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龙杞方治疗糖尿病肾脏病的作用机制:基于网络药理学和大鼠验证实验

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南方医科大学学报 2022年第2期42卷 171-180页

作者：邢磊邢文文郭宏敏南京中医药大学第一临床医学院江苏南京210004 南京市高淳中医院老年病科江苏南京211300

目的基于GEO数据库和网络药理学方法研究龙杞方治疗糖尿病肾脏病(DKD)的作用机制,并通过动物实验进一步验证龙杞方治疗DKD的信号通路。方法利用GEO、TCMSP、CNKI、ChemDraw、SwissTargetPrediction等数据库获得龙杞方和DKD靶点,VENNY获... 详细信息

目的基于GEO数据库和网络药理学方法研究龙杞方治疗糖尿病肾脏病(DKD)的作用机制,并通过动物实验进一步验证龙杞方治疗DKD的信号通路。方法利用GEO、TCMSP、CNKI、ChemDraw、SwissTargetPrediction等数据库获得龙杞方和DKD靶点,VENNY获得龙杞方-DKD交集靶点,String进行蛋白互作分析,R包进行KEGG和GO富集分析,Cytoscape 3.7.2软件构建网络图。动物实验验证分析,40只健康雄性SD大鼠随机分为5组(8只/组),采用腹腔内注射链脲佐菌素(STZ)诱导的DKD大鼠模型,龙杞方低剂量组(1 g·kg^(-1)·d^(-1)),龙杞方中剂量组(2 g·kg^(-1)·d^(-1)),龙杞方高剂量组(2 g·kg^(-1)·d^(-1)),空白组和模型组采用等体积水灌胃;HE染色观察大鼠肾脏形态,检测肾功能情况;Westernblot检测炎症指标NF-κB、p-NF-κB蛋白表达水平。结果龙杞方共760个主要靶点,通过GEO数据库获得差异基因共1026个,通过VENNY数据库获得龙杞方-DKD交集靶点共61个,通过PPI网络互作获得的核心靶点为MYC、EGF、CASP3、VEGFA、CCL2、SPP1、VCAM1、ICAM1。GO分析龙杞方主要与核受体活性、配体激活转录因子活性等有关,KEGG发现龙杞方主要通过干预NF-κB、TNF、PI3K-AKT等炎症信号通路有关。动物实验显示龙杞方高、中、低剂量干预后DKD大鼠的肾功能指标(Scr、BUN、UALB、UACR)与模型组比较有显著改善(P中剂量组>低剂量组;Westernblot结果显示龙杞方高、中、低剂量干预DKD大鼠,与模型组比较,可以使NF-κB、p-NF-κB表达显著下调,效应强度为:龙杞方高剂量组>中剂量组>低剂量组。结论龙杞方通过多成分、多靶点、多信号通路治疗DKD,龙杞方可能通过抑制炎症信号通路NF-κB起到保护肾功能的作用。

关键词：网络药理学龙杞方糖尿病肾脏病动物实验 NF-κB

Temperate Stutzerimonas Phage Encoding Toxin-Antitoxin System Genes Represents a Novel Genus

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Journal of Ocean University of China 2024年第4期23卷 1087-1101页

作者： ZHANG Hong guo Ruizhe GAO Chen ZHENG Kaiyang XIONG Yao DONG Yue LIU Yundan WANG Ziyue CHEN Ying WANG hongmin SHAO Hongbing SUNG Yeong Yik MOK Wen Jye WONG Li Lian MCMINN Andrew WANG Min LIANG Yantao College of Marine Life Sciences Institute of Evolution and Marine BiodiversityMOE Laboratory of Evolution and Marine BiodiversityFrontiers Science Center for Deep Ocean Multispheres and Earth SystemCenter for Ocean Carbon NeutralityOcean University of ChinaQingdao 266003China UMT-OUC Joint Center for Marine Studies Qingdao 266003China Institute of Marine Biotechnology Universiti Malaysia Terengganu21030 Kuala TerengganuMalaysia Institute for Marine and Antarctic Studies University of TasmaniaHobartTAS 7001Australia Haide College Ocean University of ChinaQingdao 266100China The Affiliated Hospital of Qingdao University Qingdao 266001China

