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Oleanolic acid improved intestinal immune function by activating and potentiating bile acids receptor signaling in E. coli-challenged piglets

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2137-2155页

作者： Chenyu Xue hongpeng jia Rujing Cao Wenjie Cai Weichen Hong jianing Tu Songtao Wang Qianzhi jiang Chongpeng Bi Anshan Shan Na Dong The Laboratory of Molecular Nutrition and Immunity College of Animal Science and TechnologyNortheast Agricultural UniversityHarbinP.R.China

Background Infection with pathogenic bacteria during nonantibiotic breeding is one of the main causes of animal intestinal *** acid(OA)is a pentacyclic triterpene that is ubiquitous in *** previous work demonstrated the protective effect of OA on intestinal health,but the underlying molecular mechanisms remain *** study investigated whether dietary supplementation with OA can prevent diarrhea and intestinal immune dysregulation caused by enterotoxigenic Escherichia coli(ETEC)in *** key molecular role of bile acid receptor signaling in this process has also been *** Our results demonstrated that OA supplementation alleviated the disturbance of bile acid metabolism in ETEC-infected piglets(P<0.05).OA supplementation stabilized the composition of the bile acid pool in piglets by regulating the enterohepatic circulation of bile acids and significantly increased the contents of UDCA and CDCA in the ileum and cecum(P<0.05).This may also explain why OA can maintain the stability of the intestinal microbiota structure in ETEC-challenged *** addition,as a natural ligand of bile acid receptors,OA can reduce the severity of intestinal inflammation and enhance the strength of intestinal epithelial cell antimicrobial programs through the bile acid receptors TGR5 and FXR(P<0.05).Specifically,OA inhibited NF-κB-mediated intestinal inflammation by directly activating TGR5 and its downstream c AMP-PKA-CREB signaling pathway(P<0.05).Furthermore,OA enhanced CDCA-mediated MEK-ERK signaling in intestinal epithelial cells by upregulating the expression of FXR(P<0.05),thereby upregulating the expression of endogenous defense molecules in intestinal epithelial *** In conclusion,our findings suggest that OA-mediated regulation of bile acid metabolism plays an important role in the innate immune response,which provides a new diet-based intervention for intestinal diseases caused by pathogenic bacterial infections in pig

关键词： Bile acid receptors Enterotoxigenic Escherichia coli Intestinal innate immunity Oleanolic acid

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Review of small aspheric glass lens molding technologies

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Frontiers of Mechanical Engineering 2017年第1期12卷 66-76页

作者： Shaohui YIN hongpeng jia Guanhua ZHANG Fengjun CHEN Kejun ZHU National Engineering Research Center for High Efficiency Grinding Hunan University Changsha 410082 China School of Mechanical Engineering Xiangtan University Xiangtan411105 China

Aspheric lens can eliminate spherical aberra- tions, coma, astigmatism, field distortions, and other adverse factors. This type of lens can also reduce the loss of light energy and obtain high-quality images and optical characteristics. The demand for aspheric lens has increased in recent years because of its advantageous use in the electronics industry, particularly for compact, portable devices and high-performance products. As an advanced manufacturing technology, the glass lens molding process has been recognized as a low-cost and high-efficiency manufacturing technology for machining small-diameter aspheric lens for industrial production. However, the residual stress and profile deviation of the glass lens are greatly affected by various key technologies for glass lens molding, including glass and mold-die material forming, mold-die machining, and lens molding. These key technical factors, which affect the quality of the glass lens molding process, are systematically discussed and reviewed to solve the existing technical bottlenecks and problems, as well as to predict the potential applicability of glass lens molding in the future.

