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Prognosis and outcome of intrauterine treatment of fetuses with critical congenital heart disease

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Chinese Medical Journal 2024年第12期137卷 1431-1436页

作者： Liqing Zhao Lei Wang hongping Xia Yurong Wu Xianting Jiao Hong zhu Sun Chen Kun Sun Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Diagnosis and Treatment Center for in utero Pediatric Disease Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Neonatology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

Background:Intrauterine valvuloplasty is an innovative therapy,which promotes ventricular growth and function in some congenital heart diseases(CHDs).The technique remains challenging and can only be performed in a few *** study aimed to assess the feasibility and mid-term outcomes of fetal cardiac intervention(FCI)in fetuses with critical CHD in an experienced tertiary ***:Five fetal aortic valvuloplasty(FAV)or fetal pulmonary valvuloplasty(FPV)procedures were performed in our fetal heart center between August 2018 and May *** success was defined as crossing the aortic or pulmonary valve and balloon inflation,followed by evidence of increased blood flow across the valve and/or new ***-up clinical records and echocardiography were obtained during the prenatal and postnatal ***:Five fetuses received FAV or FPV,including critical aortic stenosis(n=2)and pulmonary atresia with intact ventricular septum(n=3).The mean maternal age was 33.0±2.6 *** median gestational age(GA)at diagnosis was 24 weeks(range,22-26 weeks).The median GA at intervention was 29 weeks(range,28-32 weeks).All five cases underwent successful or partially successful *** patient had pulmonary valve perforation without balloon *** procedure-related deaths or significant complications ***,one neonatal death occurred due to heart and renal *** median follow-up period was 29.5 months(range,8.0-48.0 months).The four surviving patients had achieved biventricular circulation,exhibited improved valve,and ventricular development at the last follow-up ***:Intrauterine FCI could be performed safely with good prognosis in critical CHD.

关键词： Fetal cardiac intervention Valvuloplasty Pulmonary atresia Critical aortic stenosis Congenital heart disease

Anionic polymerization of fluorine-substituted phenyl methacrylates

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Science China Chemistry 2015年第1期58卷 107-113页

作者： Bin Li Pan Zhou Yuefei Chen Biao Jiang hongping zhu State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters College of Chemistry and Chemical Engineering Xiamen University

Synthesis and anionic polymerization of the fluorine-substituted phenyl methacrylates are herein reported.A series of mono-,di-,and multi-substituted fluorophenyl methacrylates H2C=C(CH3)C(O)OC6H4F-4(M1a),H2C=C(CH3)C(O)OC6H4F-3(M1b),H2C=C(CH3)C(O)OC6H3F2-2,4(M2),H2C=C(CH3)C(O)OC6H2F3-2,3,4(M3),H2C=C(CH3)C(O)OC6HF4-2,3,5,6(M4),and H2C=C(CH3)C(O)OC6F5(M5)were synthesized and ***,the polymerization was carried out on the monomer M1a by using n Bu Li,t Bu Li,and KH as the respective catalysts;this approach produced the polymers in yields of12%–50%,but with lower molecular *** results were obtained by using t Bu Li for catalytically polymerizing the other five *** introducing a co-catalyst Me Al(BHT)2,the catalysts Na H,Li H,and t Bu OLi each were tested to polymerize M1a,which gave the polymers in very low yields(3%–7%).Polymer yields of 13%–27%were obtained by each of the catalysts Li Al H4,n Bu Li,Ph Li,and t Bu Li in connection with Me Al(BHT)2,but a better yield(61%)was achieved with KH/Me Al(BHT)*** KH/Me Al(BHT)2 catalyst system was further employed to polymerize M1b and M2,which afforded respective polymer yields of 12%–63%and 10%–53%,depending on the molar ratios of KH:Me Al(BHT)2 as well as on the monomer *** of the polymers produced were syndiotactically rich in structure,as indicated by either 1H or 19F NMR *** polymerization mechanism by the combined catalyst system is proposed.

