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单点式应变量校准器电路设计方案分析

计量与测试技术 2024年第3期51卷 53-56页

作者：黄晓龙尧建平郭宏民中国飞机强度研究所强度与结构完整性全国重点试验室

校准器输出电路是应变量校准器的最核心技术。本文介绍了两种常规的单点式应变量校准器电路设计方案,并通过理论计算和测试试验对其优缺点及可行性进行分析,提出最优方案。

关键词：模拟应变量校准器计量数据采集系统准确度

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基于氧枪喷头磨损的熔池搅拌特性

钢铁 2024年第3期59卷 107-116页

作者：吕明陈双平郝翊杰邢相栋张朝晖郭红民西安建筑科技大学冶金工程学院陕西西安710055 陕西龙门钢铁有限责任公司生产指挥控制中心陕西韩城715405

研究氧枪喷孔出口磨损程度对射流动力学参数及熔池搅拌效果的影响可以为氧枪喷头设计和冶炼工艺优化提供理论支持。建立了0°、10°和20°磨损角度氧枪自由射流几何模型,分析了喷孔出口磨损程度对射流轴向和径向动力学参数分布的影响,... 详细信息

研究氧枪喷孔出口磨损程度对射流动力学参数及熔池搅拌效果的影响可以为氧枪喷头设计和冶炼工艺优化提供理论支持。建立了0°、10°和20°磨损角度氧枪自由射流几何模型,分析了喷孔出口磨损程度对射流轴向和径向动力学参数分布的影响,发现入口压力相同时,喷孔出口磨损程度增大,射流速度、动压和马赫数衰减加快,射流聚合程度增强。在喷孔出口0.18 m范围内,磨损后氧枪的湍动能大于未磨损氧枪,且磨损程度越大,射流湍动能越大。超过此范围后,未磨损氧枪湍动能大于磨损后氧枪。在喷孔出口1000 mm处,射流径向最大速度、动压、马赫数和湍动能均随着喷孔出口磨损程度的增大而减小。建立了120 t转炉和5孔氧枪1∶4水力学试验模型,研究了枪位和气体流量变化对不同磨损程度氧枪冲击效果和混匀时间的影响,分析了枪位和气体流量相同时氧枪喷孔出口磨损对熔池流场的影响。发现气体流量相同时,随着枪位升高,熔池冲击深度减小,冲击直径增大,混匀时间增大。枪位相同时,随着气体流量增大,熔池冲击深度和冲击直径增大,混匀时间减少。枪位和气体流量相同时,喷孔出口磨损程度增大,冲击深度和冲击直径减小,混匀时间增大,高锰酸钾溶液完全扩散时间增大。磨损角度由0°增至20°,高锰酸钾溶液完全扩散时间由47 s增至59 s。

关键词：转炉炼钢喷头磨损水模拟熔池搅拌混匀时间

铸坯头尾温差模拟及直接轧制棒材力学性能分析

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中国冶金 2024年第2期34卷 61-68页

作者：吕明薛魁习晓峰郭红民梁少鹏张朝晖西安建筑科技大学冶金工程学院陕西西安710055 陕西龙门钢铁有限责任公司陕西韩城715405

直接轧制工艺中常存在铸坯头尾温差大的问题,控制铸坯温度的均匀性有利于减小棒材性能波动,对棒材生产具有重要意义。利用数值模拟研究了铸坯切断后不同部位的温度场变化,发现3 m/min拉速下,铸坯切断后头尾表面温差约为85℃,且其随运输... 详细信息

直接轧制工艺中常存在铸坯头尾温差大的问题,控制铸坯温度的均匀性有利于减小棒材性能波动,对棒材生产具有重要意义。利用数值模拟研究了铸坯切断后不同部位的温度场变化,发现3 m/min拉速下,铸坯切断后头尾表面温差约为85℃,且其随运输时间增加而减小,但运输时间过长会导致铸坯温度无法满足轧制要求。针对铸坯头尾温差大的问题,提出了在连铸切割机后增设阶段冷却装置,同样利用数值模拟研究了增设阶段冷却装置对铸坯温度场的影响。结果表明,增设阶段冷却装置可有效减小连铸坯头尾温差,水流密度与铸坯长度基本呈抛物线关系,出冷却装置时的连铸坯头尾温差降低至约35℃,粗轧机入口处铸坯中部的芯表温差减小约9℃,尾部的芯表温差增大约19℃,阶段冷却装置对芯表温差的影响基本消除。根据计算结果对阶段冷却装置的关键工艺参数进行设计,利用某企业生产线进行阶段应用试验,对棒材屈服强度和抗拉强度等力学性能进行研究,发现屈服强度和抗拉强度的波动范围为30 MPa,棒材性能均匀性得到有效控制,同时棒材屈服强度远高于415 MPa的要求,为减少炼钢过程的合金消耗提供了有利条件。研究结果为阶段冷却装置实际应用提供参考和依据,同时为钢铁企业控制铸坯头尾温差和棒材性能均匀性提供了新思路。

