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伴有EGFR激酶结构域重复的婴儿横纹肌纤维肉瘤3例临床病理学分析

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中华病理学杂志 2025年第2期54卷 156-161页

作者：李红玲谢乐张锦晖吴燕杏韩福兰毛荣军佛山市中医院病理科佛山

目的探讨伴有EGFR激酶结构域重复(EGFR kinase domain duplication, EGFR-KDD)的婴儿横纹肌纤维肉瘤(infantile rhabdomyofibrosarcoma, IRFS)的临床病理及分子遗传学特征。方法收集佛山市中医院病理科2022年1月至2024年1月明确诊断为伴有EGFR-KDD的IRFS会诊病例3例, 对其临床、病理形态学和免疫组织化学特点进行回顾性分析, 利用PCR及二代测序技术分析其分子遗传学特征, 并复习相关文献。结果 3例患儿中男患儿1例(例1), 女患儿2例(例2, 3), 年龄分别为1岁(例1)、4岁(例2)、1岁(例3), 病变分别位于左大腿、右侧颌面部及右侧腘窝, 临床表现多为无意间发现的无痛性肿物, 肿瘤最大径3～5 cm。镜下观察, 瘤组织境界不清, 瘤细胞梭形, 呈密集弥漫、束状排列, 中等量嗜酸性淡染胞质, 核分裂象易见, 可见少许横纹肌母细胞样细胞, 未见出血、坏死。免疫组织化学表达波形蛋白、局灶表达平滑肌肌动蛋白(SMA)、肌特异性肌动蛋白(MSA)、结蛋白、Myogenin及MyoD1, Ki-67阳性指数为10%～60%。3例行逆转录-聚合酶链反应(RT-PCR)检测均发现EGFR-KDD, 3例均行二代测序检测但仅1例检测到EGFR-KDD。3例均获得随访资料, 随访时间12～36个月, 2例死亡, 1例存活(无复发转移)。结论伴有EGFR-KDD的IRFS是一种罕见的软组织肿瘤, 形态上类似于先天性纤维肉瘤, 但免疫组织化学具有横纹肌母细胞分化, 婴幼儿常见, 肿瘤好发躯干及四肢, 预后不佳, 患者需要积极的综合治疗。EGFR-KDD可能是其分子遗传学改变, 未来可能成为治疗靶点。

关键词：软组织肿瘤婴儿横纹肌纤维肉瘤 EGFR激酶结构域重复

Selective adsorption of silver ions from aqueous solution using polystyrene-supported trimercaptotriazine resin

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Journal of Environmental Sciences 2012年第12期24卷 2166-2172页

作者： Shiming Wang hongling li Xiaoya Chen Min Yang Yanxing Qi National Engineering Research Center for Fine Petrochemical Intermediates Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Graduate-University of Chinese Academy of Sciences Beijing 1001949China

Tdmercaptotriazine-functionalized polystyrene chelating resin was prepared and employed for the adsorption of Ag（I） from aqueous solution. The adsorbent was characterized according to the following techniques： Fourier transform infrared spectroscopy, elemental analysis, scanning electron microscopy and the Brunauer-Emmet-Teller method. The effects of initial Ag（I） concentration, contact time, solution pH and coexisting ions on the adsorption capacity of Ag（I） were systematically investigated. The maximum adsorption capacity of AgO） was up to 187.1 mg/g resin at pH 0.0 and room temperature. The kinetic experiments indicated that the adsorption rate of Ag（I） onto the chelating resin was quite fast in the first 60 rain and reached adsorption equilibrium after 360 min. The adsorption process can be well described by the pseudo second-order kinetic model and the equilibrium adsorption isotherm was closely fitted by the Langmuir model. Moreover, the chelating resin could selectively adsorb more Ag（I） ions than other heavy metal ions including： Cu（Ⅱ）, Zn（Ⅱ）, Ni（Ⅱ）, Pb（Ⅱ） and Cr（Ⅲ） during competitive adsorption in the binary metal species systems, which indicated that it was a highly selective adsorbent of Ag（I） from aqueous solution.

关键词： trimercaptotriazine macroporous chloromethyl resin functionalized adsorption silver ions

Synthesis and Flocculation of Polyacrylamide with Low Water Absorption for Non-dispersible Underwater Concrete

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Journal of Wuhan University of Technology(Materials Science) 2023年第6期38卷 1404-1413页

作者： li hongling YAN Na SUN Guowen ZHENG Haorui YANG Xinyu Depantment of Chemistry and Miaterials Engineering Xinxiang Normal CollegeXinxiang 453003China School of Materials Science and Engineering Shijiazhuang Tiedao UniversityShijiazhuang 050043China Hebei Key Laboratory of Advanced Materials for Transportation Engineering and Environment Shijiazhuang 050043China