关键词：甲基丙烯酸酯阴离子聚合氟取代苯基催化剂体系助催化剂正丁基锂 CH3

Finite Element Model Updating of Bridge Structures Based on Sensitivity Analysis and Optimization Algorithm

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Wuhan University Journal of Natural Sciences 2008年第1期13卷 87-92页

作者： HUANG Minshui zhu hongping School of Civil Engineering and Mechanics Huazhong University of Science and Technology Wuhan 430074 Hubei China Hubei Key Laboratory of Control Structure Huazhong University of Science and Technology Wuhan 430074 Hubei China

The dynamic characteristics of bridge structures, such as the natural frequencies, mode shapes and model damping ratio, are the basis of structural dynamic computation, seismic analysis, vibration control and structural health condition monitoring. In this paper, a three-dimensional finite-element model is established for a highway bridge over a railway on No.312 National Highway and the ambient test is carried out in site, the dynamic characteristics of the bridge are studied using the finite-element analysis and ambient vibration measurements. Comparison between the theoretical and experimental results shows that the frequency differences of the modes range between 0.44% and 8.77%. If the measurement is more reliable, the finite element model updating is necessary. Thus, a set of design variables is selected based on sensitivity analysis, then the finite element model of the bridge is updated based on optimization algorithm. The results of model updating show that the proposed updating method in this paper is more simple and effective, the updated finite element model can reflect the dynamic characteristics of the bridge better, the analytical results can provide the theoretical basis for damage identification and health condition monitoring of the bridge.

关键词： sensitivity analysis optimization algorithm model updating bridge structure

Investigation of the interior RC beam-column joints under monotonic antisymmetrical load

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Frontiers of Structural and Civil Engineering 2019年第6期13卷 1474-1494页

作者： Fei GAO Zhiqiang TANG Biao HU Junbo CHEN hongping zhu Jian MA School of Civil Engineering and Mechanics Huazhong University of Science and TechnologyWuhan 430074China Guangdong Provincial Key L aboratory of Durability for Marine Civil Engineering Shenzhen UniversityShenzhen 518060China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China

The paper presents numerical findings of reinforced concrete interior beam-column joints under monotonic antisymmetrical *** finite element models considered compression and tension damage were calibrated by test results in terms of the load-displacement,failure modes,and strains of longitudinal *** emphasis was put on studying the effects of hoop reinforcement ratio in joint core and the axial compression ratio on the responses of the *** results show that,in addition to the truss and strut-and-tie mechanisms,the confinement mechanism also existed in the joint core.A certain amount of stirrup is not only able to enhance the confinement in joint core,undertake a part of shear force and thus to increase the shear capacity,prevent the outward buckling of steel bars in column,improve the stress distribution in joint core,delay cracking and restrain the propagation of cracks,but also to increase the yield load,decrease the yield displacement of beam and improve the joint ***,excessive horizontal stirrups contribute little to the joint *** a certain range,larger axial compression ratio is beneficial for the joint mechanical behavior,while it is negative when axial compression ratio is too large.

关键词： RC beam-column joint reinforcement ratio in joint core axial compression ratio finite element test

转化生长因子β信号通路与非综合征型唇腭裂发病风险的基因-基因及基因-环境交互作用

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北京大学学报（医学版） 2024年第3期56卷 384-389页

作者：侯天姣周治波王竹青王梦莹王斯悦彭和香郭煌达李奕昕章涵宇秦雪英武轶群郑鸿尘李静吴涛朱洪平北京大学公共卫生学院流行病与卫生统计学系北京100191 重大疾病流行病学教育部重点实验室(北京大学) 北京100191 北京大学口腔医院·口腔医院口腔颌面外科国家口腔医学中心国家口腔疾病临床医学研究中心口腔生物材料和数字诊疗装备国家工程研究中心口腔数字医学北京市重点实验室国家卫生健康委员会口腔医学计算机应用工程技术研究中心国家药品监督管理局口腔材料重点实验室北京100081 北京大学公共卫生学院营养与食品卫生学系北京100191 北京大学口腔医院·口腔医院儿童口腔科国家口腔医学中心国家口腔疾病临床医学研究中心口腔生物材料和数字诊疗装备国家工程研究中心口腔数字医学北京市重点实验室国家卫生健康委员会口腔医学计算机应用工程技术研究中心国家药品监督管理局口腔材料重点实验室北京100081