Stutzerimonas have been extensively studied due to their remarkable metabolic and physiological ***,research on its phages is currently *** this study,we isolated a novel double-stranded DNA(dsDNA)phage,vB_SstM-PG1,from the marine environment that infects Stutzerimonas stutzeri *** dsDNA genome is 37204 bp long with a G/C content of 64.14%and encodes 54 open reading *** phage possesses a tail packaging structure that is different from known Stutzerimonas stutzeri phages and exhibits structural protein characteristics similar to those of temperate *** addition,two genes of toxin-antitoxin system,including YdaS_antitoxin and HEPN_SAV_6107,were found in the vB_SstM-PG1 genome and play important roles in regulating host growth and *** phylogenetic tree and comparative genomic analysis,it has been determined that vB_SstM-PG1 is not closely related to any phages previously identified in the GenBank ***,it has a connection with enigmatic,uncultured ***,the vB_SstM-PG1 virus exhibits an average nucleotide identity of over 70%with six uncultivated viruses identified in the IMG/VR v4 *** significant finding has resulted in the identification of a novel viral genus known as Metabovirus.

关键词： Stutzerimonas vB_SstM-PG1 Metabovirus temperate phage genomic and phylogenetic analysis

Emerging direct current triboelectric nanogenerator for high-entropy mechanical energy harvesting

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Science China(Technological Sciences) 2024年第5期67卷 1297-1316页

作者： CHEN Jie guo RuiLong guo HengYu College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 401331China Department of Applied Physics Chongqing UniversityChongqing 401331China

In the era of the Internet of Things(IoT),the provision of sustainable power to distributed,mobile,and low-power-consumption electronic devices is a critical *** overcome this challenge,the triboelectric nanogenerator(TENG),a highly efficient high-entropy mechanical energy harvesting device,was developed in *** device enables the direct conversion of irregular and low-frequency mechanical energy into pulsed alternating current(AC)***,the incompatibility of most electronic devices with AC signals necessitates rectifier circuits or generators that deliver direct current(DC)*** recent years,DC-TENGs have undergone extensive development,achieving significant milestones in various application fields while also facing crucial challenges that require *** this review,three categories of DC-TENG devices with distinct operating mechanisms are comprehensively explored:multiphase coupling,mechanical rectification,and air *** typical structures and working mechanisms are thoroughly discussed,and specific output performance limitations,along with corresponding optimization strategies,are ***,the applications of DC-TENGs in various scenarios are ***,the challenges faced by DC-TENGs and potential solutions are analyzed to guide further advancements in this technology.

关键词： TENG direct current working mechanisms output performance limitations optimization strategies

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三峡工程大江截流试验与实践

水力发电 1998年第1期24卷 65-68页

作者：杨文俊刘力中郭红民长江科学院

三峡工程大江截流是目前世界上截流流量最大，水深最大的截流工程。其中，有许多技术难题需要解决。由于大江截流的特殊性及重要性，施工期河势边界、水流流态异常复杂，致使常规数学模型计算分析受到限制。为此，物理模型试验研究成为... 详细信息

三峡工程大江截流是目前世界上截流流量最大，水深最大的截流工程。其中，有许多技术难题需要解决。由于大江截流的特殊性及重要性，施工期河势边界、水流流态异常复杂，致使常规数学模型计算分析受到限制。为此，物理模型试验研究成为解决大江截流设计及施工中有关问题的主要手段。研究成果为大江胜利实现截流打下了坚实基础。

关键词：模型试验坍塌平抛垫底截流三峡工程

Physicochemical principles of hydrogen metallurgy in blast furnace

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Journal of Iron and Steel Research International 2024年第1期31卷 46-63页

作者： Han-jie guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China

Based on the stoichiometric method and the free energy minimization method,an ideal model for the reduction of iron oxides by carbon and hydrogen under blast furnace conditions was established,and the reduction efficiency and theoretical energy consumption of the all-carbon blast furnace and the hydrogen-rich blast furnace were *** results show that after the reduction reaction is completed at the bottom of the blast furnace,the gas produced by reduction at 1600℃still has a certain excessive reduction capacity,which is due to the hydrogen brought in by the hydrogen-rich blast as well as the excess carbon monoxide generated by the reaction of the coke and the oxygen brought in by the *** the process of the gas with excessive reduction capacity rising from the bottom of the blast furnace and gas reduction process,the excessive reduction capacity of the gas gradually decreases with the increase in the dydrogen content in the *** the all-carbon blast furnace,the excess gas reduction capacity is the strongest,and the total energy consumption per ton of iron reduction is the *** shows that,for the current operation mode of the blast furnace,adding hydrogen in the blast furnace cannot reduce the consumption of carbon required for reduction per ton of iron,but rather increases the consumption of carbon.

