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Bullous pemphigoid associated with acquired hemophilia A: A case report

World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-Jia Hao Xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu Ying Xu pan-pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

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CEPT污泥发酵液强化前置反硝化生物滤池脱氮研究

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水处理技术 2025年第1期51卷 120-127页

作者：潘雷王琳中国海洋大学环境科学与工程学院山东青岛266000

考察不同运行参数对前置反硝化生物滤池工艺处理性能的影响,综合考虑最佳HRT为4 h,硝化液回流比为100%,投加乙酸钠调节COD/TN为5。在上述最佳条件下,采用CEPT污泥发酵液作碳源各污染物的去除效率相较于乙酸钠虽然都有所降低,但是基本能... 详细信息

考察不同运行参数对前置反硝化生物滤池工艺处理性能的影响,综合考虑最佳HRT为4 h,硝化液回流比为100%,投加乙酸钠调节COD/TN为5。在上述最佳条件下,采用CEPT污泥发酵液作碳源各污染物的去除效率相较于乙酸钠虽然都有所降低,但是基本能够满足出水要求;发酵液的平均比反硝化速率仅仅略低于乙酸钠,这进一步证明了发酵液作为反硝化碳源的可行性。微生物群落组成分析表明Y-A组中的绿弯菌和放线菌比F-A组高,这可能能解释乙酸钠的脱氮效果优于污泥发酵液;功能分析表明F-A组与Y-A组各代谢通路丰度相当,Y-A组的napAB+narGHI、nirKS相对丰度比F-A组略高,这可能是添加乙酸钠相较于CEPT污泥发酵液具有更强的反硝化性能的原因之一。

关键词： CEPT污泥发酵液前置反硝化生物滤池碳源微生物群落组成和功能

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Physarum polycephalum-inspired adaptive optimization design of artificial microtubular networks

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Science China Chemistry 2025年

作者： Si-Min Zeng Di-Wei Zheng Ting pan Xing-Lan Ding Yun Zhang Chi-Hui Yang Si-Xue Cheng Xian-Zheng Zhang Key Laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan University

Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum(P. polycephalum) extends continuously to form a protoplasmic microtubular network structure, directly connecting food *** simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine B diffusion and glucosecatalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid(UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase(UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.

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前期东北大西洋-地中海西部海温异常影响河南省干热风的可能途径

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高原气象 2025年第1期44卷 150-162页

作者：竹磊磊苏晓乐潘攀吴璐杨婷中国气象局•河南省农业气象保障与应用技术重点开放实验室河南郑州450003 河南省气候中心河南郑州450003

河南省是中国冬小麦的主产区,也是较易受干热风影响的地区。目前对干热风的研究和预报多在天气尺度,从气候的角度研究干热风是否具有可预报性,具有非常重要的意义。本文基于河南省干热风资料、NCEP/NCAR再分析资料和哈得莱环流中心海温... 详细信息

河南省是中国冬小麦的主产区,也是较易受干热风影响的地区。目前对干热风的研究和预报多在天气尺度,从气候的角度研究干热风是否具有可预报性,具有非常重要的意义。本文基于河南省干热风资料、NCEP/NCAR再分析资料和哈得莱环流中心海温资料,分析了1980-2022年前期海温异常与河南省干热风日数的关系,及其可能影响途径。结果表明:(1)豫北、豫西北和豫中多年平均干热风日数较多,其他地区则相对较少。日干热风出现的概率由南向北、由5月下旬至6月上旬逐渐增加。全省平均干热风日数有显著增加趋势。(2)河南省干热风日数与当年3-4月东北大西洋-地中海西部(关键区)海温在年代际和年际尺度上均存在着密切相关,两者与干热风发生时段500 hPa高度场在去趋势前和去趋势后的显著正相关区在东亚中纬度地区位于新疆北部至贝加尔湖尔湖北部,显著负相关区位于我国东北至日本群岛附近,与850 hPa风场在去趋势前和去趋势后的相关在上述正、负显著相关区分别呈反气旋和气旋分布,气旋后部呈偏北风的显著相关,即3-4月关键区高海温年,出现的蒙古高压脊和东亚大槽造成了河南省的干热风天气。海温与环流场的相关在去趋势前和去趋势后在中纬度地区呈现出一个更明显的由东北大西洋经欧亚大陆至东北亚的纬向遥相关波列。(3)西太平洋副热带高压(以下简称副高)偏南(北)时,干热风日数易偏多(少),而3-4月关键区高(低)海温则可以导致副高偏南(北)。(4)干热风偏多年和偏少年、3-4月关键区高海温年和低海温的干热风发生时段30°N-55°N经向平均的涡度差值,及高、低海温年的干热风发生时段500 hPa准地转流函数距平和波作用通量均显示在中纬度地区存在自东北大西洋至东北亚的纬向波列。也即表明,3-4月关键区海温可以激发出一个后期干热风发生时段的类似波列,经欧亚大陆传至东北亚,而高海温年在东亚中纬度地区的环流分布造成了河南省的干热风天气。

