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p75NTR signal transduction suppressed by BFAR and p75NTR interactions

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Science China(Life Sciences) 2012年第4期55卷 367-374页

作者： LI hongmei shi HuiLi HUO KeKe State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai 200433 China

p75NTR is a low-affinity nerve growth factor receptor, which promotes cell proliferation as a positive modulator of high-affinity receptor TrkA, as well as binds with cell ligands to induce apoptosis and mediate death signals. To analyze the regulatory mechanisms of p75NTR, the present study utilized a new membrane yeast two-hybrid system to screen a human fe- tal brain cDNA library. Results identified BFAR, a novel protein that interacts with p75NTR. Interaction specificity was veri- fied by membrane yeast two-hybrid co-transformation assays, in vitro GST pull-down assays, and in vitro co-irnmunopreci- pitation assays. The fluorescent subcellular localization assay revealed that the two proteins co-localized within the cytoplasm. BFAR overexpression in PC-12 and HEK293T cells inhibited the NFnB and JNK signaling pathway, as determined with the luciferase test. Co-transfected p75NTR and BFAR in HEK293T or PC-12 cells, respectively, increased the percentage of cells in the G2/M phase, decreased the number of S-phase cells, and did not change the number of G0/Gl-phase cells.

关键词： p75NTR BFAR membrane yeast two-hybrid protein-protein interaction apoptosis

地铁盾构隧道裂缝与渗漏水图像采集与智能识别算法研究

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中南大学学报(自然科学版) 2025年第1期56卷 370-383页

作者：田思萌王耀东刘胜智周伟史红梅朱力强先进轨道交通自主运行全国重点实验室(北京交通大学) 北京100044 北京交通大学机械与电子控制工程学院北京100044 中南大学交通运输工程学院湖南长沙410075

隧道病害是地铁运营人员定期巡检的主要任务之一,提出一种深度学习与像素级图像处理算法相结合的隧道表面病害识别方法。首先,利用自主研究的高速采集系统采集大量隧道表面图像,通过像素级标定构建高质量语义分割样本库;然后,针对裂缝... 详细信息

隧道病害是地铁运营人员定期巡检的主要任务之一,提出一种深度学习与像素级图像处理算法相结合的隧道表面病害识别方法。首先,利用自主研究的高速采集系统采集大量隧道表面图像,通过像素级标定构建高质量语义分割样本库;然后,针对裂缝和渗漏水的形态特点,提出一种改进的DeepLabV3+算法,从主干特征网络、空洞卷积金字塔模块和解码器多尺度融合3个方面进行改进;最后,提出一种基于像素级图像处理的算法,计算简单背景及病害混叠情况下的裂缝长度和渗漏水面积参数。研究结果表明,提出的改进算法使平均准确度达85.26%,平均交并比达73.62%,相较于其他5种模型,分割结果更为精细,对于复杂背景和裂缝与渗漏水混叠的复杂病害仍有很好的分割效果。同时,像素级处理可以完成典型病害及复杂情况的参数提取,实现整体地铁隧道表面病害的智能识别。研究成果不仅可以实现裂缝和渗漏水的准确检测,而且能用于分析复杂背景和2种病害混叠情况的复杂病害。

关键词：图像采集语义分割病害参数计算隧道裂缝隧道渗漏水复杂病害

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Characteristics and origin of mafic and ultramafic xenoliths in trachyandesite lavas from Heikongshan volcano,Tengchong,Yunnan Province,China

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Science China Earth Sciences 2010年第9期53卷 1295-1306页

作者： YU hongmei, LIN ChuanYong, shi LanBin, XU JianDong & CHEN XiaoDe Institute of Geology, China Earthquake Administration, Beijing 100029, China 1. Institute of Geology China Earthquake Administration Beijing 100029 China