目的:探索亚裔人群中转化生长因子β(transforming growth factor-β,TGF-β)信号通路基因多态性与非综合征型唇裂合并或不合并腭裂(non-syndromic cleft lip with or without cleft palate,NSCL/P)的关联及可能存在的基因-基因、基因-... 详细信息

目的:探索亚裔人群中转化生长因子β(transforming growth factor-β,TGF-β)信号通路基因多态性与非综合征型唇裂合并或不合并腭裂(non-syndromic cleft lip with or without cleft palate,NSCL/P)的关联及可能存在的基因-基因、基因-环境交互作用。方法:选取1038个NSCL/P核心家系作为研究对象。对TGF-β信号通路上的10个基因的343个单核苷酸多态性(single nucleotide polymorphism,SNP)位点进行了传递不平衡检验(transmission disequilibrium test,TDT),采用条件Logistic回归模型进行基因-基因交互作用分析和基因-环境交互作用分析。研究收集的环境因素包括患儿母亲孕期吸烟、被动吸烟、乙醇摄入量以及维生素使用情况。由于患儿母亲孕期吸烟和饮酒暴露率较低(<3%),因此,仅对母亲孕期被动吸烟及补充多种维生素这两个环境因素与基因之间的交互作用进行了分析。采用Bonferroni法对结果进行多重检验校正,显著性的阈值设置为P=1.46×10-4。结果:共有4个基因的23个SNP位点与NSCL/P之间存在关联(P<0.05),但经过Bonferroni多重检验校正后,这些关联均未达到统计学显著性水平。经过Bonferroni多重检验校正之后,6对SNP[rs4939874(SMAD2)与rs1864615(TGFBR2),rs2796813(TGFB2)与rs2132298(TGFBR2),rs4147358(SMAD3)与rs1346907(TGFBR2),rs4939874(SMAD2)与rs1019855(TGFBR2),rs4939874(SMAD2)与rs12490466(TGFBR2),以及rs2009112(TGFB2)与rs4075748(TGFBR2)]存在显著的统计学交互作用(P<1.46×10-4),基因-环境交互作用的分析没有达到多重检验校正阈值的显著结果。结论:未发现TGF-β通路基因多态性与NSCL/P的关联,该通路上部分基因可能通过基因-基因交互作用影响NSCL/P的发病风险。未来仍需其他独立研究的证据支持,以进一步的探索其中潜在的生物学机制。

关键词：非综合征型唇腭裂转化生长因子β信号通路全基因组关联研究核心家系

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Mechanism of the interaction between Au nano-particles and polymerase in nanoparticle PCR

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Chinese Science Bulletin 2007年第17期52卷 2345-2349页

作者： MI LiJuan zhu hongping ZHANG XiaoDong HU Jun FAN ChunHai Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Bio-X Life Research center College of Life Science and Biotechnology ShanghaiJiao TongUn'iversity Shanghai 200030 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

Nanoparticle PCR is a novel method to optimize DNA amplification. It performs well in improving specificity, enhancing sensitivity and speed. Several mechanisms were proposed in previous studies: one was based on the interaction between gold nanoparticles (AuNPs) and DNA while the other was attributed to the heat transfer property of AuNPs. In this paper, we propose that the interaction between AuNPs and DNA polymerase can significantly influence PCR. First, the addition of DNA polymerase can eliminate the inhibitory effects of excess AuNPs. Second, the addition of AuNPs will increase yield of the desired PCR product and make the optimum concentration of DNA polymerase move to higher value. Third, while excess polymerase might inhibit amplification efficiency, AuNPs can reverse this process and the yield of PCR amplification. Based on these results we propose a possible mechanism that AuNPs might modulate the activity of polymerase and improve PCR amplification.

