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Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

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Nano-Micro Letters 2024年第9期16卷 478-499页

作者： Yao Xiao Zaijin Tao Yufeng Ju Xiaolu Huang Xinshu Zhang Xiaonan Liu Pavel A.Volotovski Chao Huang hongqi chen Yaozhong Zhang Shen Liu Department of Orthopaedics Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Tongji Hospital 389 Xincun RdShanghai 200065People’s Republic of China Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Orthopedic Trauma Department Belarus Republic Scientific and Practical Center for Traumatology and OrthopedicsKizhevatova str.60/4220024 MinskBelarus Shanghai Haohai Biological Technology Limited Liability Company 1386 Hongqiao RdShanghai 200336People’s Republic of China Department of General Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Key Laboratory for High Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Post-traumatic peritendinous adhesion presents a significant challenge in clinical medicine.This study proposes the use of diamond-like carbon(DLC)deposited on polylactic acid(PLA)membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured rats.The results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane,with histological score decreasing from 3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from 21.61%to 44.72%.Mechanistically,the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxygen species level effectively;thus,the phosphorylation of NF-κB and M1 polarization of macrophages are inhibited.Consequently,excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α)is largely reduced.For biocompatibility evaluation,PLA/DLC membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA membranes.Further studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds,which further delays the fibrosis process.It was found that the PLA/DLC membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.

关键词： Diamond-like carbon Reactive oxygen species scavenging Foreign body reaction Biodegradation Antioxidant Peritendinous adhesion

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50-110 GHz,high isolation,and high-power linearity single-pole double-throw switch utilizing 100-nm GaN HEMT technology

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The Journal of China Universities of Posts and Telecommunications 2024年第2期31卷 38-43,71页

作者： Han Qunfei Hu Sanming Zhang Tianyu chen Qing Shen Yizhu Wang Weibo Tao hongqi School of Information Science and Engineering Southeast UniversityNanjing 210096China Nanjing Electronic Devices Institute Nanjing 210016China State Key Laboratory of Millimeter Waves Southeast UniversityNanjing 210096China

This article presents the design and performance of a single-pole double-throw(SPDT)switch operating in 50-110 GHz.The switch is fabricated in a 100-nm GaN high-electron-mobility transistors(HEMT)technology.To realize high-power capability,the dimensions of GaN HEMTs are selected by simulation verification.To enhance the isolation,an improved structure of shunt HEMT with two ground holes is employed.To extend the operation bandwidth,the SPDT switch with multi-section resonant units is proposed and analyzed.To verify the SPDT switch design,a prototype operating in 50-110 GHz is fabricated.The measured results show that the fabricated SPDT switch monolithic microwave integrated circuit(MMIC)achieves an input 1 dB compression point(P_(1dB))of 38 dBm at 94 GHz,and isolation within the range of 33 dB to 54 dB in 50-110 GHz.The insertion loss of the switch is less than 2.1 dB,while the voltage standing wave ratios(VSWR)of the input port and output port are both less than 1.8 in the operation bandwidth.Based on the measured results,the presented SPDT switch MMIC demonstrates high power capability and high isolation compared with other reported millimeter-wave SPDT MMIC designs.

关键词： GaN high-electron-mobility transistors(HEMT) millimeter-wave single-pole double-throw(SPDT) switch

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CXCR6-based immunotherapy in autoimmune,cancer and inflammatory infliction

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3255-3262页

作者： Tingting Li Jie Pan hongqi chen Yongliang Fang Yang Sun Department of Gastroenterology the Second Medical CenterNational Clinical Research Center for Geriatric DiseasesState Key Laboratory of Kidney DiseasesChinese PLA General HospitalBeijing 100853China State Key Laboratory of Pharmaceutical Biotechnology Department of Biotechnology and Pharmaceutical SciencesSchool of Life SciencesNanjing UniversityNanjing 210023China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Department of Urology Boston Children’s HospitalDepartments of Microbiology and SurgeryHarvard Medical SchoolBostonMA 02115USA Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China

T cells, including both CD4^(+) and CD8^(+)T cells, play a pivotal role in mediating various inflammation and immune disorders. A long-standing challenge in T cell-based immunotherapy is to precisely inactivate or delete the pathogenic T cells in inflammation and autoimmune diseases, or to selectively expand the immunocompetent T cell in tumor or other immune compromised situations, without inducing global immunosuppression or zealous immune activation respectively. To achieve this, a specific marker is needed to differentiate the pathogenic or immunocompetent T cell among the rests. Indeed,recent progress of immunology strongly suggests that CXC chemokine receptor 6(CXCR6, CD186) is such a kind of marker. Here, we review the emerging role of CXCR6 as a novel target for immunotherapy and discuss the underlying mechanism. We propose that CXCR6-based immunotherapy will play a significant role in autoimmune, nonalcoholic steatohepatitis(NASH), tumor, coronavirus disease 2019(COVID-19) and even ageing-related inflammatory infliction.

