检索结果-南通市图书馆

维普期刊数据库

伴单克隆免疫球蛋白的惰性B细胞非霍奇金淋巴瘤临床特征及预后

在线全文

学校读者我要写书评

暂无评论

中国临床研究 2024年第6期37卷 925-928,954页

作者：范洪明郭丹洪乐旻黄春群卢金凤徐宏慧陈洁黄红铭杨熙南通大学附属医院血液科江苏南通226001

目的探讨伴单克隆免疫球蛋白(McIg)惰性B细胞非霍奇金淋巴瘤(iB-NHL)患者临床特征及预后。方法回顾性分析2013年11月至2021年10月南通大学附属医院的82例初诊iB-NHL患者的临床与病理资料,根据血清免疫固定电泳(SIFE)结果分为阳性组(30例... 详细信息

目的探讨伴单克隆免疫球蛋白(McIg)惰性B细胞非霍奇金淋巴瘤(iB-NHL)患者临床特征及预后。方法回顾性分析2013年11月至2021年10月南通大学附属医院的82例初诊iB-NHL患者的临床与病理资料,根据血清免疫固定电泳(SIFE)结果分为阳性组(30例)和阴性组(52例),对其临床特征、实验室检查结果、总生存期(OS)进行分析。结果伴McIg的iB-NHL好发于男性,以IgM-κ最为多见,临床分期多为Ⅲ~Ⅳ期,以边缘区淋巴瘤(MZL)为主。与阴性组患者相比,阳性组患者更易出现骨髓浸润、国际预后指数(IPI)评分≥3分、白细胞计数减少、贫血、低白蛋白血症、球蛋白升高和胱抑素C升高(P<0.05)。Cox单因素分析显示,IPI≥3分、McIg阳性与患者较差的OS相关,多因素分析显示McIg阳性是患者OS独立预后不良因素(HR=0.074,95%CI:0.009~0.609,P=0.015)。随访截止于2021年10月31日,阳性组的中位OS为52个月,不伴McIg的患者中位OS未达到,差异有统计学意义(P<0.01)。结论在初诊iB-NHL患者中,伴有McIg患者的预后相对较差,需要在临床诊治中重点关注。

关键词：惰性B细胞非霍奇金淋巴瘤边缘区淋巴瘤单克隆免疫球蛋白血清免疫固定电泳骨髓浸润国际预后指数

维普期刊数据库

HRCT对人工耳蜗植入术中脑脊液井喷的预测价值

在线全文

学校读者我要写书评

暂无评论

临床耳鼻咽喉头颈外科杂志 2024年第5期38卷 421-425页

作者：刘智锋林晓德黄宏明董广源吴佩娜广东省心血管病研究所广东省人民医院广东省医学科学院广州510080 汕头市中心医院耳鼻咽喉头颈外科广东省人民医院耳鼻咽喉头颈外科香港中文大学(深圳)附属第二医院深圳市龙岗区人民医院体检中心

目的:探讨颞骨高分辨率CT(HRCT)多平面重组对内耳畸形患者人工耳蜗植入术中脑脊液井喷的预测价值。方法:回顾性分析33例(36耳)行CI内耳畸形患者的临床资料,评估其对CI中脑脊液井喷的预测价值。结果:蜗孔宽度(P=0.024,OR=1.735)、内听道... 详细信息

目的:探讨颞骨高分辨率CT(HRCT)多平面重组对内耳畸形患者人工耳蜗植入术中脑脊液井喷的预测价值。方法:回顾性分析33例(36耳)行CI内耳畸形患者的临床资料,评估其对CI中脑脊液井喷的预测价值。结果:蜗孔宽度(P=0.024,OR=1.735)、内听道底上下径(P=0.022,OR=6.119)是内耳畸形患者CI中脑脊液井喷的独立危险因素。蜗孔宽度预测术中井喷的AUC=0.851,敏感度为93.33%,特异度为61.90%;内听道底上下径预测术中井喷的AUC=0.848,敏感度为80.00%,特异度为80.95%;蜗孔宽度联合内听道底上下径预测术中井喷的AUC=0.930,敏感度为80.00%,特异度为95.24%。结论:基于颞骨HRCT的蜗孔宽度联合内听道底上下径预测模型对内耳畸形患者CI中“井喷”具有重要预测价值。