关键词：纳米科技金纳米颗粒聚合酶反应机制

SDS-PAGE study on photooxidation damage of lysozyme induced by riboflavin

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Science China Chemistry 2007年第1期50卷 84-90页

作者： ZHANG ZhaoXia ZHAO HongWei zhu hongping GE Min WANG WenFeng YAO SiDe LI WenXin Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Graduate University of Chinese Academy of Sciences Beijing 100049China

The photooxidation damage of lysozyme under 315-375 nm irradiation in the presence of riboflavin was studied by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE).Indica- tions showed that the mechanisms and products of oxidative damage were relative to the concentra- tion of riboflavin,the time of irradiation and the *** type I process was examined in a nitrogen saturated solution,whereas both type I and type II were observed in an aerobic atmosphere and type II was the dominant *** study also suggested that antioxidants,such as melatonin, can reduce the damage of lysozyme effectively.

关键词： lysozyme riboflavin photooxidation SDS-PAGE antioxidant

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间接测量法在盾构隧道模态识别中的应用研究

建筑结构学报 2023年第1期44卷 203-214页

作者：罗辉周剑锋朱宏平华中科技大学土木与水利工程学院湖北武汉430074 中冶南方工程技术有限公司湖北武汉430223

为了快速、经济且准确地实现盾构隧道的健康监测,将桥梁健康监测的间接测量法应用于盾构隧道结构中,在推导了移动车辆-盾构隧道耦合振动作用下车辆加速度响应解析解的基础上,分析了考虑阻尼影响的盾构隧道振型间接识别方法,从理论上证... 详细信息

为了快速、经济且准确地实现盾构隧道的健康监测,将桥梁健康监测的间接测量法应用于盾构隧道结构中,在推导了移动车辆-盾构隧道耦合振动作用下车辆加速度响应解析解的基础上,分析了考虑阻尼影响的盾构隧道振型间接识别方法,从理论上证明了间接测量法在盾构隧道模态识别中应用的可行性。通过实验室试验验证盾构隧道频率间接识别方法,试验结果表明,采用间接测量法与直接测量法测试得到的盾构隧道频率接近,误差为2.8%。同时,通过数值算例验证了基于间接测量法的盾构隧道频率、振型、阻尼比识别方法,并分析车辆速度、车辆阻尼、盾构隧道阻尼等参数对盾构隧道模态间接识别结果的影响。分析结果发现:车速对频率间接识别的影响较小,而过低的车速会导致振型无法识别,应选择5 m/s以上的车速;车辆阻尼大小对振型间接识别的影响较小,而增大车辆阻尼有利于频率间接识别;盾构隧道阻尼的增大不利于频率和振型的间接识别。

关键词：盾构隧道健康监测间接测量法模态识别车辆振动响应

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基于间接测量法的盾构隧道损伤识别

华中科技大学学报（自然科学版） 2022年第8期50卷 124-130页

作者：罗辉周剑锋朱宏平华中科技大学土木与水利工程学院湖北武汉430074 中冶南方工程技术有限公司湖北武汉430223

为准确识别盾构隧道的损伤位置和损伤程度,将桥梁健康监测领域的研究热点间接测量法应用到盾构隧道结构中,提出一种基于双车加速度响应差灵敏度分析的盾构隧道损伤识别方法.首先,建立移动车辆和盾构隧道耦合振动模型,通过理论推导分析... 详细信息

为准确识别盾构隧道的损伤位置和损伤程度,将桥梁健康监测领域的研究热点间接测量法应用到盾构隧道结构中,提出一种基于双车加速度响应差灵敏度分析的盾构隧道损伤识别方法.首先,建立移动车辆和盾构隧道耦合振动模型,通过理论推导分析了采用间接测量法中的双车系统消除轨道粗糙度对车辆加速度响应不利影响的可行性;然后,推导了双车加速度响应差对损伤系数的灵敏度矩阵,构建双车加速度响应差灵敏度方程,采用稀疏正则化优化算法求解灵敏度方程识别损伤系数实现损伤识别.数值算例结果表明:本文方法可实现盾构隧道损伤的定位和定量,具有较好的噪声鲁棒性,采用较低的车速可以获得更好的损伤识别效果.

关键词：盾构隧道损伤识别间接测量法灵敏度分析有限元模型修正