关键词： aspheric glass lens mold-die manufacturing,lens molding molding process simulation

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Sustained research fund and dedicated research center to prepare for the next pandemic

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Precision Clinical Medicine 2020年第2期3卷 94-96页

作者： hongpeng jia Min Wu Department of Surgery Division of Pediatric SurgeryJohns Hopkins University School of MedicineBaltimoreMD 21205USA Department of Biomedical Sciences School of Medicine and Health SciencesUniversity of North DakotaGrand ForksND 58203-9037USA

The current COVID-19 pandemic caused by the SARS-CoV-2 virus is imposing a great threat to human lives and international panic the like of which has not been seen since WWII,resulting in financial crisis,disturbance to daily life,transportation shutdown,industry disruption,and country/city lockdown in every corner of the *** inability to effectively contain the virus indicates that our investment and attention to research,prevention,and development of treatment for this type of deadly virus are insufficient,considering that it has been 18 years since outbreak of the“brother”coronavirus,*** biggest lesson learned fromacrimonious past experiences is that humans quickly forget and do not continue to support related research when a pandemic has *** is a wake-up call for governments,industry,and private foundations to work together and to take extraordinary measures to sustain research support and establish comprehensive research *** this level of response may give us hope to prepare for the future and adequately deal with the next potential pandemic caused by emerging devastating viral infections.

关键词： investment pandemic viral infections coronavirus SARS-CoV-2 COVID-19

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MnO_(2)负载贵金属催化剂用于CO低温催化氧化的研究

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能源环境保护 2024年第4期38卷 189-197页

作者：许文建贾宏鹏陈金李晓兰中国科学院城市环境研究所福建厦门361021 中国科学院大学北京100049

利用双氧水驱动促进贵金属沉淀的方法在MnO_(2)上负载贵金属制备了一系列Pd/MnO_(2)、Ru/MnO_(2)、Ag/MnO_(2)、Pt/MnO_(2)催化剂。通过对比贵金属负载型催化剂(负载量3.0%)催化氧化CO的活性,得到如下结果:3.0%Pd/MnO_(2)>3.0%Ru/MnO_(2)>MnO_(2)>3.0%Ag/MnO_(2)>3.0%Pt/MnO_(2)。为了探究催化剂活性与材料结构特性之间的关系,分别使用球差电镜、XRD、Raman、H_(2)-TPR、O_(2)-TPD和XPS等表征技术对催化剂表面贵金属的粒径尺寸、晶体结构、缺陷结构、低温还原性、活性氧物种以及金属元素价态分布等物理化学特性进行了系统的表征和分析。研究发现,负载了Ag或Pt的催化剂仅仅改善了MnO_(2)的低温还原性,由于在CO催化氧化过程中催化剂表面的贵金属被快速还原,因此催化活性有所下降。相反地,负载了Pd或Ru的MnO_(2)催化剂在CO氧化反应中的活性显著提高,这是材料良好的低温还原性与表面化学吸附氧物种之间的协同促进作用所致。由于3.0%Pd/MnO_(2)具有更好的低温还原性和更多的表面化学吸附氧物种,其能够在10℃条件下完全催化氧化CO气体(浓度为1%CO/4%O_(2),GHSV=40000 mL/(g·h))。通过分析不同催化氧化反应过程,推测Pd/MnO_(2)催化氧化CO遵循Langmuir-Hinshelwood(L-H)机理。

关键词： Pd/MnO_(2) CO氧化催化剂低温还原性化学吸附氧物种

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Constructing a high concentration CuO/CeO_(2) interface for complete oxidation of toluene:The fantastic application of spatial confinement strategy

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Journal of Rare Earths 2023年第6期41卷 850-861,I0002页

作者： Chao Wang Yan Li Huiao Liu Ziying Hu Xinhui Hao hongpeng jia Jing Chen Canzhong Lu CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Xiamen Institute of Rare-earth Materials Haixi InstitutesChinese Academy of SciencesXiamen 361021China Institute of Urban Environment Chinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China

