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Subcutaneous daratumumab in Chinese patients with relapsed or refractory multiple myeloma:an open-label,multicenter,phase 1 study(MMY1010)

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Blood Science 2024年第3期6卷 42-47页

作者： Gang An Zheng Ge hongmei jing jing Liu Guoping Yang Ru Feng Zhongyuan Xu Ming Qi Jianping Wang Juanjuan Song Wei Zhou Binbin Sun Dian Zhu Xi Chen Canchan Cui Lugui Qiu National Clinical Research Center for Hematological Disorders State Key Laboratory of Experimental HematologyInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China Department of Hematology Zhongda Hospital Southeast UniversityNanjing 210009China Peking University Third Hospital Beijing 100191China Department of Hematology The Third Xiangya Hospital of Central South UniversityChangsha 410013China Department of Hematology Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China Phase 1 Clinical Trial Department Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China Janssen Research&Development LLCSpring HousePA 19477USA Janssen Research&Development LLCBeijing 100025China Janssen Research&Development LLCShanghai 200231Chin

Despite recent progress in multiple myeloma(MM)treatments,most patients will relapse and require additional *** daratumumab,a human IgGκmonoclonal antibody targeting CD38,has shown good efficacy in the treatment of MM.A subcutaneous version of daratumumab was formulated to reduce the burden of intravenous *** aimed to investigate the efficacy and safety of subcutaneous daratumumab in Chinese patients with relapsed/refractory MM based on the demonstrated noninferiority of subcutaneous daratumumab to intravenous daratumumab,with a shorter administration time and reduced infusion-related reaction rate in global *** phase 1,multicenter study(MMY1010;*** Identifier:NCT04121260)evaluated subcutaneous daratumumab in Chinese patients with relapsed/refractory MM after 1 prior line(n=1)or≥2 prior lines(n=20)of therapy,including a proteasome inhibitor and an immunomodulatory *** endpoints were pharmacokinetics and ***(standard deviation)maximum trough concentration of daratumumab was 826(335)μg/mL,which was consistent with prior studies of subcutaneous daratumumab and intravenous *** was consistent with safety profiles observed in other daratumumab studies,with no new safety concerns *** of infusion-related reactions and injection-site reactions were low and consistent with other subcutaneous daratumumab *** a median follow-up of 7.5 months,the overall response rate was 57.1%,with a very good partial response or better rate of 38.1%and complete response or better rate of 19.0%.Our results demonstrate a favorable benefit/risk profile of subcutaneous daratumumab in Chinese patients with relapsed/refractory MM,potentially impacting clinical administration of daratumumab in this population.

关键词： Chinese Daratumumab Multiple myeloma Pharmacokinetic Relapse/refractory Safety Subcutaneous

Clinical features and prognostic analysis of the blastoid variant of mantle cell lymphoma: An analysis of 20 patients from two centers

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Cancer Pathogenesis and Therapy 2024年第1期2卷 62-64页

作者： Sai Huang Shaomei Liu hongmei jing Ping Chen Lili Dong Xiaoyu Hao Jian Bo Lu Sun Yu Zhao Department of Hematology Senior Department of HematologyThe Fifth Medical Center of PLA General HospitalBeijing 100039China Department of Hematology The First Medical Center of PLA General HospitalBeijing 100853China Medical School of Chinese PLA General Hospital Beijing 100853China Department of Clinical Laboratory The First Medical Center of PLA General HospitalBeijing 100853China Department of Hematology Lymphoma Research CenterPeking University Third HospitalBeijing 100191China Department of Pathology The First Medical Center of PLA General HospitalBeijing 100853China

Managing Editor:Peng Lyu Mantle cell lymphoma(MCL),a relatively uncommon subtype of non-Hodgkin's lymphoma(NHL),constitutes approximately 2%-10%of NHL *** by its inertness,aggressiveness,and incurability,MCL has a med... 详细信息

