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Comparison on Photopic Electroretinogram Negative Response between Young and Old Lewis Rats

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Eye Science 2011年第3期26卷 171-172页

作者： Yiqun Geng hongling chen Lifang Liu Hongjie Lin Mingzhi Zhang Central Laboratory of Shantou University Chinese Universtiy of Hong Kong Joint Shantou International Eye Center Shantou 515041 China

Purpose:To investigate and compare the latency and amplitude of the electroretinogram(ERG) photopic negative response(PhNR) between young and old Lewis ***:Thirteen Lewis rats were divided into two groups according to ages,young group(3-month old,n=5) and old group(24 month old,n=8).The ERGs of the left eyes were measured and the latency and amplitude of a-wave,b-wave and PhNRs were recorded and compared according to *** mean values between two groups were statistically analysed by ***:The latency of PhNRs was evidently prolonged in old group and showed significant difference(P<0.05).There was no statistically significant difference between two groups regarding the amplitude and latency,and no significant difference was noted in the amplitude of ***:The prolonged latency of PhNR in aged rats possibly associate with the influence of aging upon retinal ganglion cell layer(RGCL).

关键词：老年人年轻人大鼠反应统计学分析视网膜电图潜伏期幅度

PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

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Genes & Diseases 2024年第4期11卷 353-367页

作者： Yu Wei Dian Zhang He Shi Husun Qian hongling chen Qian Zeng Fangfang Jin Yan Ye Zuli Ou Minkang Guo Bianqin Guo Tingmei chen Key Laboratory of Clinical Laboratory Diagnostics(Ministry of Education) College of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China

Pyruvate dehydrogenase kinase 1(PDK1)phosphorylates the pyruvate dehydroge-nase complex,which inhibits its *** pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle and the reprogramming of tumor cell metabolism to glycolysis,which plays an important role in tumor *** study aims to elucidate how PDK1 pro-motes breast cancer *** found that PDK1 was highly expressed in breast cancer tissues,and PDK1 knockdown reduced the proliferation,migration,and tumorigenicity of breast cancer cells and inhibited the HIF-1α(hypoxia-inducible factor 1α)*** investigation showed that PDK1 promoted the protein stability of HIF-1αby reducing the level of ubiquitination of HIF-1α.The HIF-1αprotein levels were dependent on PDK1 kinase ***,HIF-1αphosphorylation at serine 451 was detected in wild-type breast cancer cells but not in PDK1 knockout breast cancer *** phosphorylation of HIF-1αat Ser 451 stabilized its protein levels by inhibiting the interaction of HIF-1αwith von Hippel-Lindau and prolyl hydroxylase *** also found that PDK1 enhanced HIF-1αtranscriptional *** summary,PDK1 enhances HIF-1αprotein stability by phosphorylating HIF-1αat Ser451 and promotes HIF-1αtranscriptional activity by enhancing the binding of HIF-1αto ***1 and HIF-1αform a positive feedback loop to promote breast cancer progression.

关键词： Breast cancer HIF-1α PDK1 Protein phosphorylation Transcriptional activity

Arabidopsis NIP3;1 Plays an Important Role in Arsenic Uptake and Root-to-Shoot Translocation under Arsenite Stress Conditions

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Molecular Plant 2015年第5期8卷 722-733页

作者： WenzhongXu Wentao Dai Huili Yan Sheng Li hongling Shen Yanshan chen Hua Xu Yangyang Sun Zhenyan He Mi Ma Key Laboratory of Plant Resources Institute of Botany Chinese Academy of Sciences Beijing 100093 China

In Arabidopsis, the nodulin 26-like intrinsic protein （NIP） subfamily of aquaporin proteins consists of nine members, five of which （NIP1;1, NIP1;2, NIP5;1, NIP6;1, and NIP7;1） were previously identified to be perme- able to arsenite. However, the roles of NIPs in the root-to-shoot translocation of arsenite in plants remain poorly understood. In this study, using reverse genetic strategies, Arabidopsis NIP3;1 was identified to play an important role in both the arsenic uptake and root-to-shoot distribution under arsenite stress condi- tions. The nip3;1 loss-of-function mutants displayed obvious improvements in arsenite tolerance for aboveground growth and accumulated less arsenic in shoots than those of the wild-type plants, whereas the nip3;1 nip1;1 double mutant showed strong arsenite tolerance and improved growth of both roots and shoots under arsenite stress conditions. A promoter-β-glucuronidase analysis revealed that NIP3; 1 was ex- pressed almost exclusively in roots （with the exception of the root tips）, and heterologous expression in the yeast Saccharomyces cerevisiae demonstrated that NIP3;1 was able to mediate arsenite transport. Taken together, our results suggest that NIP3;1 is involved in arsenite uptake and root-to-shoot translocation in Arabidopsis, probably as a passive and bidirectional arsenite transporter.

