweiWei Zheyu zhang QiongWu Department of Medical Oncology Shanghai Chest Hospital Shanghai JiaoTong UniversityShanghaiP.R.China Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology-Chest Hunan Cancer Hospital&The Affiliated Cancer Hospital of Central South University Xiangya School of MedicineChangshaHunanP.R.China Thoracic OncologyMedicine HarbinMedical University Cancer HospitalHarbinHeilongjiangP.R.China Department of Oncology Jinan Central HospitalJinanShandongP.R.China Department of Oncology First Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanP.R.China Department of Chest Medicine Beijing Cancer HospitalBeijingP.R.China Department of Internal Medicine Linyi Cancer HospitalLinyiShandongP.R.China Department of Respiratory Medicine Nantong Tumor HospitalNantongJiangsuP.R.China Department of Oncology Binzhou Medical University HospitalBinzhouShandongP.R.China Breath Internal Medicine Taizhou Hospital of Zhejiang ProvinceLinhaiZhejiangP.R.China Department of Respiration The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Lung Internal Medicine Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqiXinjiangP.R.China Department of Thoracic Oncology Sichuan Cancer HospitalChengduSichuanP.R.China Thoracic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)HangzhouZhejiangP.R.China Department of Thoracic Oncology The Fifth Subsidiary Sun Yat-sen University HospitalZhuhaiGuangdongP.R.China Department of Oncology The Affiliated Hospital of QingdaoUniversityQingdaoShandongP.R.China Department of Oncology Shandong Cancer HospitalJinanShandongP.R.China Department of Oncology The First BethuneHospital of Jilin UniversityChangchunJilinP.R.China Department of Respiration Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhouJiangsuP.R.China Department of Internal

Background:The initial randomized,double-blinded,actively controlled,phase III ANEAS study(NCT03849768)demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal growth factor receptor(EGFR)-mutated advanced non-small cell lung cancer(NSCLC).Metastatic disease in the central nervous system(CNS)remains a challenge in the management of *** study aimed to compare the efficacy of aumolertinib versus gefitinib among patients with baseline CNS metastases in the ANEAS ***:Eligible patients were enrolled and randomly assigned in a 1:1 ratio to orally receive either aumolertinib or gefitinib in a double-blinded *** with asymptomatic,stable CNS metastases were ***-up imaging of the same modality as the initial CNS imaging was performed every 6 weeks for 15 months,then every *** responsewas assessed by a neuroradiological blinded,independent central review(neuroradiological-BICR).The primary endpoint for this subgroup analysis was CNS progression-free survival(PFS).Results:Of the 429 patients enrolled and randomized in the ANEAS study,106 patients were found to have CNS metastases(CNS Full Analysis Set,cFAS)at baseline by neuroradiological-BICR,and 60 of them had CNS target lesions(CNS Evaluable for Response,cEFR).Treatment with aumolertinib significantly prolonged median CNS PFS compared with gefitinib in both cFAS(29.0 vs.8.3 months;hazard ratio[HR]=0.31;95%confidence interval[CI],0.17-0.56;P29.0 vs.8.3 months;HR=0.26;95%CI,0.11-0.57;P<0.001).The confirmed CNS overall response rate in cEFRwas 85.7%and 75.0%in patients treated with aumolertinib and gefitinib,*** risk analysis showed that the estimated probability of CNS progression without prior non-CNS progression or death was consistently lower with aumolertinib than with gefitinib in patients with and without CNSmetastases at *** new safety findings were ***:The

关键词： aumolertinib brain metastasis non-small cell lung cancer third-generation EGFR-TKI

Study on Environmental Multi-parameter Sensor Based on MEMS

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稀有金属材料与工程 2006年第S3期 377-380页

作者： hongquan zhang~(1,3) tong zhang~2.likai sun~3 yunbo shi~3 jianying guo~1 (1.Harbin University of Science and Technology,Harbin 150080,China) (2.Automobile Electronic Engineering Technology Research and Development Center,Harbin 150001,China) (3.Northeast Transducer Technology Research Institute,Harbin 150001,China)

A new membrane type Al2O3micromachining material is *** develop an environmental multi-parameter detection micro-system,which implements the detection to temperature,humidity,wind speed,and *** test results illustrate that the heat-release unit in micro-system intercross greatly affects other sensing units on the *** study the method of etching process,which formed cavity to reduce the heat exchange efficiency and decrease temperature intercross effect.

关键词： Al2O3 membrane sensing unit environmental multi-parameter microsystem

Integrated Gas Sensor Based on MEMS

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稀有金属材料与工程 2006年第S3期 173-175页

作者： hongquan zhang~(1,3) tong zhang~2.likai sun~3 yunbo shi~1 jianying guo~1 (1.Harbin University of Science and Technology,Harbin 150080,China) (2.Automobile Electronic Engineering Technology Research and Development Center,Harbin 150001,China) (3.Northeast Transducer Technology Research Institute,Harbin 150001,China)

Integrated gas sensor suspending bridge style micro-structure has been developed on Al2O3new type membrane based on ***4gas sensing unit and CO gas sensing unit were fabricated separately on 4 unit array style suspending bridge *** have studied on time-sequence modulation form voltage pulse heating method which forms different work temperature conditions

关键词： Al2O3 membrane micro-structure gas sensor

创面组织再生修复材料的安全性和有效性评价技术研究进展

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石油化工 2024年第8期53卷 1098-1103页

作者：王春仁戴建英佟微俞铁锋中国食品药品检定研究院北京102629 杭州英健生物科技有限公司浙江杭州310018

新型组织再生修复生物材料具有促进创面细胞增生和迁移,加速创面愈合速度和提高创面愈合质量的作用。随着这类新型材料的不断涌现,传统的评价方法和技术在一定程度上已经不完全适用,因此就新型创面再生修复材料的表征以及生物安全性和... 详细信息