关键词：干热风东北大西洋地中海西部海温遥相关波列

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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian Tang Yuan-Ming pan Wei Li Rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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Quantitative reconstruction of salinity and precipitation changes in Central Asia over the past 3200 years using diatom and pollen records of lacustrine sediment in Aibi Lake of SW Junggar Basin

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Journal of Earth Science 2025年

作者： Long pan Guoqiang Li Xiaoyan Wang Ming Jin Xinrong He Luo Qin Zhong Wang Wenwei Zhao Chunzhu Chen Yuanlu Liu Jin Yang Lele Shu Key Laboratory of Western China's Environmental Systems (Ministry of Education)， College of Earth and Environmental Sciences， Lanzhou University College of Earth Sciences， Chengdu University of Technology School of Geographic Science， Nantong University Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions， Northwest Institute of Eco-Environment and Resources， Chinese Academy of Sciences

The response of lake environments in arid Central Asia to climate change during the Late Holocene over the centennial to millennial timescales remains contentious. The reason that primarily paleoenvironmental proxies interpreting diverse and the scarcity of accurate quantitative reconstruction records. In this study， we employed diatoms and pollen records from lacustrine sediment in the Aibi Lake of SW Junggar Basin to quantitatively reconstruct salinity and watershed precipitation amounts while exploring the associated forcing mechanism. The results indicate that Aibi Lake salinity varied between 2 g/L and 47 g/L during the Late Holocene period， indicating a generally brackish environment， and corresponding to prevailing Tryblionella granulata diatom in the lake basin. Westerly-dominated annual precipitation varied between 250 mm and 320 mm during the Late Holocene period in the basin， exhibiting a generally semi-arid environment and prevailing desert steppe vegetation. The Aibi Lake has a low salinity of average value of ～15 g/L. It exhibits elevated precipitation (average value of ～280 mm) during the periods of the Roman Warm Period (2900-1990 cal yr BP)， Dark Age Cold Period (1570-1140 cal yr BP)， and Little Ice Age (590-120 cal yr BP). The reconstructed precipitation and salinity exhibit a periodicity of ～200 years， which is consistent with the cycle of phase changes of the North Atlantic Oscillation (NAO) and Total Solar Irradiance (TSI). This correlation suggests that variations in NOA and TSI significantly influence the precipitation and salinity changes in Central Asia over centennial to millennial timescales.

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Automatic calculation of the magnetometer zero offset using the interplanetary magnetic field based on the Wang-pan method

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Earth and Planetary Physics 2022年第1期6卷 52-60页

作者： XiaoWen Hu GuoQiang Wang ZongHao pan Chinese Academy of Sciences Key Laboratory of Geospace Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Institute of Space Science and Applied Technology Harbin Institute of TechnologyShenzhen 518055China

The space-borne fluxgate magnetometer(FGM)requires regular in-flight calibration to obtain its zero ***,Wang GQ and pan ZH(2021a)developed a new method for the zero offset calibration based on the properties of Alfvén *** found that an optimal offset line(OOL)exists in the offset cube for a pure Alfvén wave and that the zero offset can be determined by the intersection of at least two nonparallel *** no pure Alfvén waves exist in the interplanetary magnetic field,calculation of the zero offset relies on the selection of highly Alfvénic fluctuation ***,we propose an automatic procedure to find highly Alfvénic fluctuations in the solar wind and calculate the zero *** procedure includes three parts:(1)selecting potential Alfvénic fluctuation events,(2)obtaining the OOL,and(3)determining the zero *** tested our automatic procedure by applying it to the magnetic field data measured by the FGM onboard the Venus *** tests revealed that our automatic procedure was able to achieve results as good as those determined by the Davis-Smith *** advantage of our procedure is that the selection criteria and the process for selecting the highly Alfvénic fluctuation events are *** automatic procedure could also be applied to find fluctuation events for the Davis-Smith method.