关键词： CXCR6 CXCL16 Inflammation Autoimmune diseases Tumor Immunotherapy Nonalcoholic steatohepatitis COVID-19

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Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics

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Acta Pharmaceutica Sinica B 2022年第1期12卷 149-166页

作者： Jian Gao Zhigui Wu Mingxia Zhao Rui Zhang Manru Li Dongdong Sun Haibo cheng Xianjia Qi Yuxian Shen Qiang Xu hongqi chen Dijun chen Yang Sun State Key Laboratory of Pharmaceutical Biotechnology Chemistry and Biomedicine Innovation Center(Chem BIC)School of Life SciencesNanjing UniversityNanjin 210023China Biopharmaceutical Research Institute School of Basic Medical SciencesAnhui Medical UniversityHefei 230032China Department of Colorectal Surgery Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital&InstituteShenyang 110042China The First Clinical College of Nanjing University of Chinese Medicine Nanjing 210023China Shanghai Xu Ran Biotechnology Co. Ltd.Shanghai 201109China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Colorectal cancer(CRC), a malignant tumor worldwide consists of microsatellite instability(MSI) and stable(MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing wasperformed to explore the role of SHP2 in all cell types of tumor microenvironment(TME) from murine MC38 xenografts. Intratumoral cells were found to be functionally heterogeneous and responded significantly to SHP099, a SHP2 allosteric inhibitor. The malignant evolution of tumor cells was remarkably arrested by SHP099. Mechanistically, STING-TBK1-IRF3-mediated type I interferon signaling was highly activated by SHP099 in infiltrated myeloid cells. Notably, CRC patients with MSS phenotype exhibited greater macrophage infiltration and more potent SHP2 phosphorylation in CD68;macrophages than MSI-high phenotypes, suggesting the potential role of macrophagic SHP2 in TME. Collectively,our data reveals a mechanism of innate immunosuppression mediated by SHP2, suggesting that SHP2 is a promising target for colon cancer immunotherapy.

关键词： Tumor microenvironment PTPN11 SHP099 STING Type I interferon Colorectal cancer scRNA-seq Macrophage

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左翼立场与鲁迅对中国问题的多维透视——以20世纪30年代鲁迅杂文为中心

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鲁迅研究月刊 2024年第1期 42-55,62页

作者：陈红旗海南大学人文学院 570228

20世纪30年代,鲁迅救国救民的焦灼心理同其被强化了的左翼立场相结合之后,产生了新的思想碰撞和认知维度,这在其杂文中表现得最为明显。出于革命启蒙、反思国民性、消除社会尤其是文坛弊病等思想主旨,鲁迅杂文着重从文化和人性角度审视... 详细信息

20世纪30年代,鲁迅救国救民的焦灼心理同其被强化了的左翼立场相结合之后,产生了新的思想碰撞和认知维度,这在其杂文中表现得最为明显。出于革命启蒙、反思国民性、消除社会尤其是文坛弊病等思想主旨,鲁迅杂文着重从文化和人性角度审视中国政治、历史、文化、社会和人生问题。透过鲁迅杂文的指引,左翼文艺界确证了革命启蒙、救亡图存、联合抗日和文艺大众化的基本方向,确证了知识分子观照底层民众和民族国家命运的“当代责任”,更确证了智者思考人类“终极”命运的历史使命。在某种意义上,鲁迅杂文全面提升了中国左翼文学的精神品格,抬高了“左联”的社会和文化地位,强化了左翼文艺界的批判力度,更实现了与世界左翼文艺界的平等对话。

关键词：鲁迅杂文中国问题左翼文学嬗变

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Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer

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药物分析学报:英文版 2023年第7期13卷 726-744页

