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Numerical Analysis of Three-Layer Deep Tunnel Composite Structure

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Computer Modeling in Engineering & Sciences 2021年第4期127卷 223-239页

作者： Weiwei Sun hongping min Jianzhong Chen Chao Ruan Yanjun Zhang Lei Wang Hubei Key Laboratory of Theory and Application of Advanced Materials Mechanics School of ScienceWuhan University of TechnologyWuhan430070China China Construction Third Bureau Green Industry Investment Co. Ltd.Wuhan430035China Fujian Lutong Pipe Technology Co. Ltd.Quanzhou362000China

To date,with the increasing attention of countries to urban drainage system,more and more regions around the world have begun to build water conveyance tunnels,sewage pressure deep tunnels and so ***,the sufficient bearing capacity and corrosion resistance of the structure,which can ensure the actual service life and safety of the tunnel,remain to be further *** Fiber Reinforced Plastics(GFRP)pipe,with light weight,high strength and corrosion resistance,has the potential to be applied to the deep tunnel *** paper proposed a new composite structure of deep tunnel lined with GFRP pipe,which consisted of three layers of concrete segment,cement paste and GFRP pipe.A new pipe-soil spring element model was proposed for the pipesoil interaction with *** on the C3D8R solid model and the Combin39 spring model,the finite element numerical analysis of the internal pressure status and external pressure stability of the structure was carried *** with the checking calculation of the theoretical formula,the reliability of the two finite element models was confirmed.A set of numerical analysis methods for the design and optimization of the three-layer structure was *** results showed that from the internal GFRP pipe to the outer concrete pipe,the pressure decreased from 0.5 to 0.32 MPa,due to the internal pressure was mainly undertaken by the inner GFRP *** allowable buckling pressure of GFRP pipe under the cover of 5 GPa high modulus cement paste was 2.66 *** application of GFRP pipe not only improves the overall performance of the deep tunnel structure but also improves the construction quality and *** three-layer structure built in this work is safe and economical.

关键词： GFRP pipe deep tunnel structure finite element analysis internal pressure external pressure stability pipe-soil interaction

Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation

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Journal of Pharmaceutical Analysis 2024年第1期14卷 115-127页

作者： Yang Yi Wenzhe Li Kefang Liu Heng Xue Rong Yu Meng Zhang Yang-Oujie Bao Xinyuan Lai Jingjing Fan Yuxi Huang Jing Wang Xiaomeng Shi Junhua Li hongping Wei Kuanhui Xiang Linjie Li Rong Zhang Xin Zhao Xue Qiao Hang Yang min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing100191China Yunnan Baiyao International Medical Research Center Peking UniversityBeijing100191China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterPeking UniversityBeijing100191China Hubei Jiangxia Laboratory Wuhan430000China Shenzhen Children's Hospital ShenzhenGuangdong518036China

Currently,human health due to corona virus disease 2019(COVID-19)pandemic has been seriously *** coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)spike(S)protein plays a crucial role in virus transmission and several S-based therapeutic approaches have been approved for the treatment of ***,the efficacy is compromised by the SARS-CoV-2 evolvement and *** we report the SARS-CoV-2 S protein receptor-binding domain(RBD)inhibitor licorice-saponin A3(A3)could widely inhibit RBD of SARS-CoV-2 variants,including Beta,Delta,and Omicron BA.1,XBB and ***,A3 could potently inhibit SARS-CoV-2 Omicron virus in Vero E6 cells,with EC50 of 1.016μ*** mechanism was related to binding with Y453 of RBD determined by hydrogen-deuterium exchange mass spectrometry(HDX-MS)analysis combined with quantum mechanics/molecular mechanics(QM/MM)***,phosphoproteomics analysis and multi fluorescent immunohistochemistry(mIHC)respectively indicated that A3 also inhibits host inflammation by directly modulating the JNK and p38 mitogen-activated protein kinase(MAPK)pathways and rebalancing the corresponding immune *** work supports A3 as a promising broad-spectrum small molecule drug candidate for COVID-19.

关键词： COVID-19 Inflammation Licorice-saponin A3 Receptor-binding domain(RBD) SARS-CoV-2

女性HPV35/39/51/56/59/68感染情况分析及其遗传变异研究概述

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中华微生物学和免疫学杂志 2024年第4期44卷 368-376页

作者：蓝锶菡张红平冯敏中国医学科学院/北京协和医学院医学生物学研究所昆明650118 昆明医科大学第三附属医院(云南省肿瘤医院)妇科北京大学肿瘤医院云南医院昆明650118

高危型人乳头瘤病毒(high-risk HPV,HR-HPV)持续感染是引起宫颈癌的主要原因,接种HPV疫苗和筛查是较为有效的预防措施。但目前即使是九价疫苗也未能完全覆盖临床上可引起宫颈恶性病变的HR-HPV型别。针对非疫苗型别HR-HPV感染研究数据较... 详细信息