关键词： lymphoma NHL Clinical

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肿瘤免疫疗法中细胞来源对治疗效果的影响

中华血液学杂志 2024年第7期45卷 699-704页

作者：齐文昕张伟龙景红梅北京大学第三医院血液科北京100191

从免疫细胞层面总结了各种新型嵌合抗原受体T细胞(CAR-T细胞)疗法,健康年轻受试者的T细胞、干性记忆样T细胞、人体诱导多能干细胞、脐带血T细胞来源的CAR-T细胞疗法可增强肿瘤杀伤效应。从通用型CAR细胞方面,病毒特异性T细胞、γδT细胞... 详细信息

从免疫细胞层面总结了各种新型嵌合抗原受体T细胞(CAR-T细胞)疗法,健康年轻受试者的T细胞、干性记忆样T细胞、人体诱导多能干细胞、脐带血T细胞来源的CAR-T细胞疗法可增强肿瘤杀伤效应。从通用型CAR细胞方面,病毒特异性T细胞、γδT细胞、iNKT细胞、巨噬细胞等能有效减轻移植物抗宿主病反应。此外,增强去白细胞过程中单核细胞的清除、保持CD4^(+)/CD8^(+)T细胞均衡比例等策略也是增强CAR-T细胞扩增及杀伤效力的方法。细胞耗竭标志物高表达的T细胞对CAR-T细胞的转导、扩增及发挥杀伤效力等会产生负向影响,使用免疫检查点阻断剂等方式抑制T细胞耗竭能提高CAR-T细胞作用效应。

关键词：移植物抗宿主病肿瘤免疫疗法诱导多能干细胞特异性T细胞去白细胞脐带血巨噬细胞 γδT细胞

国内省级公共图书馆残障读者品牌活动调查研究

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山东图书馆学刊 2024年第4期 52-57页

作者：荆红美范婧山东省图书馆山东济南250100

公共图书馆创建残障活动品牌是解决活动偶发性、非持续性,为残障读者提供均等化公共文化服务的重要基础。采用文献调查法、网络调查法、线上访谈法对国内32家省级公共图书馆残障读者品牌活动进行了调研,发现其存在品牌创建意识有待增强... 详细信息

公共图书馆创建残障活动品牌是解决活动偶发性、非持续性,为残障读者提供均等化公共文化服务的重要基础。采用文献调查法、网络调查法、线上访谈法对国内32家省级公共图书馆残障读者品牌活动进行了调研,发现其存在品牌创建意识有待增强、残障活动类型有限、残健融合活动较少、与社会组织合作力度有待提高的问题。从明确活动目的、细分读者需求、构建省馆——基层——家服务模式、管理运作标准化等方面总结出可持续运作的策略,以期为其他省级公共图书馆创建残障读者品牌活动提供借鉴。

关键词：公共图书馆残障读者品牌活动

海洋暗光层颗粒附着微生物的群落演替和生态功能

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河南师范大学学报（自然科学版） 2024年第5期52卷 126-133页

作者：荆红梅刘皓张玥刘红斌中国科学院深海科学与工程研究所海南三亚572000 南方海洋科学与工程广东省实验室(珠海) 广东珠海519082 中国科学院三亚海洋科学综合实验室海南三亚572000 香港科技大学海洋科学系中国香港999077

暗光层是各类元素到达更深水域或海底的必经通道,是海洋对颗粒有机物(particulate organic matter,POM)进行显著降解和生物利用的水层.微生物参与了暗光层中有机物的迁移转化过程,但对其群落演替和代谢活性知之甚少.研究总结了暗光层的... 详细信息

暗光层是各类元素到达更深水域或海底的必经通道,是海洋对颗粒有机物(particulate organic matter,POM)进行显著降解和生物利用的水层.微生物参与了暗光层中有机物的迁移转化过程,但对其群落演替和代谢活性知之甚少.研究总结了暗光层的环境特征及相关微生物类群的结构和功能,并结合不同海域暗光层上下界面垂直水层中的颗粒附着微生物的群落演替、碳源利用及潜在的生态功能,来解析微生物在暗光层中的空间动态变化,并反映该生态位中微生物对碳源的选择偏好.在未来全球变暖与海洋生物泵作用相对增强的背景下.今后的研究更需聚焦暗光层中的微生物类群,并统一POM粒级划分标准,来阐明暗光层中微型碳泵和深海碳沉降的调控及贡献.