The trachyandesite lavas from Heikongshan volcano of the Tengchong volcanic cluster, Yunnan Province contain relatively abundant mafic and ultramafic small xenoliths comprising mainly gabbro, pyroxenite and rare lherzolites, all less than 2.5 cm in size. Gabbro xenoliths are characterized by "open" texture represented by relatively abundant vesicles and ground-mass fillings, while pyroxenite xenoliths are characterized by equigranular and poikilitic texture. Their mineral compositions (clinopyroxene ± orthopyroxene ± plagioclase) are similar to those of phenocrysts in lavas, and their equilibration temperature (1000-1125°C) is consistent with the crystallization temperature of the phenocrysts (998-1108°C). Thus, the textures and compositions of these xenoliths are different from those of lower crustal and mantle xenoliths, and were derived from the magma chamber. Among them, the gabbroic xenoliths come from the crystal-bubble-liquid zone at the top of the magma reservoir, while the pyroxenite xenoliths come from the cumulates in the bottom of magma reservoir. The studied single lherzolite xenolith with porphyroclastic texture has similar mineral compositions to the mantle xenoliths from eastern China, and is considered to be of upper mantle origin. It was brought into magma reservoir by replenishment magma, and might have experienced a cooling event before eruption. The formation of xenoliths in trachyandesite flows largely reflects the ascent, storage, evolution and eruption processes of magma.

关键词： magma chamber xenoliths geothermo-barometry trachyandesite Heikongshan volcano Tengchong

Inspirations of Oscar Wilde's Fairytales to China

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校园英语 2018年第52期 245-247页

作者： shi hongmei School of Foreign Languages Jishou University

In British literature, a writer, who had great impacts on the world, existed in literature history in a unique form. As a famous British literature playwright, Wilde was known in the world for his plays, fairytales for a lifetime. The reverse side of relatively few fairytales was high quality, and Wilde’s only nine fairytales were included into Chinese materials for junior high school students. Chinese and foreign literary circles comment Wilde differently, which reflects that Wilde has huge influence in the world on the other hand.

关键词： Wilde China’s fairytales Influence Development

Surveillance and examination of microbial contamination in ice cream in China

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Food Quality and Safety 2022年第3期6卷 446-453页

作者： Lin Yan Xiaoyan Pei Junjie Miao Ying Li Shuran Yang Zixin Peng Xiaorong Yang Lingling Mei Qingwen Yang Huan Ren Dajin Yang hongmei shi Hebei Key Laboratory of Environment and Human Health School of Public HealthHebei Medical UniversityShijiazhuangChina China National Center for Food Safety Risk Assessment(CFSA) BeijingChina Sichuan Provincial Center for Disease Control and Prevention ChengduChina Zhejiang Provincial Center for Disease Control and Prevention HangzhouChina Yunnan Provincial Center for Disease Controland Prevention KunmingChina

This study investigated the microbial contamination of ice cream in China.A total of 2887 ice cream samples were collected from different regions of *** by the aerobic plate count(APC),coliforms,and three foodborne pathogens,Listeria monocytogenes(***),Staphylococcus aureus(***),and Salmonella spp.,was detected in the *** isolates were further analyzed for antibiotic susceptibility and multi-locus sequence typing(MLST).The results showed that APC was more than 10^(5) colony forming units(CFU)/g in 6.10%(176/2887)and coliform was more than 10^(2) CFU/g in 15.69%(453/2887)of all *** positive rates of ***,***,and Salmonella *** 0.66%,0.62%,and 0.10%,*** these,*** contamination was more than 102 CFU/g in two samples,and *** in the positive sample was in the range of 0.3-240 most probable number(MPN)/*** a median of 4.3 MPN/*** hygienic status of the packaged samples was much better than that of the bulk samples(P0.05).For 18 *** strains isolated from ice cream,the resistance rate of nine antibiotics was 5.56%(1/18).By MLST,the *** strains were classified into nine sequence types(STs),of which ST8 was the most common(six isolates).These results indicate that a potential health risk to the public may be caused by ice cream,particularly in susceptiblepopulations.

关键词： Frozen dessert microbial contamination foodborne pathogens antibiotic susceptibility multi-locus sequence typing

基于高阶谱特征提取的高速列车车轮擦伤识别算法研究

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机械工程学报 2017年第6期53卷 102-109页

作者：赵蓉史红梅北京交通大学机械与电子控制工程学院北京100044

随着列车运行速度和轴重增加,车轮踏面擦伤现象不断加剧。提出一种对列车经过时钢轨振动信号进行高阶谱特征提取并结合粒子群-支持向量机(PSO-SVM)进行车轮擦伤识别的算法。通过建立车辆轨道垂向耦合模型和车轮擦伤模型,计算正常车轮与... 详细信息