高危型人乳头瘤病毒(high-risk HPV,HR-HPV)持续感染是引起宫颈癌的主要原因,接种HPV疫苗和筛查是较为有效的预防措施。但目前即使是九价疫苗也未能完全覆盖临床上可引起宫颈恶性病变的HR-HPV型别。针对非疫苗型别HR-HPV感染研究数据较少,以及未来大范围接种HPV疫苗后,不同型别HPV的人群感染分布可能有所变化,疫苗开发和接种策略也会相应调整等情况,本综述对目前九价疫苗中未包括的高危型别HPV35/39/51/56/59/68在不同人群、不同国家/地区的流行病学调查数据及其遗传变异研究进行整理分析,不仅有利于明确非疫苗型别HR-HPV在女性人群中的感染变化趋势和病毒进化特征,还可对未来相关疫苗的开发应用等提供参考。

关键词：人乳头瘤病毒非九价疫苗高危型别感染情况遗传变异分析

A Method to Estimate DCB of COMPASS Satellites based on Global Ionosphere Map

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A Method to Estimate DCB of COMPASS Satellites based on Glob...

旋耕刀表面硬质WC合金涂层的电弧热喷涂工艺研究

第三届中国卫星导航学术年会

作者： JIAO WenHai,GENG ChangJiang,MA YinHu,HUANG XiaoRui Testing and Assessment Research Center of China Satellite Navigation Office,Beijing,100094,China ZHANG hongping,LI min,HU ZhiGang,GNSS Research Center of Wuhan University,Wuhan 430079,China

DCB（Differential Code Bias） is a key parameter to convert code of different navigation frequency to the same time *** the limited number of COMPASS satellites and tracking stations in current time,it’s difficult to build precise ionosphere model for DCB ***,in this paper,CODE’s（Center for Obit Determination in Europe） Global Ionosphere Map is used as a reference for DCB estimation,which means only DCB parameters are need to be estimated with ionospheric delay *** result of two months’ observation data shows that it can obtain COMPASS satellite DCB with repeatability of less than 1ns.

关键词： Differential Code Bias COMPASS Global Ionosphere Map

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表面技术 2024年第15期53卷 234-241,251页

作者：陈吉朋王计安周宏平南京林业大学机械电子工程学院南京210014

目的旋耕刀是重要的农机土壤部件,“表硬芯韧”是制造高性能旋耕刀的关键。尝试利用电弧热喷涂方法在旋耕刀表面直接制备含硬质碳化钨(WC)的合金涂层,以提高其综合力学性能。方法以旋耕刀常用制造材料65Mn为基材,以含WC的合金材料为电... 详细信息

目的旋耕刀是重要的农机土壤部件,“表硬芯韧”是制造高性能旋耕刀的关键。尝试利用电弧热喷涂方法在旋耕刀表面直接制备含硬质碳化钨(WC)的合金涂层,以提高其综合力学性能。方法以旋耕刀常用制造材料65Mn为基材,以含WC的合金材料为电极丝材,搭建电弧喷涂实验平台,开展三因素两水平工艺实验。重点探讨喷涂电压、送丝速度、扫描速度对涂层制备的影响。结果所制备的涂层表面光滑、平整,无宏观裂纹或可见缺陷。在喷涂电压30V、送丝速度40mm/s、扫描速度30mm/s时,电弧热喷涂的涂层沉积速率为174.7g/min,其平均硬度可达HRC51,表面粗糙度Ra为2.366μm。扫描电镜(SEM)、能谱仪(EDS)等测试结果表明,WC合金涂层具有典型的层状结构,结构均匀致密,涂层与基体之间形成了良好的机械结合。结论在基础工艺研究基础上,成功制备了表面含有硬质WC合金涂层的旋耕刀样件,进一步验证了工艺可行性,为高性能旋耕刀制备提供了新的思路和方法。

关键词：旋耕刀电弧喷涂碳化钨涂层工艺特性

絮凝调理对疏浚底泥絮体特性及污染物释放过程的影响作用研究

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环境卫生工程 2021年第4期29卷 52-58页

作者：黄文海闵红平聂怀军江东彭冠平薛强王民珉张文中建三局绿色产业投资有限公司湖北武汉430056 中建三局水务环保设计院湖北武汉430014 佛山水木金谷环境科技有限公司广东佛山528200

考察了典型的无机絮凝剂和有机高分子絮凝剂对清淤底泥脱水性能的改善作用,解析了调理过程中底泥絮体特性的变化特征,探究了絮凝处理过程中污染物的释放规律。研究结果表明:各种絮凝剂均可通过增加底泥絮体颗粒粒径和降低底泥表面电荷... 详细信息

