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介质微球超分辨光学成像:原理、技术与应用

北京工业大学学报 2025年第1期51卷 100-120页

作者：李红梅闫胤洲蒋毅坚北京工业大学机械与能源工程学院北京100124 北京工业大学物理与光电工程学院北京100124

光学显微技术在生物学、医学、材料学、精密测量学等领域扮演着至关重要的角色,为微纳尺度的探索提供了强大的工具。然而,传统光学显微系统受到衍射极限的制约,最大分辨率极限约为光波长的一半(λ/2)。近年来,突破衍射极限、实现更高成... 详细信息

光学显微技术在生物学、医学、材料学、精密测量学等领域扮演着至关重要的角色,为微纳尺度的探索提供了强大的工具。然而,传统光学显微系统受到衍射极限的制约,最大分辨率极限约为光波长的一半(λ/2)。近年来,突破衍射极限、实现更高成像分辨率成为显微成像领域的研究热点。介质微球透镜通过调控光场,能够将入射光束聚焦于微球底部的极窄区域形成光子纳米射流,打破了阿贝(Abbe)衍射极限,使出射光束半峰全宽小于λ/2。与其他超分辨成像技术相比,微球超分辨成像具有简单直接、无须荧光染料标记、实时成像、可与现有显微系统相兼容等优势,为学术研究和实际应用开辟了新的机遇。该综述首先介绍了介质微球超分辨光学成像原理;随后,详细分析了影响微球超分辨光学成像能力的关键因素,包括微球光学性质、适用环境以及可控性等;最后,探讨了微球超分辨光学成像技术在生物医学、半导体器件、纳米材料科学领域中的应用。此外,还展望了微球超分辨光学成像技术未来发展面临的主要挑战。

关键词：介质微球透镜超分辨成像光学纳米成像远场纳米显微镜光子纳米射流非荧光纳米显微镜

Plasmon-induced local electric field improved hydrogen evolution reaction on Ag/Mo_(2)C nanosheets

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Nano Research 2025年第1期18卷 270-277页

作者： HuangJingWei li Xin Zi Jun Wu Xinli Wang li Zhu Qiyou Wang Jianfu Han Junwei Fu hongmei li Kai Huang Yu Chen Min liu School of Physics State Key Laboratory of Powder MetallurgyHunan Joint International Research Center for Carbon Dioxide Resource UtilizationCentral South UniversityChangsha 410083China School of Metallurgy and Environment Central South UniversityChangsha 410083China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Nano-Institute Munich Faculty of PhysicsLudwig-Maxilimians-Universität MünchenMünchen 80539Germany Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China

Electrocatalytic water splitting offers a promising way for hydrogen production with near-zero ***,such as molybdenum carbides(Mo_(2)C),are promising materials for hydrogen evolution reaction(HER)but still suffer from poor intrinsic water activation ***,we developed a plasmon-induced local electric field(PILEF)strategy to solve this ***(Ag)nanoparticles decorated Mo_(2)C nanosheets(Ag/Mo_(2)C)were successfully prepared by electrostatic *** visible light excited the PILEF on Ag/Mo_(2)C remarkably reducing the activation energy by 92.7 kJ·mol^(-1)from 147.3 kJ·mol^(-1)of Mo_(2)C to 54.6 kJ·mol^(-1).As a result,the plasmonic Ag/Mo_(2)C significantly enhances~2.3-fold of the current density from 2.8 mA·cm^(-2)of Mo_(2)C to 6.5 mA·cm^(-2)at-3 V *** and reduces the overpotential by 104 mV from 403 mV of dark state to 299 mV of light state at the current density of 10 mA·cm^(-2),achieving better performance than reported *** research demonstrates that PILEF enhances HER activities,offering a potential strategy for boosting the intrinsic activities of catalysts.

关键词： sliver particles plasmon effect field effect hydrogen evolution reaction(HER) electrocatalysis

Photosensitivity in Ce/Sm-decorated Keggin polyoxomolybdates:an interesting photoinduced coloration phenomenon of mixed- metal clusters involving energy transfer from rare-earth fluorescence

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Science China Chemistry 2014年第6期57卷 918-922页

作者： liU li li hongmei DAI JingCao Institute of Materials Physical Chemistry Huaqiao University

Ce/Sm ions are covalently grafted to a Keggin polyoxomolybdate cluster[PMo12O40]3-to yield interesting fluorescent-photodarkening molecular *** photoresponce processes are observed to be activated via energy transfer ... 详细信息

关键词： lanthanide-decorated polyoxomolybdates photocoloration solar-furnace photoactivation energy transfer

Nutrient Structure of the Taiwan Warm Current and Estimation of Vertical Nutrient Fluxes in Upwelling Areas in the East China Sea in Summer

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Journal of Ocean University of China 2014年第4期13卷 613-620页

作者： SHI Xiaoyong li hongmei WANG Hao College of Chemistry and Chemical Engineering Ministry of Education Ocean University of China Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education Ocean University of China National Marine Hazard Mitigation Service Fujian Marine Environment and Fishery Resource Monitoring Center