关键词：方坯连铸直接轧制数值模拟头尾温差力学性能

Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 233-243页

作者： hongmin LU Tiantian guo Yue ZHANG Dewang LIU Lulu HOU Chengxue MA Mingwei XING College of Wildlife and Protected Area Northeast Forestry UniversityHarbin 150040China

Microplastics(MPs)have attracted growing attention worldwide as an increasingly prevalent environmental *** addition,chicken meat is currently the most widely consumed kind of poultry in the global *** demand for chicken is on the rise both at home and *** a result,the safety of chicken raising has also received significant *** lungs play an essential role in the physiological activities of chickens,and they are also the most vulnerable *** injury is difficult to repair after the accumulation of contaminants,and the mortality rate is high,which brings huge economic losses to *** research on the toxicity of MPs has mainly focused on the marine ecosystem,while the mechanisms of toxicity and lung damage in chickens have been poorly ***,this study explored the effects of exposure to polystyrene microplastics(PS-MPs)at various concentrations for 42 d on chicken ***-MPs could cause lung pathologies and ultrastructural abnormalities,such as endoplasmic reticulum(ER)swelling,inflammatory cell infiltration,chromatin agglutination,and plasma membrane ***,PS-MPs increased the expression of genes related to the heat shock protein family(Hsp60,Hsp70,and Hsp90),ER stress signaling(activating) transcription factor 6(ATF0),ATF4,protein kinase RNA-like ER kinase(PERK),and eukaryotic translation initiation factor 2 subunitα(eIF2a),pyroptosis-related genes(NOD)-,LRR-and pyrin domain-containing protein 3(NLRP3),apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC),interleukin-1β(IL-1β),cysteinyl aspartate-specific proteinase 1(Caspasel),and gasdermin-D(GSDMD),and the inflammatory signaling pathway(nuclear factor-kB(NF-kB),inducible nitric oxide synthase(iNOS),and cyclooxygenase-2(COX-2).The above results showed that PS-MP exposure could result in lung stress,ER stress,pyroptosis,and inflammation in *** findings provide new scientific clues for further research o

关键词： Polystyrene microplastics Endoplasmic reticulum stress Lung NLRP3 inflammasome Inflammation

Identification of prognostic molecular subtypes and model based on CD8+ T cells for lung adenocarcinoma

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BIOCELL 2024年第3期48卷 473-490页

作者： hongmin CAO YING XUE FEI WANG GUANGYAO LI YULAN ZHEN JINGWEN guo Internal Medicine-Oncology Dongguan Songshan Lake Central HospitalDongguan523326China Tumor Center First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguan523888China

Background:Cytotoxic T lymphocytes(CD8+T)cells function critically in mediating anti-tumor immune response in cancer *** the speciﬁc functions of CD8+T cells in lung adenocarcinoma(LUAD)could help better understand local anti-tumor immune responses and estimate the effect of ***:Gens related to CD8+T cells were identiﬁed by cluster analysis based on the single-cell sequencing data of three LUAD tissues and their paired normal *** gene co-expression network analysis(WGCNA),consensus clustering,differential expression analysis,least absolute shrinkage and selection operator(LASSO)and Cox regression analysis were conducted to classify molecular subtypes for LUAD and to develop a risk model using prognostic genes related to CD8+T *** of the genes in the prognostic model,their effects on tumor cell invasion,and interactions with CD8+T cells were veriﬁed by cell ***:This study deﬁned two LUAD clusters(CD8+0 and CD8+1)based on CD8+T cells,with cluster CD8+0 being signiﬁcantly associated with the prognosis of *** heterogeneous subtypes(clusters 1,2,and 3)differing in prognosis,genome mutation events,and immune status were categorized using 42 prognostic genes.A prognostic model created based on 11 signiﬁcant genes(including CD200R1,CLEC17A,ZC3H12D,GNG7,SNX30,CDCP1,NEIL3,IGF2BP1,RHOV,ABCC2,and KRT81)was able to independently estimate the death risk for patients in different LUAD ***,the model also showed general applicability in external validation ***-risk patients could beneﬁt more from taking immunotherapy and were signiﬁcantly related to the resistance to anticancer *** results from cell experiments demonstrated that the expression of CD200R1,CLEC17A,ZC3H12D,GNG7,and SNX30 was signiﬁcantly downregulated,while that of CDCP1,NEIL3,IGF2BP1,RHOV,ABCC2 and KRT81 was upregulated in LUAD *** of CD200R1 greatly increased the invasiveness of the LUAD cell

关键词： CD8+T cell Lung adenocarcinoma Molecular subtype Prognostic model Immunotherapy

Remaining oil distribution characteristics in an oil reservoir with ultra-high water-cut

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Energy Geoscience 2024年第1期5卷 219-223页

作者： hongmin Yu Youqi Wang Li Zhang Qingxin Zhang Zhenhai guo Benzhe Wang Tao Sun SINOPEC Petroleum Exploration and Development Research Institute Beijing100083China Shengli Oil Production Plant SINOPEC Shengli Oilfield BranchDongyingShandong257051China