关键词：暗光层颗粒有机物群落演替碳源利用生态功能

利用全基因组光学图谱检测多发性骨髓瘤细胞遗传学异常

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中华血液学杂志 2024年第3期45卷 303-307页

作者：王艳芳张朕豪王化郤连永董菲景红梅北京大学第三医院血液内科北京100191

多发性骨髓瘤(MM)是一种以单克隆浆细胞在骨髓中异常增殖为特征的血液肿瘤,MM细胞具有复杂的染色体数目异常和结构异常,这些异常对于患者的危险度分层以及疗效评估具有重要的意义。全基因组光学图谱(OGM)是一项新型的细胞遗传学检测技术... 详细信息

多发性骨髓瘤(MM)是一种以单克隆浆细胞在骨髓中异常增殖为特征的血液肿瘤,MM细胞具有复杂的染色体数目异常和结构异常,这些异常对于患者的危险度分层以及疗效评估具有重要的意义。全基因组光学图谱(OGM)是一项新型的细胞遗传学检测技术,目前在肿瘤、辅助生殖、发育异常等领域已经显示出一定的应用前景,本研究首次利用OGM技术对5例新发MM患者的细胞遗传学异常进行检测,并将其与传统细胞遗传学检测技术进行了比较,从而评估该技术对染色体异常的检出能力以及在MM中的临床应用价值。

关键词：细胞遗传学异常异常增殖危险度分层染色体异常染色体数目异常血液肿瘤辅助生殖发育异常

基于艾宾浩斯遗忘曲线规律联合CBL教学模式在八年制本科生血液内科实习教学中的应用

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中国病案 2024年第7期25卷 97-100页

作者：高锦洁马兰董菲景红梅北京大学第三医院血液内科北京市100191

目的探讨在器官系统整合课程背景下,基于艾宾浩斯遗忘曲线规律联合以案例为基础的教学法(Case-based learning,CBL)的混合教学法在临床八年制本科生血液内科实习教学中的应用效果。方法选取2023年3月1日-10月31日进入北京大学某医院血... 详细信息

目的探讨在器官系统整合课程背景下,基于艾宾浩斯遗忘曲线规律联合以案例为基础的教学法(Case-based learning,CBL)的混合教学法在临床八年制本科生血液内科实习教学中的应用效果。方法选取2023年3月1日-10月31日进入北京大学某医院血液内科实习的临床八年制本科生共38人,随机分为实验组和对照组,每组19人。所有学生进行相同内容的学习,实验组采用结合遗忘曲线规律和CBL的混合教学法,对照组采用传统教学法。课后实验组学生根据艾宾浩斯遗忘曲线规律在特定时间点,由教师通过线上应用统一进行复习及答疑。对照组学生自行复习,在实习中带教教师随时答疑。两组学生实习结束后安排统一出科考试,比较两组学生理论考试成绩,并通过问卷星平台制作调查问卷,调查两组学生对当前教学模式的评价。结果实验组理论考试成绩中位数为100.00(94.50,100.00)分,对照组理论考试成绩中位数94.50(89.50,97.50)分,经独立样本非参数检验,实验组成绩明显高于对照组,差异有统计学意义(P<0.05)。教学反馈上,实验组学生评价该教学模式在激发学习兴趣、提高学习主动性、培养开拓性思维及创新能力、提高基础理论掌握情况及提高临床思维能力的主观量化评分明显高于对照组(P<0.05)。结论在器官系统整合课程背景下,基于艾宾浩斯遗忘曲线规律联合CBL的混合教学模式在八年制本科生血液内科临床实习教学中具备比较好的可操作性,有助于提高学生对血液病学基础和临床理论的掌握水平,提高教学效果。

关键词： CBL教学艾宾浩斯遗忘曲线混合式教学血液内科实习教学

Thermodynamic instability of 3D Einstein-Born-Infeld AdS black holes

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Chinese Physics C 2021年第6期45卷 202-208页