The polyacrylamide which is directly added into concrete shows strong water absorption *** the construction of underwater constructure would demand high amount of water,resulting in poor workability of concrete and strength shrinkage after ***,a kind of anionic polyacrylamide(APAM)grafted with water reducing functional group(-COOH)was synthesized at low temperatures by partial factor design and response surface *** structure and morphology of APAM were characterized by UV,FTIR and SEM *** experimental results show that the molecular weight of the synthesized APAM could reach 11 million,under the condition that the temperature was 35℃,the pH value was 8,the monomer concentration was 27wt%,the initiator dosage was 0.6wt%,and the monomer ratio(n(AM):n(AA))was *** the APAM was applied into the underwater slurry,it presented good flocculation and low water *** the dosage was 1%of the mass of the cement,the water demand increased by 12%,which could meet the self-leveling and anti-dispersity of the underwater slurry at the same *** technology provides technical guidance for the large-scale industrial production of polyacrylamide for underwater concrete construction while achieving environmental protection during production.

关键词： non-dispersible underwater concrete anionic polyacrylamide partial factor design response surfacedesign flocculation

PG-CODE:Latent Dirichlet Allocation Embedded Policy Knowledge Graph for Government Department Coordination

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Tsinghua Science and Technology 2022年第4期27卷 680-691页

作者： Yilin Kang Renwei Ou Yi Zhang hongling li Shasha Tian School of Computer Science South-Central University for NationalitiesWuhan 430074China School of Public Management SouthCentral University for NationalitiesWuhan 430074China

Government policy-group integration and policy-chain inference are significant to the execution of strategies in current Chinese ***,the coordination of hierarchical policies implemented among government departments is one of the key challenges to rural *** recent years,various well-established quantitative methods have been proposed to evaluate policy coordination,but the majority of these relied on manual analysis,which can lead to subjective ***,in this paper,a novel approach called“policy knowledge graph for the coordination among the government departments”(PG-CODE)is proposed,which incorporates topic modeling into policy knowledge *** to a knowledge graph,a policy knowledge graph uses a graph-structured data model to integrate policy *** latent Dirichlet allocation embedding,a policy knowledge graph could capture the underlying topics of the ***,coordination strength and topic diffusion among hierarchical departments could be inferred from the PG-CODE,as it can provide a better representation of coordination within the policy *** implemented and evaluated the PG-CODE in the field of rural innovation and entrepreneurship policy,and the results effectively demonstrate improved coordination among departments.

关键词： policy knowledge graph department coordination topic diffusion latent dirichlet allocation rural revitalization

肾病综合征合并耶氏肺孢子菌感染1例多因素肾功能损害分析及思考

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临床医学研究与实践 2025年第1期10卷 22-25页

作者：郭春旭葛紫贺李红玲闫莉河北医科大学研究生学院河北石家庄050017 河北北方学院河北张家口075000 河北省人民医院急诊医学科河北石家庄050051 河北省人民医院呼吸与危重症医学科河北石家庄050051

本文对1例随病情进展肾功能逐渐恶化、预后极差的肾病综合征合并耶氏肺孢子菌感染患者进行病例报道,分析噬血细胞综合征(HPS)、应用美罗培南及多黏菌素B等可能造成该患者肾功能损害的因素,并总结早期评估应对措施,旨在为日后相关疾病的... 详细信息

本文对1例随病情进展肾功能逐渐恶化、预后极差的肾病综合征合并耶氏肺孢子菌感染患者进行病例报道,分析噬血细胞综合征(HPS)、应用美罗培南及多黏菌素B等可能造成该患者肾功能损害的因素,并总结早期评估应对措施,旨在为日后相关疾病的诊疗提供帮助。

关键词：肾病综合征耶氏肺孢子菌肾功能损害

Mesenchymal stem cells and immune disorders: from basic science to clinical transition

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Frontiers of Medicine 2019年第2期13卷 138-151页

作者： Shihua Wang Rongjia Zhu hongling li Jing li Qin Han Robert Chunhua Zhao Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegePeking Union Medical College HospitalCenter of Excellence in Tissue EngineeringChinese Academy of Medical SciencesBeijing 100005China

As a promising candidate seed cell type in regenerative medicine, mesenchymal stem cells (MSCs) have attracted considerable attention. The unique capacity of MSCs to exert a regulatory effect on immunity in an autologous/allergenic manner makes them an attractive therapeutic cell type for immune disorders. In this review, we discussed the current knowledge of and advances in MSCs, including its basic biological properties, i.e., multilineage differentiation, secretome, and immunomodulation. Specifically, on the basis of our previous work, we proposed three new concepts of MSCs, i.e.,“subtotipotent stem cell” hypothesis, MSC system, and “Yin and Yang” balance of MSC regulation, which may bring new insights into our understanding of MSCs. Furthermore, we analyzed data from the Clinical Trials database (http://***) on registered clinical trials using MSCs to treat a variety of immune diseases, such as graft-versus-host disease, systemic lupus erythematosus, and multiple sclerosis. In addition, we highlighted MSC clinical trials in China and discussed the challenges and future directions in the field of MSC clinical application.

