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Sphingosine kinase 1 promotes growth of glioblastoma by increasing inflammation mediated by the NF-κB/IL-6/STAT3 and JNK/PTX3 pathways

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4390-4406页

作者： Wan Li Hongqing Cai Liwen Ren Yihui Yang Hong Yang Jinyi Liu Sha Li Yizhi Zhang Xiangjin Zheng Wei Tan Guanhua Du Jinhua Wang The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Department of Neurosurgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology Center for Cancer Precision MedicineNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China School of Pharmacy Xinjiang Medical UniversityUrumqi 830011China Xinjiang Institute of Materia Medica Urumqi 830004China

Glioblastoma(GBM)is the most challenging malignant tumor of the central nervous system because of its high morbidity,mortality,and recurrence rate.Currently,mechanisms of GBM are still unclear and there is no effective drug for GBM in the clinic.Therefore,it is urgent to identify new drug targets and corresponding drugs for GBM.In this study,in silico analyses and experimental data show that sphingosine kinase 1(SPHK1)is up-regulated in GBM patients,and is strongly correlated with poor prognosis and reduced overall survival.Overexpression of SPHK1 promoted the proliferation,invasion,metastasis,and clonogenicity of GBM cells,while silencing SPHK1 had the opposite effect.SPHK1 promoted inflammation through the NF-κB/IL-6/STAT3 signaling pathway and led to the phosphorylation of JNK,activating the JNK-JUN and JNK-ATF3 pathways and promoting inflammation and proliferation of GBM cells by transcriptional activation of PTX3.SPHK1 interacted with PTX3 and formed a positive feedback loop to reciprocally increase expression,promote inflammation and GBM growth.Inhibition of SPHK1 by the inhibitor,PF543,also decreased tumorigenesis in the U87-MG and U251-MG SPHK1 orthotopic mouse models.In summary,we have characterized the role and molecular mechanisms by which SPHK1 promotes GBM,which may provide opportunities for SPHK1-targeted therapy.

关键词： Glioblastoma Drug target SPHK1 Inflammation NF-κB/IL-6/STAT3 signal pathway ATF3 PXT3

2,5-Diformylfuran production by photocatalytic selective oxidation of 5-hydroxymethylfurfural in water using MoS_(2)/CdIn_(2)S_(4) flower-like heterojunctions

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Chinese Journal of Chemical Engineering 2023年第2期54卷 180-191页

作者： Qian Zhu Yan Zhuang hongqing Zhao Peng Zhan Cong Ren Changsheng Su Wenqiang Ren Jiawen Zhang Di cai Peiyong Qin National Energy R&D Center for Biorefinery Beijing University of Chemical TechnologyBeijing 100029China Collage of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Research Center for Eco-environmental Sciences Chinese Academy of ScienceBeijing 100085China

The selective oxidation of 5-hydroxymethylfurfural(HMF) into 2,5-diformylfuran(DFF) is an important reaction for renewable biomass building blocks. Compared with thermal catalytic processes, photocatalytic production of DFF from HMF has attracted tremendous attention. Herein, the MoS_(2)/CdIn_(2)S_(4)(MC)flower-like heterojunctions were prepared and considered as photocatalysts for selective oxidation of HMF into DFF under visible-light irradiation in aqueous solution. Results demonstrated MoS_(2) in MC heterojunction could promote the separation of photoexcited electron-hole pairs, while the amount of MoS_(2) dropping was proved influenced on the photocatalytic performance. 80.93% of DFF selectivity was realized when using 12.5% MC as photocatalyst. In addition, the MC catalyst also showed great potential in transformation of other biomass derived benzyl-and furyl-alcohols. The catalytic mechanism suggested that ·O_(2)^(-) was the decisive active radical for HMF oxidation. Therefore, the MC heterojunction could be applied in photocatalytic conversion of biomass to valuable chemicals under ambient condition.