关键词：高分辨率CT 人工耳蜗植入术脑脊液井喷预测内耳畸形

维普期刊数据库

Role of inactivated SARS-CoV-2 vaccine induced T cell responses in ameliorating COVID-19 severity

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2023年第2期38卷 324-326页

作者： hongming huang Jia Liu Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Joint International Laboratory of Infection and Immunity Huazhong University of Science and TechnologyWuhan430022China

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccine is one of the most effective weapons to fight the coronavirus disease 2019(COVID-19)pandemic(Lazarus et al.,2022).Among all SARS-CoV-2 vaccines generated on different platforms,those consisting of the inactivated virus,such as BBIBP-CorV and CoronaVac,have been frequently used(WHO,2023).By January 30,2023,92.9%of the entire,all-ages population had initiated vaccination and 90.6%had completed their primary series based on the whole population size reported in the seventh census of Chinese mainland(China CDC,2023).However,compared to SARS-CoV-2 mRNA vaccines,which can elicit extremely high quantities of anti-spike(S)antibodies,the levels of neutralizing antibodies induced by inactivated SARS-CoV-2 vaccines are quite lower and wane quickly(Peng et al.,2022;Lim et al.,2021).

关键词： vaccine severity acute

On the Use of Recycled Asphalt and Trinidad Lake Asphalt(TLA)for the Preparation of High Modulus Asphalt Concrete

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2023年第7期19卷 1939-1950页

作者： Chao Li Guodong Zeng Yang Fang hongming huang Foshan Transportation Science and Technology Co. Ltd.Foshan528315China Key Laboratory of Road Structure and Material of Ministry of Transport(Changsha) Changsha University of Science&TechnologyChangsha410114China

Rutting of asphalt pavement occurs earlier and is more serious under the increasingly heavy traffic load conditions that can be found in subtropical monsoon climate *** modulus asphalt concrete(HMAC)with excellent anti-rutting and anti-fatigue properties is generally used to mitigate this *** the relatively high cost of the additives used in this type of asphalt,in this study the feasibility of using recycled asphalt mixture(RAP)and Trinidad lake asphalt(TLA)for the preparation of HMAC is *** mineral composition of the RAP is first analyzed,then the TLA modified asphalt with different levels of RAP content is used to assess the effect of RAP on the performance of the ***,the high-temperature rheological properties of extracted bitumen and the adhesion characteristic between mineral and bitumen are *** results show that after RAP combustion,the yellowish and greyish minerals display different alkalinity values,while the greyish mineral exhibits an improved ability to combine with ***,RAP can significantly enhance the high-temperature rutting resistance of TLA modified asphalt *** aged bitumen in RAP makes the mixed binder harder and improves its rheological properties at high temperatures.

关键词： Recycled asphalt mixture trinidad lake asphalt high-temperature properties

南宁盛产期资阳香橙砧沃柑生物量及矿质元素累积特征

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国南方果树 2024年第3期53卷 21-27页

作者：汪妮娜苏祖祥廖惠红刘福平黄宏明王茜韦持章黄其椿广西农业科学院园艺研究所/农业农村部南宁南亚热带果树科学观测实验站南宁530007 广西农业科学院生物技术研究所南宁530007

通过研究果实成熟期树体矿质元素积累与养分分配规律,可明确树体矿质养分需求,为“以果定肥”提供科学依据,从而实现养分的数字化管理。在南宁一个管理水平较高、中高产量的沃柑园中,于果实成熟期随机选择3株5年生资阳香橙砧沃柑植株进... 详细信息