考察了典型的无机絮凝剂和有机高分子絮凝剂对清淤底泥脱水性能的改善作用,解析了调理过程中底泥絮体特性的变化特征,探究了絮凝处理过程中污染物的释放规律。研究结果表明:各种絮凝剂均可通过增加底泥絮体颗粒粒径和降低底泥表面电荷而有效改善底泥的脱水性能;不同絮凝剂调理后,余水中氨氮浓度均明显上升,PAM系絮凝剂能有效抑制底泥中有机物的释放,而无机絮凝剂能有效抑制底泥中总磷的释放。三维荧光光谱分析(3D-EEM)表明,底泥中溶解性有机质以芳香族类蛋白质和色氨酸类蛋白质为主,不同絮凝剂均能去除上清液中的蛋白类物质。PAC去除底泥中蛋白类物质的效能对碱化度的变化不敏感,而PAM系絮凝剂的分子量越大,对蛋白类物质的絮凝去除效果越明显。

关键词：絮凝剂疏浚底泥余水水质污染物释放

基于复杂网络的谣言传播模型稳定性和最优控制研究

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湖北民族大学学报（自然科学版） 2024年第3期42卷 442-450页

作者：庄洪萍向会立周敏湖北民族大学数学与统计学院湖北恩施445000

为深入理解谣言传播规律和探究如何有效地控制谣言传播,基于复杂网络构建无知者-潜伏者-传播者-稳定者(uninformed-susceptible,latent-exposed,spreader-infected,stable-recovered,SEIR)谣言传播模型,研究其动力学行为和最优控制问题。首先,利用下一代矩阵法计算基本再生数,通过相应的雅可比矩阵和构造李雅普诺夫函数讨论无谣言平衡点的局部和全局渐近稳定性。其次,通过特征方程证明谣言盛行平衡点的全局渐近稳定性。最后,利用庞特里亚金最值原理,研究该模型的最优控制问题,证明最优控制解的存在性和具体形式;此外,通过正向和反向扫描方法得到最优控制问题的数值解。结果表明,谣言在系统中是否传播受网络异质性水平的影响;当控制■时,目标函数取得最小值,表明对无知者和潜伏者施加控制是有效的。该研究在谣言传播控制方面具有重要意义。

关键词：复杂网络谣言传播模型网络异质性水平稳定性最优控制数值模拟

Global modeling 2^(nd)-order ionospheric delay and its effects on GNSS precise positioning

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Science China(Physics,Mechanics & Astronomy) 2011年第6期54卷 1059-1067页

作者： ZHANG hongping LV HaiXia LI min SHI Chuang State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430070China GNSS Research Center Wuhan UniversityWuhan 430079China School of Geodesy and Geomatics Wuhan UniversityWuhan 430079China

Ionospheric delay is one of the major error sources in GNSS navigation and ***,the dual-frequency technique is the most widely used in ionospheric refraction ***,dual-frequency measurements can only eliminate the first-order term of ionospheric delay,while the effect of the second-order term on GNSS observations may be several *** this paper,two models,the International Reference Ionosphere (IRI) 2007 and International Geomagnetic Reference Field (IGRF) 11 are used to estimate the second-order term through the integral calculation ***,the simplified single layer ionosphere model in a dipole moment approximation for the earth magnetic field is *** the traditional integral calculation method requires large calculation load and takes much time,it is not convenient for practical ***,although the simplified single layer ionosphere model is simple to implement,it results in larger *** this study,second-order term ionospheric correction formula proposed by Hoque (2007) is improved for estimating the second-order term at a global ***,it is more practicable to estimate the second-order *** importantly,its results have a higher precision of the sub-millimeter level for a global scale in normal *** with Hoque's original regional correction model,which calculates coefficients through polynomial fitting of elevation and latitudes,this study proposes a piece-wise look-up table and interpolation technique to modify Hoque *** utilizing a table file,the modified Hoque model can be conveniently implemented in an engineering software package,like as PANDA in this *** applying the proposed scheme for the second-order ionospheric correction into GNSS precise positioning in both PPP daily and epoch solutions,the results have shown south-shift characteristics in daily solution at a global scale and periodic change with VTEC daily variation in epoch positioning s

关键词： ionospheric delay second-order ionospheric correction GNSS precise positioning

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关于城市深层排水隧道立法保护的思考与建议

市政技术 2021年第3期39卷 90-92页

作者：王涛朱海军闵红平刘畅阮超杨怀中建三局绿色产业投资有限公司湖北武汉430000

回顾了城市深层排水隧道的发展历程,针对城市排水深隧的特点,从地下空间设施易遭受破坏和深隧工程的特殊性两方面分析了立法保护的必要性,对现行国家层面、地方层面相关法规条文进行了归集分析,对国外相关成熟经验进行了梳理,并以此为基... 详细信息

回顾了城市深层排水隧道的发展历程,针对城市排水深隧的特点,从地下空间设施易遭受破坏和深隧工程的特殊性两方面分析了立法保护的必要性,对现行国家层面、地方层面相关法规条文进行了归集分析,对国外相关成熟经验进行了梳理,并以此为基础,对城市深层排水隧道立法保护提出了几点建议。该建议为城市排水深隧事业的发展创造更好的外部环境、更好地推动城市排水深隧事业健康发展具有一定的参考价值。

关键词：城市排水深隧外部损害立法