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Role of preoperative selective portal vein embolization in two-step curative hepatectomy for hepatocellular carcinoma

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World Journal of Gastroenterology 2003年第8期9卷 1702-1706页

作者： wuJi Jie-ShouLi Ung-TangLi wu-hongliu Kuan-ShengMa Xiang-TianWang Zhen-PingHe Jia-HongDong ResearchInstituteofGeneralSurge NanjingGeneralHospitaloiNanjingPLACommandAreaNanjing210002.JiangsuProvince.China DepartmentofGeneralSurgery KunmingGeneralHospitalofChengduPLACommandAreaKunming650032YunnanProvinceChina HepatobiliarySurgeryCenter SouthwestHospitalThirdMilitaryMedicalUniversityChongqing400038China

AIM: To determine the feasibility and role of ultrasoundguided preoperative selective portal vein embolization (POSPVE) in the two-step hepatectomy of patients with advanced primary hepatocellular carcinoma (HCC).METHODS: Fifty patients with advanced HCC who were not suitable for curative hepatectomy were treated by ultrasound-guided percutaneous transhepatic POSPVE with fine needles. The successful rate, side effects and complications of POSPVE, changes of hepatic lobe volume and two-step curative hepatectomy rate after POSPVE were ***: POSPVE was successfully performed in 47(94.0 %) patients. In patients whose right portal vein branches were embolized, their right hepatic volume decreased and left hepatic volume increased gradually. The ratio of right hepatic volume to total hepatic volume decreased from 62.4 % before POSPVE to 60.5 %, 57.2 %and 52.8 % after 1, 2 and 3 weeks respectively. The side effects included different degree of pain in liver area (38cases), slight fever (27 cases), nausea and vomiting (9cases). The level of aspartate alanine transaminase (AST),alanine transaminase (ALT) and total bilirubin (TBIL)increased after POSPVE, but returned to preoperative level in 1 week. After 2-4 weeks, two-step curative hepatectomy for HCC was successfully performed on 23 (52.3 %) *** were no such severe complications as ectopic embolization, local hemorrhage and bile ***: Ultrasound-guided percutaneous transhepatic POSPVE with fine needles is feasible and safe. It can extend the indications of curative hepatectomy of HCC, and increase the safety of hepatectomy.

关键词：肝细胞癌肝切除术术前选择性血管栓塞化疗

Study of Cell Behaviors on Anodized TiO_2 Nanotube Arrays with Coexisting Multi-Size Diameters

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Nano-Micro Letters 2016年第1期8卷 61-69页

作者： Yifan Chen Jiahua Ni hongliu wu Ruopeng Zhang Changli Zhao Wenzhi Chen Feiqing Zhang Shaoxiang Zhang Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Material Science and Engineering Shanghai Jiao Tong University Suzhou Origin Medical Technology Co. Ltd.

It has been revealed that the different morphologies of anodized TiO_2 nanotubes, especially nanotube diameters, triggered different cell behaviors. However, the influence of TiO_2 nanotubes with coexisting multi-size diameters on cell behaviors is seldom reported. In this work, coexisting four-diameter TiO_2 nanotube samples, namely,one single substrate with the integration of four different nanotube diameters(60, 150, 250, and 350 nm), were prepared by repeated anodization. The boundaries between two different diameter regions show well-organized structure without obvious difference in height. The adhesion behaviors of MC3T3-E1 cells on the coexisting fourdiameter TiO_2 nanotube arrays were investigated. The results exhibit a significant difference of cell density between smaller diameters(60 and 150 nm) and larger diameters(250 and 350 nm) within 24 h incubation with the coexistence of different diameters, which is totally different from that on the single-diameter TiO_2 nanotube arrays. The coexistence of four different diameters does not change greatly the cell morphologies compared with the singlediameter nanotubes. The findings in this work are expected to offer further understanding of the interaction between cells and materials.

关键词： Coexisting multi-size TiO2 nanotubes Repeated anodization MC3T3-E1 cells Cell adhesion behaviors Cell-material interaction

Doping inorganic ions to regulate bioactivity of Ca–P coating on bioabsorbable high purity magnesium

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Progress in Natural Science:Materials International 2014年第5期24卷 479-485页

作者： hongliu wu Ruopeng Zhang Xiao Li Jiahua Ni Changli Zhao Yang Song Jiawei Wang Shaoxiang Zhang Yufeng Zheng Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Department of Mechanical Engineering The University of Hong Kong Suzhou Origin Medical Technology Co. Ltd. 4. State Key Laboratory for Turbulence and Complex System Department of Materials Science and EngineeringCollege of EngineeringPeking University

Performance of biomaterials was strongly affected by their surface properties and could be designed artificially to meet specific biomedical requirements. In this study, F(F), Si O2 4(Si), or HCO 3(C)-doped Ca–P coatings were fabricated by biomimetic deposition on the surface of biodegradable high-purity magnesium(HP Mg). The crystalline phases, morphologies and compositions of Ca–P coatings had been characterized by X-ray diffraction(XRD), scanning electron microscopy(SEM) and energy-dispersive spectroscopy(EDS). The biomineralization and corrosion resistance of doped Ca–P coatings had also been investigated. The results showed that the Ca–P coating with or without doped elements mainly contained the plate-like dicalcium phosphate dehydrate(DCPD) phase. The doped F, Si, or C changed the surface morphology of Ca–P coatings after mineralization. Doped F enhanced the mineralization of Ca–P coating, and doped Si retarded the mineralization of Ca–P ***, H2 evolution of HP Mg discs with different Ca–P coatings was close to 0.4–0.7 ml/cm2 after two-week immersion. That meant that the corrosion resistance of the Ca–P coatings with different or without doped elements did not change significantly.