Based on field data for nutrients collected on the continental shelf of the East China Sea(ECS) during summer 2006, the structure and variations of nutrients in every water mass related to the Taiwan Warm Current(TWC) were analyzed. The supplementary effect of nutrient of upwelling on harmful algal blooms(HABs) in the ECS was also estimated, based on upwelling data. Then the maintenance contribution of nutrient of upwelling to HABs was assessed. The results showed that N/P ratio is fairly low in both surface and deep layers of the TWC, which possibly controls nutrient structure of the HABs-frequently-occuring areas. In upwelling areas, the rate of phosphate(PO4-P) uptake exceeds that of nitrate(NO3-N) of the TWC. The TWC may relieve PO4-P limitation during the process of HABs. Furthermore, upwelling plays an important role in providing nutrients to HABs. After estimating nutrient fluxes(NO3-N, PO4-P, Si O3-Si) in the upwelling areas along a typical section(S07), the results showed that the nutrient uptake rate is the greatest at 10-20 m below euphotic zone, sustaining the ongoing presence of HABs. The uptake rate of PO4-P is the highest among dissolved inorganic nutrients. Therefore, upwelling is most likely the main source of PO4-P supply to HABs.

关键词： nutrient structure flux Taiwan Warm Current upwelling East China Sea

Progress in the research of GSH in cells

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Chinese Science Bulletin 2011年第28期56卷 3057-3063页

作者： ZHAO hongmei RUAN HaiHua li HongTao Tianjin Key Laboratory of Food Biotechnology College of Biotechnology and Food Science Tianjin University of Commerce Tianjin 300134China

Glutathione (GSH), γ-Glu-Cys-Gly, is one of the most abundant small non-protein thiol molecules in mammalian tissues, particu- larly in the liver. Although glutathione is present in thiol-reduced (GSH) and disulfide oxidized (GSSG) forms, the predominant form is GSH and its content can exceed 10 mmol/L in liver cells. As an important intracellular reductant, GSH has many biological functions in cells. Its major function is as an anti-oxidant as it can protect proteins from oxidation by reversible posttranslational modification (glutathionylation) and decrease reactive oxygen species-mediated damage. However, it does have numerous other functions, including to chelate metal irons; enhance the absorption of iron, selenium and calcium; participate in lipid and insulin metabolism; regulate cellular events such as gene expression, DNA and protein synthesis, cell proliferation and apoptosis, redox-dependent signal transduction pathways, cytokine production and the immune response; and control protein glutathionylation. Therefore, GSH plays important roles in cell survival and health, and an imbalance in the GSH level can lead to many diseases. In this review, we provide an overview of the function of GSH in mammalian cells and discuss future research of GSH.

关键词： GSH 细胞内哺乳动物细胞抗氧化剂信号转导通路谷胱甘肽蛋白质半胱氨酸

p75NTR signal transduction suppressed by BFAR and p75NTR interactions

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Science China(life Sciences) 2012年第4期55卷 367-374页

作者： li hongmei SHI Huili HUO KeKe State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai 200433 China

p75NTR is a low-affinity nerve growth factor receptor, which promotes cell proliferation as a positive modulator of high-affinity receptor TrkA, as well as binds with cell ligands to induce apoptosis and mediate death signals. To analyze the regulatory mechanisms of p75NTR, the present study utilized a new membrane yeast two-hybrid system to screen a human fe- tal brain cDNA library. Results identified BFAR, a novel protein that interacts with p75NTR. Interaction specificity was veri- fied by membrane yeast two-hybrid co-transformation assays, in vitro GST pull-down assays, and in vitro co-irnmunopreci- pitation assays. The fluorescent subcellular localization assay revealed that the two proteins co-localized within the cytoplasm. BFAR overexpression in PC-12 and HEK293T cells inhibited the NFnB and JNK signaling pathway, as determined with the luciferase test. Co-transfected p75NTR and BFAR in HEK293T or PC-12 cells, respectively, increased the percentage of cells in the G2/M phase, decreased the number of S-phase cells, and did not change the number of G0/Gl-phase cells.

关键词： p75NTR BFAR membrane yeast two-hybrid protein-protein interaction apoptosis

Efficacy of Yiqigubiao pill on chronic obstructive pulmonary disease in rats with the disease induced by lipopolysaccharide and cigarette-smoke fumigation

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Journal of Traditional Chinese Medicine 2020年第6期40卷 983-991页