An accurate mapping and understanding of remaining oil distribution is very important for water control and stabilize oil production of mature oilfields in ultra-high water-cut ***,the Tuo-21 Fault Block of the Shengtuo Oilfield has entered the stage of ultra-high water cut(97.2%).Poor adaptability of the well pattern,ineffective water injection cycle and low efficiency of engineering measures(such as workover,re-perforation and utilization of high-capacity pumps)are the significant problems in the ultra-high water-cut *** order to accurately describe the oil and water flow characteristics,relative permeability curves at high water injection multiple(injected pore volume)and a semiquantitative method is applied to perform fine reservoir simulation of the Sand group 3e7 in the *** accurate reservoir model is built and history matching is *** distribution characteristics of remaining oil in lateral and vertical directions are quantitatively simulated and *** results show that the numerical simulation considering relative permeability at high injection multiple can reflect truly the remaining oil distribution characteristics after water flooding in an ultrahigh water-cut *** distribution of remaining oil saturation can be mapped more accurately and quantitatively by using the‘four-points and five-types’classification method,providing a basis for potential tapping of various remaining oil types of oil reservoirs in late-stage of development with high water-cut.

关键词： Ultra-high water-cut High water injection multiple Four-points and five-types Numerical simulation Remaining oil distribution

Fibroblast growth factor 9 promotes kidney cell proliferation via WNT signaling-mediated activation of ANXA4

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BIOCELL 2021年第4期45卷 985-994页

作者： TING LI XINHUI SUN NANNAN LI hongmin guo School of Bioengineering Wuhu Institute of TechnologyWuhu241003China Department of Reproductive Medicine Liaocheng People’s HospitalLiaocheng252000China

Fibroblast growth factors(FGFs)play pivotal roles in cell migration and ***,the identity of the FGF that plays a dominant role in kidney cell proliferation remains ***,in this study,we investigated the dominant FGF among all *** this end,RNA-sequencing,qRT-PCR,western blotting,and ChIP assays were ***9 showed the highest expression among all FGFs,and its overexpression significantly promoted proliferation in the mouse kidney cell line C57BL/6 and increased JNK and AKT phosphorylation ***,RNA-seq analysis identified 365 upregulated and 276 downregulated genes in FGF9-overexpressed *** differentially expressed genes were classified primarily into 20 biological pathways and were enriched in 31 gene ontology ***-PCR revealed that the expression of WNT and NF-κB signaling genes,as well as ANXA4 expression patterns,correlated with the RNA-seq data,while FGF9-overexpressed cells accumulated moreβ-catenin,a key WNT signaling protein,compared to control ***,downregulation of the gene that encodesβ-catenin or ANXA4 inhibited C57BL/6 cell ***,the expression of ANXA4 was lower in CTNNB1-knockdown cells than in the control ***,the ChIP assay revealed that a transcription factor complex containing TCF4 andβ-catenin directly binds to the ANXA4 *** together,these results suggest a role of FGF9 in the regulation of kidney cell *** findings may prove useful in the development of future therapies.

关键词： Fibroblast growth factor Kidney cell Proliferation ANXA4 WNT

Innovations in metallurgical and materials processes:advancing liquid theory and honoring ***-jie guo's contributions to physical chemistry in metallurgy

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Journal of Iron and Steel Research(International) 2024年第1期31卷 1-2页

作者： Shuai Liu Jing guo Han-jie guo School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China

Spanning three decades,***-jie guo's research group has dedicated itself to exploring the fundamental theories and practical applications of physical chemistry within the realm of *** under the assumption that molecul... 详细信息

关键词： chemistry liquid complexes

Composition and phase structure dependence of mechanical and magnetic properties for AlCoCuFeNi_x high entropy alloys

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Journal of Materials Science & Technology 2019年第6期35卷 1175-1183页

作者： Cong Liu Wenyi Peng C.S. Jiang hongmin guo Jun Tao Xiaohua Deng Zhaoxia Chen School of Materials Science and Engineering Nanchang University Nanchang 330031 China Institute of Space Science and Technology. Nanchang University Nanchang 330031 China

In this study, the effects of composition and phase constitution on the mechanical properties and magnetic performance of AlCoCuFeNix(x = 0.5, 0.8, 1.0, 1.5, 2.0, 3.0 in molar ratio) high entropy alloys(HEAs)were investigated. The results show that Ni element could lead to the evolution from face centered cubic(FCC), body centered cubic(BCC) and ordered BCC coexisting phase structure to a single FCC phase. The change of phase constitution enhances the plasticity but reduces the hardness and strength. One of the interesting points is the excellent soft magnetic properties of AlCoCuFeNixHEAs. Soft magnetic performance is dependent on composition and phase transition. AlCoCuFeNi1.5 alloy, achieving a better balance of mechanical and magnetic properties, could be applied as structure materials and soft magnetic materials(SMMs). High Curie temperature(>900 K) and strong phase stability below 1350 K of AlCoCuFeNi0.5 alloy confirm its practicability in a high-temperature environment. Atomic size difference(δ) is utilized as the critical parameter to explain the lattice strain and phase transformation induced by Ni addition.

关键词： High entropy alloy Phase transformation Mechanical property Soft magnetic performance Atomic size difference