关键词： fluxgate magnetometer in-flight calibration zero offset highly Alfvénic fluctuations automatic procedure

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大邻域多约束无人机数据收集路径规划

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计算机科学与探索 2025年第1期19卷 158-168页

作者：潘淼鑫陈崇成福建师范大学计算机与网络空间安全学院福州350117 数字福建大数据安全技术研究所福州350117 福建省高校大数据分析与应用工程技术研究中心福州350117 福州大学地理空间信息技术国家地方联合工程研究中心福州350116

在公网受限的应急环境中,利用无人机辅助物联网能促进传感数据的及时传递。当考虑无线通信距离时,无人机作为移动收集器在有限续航时间内收集尽可能多的传感数据的路径规划可建模为足够近定向问题(CEOP)。现有求解CEOP的算法是逐个计算... 详细信息

在公网受限的应急环境中,利用无人机辅助物联网能促进传感数据的及时传递。当考虑无线通信距离时,无人机作为移动收集器在有限续航时间内收集尽可能多的传感数据的路径规划可建模为足够近定向问题(CEOP)。现有求解CEOP的算法是逐个计算目标节点的访问顺序及其邻域内的采集点,这在节点邻域较大并覆盖周围多个节点时效率低下,这些方法也没有考虑数据传输时间和无人机遥控距离等约束。为此,建立了大邻域多约束无人机数据收集路径规划的数学模型,提出了基于贪婪随机自适应搜索过程(GRASP)的GRASP-LN算法进行求解。该算法不重复计算重合的采集点,而是维护路径每个航点采集的节点集合,无人机在每个航点悬停一段时间以收集集合内节点的数据。公开的CEOP数据集的实验结果表明,GRASP-LN比GSOA、VNS和GRASP_(opt)具有更好的求解质量和更短的计算时间。与基线算法GRASP_(opt)相比,GRASP-LN的路径奖励平均提高了5.86%,最大提高了14.91%,执行时间平均减少了69%,特别在节点邻域平均覆盖4.67个以上节点时,GRASP-LN的路径奖励和稳定性均优于GRASP_(opt)。考虑数据传输时间和无人机遥控距离约束的实验验证了GRASP-LN算法对考虑这些约束的无人机数据收集路径规划问题的有效性。

关键词：无人机贪婪随机自适应搜索过程数据收集足够近定向问题路径规划物联网

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非物质文化遗产系统性保护的措施

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中国非物质文化遗产 2025年第1期 14-21页

作者：潘鲁生中国文学艺术界联合会中国民间文艺家协会

非物质文化遗产系统性保护的学理性研究是保护落实的基础。理清家底与资源存量,总结发展经验,有利于推进系统性保护措施落实,形成非物质文化遗产保护与传承的社会氛围,提升公众参与度,使文化遗产项目回归生活。发挥数字技术与产业力量,... 详细信息

非物质文化遗产系统性保护的学理性研究是保护落实的基础。理清家底与资源存量,总结发展经验,有利于推进系统性保护措施落实,形成非物质文化遗产保护与传承的社会氛围,提升公众参与度,使文化遗产项目回归生活。发挥数字技术与产业力量,合理开发,适度应用,以系统性保护适应不同类目发展需要,促进非物质文化遗产资源创造性转化,实现可持续发展。非物质文化遗产系统性保护的宏观规划与微观举措,都要落实于国家、团体、个人权益保护,使传承人成为非物质文化遗产系统性保护的最大受益者,成为传承创新的最大活力来源。完善相关立法,以法律保护文化遗产本身及其传承环境。加强传承群体知识产权保护意识形成有益于文化遗产传承的发展环境,在适应社会需求中实现创新和衍生。

关键词：非物质文化遗产系统性保护传承权益保护创新发展

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收获工况对甘蔗联合收获机关键机构功耗的影响

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农机化研究 2025年第3期47卷 35-40页

作者：冯玉珍潘明章梁科唐永治潘荥春广西大学机械工程学院南宁530004 广西大学亚热带农业生物资源保护与利用国家重点实验室南宁530004 广西柳工农业机械股份有限公司广西柳州545007

为提高甘蔗联合收获机对不同收获天气、不同甘蔗疏密程度,以及不同收获地形的适应性,将甘蔗联合收获机的收获工况分为晴天收获、雨天收获、甘蔗密度较疏收获、甘蔗密度较密收获、上坡收获和下坡收获6种工况,并对其关键机构进行功耗研究... 详细信息

为提高甘蔗联合收获机对不同收获天气、不同甘蔗疏密程度,以及不同收获地形的适应性,将甘蔗联合收获机的收获工况分为晴天收获、雨天收获、甘蔗密度较疏收获、甘蔗密度较密收获、上坡收获和下坡收获6种工况,并对其关键机构进行功耗研究。田间试验结果可为甘蔗联合收获机的动力系统设计和动力分配提供依据。

关键词：甘蔗联合收获机载荷特征功率分配

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