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Journal of Materials Science & Technology 2014年第1期30卷 90-96页

作者： Qingping Feng Jiaoping Yang Yu Liu hongmei xiao Shaoyun Fu Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Rubbers have been well accepted for modifying brittle epoxies but rubber modified epoxies usually posses lowered tensile strength though enhanced ductility and fracture resistance. In this work, a polyethylene glycol （PEG-4000） is used to modify diglycidyl ether of bisphenol A/methyltetrahydrophthalic anhydride system for enhancing cryogenic tensile strength, ductility and impact resistance. The results display that the cryogenic tensile strength, ductility （failure strain） and fracture resistance （impact strength） are all enhanced for the modified epoxy system at proper PEG contents. The maximum tensile strength （127.8 MPa） at the cryogenic temperature （77 K） with an improvement of 30.1% is observed for the modified system with the 15 wt% PEG content. The ductility and impact resistance at both room temperature and cryogenic temperature are all improved for the modified epoxy system with proper PEG-4000 contents. These observations are explained by the positron annihilation lifetime spectroscopy results and scanning electron microscopy results. Moreover, the glass transition temperature decreases slightly with increasing PEG content.

关键词： Epoxy resin Modification Polymer composite Tensile strength

Influence of luteolin on the apoptosis of esophageal cancer Eca109 cells and its mechanism of action

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Food Science and Human Wellness 2019年第2期8卷 189-194页

作者： Shaokang Wang Lingmeng Fu Yi Wu hongmei xiao Jing Wang Guiju Sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009PR China

The present study was conducted to verify the influence of luteolin on apoptosis of Eca109 cells and to further investigate the possible mechanisms underlying its effect on *** cells were exposed to different concentrations of luteolin(0,40,80,120,160,200,240M)for 24,48,and 72 h *** influence of luteolin on proliferation of Eca109 cells was detected using MTT ***109 cells were then treated with luteolin(0,40,160,240M)for 24 *** effect of luteolin on cell cycle progression and apoptosis was assayed by using flow cytometry(FCM).Expression of caspase9 and caspase3 mRNA and protein was analyzed by real-time PCR and Western blot *** results showed that luteolin could inhibit the proliferation of Eca109 cells at all concentrations in a time-dependent manner and the relative inhibition rate showed an inverted U-shaped association with the concentration of ***,the cell cycle was arrested in the S phase following treatment with *** analysis indicated that luteolin could induce the apoptosis of Eca109 cells across the three concentration groups,which exhibited a trend of first promotional and then inhibitory with the increases in luteolin *** effect of luteolin on the mRNA and protein expression of caspase 9 and caspase3 first manifested as promotion,then ***,luteolin may serve a role in promoting cell apoptosis by inducing Eca109 cell apoptosis that involves the expression of caspase3,caspase9 mRNA and *** study provides theoretical basis for further study and clinical application of *** specific mechanism has not yet been clarified and the other activation pathways inducing apoptosis need to be further studied.

关键词： Esophageal cancer Luteolin Apoptosis

Gene interactions analysis of brain spatial transcriptome for Alzheimer's disease

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Genes & Diseases 2024年第6期11卷 525-540页

作者： Shengran Wang Jonathan Greenbaum Chuan Qiu Russell HSwerdlow Mohammad Haeri Yun Gong Hui Shen hongmei xiao Hongwen Deng Reproductive Medicine Center The Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Center for System Biology Data Sciences and Reproductive HealthSchool of Basic Medical ScienceCentral South UniversityChangshaHunan 410008China Tulane Center of Biomedical Informatics and Genomics Deming Department of MedicineTulane University School of MedicineTulane UniversityNew OrleansLA 70112USA Department of Pathology and KU Alzheimer's Disease Research Center University of Kansas Medical CenterKansas CityKS 66160USA Institute of Reproductive&Stem Cell Engineering School of Basic Medical ScienceCentral South UniversityChangshaHunan 410008China Center of Reproductive Health School of Basic Medical ScienceCentral South UniversityChangshaHunan 410008China