关键词： Calcium phosphate coating Adjustable bioactivity Magnesium Biomimetic deposition In vitro

Research of a novel biodegradable surgical staple made of high purity magnesium

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Bioactive Materials 2016年第2期1卷 122-126页

作者： hongliu wu Changli Zhao Jiahua Ni Shaoxiang Zhang Jingyi Liu Jun Yan Yigang Chen Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Suzhou Origin Medical Technology Co.Ltd. Jiangsu 215513China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai200233China Department of General Surgery Wuxi No.2 People's HospitalNanjing Medical UniversityWuxi214002China

Surgical staples made of pure titanium and titanium alloys are widely used in gastrointestinal *** the Ti staple cannot be absorbed in human body and produce artifacts on computed tomography(CT)and other imaging examination,and cause the risk of incorrect *** bioabsorbable staple made from polymers that can degrade in human body environment,is an *** the present study,biodegradable high purity magnesium staples were developed for gastric anastomosis.U-shape staples with two different interior angles,namely original 90and modified 100,were *** element analysis(FEA)showed that the residual stress concentrated on the arc part when the original staple was closed to B-shape,while it concentrated on the feet for the modified staple after *** in vitro tests indicated that the arc part of the original staple ruptured firstly after 7 days immersion,whereas the modified one kept intact,demonstrating residual stress greatly affected the corrosion behavior of the HP-Mg *** in vivo implantation showed good biocompatibility of the modified Mg staples,without inflammatory reaction 9 weeks *** Mg staples kept good closure to the Anastomosis,no leaking and bleeding were found,and the staples exhibited no fracture or severe corrosion cracks during the degradation.

关键词： Biodegradable staple High purity magnesium Finite element analysis Corrosion In vivo

In vitro crevice corrosion of biodegradable magnesium in different solutions

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Journal of Materials Science & Technology 2020年第17期52卷 83-88页

作者： Bowei Chen hongliu wu Ruibang Yi Wenhui Wang Haidong Xu Shaoxiang Zhang Hongzhou Peng Junwei Ma Haomiao Jiang Rui Zan Shuang Qiao Yu Sun Peng Hou Pei Han Jiahua Ni Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Materials Science and Engineering Central South UniversityChangsha 410083China Suzhou Origin Medical Technology Co.Ltd. Suzhou 215513China Orthopaedic Department Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA

Magnesium(Mg)is a promising biomedical metal because of its *** crevice between tissue and Mg implant can not be neglected in some implantation sites due to inducing crevice corrosion of *** this paper,a new single mold was designed to build the in vitro experimental setup and four kinds of solutions,*** deionized water(DW),the 0.9 wt.%sodium chloride solution(NaCl),the phosphate buffer saline(PBS)and the modified simulated body fluid(m-SBF)were used to explore necessary factors of crevice corrosion in *** was observed that crevice corrosion in Mg sheets would occur in NaCl and PBS solution under 0.2,0.5 and 0.8 mm crevice *** it was found that there were two necessary factors,*** ion and crevice dimension,in crevice *** the high-purity Mg cannulated screws,crevice corrosion could occur inside tunnel when immersed in PBS.

关键词： Mg Crevice corrosion Cannulated screw Chloride ion Crevice size

Biodegradable magnesium implants:a potential scaffold for bone tumor patients

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Science China Materials 2021年第4期64卷 1007-1020页

作者： Rui Zan Weiping Ji Shuang Qiao hongliu wu Wenhui Wang Tianjiao Ji Bangcheng Yang Shaoxiang Zhang Congfeng Luo Yang Song Jiahua Ni Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Orthopedic Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Laboratory for Biomaterials and Drug Delivery Department of AnesthesiologyBoston Children’s HospitalHarvard Medical SchoolBostonMassachusetts 02115USA Engineering Research Center in Biomaterials Sichuan UniversityChengdu 610064China Suzhou Origin Medical Technology Co.Ltd. Suzhou 215513China Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA

Relapse and metastasis of tumor may occur for osteosarcoma(OS)patients after clinical *** metallic scaffolds provide sufficient mechanical support to the defected bone but fail to eradicate recurring *** we report that biodegradable magnesium(Mg)wirebased implant can inhibit OS *** brief,the Mg wires release Mg ions to activate the transport of zinc finger protein Snail1 from cytoplasm to cell nucleus,which induces apoptosis and inhibits proliferation of OS cells through a parallel antitumor signaling pathway of miRNA-181d-5p/TIMP3 and miRNA-181c-5p/NLK ***,the hydrogen gas evolution from Mg wires eliminates intracellular excessive reactive oxygen species,by which the growth of bone tumor cells is *** subcutaneous tumor-bearing experiment of OS cells in nude mice further confirms that Mg wires can effectively inhibit the growth of tumors and prolong the survival of tumor-bearing *** addition,Mg wires have no toxicity to normal cells and *** results suggest that Mg implant is a potential anti-tumor scaffold for OS patients.