In this paper,CeO_(2) substrate was prepared by the sol-gel method,further CuO was introduced by adding the copper complexes with chelating agents into the sol-gel precursors of CeO_(2),in which different chelating agents(β-cyclodextrin,glucose and trimesic acid)were *** synthesis method helps the CuO species to disperse very uniformly in the CeO_(2) *** the amount of copper oxide is up to33 mol%,the CuO/CeO_(2) samples can still maintain a highly dispersed *** CeO_(2) and CuO/CeO_(2)samples were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS),temperature-programmed reduction of hydrogen(H_(2)-TPR),temperature-programed desorption(O_(2)-TPD),*** is found that the CuO/CeO_(2) catalyst prepared byβ-cyclodextrin(βCuO/CeO_(2)) exhibits better catalytic performance owing to the higher dispersion,higher specific surface area,more defects,more active Ce3+and Cu^(+) ions,more oxygen vacancies,more surface active oxygen,relatively better low temperature reducibility,and the exposed(110) active *** the condition of 1000×10-6toluene in air and WHSV=60000 mL/(g·h),the T90for toluene conversion is 227℃.The reaction mechanism of toluene catalytic oxidation over CeO_(2)andβCuO/CeO_(2) is discussed by the study of in-situ *** work affords a simple and efficient method for the synthesis of highly dispersed bimetal oxide catalysts with high contents.

关键词： Catalytic oxidation Toluene Confinement strategy Chelating agent Rare earths Copper

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Quartz-enhanced multiheterodyne resonant photoacoustic spectroscopy

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Light(Science & Applications) 2024年第4期13卷 696-705页

作者： jiapeng Wang hongpeng Wu Angelo Sampaolo Pietro Patimisco Vincenzo Spagnolo Suotang jia Lei Dong State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China. Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China. PolySense Lab Dipartimento Interateneo di FisicaUniversity and Politecnico of BariCNR-IFNVia Amendola 17370126 BariItaly

The extension of dual-comb spectroscopy(DCS)to all wavelengths of light along with its ability to provide ultralarge dynamic range and ultra-high spectral resolution,renders it extremely useful for a diverse array of applications in physics,chemistry,atmospheric science,space science,as well as medical *** this work,we report on an innovative technique of quartz-enhanced multiheterodyne resonant photoacoustic spectroscopy(QEMR-PAS),in which the beat frequency response from a dual comb is frequency down-converted into the audio frequency *** this way,gas molecules act as an optical-acoustic converter through the photoacoustic effect,generating heterodyne sound *** conventional DCS,where the light wave is detected by a wavelengthdependent photoreceiver,QEMR-PAS employs a quartz tuning fork(QTF)as a high-Q sound transducer and works in conjunction with a phase-sensitive detector to extract the resonant sound component from the multiple heterodyne acoustic tones,resulting in a straightforward and low-cost hardware *** novel QEMRPAS technique enables wavelength-independent DCS detection for gas sensing,providing an unprecedented dynamic range of 63 dB,a remarkable spectral resolution of 43 MHz(or~0.3 pm),and a prominent noise equivalent absorption of 5.99×10^(-6)cm^(-1)·Hz-1/2.

关键词： Quartz hardware resonant

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In Situ High-Temperature Reaction-Induced Local Structural Dynamic Evolution of Single-Atom Pt on Oxide Support

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Precision Chemistry 2023年第5期1卷 299-308页

作者： Dongxu Yan Yanxia Gao Ming-Yu Qi hongpeng jia Yi-Jun Xu Xiamen Key Laboratory of Materials for Gaseous Pollutant Control Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350116China

The dynamic evolution of active site coordination structure during a high-temperature reaction is critically significant but often difficult for the research of efficient single-atom catalysts(SACs).Herein,we for the first time report the in situ activation behaviors of the local coordination structure of Pt single atoms(Pt_(1))during the high-temperature oxidation of light *** distinctly enhanced activity of the catalyst is attributed to the in situ evolved Pt_(1)−oxygen vacancy(Pt_(1)−OV)combination ensemble as an efficient and stable active *** calculations reveal that the lattice oxygen adjacent to Pt_(1)and the H dissociated from CH4 constitute the lattice hydroxyl,which is the initial step in the formation of the Pt_(1)−OV ***_(1)and nearby unsaturated Mn can donate the charge back to O−O to promote the dissociation of O_(2).This work provides molecular-level insight into the in situ reaction-induced evolution of a single-atom coordination environment for designing efficient SACs under harsh conditions.