Recent studies have explored the spatial transcriptomics patterns of Alzheimer's disease(AD)brain by spatial sequencing in mouse models,enabling the identification of unique genome-wide transcriptomic features associated with different spatial regions and pathological ***,the dynamics of gene interactions that occur during amyloid-βaccumulation remain largely *** this study,we performed analyses on ligand-receptor communication,transcription factor regulatory network,and spot-specific network to reveal the dependence and the dynamics of gene associations/interactions on spatial regions and pathological status with mouse and human *** first used a spatial transcriptomics dataset of the AppNL-G-F knock-in AD and wild-type mouse *** revealed 17 ligand-receptor pairs with opposite tendencies throughout the amyloid-βaccumulation process and showed the specific ligand-receptor interactions across the hippocampus layers at different extents of pathological *** then identified nerve function related transcription factors in the hippocampus and entorhinal cortex,as well as genes with different transcriptomic association degrees in AD versus wild-type ***,another independent spatial transcriptomics dataset from different AD mouse models and human single-nuclei RNA-seq data/AlzData database were used for *** is the first study to identify various gene associations throughout amyloid-βaccumulation based on spatial transcriptomics,establishing the foundations to reveal advanced and in-depth AD etiology from a novel perspective based on the comprehensive analyses of gene interactions that are spatio-temporal dependent.

关键词： Alzheimer's disease Amyloid-β Ligand-receptor Spatial transcriptomics Transcription factor

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卵母细胞成熟障碍研究进展

山东大学学报（医学版） 2018年第4期56卷 18-22页

作者：肖红梅中南大学基础医学院生殖与干细胞工程研究所湖南长沙410078

卵母细胞成熟经历恢复减数分裂、生殖泡消失、排出极体等一系列复杂的生理变化与分子调节等过程,方能获得受精并发育成新个体的潜能。当卵母细胞因各种原因导致上述成熟过程发生异常时,卵母细胞无法成熟,无法完成受精过程,从而导致不孕... 详细信息

卵母细胞成熟经历恢复减数分裂、生殖泡消失、排出极体等一系列复杂的生理变化与分子调节等过程,方能获得受精并发育成新个体的潜能。当卵母细胞因各种原因导致上述成熟过程发生异常时,卵母细胞无法成熟,无法完成受精过程,从而导致不孕。随着二代测序技术的广泛应用,围绕人卵发育成熟障碍的遗传病因学研究取得突破,先后发现多个与卵母细胞成熟障碍相关的致病基因,其研究方法与思路有助于推动人卵母细胞成熟障碍的遗传与分子机制研究的进一步深入。

关键词：卵母细胞成熟障碍不孕减数分裂全外显子测序基因突变

加工过程对转Bt抗虫水稻内、外源基因的降解研究

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南京农业大学学报 2015年第4期38卷 667-675页

作者：郭帅帅肖红梅南京农业大学食品科技学院江苏南京210095

[目的]本文旨在了解不同加工方法对转Bt抗虫水稻的内、外源基因的降解作用。[方法]以转Bt抗虫水稻‘华恢1号’及其阴性对照‘明恢63’为原料,选择煮制(10、15、20、25和30 min)、高温高压处理(20、25和30 min)、米果加工(煮制、一次干... 详细信息

[目的]本文旨在了解不同加工方法对转Bt抗虫水稻的内、外源基因的降解作用。[方法]以转Bt抗虫水稻‘华恢1号’及其阴性对照‘明恢63’为原料,选择煮制(10、15、20、25和30 min)、高温高压处理(20、25和30 min)、米果加工(煮制、一次干燥、二次干燥、微波、焙烤、油炸)和米酒发酵(1、2、3和4 d)等加工方法,并针对其加工品中内源基因(SPS基因)、外源基因或元件(包括actin1启动子、Cry1Ab/Ac基因、外源基因3'端接合序列、NOS终止子)设计不同扩增片段大小的引物,PCR扩增后进行琼脂糖凝胶电泳检测。[结果]高温高压处理对转基因水稻内、外源基因的降解作用大于煮制;在米果加工中,经过煮制、一次干燥和二次干燥加工后,油炸处理对转基因水稻内、外源基因的降解作用最大,随后依次是焙烤和微波处理;在米酒加工中,经过煮制对转基因水稻内、外源基因降解后,米酒发酵过程并没有使转基因水稻内、外源基因产生进一步的降解;试验中长度小于200 bp的扩增片段均具有较高的稳定性。[结论]试验中不同形式的加工方法对水稻的内、外源基因产生了不同程度的降解作用。