关键词： Arabidopsis, arsenite, NIP3 1, root-to-shoot translocation, tolerance

The relationships between step count and all-cause mortality and cardiovascular events:A doseresponse meta-analysis

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Journal of Sport and Health Science 2021年第6期10卷 620-628,F0003页

作者： Mingxin Sheng Junyue Yang Min Bao Tianzhi chen Ruixue Cai Na Zhang hongling chen Minqi Liu Xueyu Wu Bowen Zhang Yiting Liu Jianqian Chao Key Laboratory of Environmental Medicine Engineering of Ministry of Education Department of Epidemiology and BiostatisticsSchool of Public HealthSoutheast UniversityNanjing 210009China Department of Health Policy and Management School of Public HealthPeking UniversityBeijing 100191China

Background:A goal of 10,000 steps per day is widely advocated,but there is little evidence to support that *** purpose was to examine the doseresponse relationships between step count and all-cause mortality and cardiovascular disease ***:Cochrane Central Register of Controlled Trials,EMBASE,OVID,PubMed,Scopus,and Web of Science databases were systematically searched for studies published before July 9,2021,that evaluated the association between daily steps and at least 1 ***:Sixteen publications(12 related to all-cause mortality,5 related to cardiovascular disease;and 1 article contained 2 outcomes:both allcause death and cardiovascular events)were eligible for inclusion in the *** was evidence of a nonlinear doseresponse relationship between step count and risk of all-cause mortality or cardiovascular disease(p=0.002 and p=0.014 for nonlinearity,respectively).When we restricted the analyses to accelerometer-based studies,the third quartile had a 40.36%lower risk of all-cause mortality and a 35.05%lower risk of cardiovascular event than the first quartile(all-cause mortality:Q1=4183 steps/day,Q3=8959 steps/day;cardiovascular event:Q1=3500 steps/day,Q3=9500 steps/day;respectively).Conclusion:Our meta-analysis suggests inverse associations between higher step count and risk of premature death and cardiovascular events in middle-aged and older adults,with nonlinear doseresponse patterns.

关键词： All-cause death Cardiovascular disease Daily steps Dose-response Healthy lifestyle Primary prevention

Disaster Situation from July to December in 1998 in China

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Natural Disaster Reduction in China 2000年第2期 32-41页

作者： chen hongling (Ministry of Civil Affairs of PRC, Beijing 100721)

SeismicDisastersAt12:51a.m.,July28,anearthquakeof5.5Ms,whichwasaccompaniedbylandslide,shockedtheBaichengCountyofAksuPrefectureandcausedseriousdestructiontothebuildingsofthecounty,withtheepicenteroftheearthquakelocated... 详细信息

关键词： disaster situation

Disaster Situation in China in 1999

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Natural Disaster Reduction in China 2000年第3期 23-41页

作者： chen hongling (Ministry of Civil Affairs of PRC, Beijing 100721)

Disaster Situation from January to June in 1998 in China

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Natural Disaster Reduction in China 2000年第1期 26-41页

作者： chen hongling (Ministry of Civil Affairs of PRC, Beijing 100721)

JanuaryEarthquakeDisasterAt11:***.10,anearthquakeof6.2MsoccurredinZhangjiakuo,***41.12°N,114.337°***,Shangyi,WanquanandKangbaocountieswereseverelyaffected.471000peoplewereaffected,417000wereseriouslyaffe... 详细信息

关键词： disaster situation

China National Disaster Situation and Disaster Relief in 1999

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Natural Disaster Reduction in China 2000年第4期 7-12页

作者： chen hongling (Ministry of Civil Affairs of PRC, Beijing 100721)

可聚合有机硅乳化剂在苯丙乳液聚合反应中的应用

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高分子材料科学与工程 2011年第4期27卷 110-113页

作者：许澎陈洪龄南京工业大学化学化工学院江苏南京210009

将可聚合有机硅乳化剂马来酸硅聚氧乙烯醚单酯羧酸盐(PMSC)与传统十二烷基硫酸钠(SDS)/壬基酚聚氧乙烯醚(TX-10)复合乳化剂分别应用到苯丙乳液的半连续聚合反应。用红外光谱(FT-IR)、粒度分布、热重分析(TG)、接触角等表征了聚合物的结... 详细信息

将可聚合有机硅乳化剂马来酸硅聚氧乙烯醚单酯羧酸盐(PMSC)与传统十二烷基硫酸钠(SDS)/壬基酚聚氧乙烯醚(TX-10)复合乳化剂分别应用到苯丙乳液的半连续聚合反应。用红外光谱(FT-IR)、粒度分布、热重分析(TG)、接触角等表征了聚合物的结构和乳液性能。结果表明,PMSC参与聚合反应,制得的聚合物乳液呈单分散性,平均粒径0.5μm,电解质稳定性好。乳液制成的涂膜热分解温度为417.4℃,耐水性好,浸入水中30 d,吸水率为28.53%。由PMSC制备乳液涂覆的玻璃和织物表面对水的接触角分别为81.57°和128.03°。可聚合有机硅乳化剂PMSC较一般SDS/TX-10复合乳化剂有较多的优势。

关键词：可聚合乳化剂乳液聚合苯丙乳液有机硅