关键词： 2 5-Diformylfuran(DFF) Photocatalysis MoS_(2)/CdIn_(2)S_(4)(MC) Selective oxidation Visible light irradiation

3-D discontinuum numerical modeling of subsidence incorporating ore extraction and backfilling operations in an underground iron mine in China

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International Journal of Mining Science and Technology 2017年第2期27卷 191-201页

作者： Huang Gang Kulatilake Pinnaduwa H.S.W. Shreedharan Srisharan cai Sijing Song hongqing School of Resources and Environmental Engineering Wuhan University of Technology School of Civil and Environmental Engineering University of Science and TechnologyBeijing Rock Mass Modeling and Computational Rock Mechanics Laboratories University of Arizona

An underground iron mine in China has been used as a case-study to research the subsidence due to ore extraction and backfilling during open stoping operations. A 3-D discontinuum numerical model was built incorporating geologic complexities including faults and interfaces between different lithologies,and the stoping and backfilling sequence adopted from the mine plans. The stoping was carried out in two vertically stacked horizontal layers, with a total of 16 stopes. Large displacements of up to 50 cm were observed along the roof of the stopes, and a maximum surface subsidence of 22.5 cm was observed.Backfilling was found to eliminate subsequent displacements and subsidence. The extraction of the upper orebody was found to influence displacements in the lower orebody. Finally, a subsidence profile was constructed to show the subsidence at all locations along the length of the surface and region of influence on the surface.

关键词：尾砂充填采矿法非连续介质作业期铁矿山矿山沉陷数值模拟中国矿石

Hierarchical ZnIn2S4 microspheres as photocatalyst for boosting the selective biohydrogenation of furfural into furfuryl alcohol under visible light irradiation

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Green Chemical Engineering 2022年第4期3卷 385-394页

作者： hongqing Zhao Qian Zhu Yan Zhuang Peng Zhan Yanou Qi Wenqiang Ren Zhihao Si Di cai Senshen Yu Peiyong Qin National Energy R&D Center for Biorefinery Beijing University of Chemical TechnologyBeijing100029China School of International Education Beijing University of Chemical TechnologyBeijing100029China Research Center for Eco-environmental Sciences Chinese Academy of ScienceBeijing100085China R&D Center Yunnan Yuntianhua Co.Ltd.No.1417th Dianchi Road650000KunmingChina College of Life Science and Technology Beijing University of Chemical TechnologyBeijing100029China

Photocatalyst-enzyme coupling process for visible light driven biotransformation holds promise in producing solar chemicals.In this work,aiming to produce furfuryl alcohol,the important bulk chemical that is typically derived from renewable lignocellulose,a highly selective furfural hydrogenation process is proposed by coordinating the alcohol dehydrogenase with the ZnIn2S4 assistant reduced form of nicotinamide adenine dinucleotid(NADH)regeneration.Results indicated that under visible light irradiation,the hierarchical ZnIn2S4 microspheres exhibited excellent holes and electrons separating efficiency,affording to high NADH regeneration(yield of 90.2±3.28%).When adopting the photo-biocoupled reduction process in furfural transformation,a furfuryl alcohol yield of 79.4±1.95%was achieved under the optimized conditions.The photocatalyst-enzyme coupling process also showed good stability,exceeding 70%of catalytic activity was reserved after reusing the catalysts for 10 cycles.The novel photo-biocoupled system showed promising in extending to the highly selective hydrogenation of other biochemicals from lignocelluloses.

关键词： NADH regeneration Photobiocatalysis Furfural Furfuryl alcohol Selective hydrogenation

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《我们共同的财富:美国公有制的回归》摘介

国际研究参考 2021年第2期 53-57,47页

作者：李鸿庆蔡壁岭(编译) 中国现代国际关系研究院

英国曼彻斯特大学出版社2018年出版的《我们共同的财富:美国公有制的回归》(Our Common Wealth:The Return of Public Ownership in the United States,以下简称《美国公有制的回归》)(1)一书,就美国的公有制作了系统深入的研究。作者... 详细信息

英国曼彻斯特大学出版社2018年出版的《我们共同的财富:美国公有制的回归》(Our Common Wealth:The Return of Public Ownership in the United States,以下简称《美国公有制的回归》)(1)一书,就美国的公有制作了系统深入的研究。作者托马斯·汉娜为美国华盛顿民主协作组织研究主任。此书的出版恰逢全球金融危机爆发十周年之际,金融危机给欧美国家的经济、政治、社会带来了巨大冲击。