通过研究果实成熟期树体矿质元素积累与养分分配规律,可明确树体矿质养分需求,为“以果定肥”提供科学依据,从而实现养分的数字化管理。在南宁一个管理水平较高、中高产量的沃柑园中,于果实成熟期随机选择3株5年生资阳香橙砧沃柑植株进行挖掘和解剖取样,对不同器官的生物量和矿质元素进行测定分析。结果表明:沃柑平均单株鲜果产量为75.90 kg,占全株鲜质量的63.88%。根系、枝干、叶片和果实干质量分别占植株总干质量的13.31%、39.23%、13.74%和33.72%。从同一元素在不同植物器官中的含量(以干质量计)来看,叶片中N、Ca、Mg、S、Mn、Cu、Zn和B含量最高,根系中P和Fe含量最高,果实中K含量最高。按每株果实产量50 kg计,采收果实带走N、P、K、Ca、Mg、S、Fe、Mn、Cu、Zn和B的量分别为80.84 g、8.29 g、72.91 g、30.79 g、4.82 g、3.50 g、218.75 mg、35.21 mg、41.87 mg、35.99 mg和91.42 mg,分别占树体相应元素总量的31.36%、38.96%、57.87%、9.04%、31.74%、22.20%、12.99%、14.64%、15.07%、25.78%和19.03%。研究探明了沃柑果实养分携出量以及果实养分分配系数,可为沃柑养分需求决策和优化施肥提供依据。

关键词：沃柑生物量矿质元素养分需求施肥

维普期刊数据库博看期刊

Influence of Hydrodynamic Pore Pressure Damage on the Performance of Hot-Mixed Renewable Asphalt Mixture

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2023年第5期11卷 2453-2467页

作者： Guodong Zeng Chao Li Yang Fang hongming huang Hao Li Yishen Xu Foshan Transportation Science and Technology Co. Ltd.Foshan528315China Key Laboratory of Road Structure and Material of Ministry of Transport(Changsha) Changsha University of Science&TechnologyChangsha410114China School of Highway Engineering Chang’an UniversityXi’an710064China

For evaluating the water stability of hot-mixed renewable asphalt mixture(HRM),the traditional methods are all tested under still water *** for damage in still water conditions,the hydrodynamic pore pressure generated by the tire driving on the surface water has a great ***,the RAP contents of the HRMs were designed at 0%,30%,45%and 60%with AC-25 ***,the self-designed evaluation methods of water stability and dynamic modulus were ***,the mechanism of the influence of hydrodynamic pore pressure damage on HRMs was *** results show that the water stability of HRM containing 30%RAP is equivalent to that of 45%RAP,and the water stability of HRM containing 60%RAP decreases *** Contabro test after MIST treatment can be used as an evaluation method for hydrodynamic pore pressure damage on ***-speed,heavy-load traffic and larger RAP content have greater damage to the mixture after hydrodynamic pore pressure *** performance differences between the aged bitumen and pure bitumen,as well as the aged minerals and new minerals,are continuing to be enlarged in hydrodynamic pore pressure conditions,finally affecting the water stability and dynamic modulus of the HRMs.

关键词： Hot-mixed renewable asphalt mixture water stability dynamic modulus hydrodynamic pore pressure

CAR-T细胞治疗复发难治性弥漫大B细胞淋巴瘤1例报告并文献复习

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

当代医学 2024年第1期30卷 120-123页

作者：吕悦杨力黄红铭刘红林赠华南通大学附属医院血液内科江苏南通226001

1例复发难治性弥漫大B细胞淋巴瘤(R/RDLBCL)患者在接受多线治疗后,疾病仍进展,后采用嵌合抗原受体T细胞(CAR-T)治疗。该患者在输注CAR-T细胞后第1天出现3级细胞因子释放综合征,经治疗后缓解,目前处于部分缓解状态。证实CAR-T可被视为治... 详细信息

1例复发难治性弥漫大B细胞淋巴瘤(R/RDLBCL)患者在接受多线治疗后,疾病仍进展,后采用嵌合抗原受体T细胞(CAR-T)治疗。该患者在输注CAR-T细胞后第1天出现3级细胞因子释放综合征,经治疗后缓解,目前处于部分缓解状态。证实CAR-T可被视为治疗R/RDLBCL的有效选择。

关键词：复发难治性弥漫大B细胞淋巴瘤嵌合抗原受体T细胞细胞因子释放综合征

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

降解膜对高粱根际土壤微生物群落结构的影响

山西农业大学学报（自然科学版） 2024年第3期44卷 66-74页

作者：刘玉兵曹春信黄洪明卢华兵吕学高刘新华金华市农业科学研究院浙江金华321000 浙中特色粮作资源创新利用重点实验室浙江金华321000 兰溪市农技推广中心浙江兰溪321100 浙江省农业科学院玉米与特色旱粮研究所浙江杭州322100