关键词： mesenchymal stem cell clinical transition immune disorders

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刘燕平教授治疗小儿泄泻临证经验

广西中医药 2025年第1期48卷 35-37页

作者：黄娜李鸿玲马艳君刘燕平(指导) 广西中医药大学赛恩斯新医药学院广西南宁530222 广西中医药大学广西南宁530200 不详

小儿泄泻是儿科常见的脾胃病证,四季皆可发病,尤以夏、秋两季多见。刘燕平教授在临证过程中从总体出发,辨证论治,按“治病必求于本”原则,治疗时把握疾病的病因病机,将辨病与辨证相结合,治疗小儿泄泻,辨证准确,收效甚佳。

关键词：小儿泄泻刘燕平临证经验

The Epstein-Barr virus-miRNA-BART6-5p regulates TGF-β/SMAD4 pathway to induce glycolysis and enhance proliferation and metastasis of gastric cancer cells

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Oncology Research 2024年第5期32卷 999-1009页

作者： XUHUI ZHAO XIAOMIN HUANG CHUNYAN DANG XIA WANG YUJIAO QI hongling li The First Clinical Medical College Gansu University of Traditional Chinese MedicineLanzhou730000China Department of Oncology Gansu People’s HospitalLanzhou730000China The Clinical Medical College Ningxia Medical UniversityNingxia750004China

Background:EBV-miR-BARTs exhibit significant relevance in epithelial tumors,particularly in EBVassociated gastric and nasopharyngeal ***,their specific mechanisms in the initiation and progression of gastric cancer remain insufficiently *** and Methods:Initially,EBV-miRNA-BART6-5p and its target gene SMAD4 expression were assessed in EBV-associated gastric cancer tissues and cell *** transfection induced overexpression of EBV-miRNA-BART6-5p in AGS and MKN-45,and downregulation in EBVpositive cells(SUN-719).The subsequent evaluation aimed to observe their impact on gastric cancer cell proliferation,migration,and glycolytic processes,with the TGF-β/SMAD4 signaling pathway value clarified using a TGF-β***:EBV-miRNA-BART6-5p exhibits pronounced upregulation in EBV-associated gastric cancer tissues and EBV-positive cells,while its target gene SMAD4 demonstrates downregulated *** of it can promote the proliferation and migration of gastric cancer ***,We found EBV-miRNA-BART6-5p promotes glycolysis of gastric cancer *** of the TGF-β/SMAD4 signaling pathway resulted in suppressed proliferation and migration of gastric cancer cells,concomitant with a diminished glycolytic ***:In this study,we found that EBV-miRNA-BART6-5p can target SMAD4,effectively increasing glycolysis in gastric cancer cells by regulating the TGF-β/SMAD4 signaling pathway,thereby enhancing the proliferation and metastasis of gastric cancer *** findings may offer new insights into the metabolic aspects of gastric cancer.

关键词： EBV TGF-β/SMAD4 Glycolysis Gastric cancer

Comparison of thermal and light performance in two typical Chinese solar greenhouses in Beijing

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International Journal of Agricultural and Biological Engineering 2019年第1期12卷 24-32页

作者： Fan Xu Chao Shang hongling li Xuzhang Xue Weituo Sun Hong Chen Yinkun li Zhenhe Zhang Xinxu li Wenzhong Guo Beijing Research Center of Intelligent Equipment for Agriculture Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China Plant Science and Technology College Beijing University of AgricultureBeijing 102206China Beijing Extension Station for Agricultural Technology Beijing 100101China National Agricultural Technology Extension and Service Center Ministry of Agriculture and Rural Affairs of the People’s Republic of ChinaBeijing 100125China

Solar greenhouses have been used for producing vegetables in northern China during early spring,late autumn or *** improve the thermal performance of solar greenhouses,a traditional type and a retrofitted design were comparatively *** the retrofitted design,three adjustments were incorporated:the material and structure of the walls,south-facing roof angle,and structure of the north-facing *** results indicated that the thermal and light performance of the retrofitted greenhouse was much better than that of the traditional ***,the daily mean temperature,minimum air temperature,and soil temperature inside the greenhouses after retrofit ting were increased by 1.3,2.4,and 1.9℃,respectively,meanwhile,the daily total solar radiation and PAR were increased by 28.2%and 9.2%,*** wall temperature and its daily variation range were reduced with increasing depth and *** characteristic analysis of heat storage and release indicated that higher locations have longer heat storage,and shorter heat release time in vertical direction,as well as a lower ratio of heat release to *** horizontal direction,the western wall has the shortest heat storage time but the highest heat release flux ***,the heat storage time of the wall is 1.5 h less than that of the *** heat storage flux density of the wall is 1.5 times of that of the soil,but the heat release flux is only 61%of the soil’s *** total wall heat storage is half of that of the soil in the greenhouse;the total wall heat release amount is only a quarter of that of the ***,the thermal environment of solar greenhouses can be further improved by improving the thermal insulation properties of the wall.

关键词： structural change heat storage performance heat flux back wall thermal environment