关键词：协作组织公有制托马斯深入的研究回归

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螺旋钻采煤地表岩移观测站设计与观测探讨

山东煤炭科技 2009年第1期27卷 106-106,108页

作者：蔡洪青山东里能里彦矿业有限公司山东邹城273517

薄煤层螺旋钻采煤引起的岩层与地表移动规律目前尚无可借鉴的资料,笔者通过实地观测获得了第一手资料,并通过对第一手资料的研究提出了薄煤层螺旋钻采煤地表岩移观测站的设计与观测方法的新思路。

关键词：螺旋钻岩移观测站

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颅底恶性肿瘤的临床研究

国际肿瘤学杂志 2015年第3期42卷 192-195页

作者：蔡洪庆万经海北京协和医学院中国医学科学院肿瘤医院神经外科 100021

颅底恶性肿瘤发病率低、病理类型复杂、临床表现常不特异。治疗方案因病理类型、部位、分期等不同而迥异，且治疗过程中常需要多学科共同参与方能取得较好的疗效。更好地了解颅底恶性肿瘤将有助于其规范化治疗。

关键词：颅底肿瘤治疗预后

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从文化的视角规划布设水利工程设施

中国水利 2010年第14期 66-67页

作者：张元刚蔡洪卿江苏省盐城市西潮河闸管理所盐城224333 江苏省盐城市水利工程管理处盐城224002

随着我国经济社会的快速发展，水利与经济、社会和环境的交融不断加深，文化的影响力日渐凸显。传统的以水论水、以河论河、以工程论工程的方法已不适应社会快速发展的需要，从文化的视角规划布设水利工程设施，努力提升水利工程的文化... 详细信息

随着我国经济社会的快速发展，水利与经济、社会和环境的交融不断加深，文化的影响力日渐凸显。传统的以水论水、以河论河、以工程论工程的方法已不适应社会快速发展的需要，从文化的视角规划布设水利工程设施，努力提升水利工程的文化内涵和文化品位，以先进水文化推进现代水利事业科学发展、和谐发展，已成为当前一项重大课题。

关键词：文化水工程规划

山东省预防医学生对岗位胜任力要素认同现状与影响因素分析

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中国医药导报 2023年第30期20卷 85-88页

作者：陈星月蔡伟芹王素珍安洪庆潍坊医学院公共卫生学院山东潍坊261053 潍坊医学院管理学院山东潍坊261053

目的了解当前山东省预防医学专业学生岗位胜任力要素的认同现状,并探讨其与专家建议一致性的影响因素。方法于2021年4月至6月,将山东地区按地域划分为东、中、西3个部分,各个部分选取两所学校,选用分层随机整群抽样方法,抽取医学院校的... 详细信息

目的了解当前山东省预防医学专业学生岗位胜任力要素的认同现状,并探讨其与专家建议一致性的影响因素。方法于2021年4月至6月,将山东地区按地域划分为东、中、西3个部分,各个部分选取两所学校,选用分层随机整群抽样方法,抽取医学院校的预防医学专业本科、硕士和博士应届毕业生填写问卷,采用多因素logistic回归分析预防医学专业学生岗位胜任力相关要素认同与专家建议不一致的影响因素。结果共回收问卷1549份,其中有效问卷共1488份,有效回收率为96.06%。预防医学专业学生岗位胜任力相关要素认同指标总分为(3.46±0.68)分,一级指标中职业素养得分(3.62±0.71)分,专业知识与技能得分(3.30±0.86)分。两组性别、担任学生干部比例比较,差异有统计学意义(P<0.05)。多因素回归分析结果显示,性别(OR=0.419)和担任学生干部(OR=0.627)是预防医学专业学生对岗位胜任力相关要素认同与专家建议不一致的影响因素(P<0.05)。结论重视对预防医学专业学生各种综合素质能力的培养,加强公共卫生人才队伍的建设。

关键词：预防医学岗位胜任力一致性分析影响因素