作者： Xiaofan Sun Lisha Zhou Yi Wang Guoliang Deng Xinran Cao Bowen Ke Xiaoqi Wu Yanhong Gu Haibo cheng Qiang Xu Qianming Du hongqi chen Yang Sun Department of Rheumatology and Immunology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing210008China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing210023China Colon and Rectal Surgery Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing210001China Laboratory of Anesthesia and Critical Care Medicine Department of AnesthesiologyTranslational Neuroscience CenterWest China Hospital and State Key Laboratory of BiotherapySichuan UniversityChengdu610044China Genergy Bio-technology(Shanghai)Co. LtdShanghai200241China The First Affiliated Hospital of Nanjing Medical University Jiangsu Province HospitalNanjing210029China Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor The First Clinical College of Nanjing University of Chinese MedicineNanjing210023China General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjing210006China School of Basic Medicine&Clinical Pharmacy China Pharmaceutical UniversityNanjing210009China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai200030China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhouJiangsu221004China

Colorectal tumors often create an immunosuppressive microenvironment that prevents them from responding to immunotherapy.Cannabidiol(CBD)is a non-psychoactive natural active ingredient from the cannabis plant that has various pharmacological effects,including neuroprotective,antiemetic,anti-inflammatory,and antineoplastic activities.This study aimed to elucidate the specific anticancer mechanism of CBD by single-cell RNA sequencing(scRNA-seq)and single-cell ATAC sequencing(scATAC-seq)technologies.Here,we report that CBD inhibits colorectal cancer progression by modulating the suppressive tumor microenvironment(TME).Our single-cell transcriptome and ATAC sequencing results showed that CBD suppressed M2-like macrophages and promoted M1-like macrophages in tumors both in strength and quantity.Furthermore,CBD significantly enhanced the interaction between M1-like macrophages and tumor cells and restored the intrinsic anti-tumor properties of macrophages,thereby preventing tumor progression.Mechanistically,CBD altered the metabolic pattern of macrophages and related anti-tumor signaling pathways.We found that CBD inhibited the alternative activation of macrophages and shifted the metabolic process from oxidative phosphorylation and fatty acid oxidation to glycolysis by inhibiting the phosphatidylinositol 3-kinase-protein kinase B signaling pathway and related downstream target genes.Furthermore,CBD-mediated macrophage plasticity enhanced the response to anti-programmed cell death protein-1(PD-1)immunotherapy in xenografted mice.Taken together,we provide new insights into the anti-tumor effects of CBD.

关键词： scRNA-seq scATAC-seq Cannabidiol Colorectal cancer Tumor microenvironment Macrophage

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基于改进信息最大化生成对抗网络的风光出力场景可控生成方法

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电网技术 2024年第4期48卷 1477-1486,I0030,I0031-I0033页

作者：陈凡陈刘明王曼徐鸿琪周小雨南京工程学院电力工程学院江苏省南京市211167 智能电网保护和运行控制国家重点实验室江苏省南京市211106

基于深度学习的场景生成方法能够自适应挖掘历史数据中高维非线性特征,在风光出力的不确定性建模中得到了广泛应用。然而,基于深度学习的场景生成方法多为黑盒模型,存在可解释性差、生成不可控等问题。为此,提出了一种基于改进信息最大... 详细信息

基于深度学习的场景生成方法能够自适应挖掘历史数据中高维非线性特征,在风光出力的不确定性建模中得到了广泛应用。然而,基于深度学习的场景生成方法多为黑盒模型,存在可解释性差、生成不可控等问题。为此,提出了一种基于改进信息最大化生成对抗网络(information maximizing generative adversarial nets,Info GAN)的风光出力场景生成方法。该方法在目标函数中增加了基于互信息的正则化项,最大化控制编码与生成场景之间的互信息,无监督学习控制编码与生成场景统计特征的映射关系,并引入Gumbel-Softmax分布提高了生成场景的质量。结合风电场和光伏电站的真实数据进行了算例分析,算例结果表明,所提方法不仅能准确描述风光出力不确定性,而且具有可解释性,能够可控生成指定风光出力场景。

关键词：场景生成风光出力可解释性信息最大化生成对抗网络 Gumbel-Softmax分布可控生成

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Atomically Dispersed Ruthenium Catalysts with Open Hollow Structure for Lithium-Oxygen Batteries

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Nano-Micro Letters 2024年第2期16卷 154-164页

作者： Xin chen Yu Zhang Chang chen Huinan Li Yuran Lin Ke Yu Caiyun Nan chen chen Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Solid State ChemistryUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084People’s Republic of China Beijing Key Laboratory of Energy Conversion and Storage Materials Institution College of ChemistryBeijing Normal UniversityBeijing 100875People’s Republic of China