关键词： magnesium wire osteosarcoma inhibition hydrogen evolution Snail1 miRNA-181

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医用可降解血管支架临床研究进展

金属学报 2017年第10期53卷 1215-1226页

作者：张小农左敏超张绍翔吴宏流王文辉陈文智倪嘉桦上海交通大学材料科学与工程学院上海200240 苏州奥芮济医疗科技有限公司苏州215513

心血管疾病是危害国人身体健康的第一大疾病,介入治疗已成为患者的重要选择,植入血管支架被认为是目前最便捷有效的技术。本文在简单介绍经皮冠脉介入治疗的发展历程的基础上,综合比较了美国雅培公司研发的生物可吸收高分子支架以及德... 详细信息

心血管疾病是危害国人身体健康的第一大疾病,介入治疗已成为患者的重要选择,植入血管支架被认为是目前最便捷有效的技术。本文在简单介绍经皮冠脉介入治疗的发展历程的基础上,综合比较了美国雅培公司研发的生物可吸收高分子支架以及德国百多力公司研发的生物可降解镁合金支架的一系列随机临床实验数据,总结了可降解吸收支架目前存在的缺陷并分析了其未来的发展趋势。

关键词：介入治疗生物可吸收高分子支架可降解镁合金支架血栓管腔丢失

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远海梭子蟹渔业生物学的初步调查

海洋科学 2001年第1期25卷 36-39页

作者：王红勇吴洪流王子武王小扬王圣超海南大学水产系海口570228

对海南岛北部湾远海梭子蟹进行了生物学调查。初步结果表明,周年雌雄性比约1∶1。当年生蟹的交配期在8～10月 ,越年蟹在6～8月。初次性成熟的甲宽为75mm ,体重48g。大量性成熟甲宽100～120mm ,体重70～100g。此外生殖期较长 ,且周年有... 详细信息

对海南岛北部湾远海梭子蟹进行了生物学调查。初步结果表明,周年雌雄性比约1∶1。当年生蟹的交配期在8～10月 ,越年蟹在6～8月。初次性成熟的甲宽为75mm ,体重48g。大量性成熟甲宽100～120mm ,体重70～100g。此外生殖期较长 ,且周年有两个繁殖高峰期 ,分别在3～5月和8～10月。其群体甲宽优势组为110～150mm 。

关键词：远海梭子蟹生物学海南岛北部湾

Submarine Landslides on the North Continental Slope of the South China Sea

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Journal of Ocean University of China 2018年第1期17卷 83-100页

作者： WANG Weiwei WANG Dawei wu Shiguo VOKER David ZENG hongliu CAI Guanqiang LI Qingping College of Information and Control Engineering China University of Petroleum(East China)Qingdao 266580China Laboratory of Marine Geophysics and Georeource Institute of Deep-Sea Science and EngineeringChinese Academy of SciencesSanya 572000China Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China College of Earth Sciences University of Chinese Academy of SciencesBeijing 100049China MARUM Center for Marine Environmental Sciences University of BremenBremen 28359Germany Bureau of Economic Geology The University of Texas at AustinAustin 78713USA Guangzhou Marine Geology Survey Guangzhou 510760China Research Center of China National Offshore Oil Corporation Beijing 100027China

Recent and paleo-submarine landslides are widely distributed within strata in deep-water areas along continental slopes, uplifts, and carbonate platforms on the north continental margin of the South China Sea(SCS). In this paper, high-resolution 3D seismic data and multibeam data based on seismic sedimentology and geomorphology are employed to assist in identifying submarine landslides. In addition, deposition models are proposed that are based on specific geological structures and features, and which illustrate the local stress field over entire submarine landslides in deep-water areas of the SCS. The SCS is one of the largest fluvial sediment sinks in enclosed or semi-enclosed marginal seas worldwide. It therefore provides a set of preconditions for the formation of submarine landslides, including rapid sediment accumulation, formation of gas hydrates, and fluid overpressure. A new concept involving temporal and spatial analyses is tested to construct a relationship between submarine landslides and different time scale trigger mechanisms, and three mechanisms are discussed in the context of spatial scale and temporal frequency: evolution of slope gradient and overpressure, global environmental changes, and tectonic events. Submarine landslides that are triggered by tectonic events are the largest but occur less frequently, while submarine landslides triggered by the combination of slope gradient and overpressure evolution are the smallest but most frequently occurring events. In summary, analysis shows that the formation of submarine landslides is a complex process involving the operation of different factors on various time scales.

关键词： South China Sea submarine landslides seismic identification triggering mechanism