关键词： Hydrogen metallurgy Excess gas reduction capacity Theoretical energy consumption Hydrogen-rich blast furnace Thermodynamic model Gibbs minimum free energy method

Control Strategies for Digital Twin Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 170-180页

作者： guo-Ping Liu IEEE the Center for Control Science and Technology Southern University of Science and TechnologyShenzhen 518055China

With the continuous breakthrough in information technology and its integration into practical applications, industrial digital twins are expected to accelerate their development in the near future. This paper studies various control strategies for digital twin systems from the viewpoint of practical *** make full use of advantages of digital twins for control systems, an architecture of digital twin control systems, adaptive model tracking scheme, performance prediction scheme, performance retention scheme, and fault tolerant control scheme are proposed. Those schemes are detailed to deal with different issues on model tracking, performance prediction, performance retention, and fault tolerant control of digital twin systems. Also, the stability of digital twin control systems is analysed. The proposed schemes for digital twin control systems are illustrated by examples.

关键词： Digital twin control systems fault tolerant control model tracking performance prediction performance retention

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高强铝合金流变成形的研究现状与展望

特种铸造及有色合金 2018年第6期38卷 612-615页

作者：郭洪民刘斌杨湘杰南昌大学材料科学与工程学院江西省高性能精确成形重点实验室

高强铝合金是流变成形实现"以铸代锻"的关键材料,流变成形是高强铝合金实现复杂结构件近净成形的有效途径。高强铝合金流变成形存在2个主要矛盾:一是成形件的强度和塑性之间的矛盾;二是合金的成形工艺性能与热处理强化能力之间的矛盾。... 详细信息

高强铝合金是流变成形实现"以铸代锻"的关键材料,流变成形是高强铝合金实现复杂结构件近净成形的有效途径。高强铝合金流变成形存在2个主要矛盾:一是成形件的强度和塑性之间的矛盾;二是合金的成形工艺性能与热处理强化能力之间的矛盾。从半固态浆料制备、专用合金成分设计以及特征微结构调控等三方面探讨了高强铝合金流变成形存在的关键问题。

关键词：高强铝合金流变成形力学性能合金成分

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电厂湿烟羽消白烟气参数计算

山东电力技术 2019年第10期46卷 42-46页

作者：郭红闵安徽华电六安电厂有限公司

采用湿法脱硫的电厂,脱硫系统出口烟气温度低且含水量大,未经处理直接排向大气会引起电厂周边环境污染问题。对烟气进行加热,或冷凝回收烟气中一部分水蒸汽是解决此问题的有效方法。给出了电厂湿烟羽“消白”过程中烟气参数计算方法,一... 详细信息

采用湿法脱硫的电厂,脱硫系统出口烟气温度低且含水量大,未经处理直接排向大气会引起电厂周边环境污染问题。对烟气进行加热,或冷凝回收烟气中一部分水蒸汽是解决此问题的有效方法。给出了电厂湿烟羽“消白”过程中烟气参数计算方法,一台350 MW超临界压力发电机组的计算表明:水蒸汽凝结时释放的潜热是冷凝过程主要热量来源;冷凝烟气中水蒸汽的“消白”方案投资较大,运行成本较高;采用辅助加热器对烟气进一步升温,将烟囱入口烟气温度提高到75℃,是一种较好的烟气“消白”方法。

关键词：锅炉烟气污染排放湿烟羽

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ML35冷镦钢热轧盘条的开发与实践

铸造技术 2017年第4期38卷 955-956页

作者：郭红民胡煜杨军陕西龙门钢铁有限责任公司陕西韩城715405 西安建筑科技大学冶金工程学院陕西西安710055

主要介绍冷镦钢系列中的代表钢种ML35冷镦钢热轧盘条的开发和生产过程。通过分析研究主要化学元素对钢的作用,在国标的基础上确定ML35冷镦钢热轧盘条化学成分,并根据冷镦钢产品的技术特点,制定合适的轧制工艺,采用加热段≤1 050℃,均热... 详细信息

主要介绍冷镦钢系列中的代表钢种ML35冷镦钢热轧盘条的开发和生产过程。通过分析研究主要化学元素对钢的作用,在国标的基础上确定ML35冷镦钢热轧盘条化学成分,并根据冷镦钢产品的技术特点,制定合适的轧制工艺,采用加热段≤1 050℃,均热段(980±20)℃,开轧温度(920±30)℃,吐丝温度860~880℃,延迟冷却方式,最终在龙钢公司成功开发出符合标准要求的ML35冷镦钢热轧盘条产品。

关键词： ML35 冷镦钢盘条轧制