新型组织再生修复生物材料具有促进创面细胞增生和迁移,加速创面愈合速度和提高创面愈合质量的作用。随着这类新型材料的不断涌现,传统的评价方法和技术在一定程度上已经不完全适用,因此就新型创面再生修复材料的表征以及生物安全性和有效性评价的最新研究进展进行了总结。介绍了这类材料的化学性能、降解吸收、物理性能以及生物相容性评价要求,重点综述了新建立的有效评价技术,包括体外细胞增殖、细胞迁移、体外屏蔽保护、微血管形成试验,以及体内动物创伤模型的建立和创面愈合有效性评价方法。

关键词：再生材料创面修复安全性有效性评价

100 Hz快速磁抽搐治疗难治性抑郁症共病强迫症1例

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中华精神科杂志 2024年第1期57卷 41-45页

作者：郭政隆仝玉杰刘超杰程龙李剑虹李建英刘志芬徐勇刘莎山西医科大学第一医院、第一临床医学院精神卫生科太原030001

抑郁症(major depressive disorder,MDD)是致残率最高的疾病之一,临床上约有1/3的MDD患者在连续服用抗抑郁药多个疗程后没有显著改善,最终转变为难治性抑郁症(treatment-resistant depression,TRD)。TRD是一种更为严重、复杂的疾病亚型... 详细信息

抑郁症(major depressive disorder,MDD)是致残率最高的疾病之一,临床上约有1/3的MDD患者在连续服用抗抑郁药多个疗程后没有显著改善,最终转变为难治性抑郁症(treatment-resistant depression,TRD)。TRD是一种更为严重、复杂的疾病亚型,临床治疗具有挑战性。强迫症(obsessive-compulsive disorder,OCD)是以反复出现强迫观念和(或)强迫行为为基本特征的一类精神障碍,与其他精神疾病的高共病率已被确定为OCD的标志性特征,其中以MDD共病OCD最为常见,且症状更为严重,自杀发生概率更高。磁抽搐治疗(magnetic seizure therapy,MST)是一种新型非侵入性神经调控技术,可安全有效治疗TRD,且认知损伤更小。本文报道了1例TRD共病OCD的患者在经100 Hz快速MST治疗后症状显著改善的案例。作为一种新的治疗选择,未来仍需要更多的大型临床研究进一步探索。

关键词：强迫性障碍难治性抑郁症神经调控技术磁抽搐治疗

Ti-Fe_(2)O_(3)/Ni(OH)_(x) as an efficient and durable photoanode for the photoelectrochemical catalysis of PET plastic to formic acid

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Journal of Energy Chemistry 2023年第3期78卷 487-496,I0014页

作者： Xin Li jianying Wang Mingze sun Xufang Qian Yixin Zhao School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200240China

Photoelectrochemical(PEC) technology provides a promising prospect for the transformation of polyethylene terephthalate(PET) plastic wastes to produce value-added *** PEC catalytic systems with high activity,selectivity and long-term durability are required for the future up-scaling industrial ***,we employed the interfacial modification strategy to develop an efficient and stable photoanode and evaluated its PEC activity for ethylene glycol(EG,derived from PET hydrolysate) oxidation to formic *** interfacial modification between Fe_(2)O_(3)semiconductor and Ni(OH)xcocatalyst with ultrathin TiO_(x) interlayer not only improved the photocurrent density by accelerating the kinetics of photogenerated charge carriers,but also kept the high Faradaic efficiency(over 95% in 30 h) towards the value-added formic acid *** work proposes an effective method to promote the PEC activity and enhance the long-term stability of photoelectrodes for upcycling PET plastic wastes.

关键词： Plastic waste Formic acid Photoelectrochemical catalysis High durability Interfacial modiﬁcation

钢铁冶炼行业二噁英排放特性和厂区内大气中二噁英分布规律

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环境科学学报 2018年第4期38卷 1404-1409页

作者：王凤炜付建英林晓青陈彤詹明秀天津市环境监测中心天津300000 中国联合工程公司杭州310052 浙江大学热能工程研究所能源清洁利用国家重点实验室杭州310027 中国计量大学计量测试工程学院杭州310018

对我国某市6家钢铁企业烟气中的二噁英(PCDD/Fs)污染水平和排放特性做了初步研究,同时对厂区内大气中的二噁英浓度水平进行了分析.结果表明,6家钢铁企业中,铁矿石烧结炉排放的二噁英浓度远高于炼钢精炼炉,烧结炉二噁英排放浓度为0.098~3... 详细信息

对我国某市6家钢铁企业烟气中的二噁英(PCDD/Fs)污染水平和排放特性做了初步研究,同时对厂区内大气中的二噁英浓度水平进行了分析.结果表明,6家钢铁企业中,铁矿石烧结炉排放的二噁英浓度远高于炼钢精炼炉,烧结炉二噁英排放浓度为0.098~3.6 ng·Nm^(-3)(以ITEQ计),2个炼钢精炼炉烟气中二噁英的浓度分别为0.0037和0.078 ng·Nm^(-3)(以I-TEQ计),烟气排放达标率为66.67%.6家钢铁企业厂区内大气环境中的二噁英浓度变化范围为0.17~0.69 pg·m^(-3)(以I-TEQ计),平均值为0.41 pg·m^(-3)(以I-TEQ计),其中有两家企业略高于大气质量二噁英的推荐值.对烟气和大气中17种有毒二噁英的分布进行对比分析发现,污染源和大气中二噁英分布具有相似的指纹特性,推测厂区内大气中二噁英分布主要与污染源排放有关.

关键词：二噁英钢铁行业烧结炉精炼炉指纹特性