作者： hongmei jing Benrong Mu Jun Tao Peng Wang Center for Theoretical Physics College of PhysicsSichuan UniversityChengdu 610065China Physics Teaching and Research Section College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu 611137China

Super-entropic black holes possess finite-area but noncompact event horizons and violate the reverse iso-perimetric *** has been conjectured that such black holes always have negative specific heat at constant volume C_(V)or negative specific heat at constant pressure C_(p)whenever Cy>0,making them unstable in extended *** this paper,we describe a test of this instability conjecture with a family of nonlinear electro-dynamic black holes,namely 3D Einstein-Bom-Infeld(EBI)AdS black *** results show that when nonlinear electrodynamics effects are weak,the instability conjecture is ***,the conjecture can be violated in some parameter region when nonlinear electrodynamics effects are strong *** observation thus provides a counter example to the instability conjecture,which suggests that super-entropic black holes may be thermodynamically stable.

关键词： Einstein-Bom-Infeld black holes super-entropic black holes black hole thermodynamics thermodynamic instability

Evidence-based expert consensus on clinical management of safety of Bruton’s tyrosine kinase inhibitors(2024)

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Chinese Journal of Cancer Research 2024年第3期36卷 240-256页

作者： Zaiwei Song Dan Jiang Lingling Yu Yixuan Chen Daobin Zhou Yue Li Depei Wu Lingli Zhang Liyan Miao Jun Ma Jun Zhu hongmei jing Rongsheng Zhao the Steering Committee,the Consensus Panel and the Evidence Synthesis Group Evidence-based Pharmacy Professional Committee of Chinese Pharmaceutical Association(CPA) Hospital Pharmacy Professional Committee of Chinese Pharmaceutical Association(CPA) Division of Therapeutic Drug Monitoring of Chinese Pharmacological Society(CPS) Expert Committee on Lymphoma of Chinese Society of Clinical Oncology(CSCO) Expert Committee on Leukemia of Chinese Society of Clinical Oncology(CSCO) Society of Integrative Cardio-Oncology of China Anti-Cancer Association(CACA) Chinese Society of Hematology of Chinese Medical Association(CMA) Hospital Pharmacy Professional Committee of Cross-Straits Medicine Exchange Association(SMEA) Department of Pharmacy Peking University Third HospitalBeijing 100191China Institute for Drug Evaluation Peking University Health Science CenterBeijing 100191China Therapeutic Drug Monitoring and Clinical Toxicology Center Peking UniversityBeijing 100191China Department of Pharmacy Administration and Clinical Pharmacy School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbin 150001China Department of Hematology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Pharmacy Evidence-based Pharmacy CenterWest China Second HospitalSichuan UniversityChengdu 610041China Department of Pharmacy the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Hematology and Oncology Harbin Institute of Hematology and OncologyHarbin 150010China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China Department of Hematology Peking University Third HospitalBeijing 100191China 不详

Bruton’s tyrosine kinase inhibitors(BTKis)have revolutionized the treatment of B-cell ***,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy.A comprehensive and systematic expert consensus from a pharmacological perspective is lacking for safety issues associated with BTKi treatment.A multidisciplinary consensus working group was established,comprising 35 members from the fields of hematology,cardiovascular disease,cardio-oncology,clinical pharmacy,and evidencebased *** evidence-based expert consensus was formulated using an evidence-based approach and the Delphi *** Joanna Briggs Institute Critical Appraisal(JBI)tool and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)approach were used to rate the quality of evidence and grade the strength of recommendations,*** consensus provides practical recommendations for BTKis medication based on nine aspects within three domains,including the management of common adverse drug events such as bleeding,cardiovascular events,and hematological toxicity,as well as the management of drug-drug interactions and guidance for special *** multidisciplinary expert consensus could contribute to promoting a multi-dimensional,comprehensive and standardized management of BTKis.

关键词： Consensus BTK inhibitors safety adverse drug events drug-drug interactions