关键词：转基因水稻加工内外源基因降解

聚合-热解法制备Co_(0．2)Zn_(0．2)Mn_(0．6)Fe_2O_4纳米颗粒及其表征

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金属学报 2006年第5期42卷 497-499页

作者：刘献明付绍云肖红梅李元庆中国科学院理化技术研究所

采用聚合-热解法制备了Co0．2Zn0．2Mn0．6Fe2O4磁性纳米颗粒,借助热重分析法(TG)、X射线衍射(XRD)、透射电镜(TEM)和振动样品磁强计(VSM)对产物进行了表征．结果表明,产物具有尖晶石结构,无杂相,粒径分布范围在 8-15nm之间．常温下该... 详细信息

采用聚合-热解法制备了Co0．2Zn0．2Mn0．6Fe2O4磁性纳米颗粒,借助热重分析法(TG)、X射线衍射(XRD)、透射电镜(TEM)和振动样品磁强计(VSM)对产物进行了表征．结果表明,产物具有尖晶石结构,无杂相,粒径分布范围在 8-15nm之间．常温下该材料的剩磁强度和矫顽力分别为0．516和2．388 kA／m．

关键词：纳米颗粒聚合-热解法磁性剩磁强度矫顽力

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饮茶和食管癌关系的研究进展

食品科学 2016年第23期37卷 280-284页

作者：肖红梅王少康孙桂菊东南大学公共卫生学院环境医学工程教育部重点实验室江苏南京210009

茶是除水以外消耗最多的一种饮料,在日常生活中随处可见。茶多酚是茶叶中主要的活性成分之一,研究表明,茶多酚具有抗氧化、抗肿瘤等作用,可作为癌症的保护因素。而喜食烫食可能会损伤食管黏膜,使食道上皮细胞脱落、更新加快,从而增加食... 详细信息

茶是除水以外消耗最多的一种饮料,在日常生活中随处可见。茶多酚是茶叶中主要的活性成分之一,研究表明,茶多酚具有抗氧化、抗肿瘤等作用,可作为癌症的保护因素。而喜食烫食可能会损伤食管黏膜,使食道上皮细胞脱落、更新加快,从而增加食管癌的发病风险。关于饮茶与食管癌关系的研究至今还没有得到一致的结论。本文主要从茶的消耗量、茶的种类、饮茶温度3方面对近年来茶和食管癌关系的研究进行综述,并对未来的研究重点进行展望。

关键词：饮茶食管癌茶多酚高温

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失智患者照护者获益感研究进展

中华护理杂志 2021年第12期56卷 1889-1893页

作者：肖红梅王志稳北京大学护理学院北京市100191

人口老龄化加剧使失智患者逐年增多,失智患者照护者的照护负担较重,获益感影响照护者的身心健康,该文从失智患者照护者获益感的评估工具、获益感现状、影响因素、干预现状4个方面进行综述,为探究获益感的可控因素和干预方案研究提供参考。

关键词：失智照护获益感社区保健护理综述

新形势下城市基层党建工作探析——基于广东省的调查与研究

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中共珠海市委党校珠海市行政学院学报 2019年第2期 10-15页

作者：萧红梅中共云浮市委党校广东云浮527300

近年来,广东省各地城市基层党组织积极探索和创新具有广东特色的城市基层党建工作,成绩显著。但是,当前广东省城市基层党建工作还存在政治功能弱化、党建工作碎片化倾向,组织生活不规范不严肃和党建工作覆盖有肓区的突出问题。为此,要... 详细信息

近年来,广东省各地城市基层党组织积极探索和创新具有广东特色的城市基层党建工作,成绩显著。但是,当前广东省城市基层党建工作还存在政治功能弱化、党建工作碎片化倾向,组织生活不规范不严肃和党建工作覆盖有肓区的突出问题。为此,要从突出政治功能、加大体制机制改革力度、严肃党内政治生活和扩大城市基层党组织覆盖面这四个维度,进一步加强和改进新形势下广东省城市基层党建工作,切实走出一条符合广东省各地城市治理特点和规律的城市基层党建新路子。

关键词：城市基层党组织党建实践探索

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十八届四中全会开创法治反腐的新局面

中共桂林市委党校学报 2014年第4期14卷 1-4页

作者：萧红梅中共云浮市委党校广东云浮527300

党的十八届四中全会通过的《中共中央关于全面推进依法治国若干重大问题的决定》提出了一系列反腐的新部署、新观点和新举措,开创了法治反腐的新局面。法治引领治腐、防腐,规范、制约权力和对腐败问题"零容忍",每一项都直接遏制权力腐败。

关键词：十八届四中全会法治反腐责任追究制