随着列车运行速度和轴重增加,车轮踏面擦伤现象不断加剧。提出一种对列车经过时钢轨振动信号进行高阶谱特征提取并结合粒子群-支持向量机(PSO-SVM)进行车轮擦伤识别的算法。通过建立车辆轨道垂向耦合模型和车轮擦伤模型,计算正常车轮与擦伤车轮作用下的钢轨振动响应。利用高阶谱方法对两种情况下钢轨振动信号进行信号处理得到二维等高线图和三维双谱图,通过灰度-梯度共生矩阵提取其二维等高线图的6个纹理特征,与车速共同输入PSO-SVM模型识别车轮是否擦伤;再结合三维双谱图对角切片峰值、二维等高线图内扩对角频率,对擦伤等级进行识别。结果表明:利用高阶谱进行特征提取的方法识别正常与擦伤车轮准确率可以达到100%,擦伤等级的准确率可以达到94.6%。最后将该方法与EMD方法进行特征提取做比较分析,EMD方法识别正常与擦伤车轮准确率为98.3%,而擦伤级别准确率仅为56.4%。研究结果表明,基于高阶谱的PSO-SVM方法更能有效识别擦伤车轮并确定其擦伤等级。

关键词：车轮擦伤钢轨振动响应高阶谱灰度-梯度共生矩阵 PSO-SVM

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一种传感器优化布置的高能有效独立法

仪器仪表学报 2022年第11期43卷 53-61页

作者：史红梅孙傲雨北京交通大学机械与电子控制工程学院北京100044

针对结构健康监测的传感器优化布置问题,考虑模态动能和模态应变能对传感器布点选择的影响,提出了一种高能有效独立法(E-EI),解决了有效独立法(EI)容易丢失能量较大测点的问题。推导了多能量参数的归一化等效能量矩阵,通过矩阵对角线元... 详细信息

针对结构健康监测的传感器优化布置问题,考虑模态动能和模态应变能对传感器布点选择的影响,提出了一种高能有效独立法(E-EI),解决了有效独立法(EI)容易丢失能量较大测点的问题。推导了多能量参数的归一化等效能量矩阵,通过矩阵对角线元素的大小评价测点的能量分布。为验证E-EI法的有效性和泛化性,进行了空间桁架输电铁塔仿真算例分析以及铁路尖轨的实验验证,利用5种评价准则从测点能量分布、正交性、所含信息量3个方面对比分析了E-EI法、EI法以及3种EI法的改进方法。结果表明,E-EI法与其他改进方法相比同时实现了高能测点筛选以及测点高线性独立性。其中,布置12个传感器的尖轨实验中E-EI法的MAC矩阵非对角元素平均值比EI法的减少了5.48%,模态动能平均值比EI法的增长了133.27%,模态应变能比EI法的增长了35.82%。

关键词：传感器优化布置有效独立法模态测试结构健康监测

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基于激光三角测量原理的轨距检测系统研究

仪器仪表学报 2013年第9期34卷 1934-1940页

作者：史红梅张继科北京交通大学机械与电子控制工程学院北京100044

轨距是轨道几何尺寸中的一个重要参数,及时掌握轨距信息对保证行车安全具有重要意义。基于激光三角测量原理研发了一种安装于路轨两栖综合检测车上的轨距检测系统。该系统使用2组共6台二维激光扫描传感器获得左右钢轨断面轮廓,利用基于C... 详细信息

轨距是轨道几何尺寸中的一个重要参数,及时掌握轨距信息对保证行车安全具有重要意义。基于激光三角测量原理研发了一种安装于路轨两栖综合检测车上的轨距检测系统。该系统使用2组共6台二维激光扫描传感器获得左右钢轨断面轮廓,利用基于CPLD的同步信号触发模块保证各传感器数据同步。通过对采集的钢轨断面轮廓数据采用基于不连续度的自适应滤波和钢轨弧形区特征提取算法,实时提取轨距特征点并计算显示当前断面轨距值。实验结果表明,该轨距检测系统可实现轨距参数的非接触式动态实时测量,检测车运行速度为40 km/h时钢轨断面采样间隔3.7 mm,轨距检测精度±0.8 mm。

关键词：轨距测量激光扫描传感器钢轨断面轮廓平滑滤波器

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1