关键词： Pt single atom in situ reaction high temperature coordination structure alkane

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Secure Containment Control for Multi-Agent Systems Under Distributed Denial of Service Attacks

Secure Containment Control for Multi-Agent Systems Under Dis...

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第35届中国过程控制会议

作者： Zhongbao Wang Xin-chun jia Suna Duan Wenbiao Zhai hongpeng Li School of Automation and Software Engineering Shanxi University School of Mathematical Sciences Shanxi University

This paper investigates the secure containment control problem of general linear multi-agent systems(MASs) under the distributed denial of service(DoS) attacks. Firstly, in order to save communication resources, an distributed event-triggered mechanism is proposed. Based on the proposed distributed event-triggered mechanisms and the distributed DoS attacks, a distributed controller is designed. Secondly, by utilizing Lyapunov stability theory, some sufficient conditions for general linear MASs to achieve the secure containment control are obtained. Furthermore, it proves that Zeno behavior can be effectively eliminated. Finally, a simulation example is provided to verify the effectiveness of the proposed control protocol.

关键词： Multi-Agent Systems(MASs) Distributed Denial of Service(DoS) Attacks Event-Triggered Containment Control

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耦合光热储能的小麦秸秆超临界水气化制氢系统的热力学研究

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太阳能学报 2024年第9期45卷 170-178页

作者：薛强坤许宏鹏贾明孙煜皓吴少华大连理工大学能源与动力学院大连116024 燕山大学车辆与能源学院秦皇岛066004 前海深港国际先进技术研究院深圳518102

提出一种基于太阳能驱动的小麦秸秆超临界水气化系统模型,并结合熔融盐储能系统,有效克服了太阳能的间歇性问题,为生物质制氢的碳中和路径提供了新思路。热力学分析发现热解温度和能量输入是该系统制氢产率的主要影响因素,在较高热解温... 详细信息

提出一种基于太阳能驱动的小麦秸秆超临界水气化系统模型,并结合熔融盐储能系统,有效克服了太阳能的间歇性问题,为生物质制氢的碳中和路径提供了新思路。热力学分析发现热解温度和能量输入是该系统制氢产率的主要影响因素,在较高热解温度(700℃)和低能量输入(215.14 kW)的条件下氢气产率达到最大;通过耦合熔融盐储能,该系统实现了全天不间断高效运行,其能量效率和[火用]效率分别达到36.3%和36%以上。

关键词：生物质气化太阳能超临界水光热储能

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人格特质与认知功能的相关性研究进展

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首都医科大学学报 2024年第3期45卷 466-471页

作者：滕飞宋明康吕宏蓬贾竑晓首都医科大学附属北京安定医院国家精神疾病医学中心、国家精神心理疾病临床医学研究中心、精神疾病诊断与治疗北京市重点实验室北京100088 人脑保护高精尖创新中心首都医科大学北京100069

人格是指与生物学和环境因素相关的行为、认知、情感的综合,人格特质是区分不同人格的重要标准,在整个生命过程中具有阶段性稳定和阶段性波动的特点。认知功能是指包括学习、思考、推理、记忆、解决问题、决策和注意力在内的多种心理能... 详细信息

人格是指与生物学和环境因素相关的行为、认知、情感的综合,人格特质是区分不同人格的重要标准,在整个生命过程中具有阶段性稳定和阶段性波动的特点。认知功能是指包括学习、思考、推理、记忆、解决问题、决策和注意力在内的多种心理能力。研究人格特质同认知功能之间的相关性及神经机制,对理解二者的关系,预测个人的发展成长及预防和诊治潜在疾病具有重要作用。

关键词：人格特质认知功能神经机制遗传机制

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