[目的]本研究旨在明确降解膜对农田土壤微生物群落结构特征的影响。[方法]设置4个月降解(4J)、6个月降解(6J)、普通黑膜(PT)3种不同降解膜,以不覆膜为对照(CK),利用高通量测序技术分析土壤细菌群落结构变化,探讨降解膜覆盖农田土壤中微... 详细信息

[目的]本研究旨在明确降解膜对农田土壤微生物群落结构特征的影响。[方法]设置4个月降解(4J)、6个月降解(6J)、普通黑膜(PT)3种不同降解膜,以不覆膜为对照(CK),利用高通量测序技术分析土壤细菌群落结构变化,探讨降解膜覆盖农田土壤中微生物群落的变化及其对微生物生态环境效应的影响。[结果]与不覆膜处理相比,覆膜后土壤中的全氮(PT处理除外)、速效磷、速效钾以及有机质含量均得到了提升。α-蛋白细菌(Alphaproteobacteria)、放线菌(Actinobacteria)、酸杆菌Gp1(Acidobacteria_Gp1)和伽马杆菌(Gammmaproteobacteria)为双季高粱根际土壤中共同优势细菌类群。主季覆膜处理下土壤中放线菌和酸杆菌Gp1和酸杆菌Gp2(Acidobacteria_Gp2)的相对丰度均高于不覆膜的土壤;再生季覆膜处理下土壤Deltaproteobacteria相对丰度均显著高于不覆膜的土壤,且土壤细菌群落OTU(OperationalTaxonomicUnit)数大于2000,具有更高的微生物多样性。通过KEGG代谢途径分析,再生季覆膜处理下土壤中碳水化合物代谢(Carbohydrate metabolism)、氨基酸代谢(Amino acid metabolism)、辅因子和维生素代谢(Me-tabolism of cofactors and vitamins)和萜类化合物和聚酮类化合物代谢(Metabolism of terpenoids and polyketides)高于主季覆膜处理,其中以6J处理较佳。[结论]综上,6个月的降解膜(6J处理)可以有效提升土壤理化性质,改善土壤根际细菌群落生物降解,增加微生物多样性和丰富度。

关键词：生物降解膜根际土壤微生物群落高通量测序

维普期刊数据库博看期刊

同方期刊数据库

Gut Microbiota Dysbiosis Strengthens Kupffer Cell-mediated Hepatitis B Virus Persistence through Inducing Endotoxemia in Mice

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2022年第1期10卷 17-25页

作者： Wenqing Zhou Jinzhuo Luo Xiaohong Xie Shangqing Yang Dan Zhu hongming huang Dongliang Yang Jia Liu Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Background and Aims:Change of gut microbiota com-position is associated with the outcome of hepatitis B virus(HBV)infection,yet the related mechanisms are not fully *** objective of this study was to investigate the immune mechanism associated with HBV persistence induced by gut microbiota ***:C57BL/6 mice were sterilized for gut-microbiota by using an antibi-otic(ABX)mixture protocol,and were monitored for their serum endotoxin(lipopolysaccharide[LPS])*** HBV-replicating mouse model was established by performing HBV-expressing plasmid pAAV/HBV1.2 hydrodynamic injec-tion(HDI)with or without LPS,and was monitored for se-rum hepatitis B surface antigen,hepatitis B e antigen,HBV DNA,and cytokine *** cells(KCs)were purified from antibiotic-treated mice and HBV-replicating mice and analyzed for IL-10 production and T cell suppression ***:ABX treatment resulted in increased serum LPS levels in *** KCs separated from both ABX-treated and LPS-treated HBV-replicating mice showed significantly increased IL-10 production and enhanced ability to suppress IFN-γproduction of TCR-activated T cells than the KCs sep-arated from their counterpart *** of pAAV/HBV1.2 in combination with LPS in mice led to a delayed HBV clear-ance and early elevation of serum IL-10 levels compared to pAAV/HBV1.2 HDI ***,IL-10 function blockade or KC depletion led to accelerated HBV clearance in LPS-treated HBV-replicating ***:Our results suggest that dysbiosis of the gut microbiota in mice leads to endotoxemia,which induces KC IL-10 production and strengthens KC-mediated T cell suppression,and thus fa-cilitates HBV persistence.

关键词： Chronic hepatitis B Gut microbiota Kupffer cells T cell IL-10