作者： Jiang lin li Fengsen Sun Jianhui Huo Hairu li Xiaoqin li hongmei Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region Urumqi830000China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE:To investigate the efficacy of Yiqigubiao pill(YQGB)on chronic obstructive pulmonary disease(COPD)in rats with the COPD induced by lipopolysaccharide(LPS)and cigarettesmoke ***:In this study,six groups of rats were set up,including control group,model group,positive control group(aminophylline)and YQGB(high,medium and low doses)*** injection of lipopolysaccharide(LPS)and cigarette-smoke fumigation induced COPD in *** general condition,incubation period and coughing times,lung function,level of inflammatory factors,leukocyte condition and pathological changes of bronchus and lung tissue were observed in rats of each ***:In the COPD rats,the latent period of coughing was shortened and the cough frequency was increased significantly;the pulmonary function was significantly decreased,which was manifested by the increased lung tissue resistance and respiratory system resistance,and the decreasing percentage of forced expiratory volume and forced expiratory volume in the 0.3 s(FEV0.3/FVC);the contents of tumor necrosis factor-alpha(TNF-α)and interleukin-4 in serum were obviously increased,and the NEUT%in bronchoalveolar lavage fluid was significantly *** could obviously prolong the latent period of cough,and reduce the cough frequency and the content of TNF-αin *** can also significantly reduce respiratory resistance and increase FEV0.3/FVC *** results of histopathology showed that YQGB significantly reduced the pathological changes of tracheal mucosa and lung caused by *** obviously increased level of AQP1,which was down-regulated in the COPD ***:YQGB could significantly improve the pulmonary function,reduce inflammation and alleviate lung and bronchial diseases in the COPD rats.

关键词： Pulmonary disease chronic obstructive Respiratory function tests Bronchoalveolar lavage fluid Inflammatory cytokines Yiqigubiao pill

Effect of acupuncture therapies combined with usual medical care on knee osteoarthritis

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Journal of Traditional Chinese Medicine 2019年第1期39卷 103-110页

作者： Zhang Lele Yuan Haixin Zhang Lei li Jian li hongmei The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and TechnologyLuoyang 471003China

OBJECTIVE: To observe the effect of acupuncture or electroacupuncture(EA) combined with usual medical care for treating knee osteoarthritis(KOA).METHODS: A total of 90 patients with KOA were randomly allocated to 3 groups: usual care group(UC group, n = 30) was treated by pharmacological treatment of non-steroidal anti-inflammatory drugs(NSAIDs) and drugs for activating blood circulation(Ds-ABC), acupuncture(AP) combined with usual care group(UC group)(AP + UC group, n =30) and EA combined with UC group(EA + UC group, n = 30). The primary outcome measurements included pain visual analogue scale/score(VAS), Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC Index) and its subscales. Secondary outcome measurement was Assessment of Quality of life instrument version of the 36-item Short Form Health Survey(AQoL-SF36).RESULTS: By the end of the 1 st week, AP + UC group and EA + UC group exhibited statistically significant improvements in primary outcome measures, except for WOMAC stiffness, compared with the UC group(P < 0.05). Moreover, the energy/fatigue domain of AQoL-SF36 in the AP + UC group showed better results than UC group(P < 0.05). By the end of the 2 nd week, all the primary outcome measures revealed that either the AP + UC or EA +UC group demonstrating remarkable advantages compared with the UC group(P < 0.05). The social functioning and general health domains of AQoLSF36 in the two acupuncture-intervention groups were improved significantly than UC group(P <0.05). We also found the energy/fatigue and emotional wellbeing domains of AQoL-SF36 in the EA +UC group demonstrated better results than UC group(P < 0.05).CONCLUSION: AP or EA combined with usual care is more effective than usual care alone for the treatment of KOA, the intervention of electric current in the process of acupuncture may improve more domains of AQoL-SF36 in KOA patients.

关键词： Osteoarthritis,knee Acupuncture Electroacupuncture Pain measurement

An estimation of nutrient fluxes to the East China Sea continental shelf from the Taiwan Strait and Kuroshio subsurface waters in summer

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Acta Oceanologica Sinica 2014年第11期33卷 1-10页

作者： li hongmei SHI Xiaoyong WANG Hao HAN Xiurong College of Chemistry and Chemical Engineering Ocean University of China National Marine Hazard Mitigation Service Fujian Marine Environment and Fishery Resource Monitoring Center

According to historical mean ocean current data through the field observations of the Taiwan Ocean Research Institute during 1991–2005 and survey data of nutrients on the continental shelf of the East China Sea（ECS） in the summer of 2006, nutrient fluxes from the Taiwan Strait and Kuroshio subsurface waters are estimated using a grid interpolation method, which both are the sources of the Taiwan Warm Current. The nutrient fluxes of the two water masses are also compared. The results show that phosphate（PO4-P）, silicate（SiO3-Si） and nitrate（NO3-N） fluxes to the ECS continental shelf from the Kuroshio upwelling water are slightly higher than those from the Taiwan Strait water in the summer of 2006. In contrast, owing to its lower velocity, the nutrient flux density（i.e., nutrient fluxes divided by the area of the specific section） of the Kuroshio subsurface water is lower than that of the Taiwan Strait water. In addition, the Taiwan Warm Current deep water, which is mainly constituted by the Kuroshio subsurface water, might directly reach the areas of high-frequency harmful alga blooms in the ECS.

关键词： nutrient flux Taiwan Warm Current summer East China Sea