Lithium–oxygen battery with ultrahigh theoretical energy density is considered a highly competitive next-generation energy storage device,but its practical application is severely hindered by issues such as difficult decomposition of discharge products at present.Here,we have developed N-doped carbon anchored atomically dispersed Ru sites cathode catalyst with open hollow structure(h-RuNC)for Lithium–oxygen battery.On one hand,the abundance of atomically dispersed Ru sites can effectively catalyze the formation and decomposition of discharge products,thereby greatly enhancing the redox kinetics.On the other hand,the open hollow structure not only enhances the mass activity of atomically dispersed Ru sites but also improves the diffusion efficiency of catalytic molecules.Therefore,the excellent activity from atomically dispersed Ru sites and the enhanced diffusion from open hollow structure respectively improve the redox kinetics and cycling stability,ultimately achieving a high-performance lithium–oxygen battery.

关键词： Atomically dispersed Open hollow structure Discharge product Lithium Oxygen battery

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Advances in the application of hydrogel-based scaffolds for tendon repair

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Genes & Diseases 2024年第4期11卷 296-313页

作者： Renqiang chen Fanglin chen Kenian chen Jian Xu Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Orthopedics The Fourth Affiliated Hospital of Guangxi Medical UniversityLiuzhou Guangxi 545005China

Tendon injuries often lead to joint dysfunction due to the limited self-regeneration capacity of tendons.Repairing tendons is a major challenge for surgeons and imposes a signif-icant financial burden on society.Therefore,there is an urgent need to develop effective stra-tegies for repairing injured tendons.Tendon tissue engineering using hydrogels has emerged as a promising approach that has attracted considerable interest.Hydrogels possess excellent biocompatibility and biodegradability,enabling them to create an extracellular matrix-like growth environment for cells.They can also serve as a carrier for cells or other substances to accelerate tendon repair.In the past decade,numerous studies have made significant prog-ress in the preparation of hydrogel scaffolds for tendon healing.This review aims to provide an overview of recent research on the materials of hydrogel-based scaffolds used for tendon tis-sue engineering and discusses the delivery systems based on them.

关键词： Application Hydrogel-based Repairscaffolds Review Tendon injury Tissue engineering

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Photodegradation of xylene isomers:Kinetics,mechanism,secondary pollutant formation potential and health risk evaluation

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Journal of Environmental Sciences 2024年第2期136卷 658-669页

作者： Xiaoyan chen Weikun Zhu Sufen Feng Jiangyao chen Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control Guangdong Technology Research Center for Photocatalytic Technology Integration and Equipment EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and HealthSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China

Photodegradation technology has been widely applied in the purification of industrial aromatic hydrocarbons.However,whether this technology efficiently removes the pollutants to prevent secondary pollution and health risk is still unclear.Here,the photodegradation processes of three xylenes were compared under designed reaction atmospheres and light sources.Xe lamp showed poor photodegradation ability toward xylenes,no matter in N_(2) or N_(2)+O_(2)system,while much higher photodegradation performance of xylenes were obtained under ultraviolet(UV)and vacuum ultraviolet(VUV)irradiation,especially in N_(2)+O_(2)+VUV system,where 97.9%of m-xylene,99.0%of o-xylene or 87.5%of p-xylene with the initial concentration of 860 mg/m^(3) was removed within 240 min.The xylenes underwent three processes of photo-isomerization,photodecomposition and photo-oxidation to produce intermediates of aromatics,alkanes and carbonyls.Among them,the photo-isomerization products showed the highest concentration percentage(e.g.,≥50%in o-xylene system),confirming that photo-isomerization reaction was the dominated photodegradation process of xylenes.Moreover,these isomerized products not only contributed about 97%and91%to the formation potential of O3(OFP)and secondary organic aerosols(SOAFP),but also displayed obvious non-carcinogenic risk,although one of photodecomposition product—benzene showed the highest occupational exposure risk.Therefore,the secondary pollution and health risks of photodegradation products of xylenes were non-ignorable,although the OFP,SOAFP and health risks of the generated products reduced at least 4.5 times in comparison with that of the degraded xylenes.The findings are helpful for the appropriate application of this technology in the purification of industrial organic waste gas.

关键词： Isomer aromatics Photodegradation Ozone formation Secondary organic aerosols Health risk

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