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The Characteristic of Transient HC Emissions During Cold Start on a Port-fuel-injection Gasoline Engine

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The Characteristic of Transient HC Emissions During Cold Sta...

A combined genome-wide transcription analysis and DNA methylation identified genes related with pathogenesis of lupus nephritis

2018中国汽车工程学会年会

作者： CHEN Huan CHENG Chuanhui XU honglin WU tao XU Zheng WANG Yunchao SAIC Motor Technical Center Shanghai Key Laboratory of Automobile Power-train

The percentage of HC emission before catalyst light off is beyond 90%in WLTC driving *** is a big challenge to reduce the HC emission during cold start phase due to poor mixture preparation from port injection spark ignition *** study focus on cold start period to investigate HC emissions based on cycle-by-cycle method,using fast FID HC analyzer（HFR500） and cylinder pressure indicating *** results have been compared with two different types of fuel injectors installed on a 1.5 L port fuel injection gasoline *** transient HC emission of first 10 cycles has been *** test results also show that HC emissions of the type B injector（8-hole） are 11%lower than that of the type A injector（6-hole） under same fuel injection strategy.

关键词： port fuel injection gasoline engine cold start transient HC emissions injector

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A combined genome-wide transcription analysis and DNA methyl...

A combined genome-wide DNA methylation and transcription analysis identified genes related with pathogenesis of systemic sclerosis

第十届全国免疫学学术大会

作者： honglin Zhu Luo Hui Chen tao Shengxi Liu Quanzhen Li Xiaoxia Zuo Department of Rheumatology Xiangya Hospital Central South University Department of Immunology and Internal Medicine University of Texas Southwestern Medical Center 5323 Harry Hines Blvd

Objectives:Lupus nephritis(LN)is one of the most devastating complications and a main cause of morbidity and mortality in systemic lupus erythematosus(SLE).Genetic,hormonal and environment factors and its complexity interaction contributed to the pathogenitic mechanisms of SLE,but the etiology of LN is not clear,a better understand the pathogenesis of LN is ***:A genome-wide transcription analysis and DNA methylation were performed on PBMC from 30 SLE patients(15 SLE with LN,15 SLE without LN)and 25 matched normal controls(NC)using the Human HT-12 Beadchips and Illumina Human *** autoantibodies were detected by using 98 autoantigen *** proinflammatory cytokines were analyzed by Bioplex human cytokine 27 plex *** methylated Cp G sites and genes were identified with Genomstudio,R and SAM *** was analyzed by IPA ***:24 antinuclear antibodies titers were markedly higher in SLE patients,most of them were even higher in SLE patients with *** expression and DNA methylation profiling suggests common changes found in the two groups of *** genes participated in interferon Signaling,recognition of bacteria and viruses,T cell and B cell signaling and et *** were 34 different expressed genes in SLE with LN compared with SLE without LN.6 genes were up-regulated and 28 genes were down-regulated in SLE with LN.E2F2 and MX1 was upregulated and *** concentrate of inflammatory cytokines IL17A,IP10,BASIC-FGF,TNFα,IL6,IL15,GM-CCSF,IL1RA,IL5 and IL12P70 were significant higher in SLE compared with NC,but there was no significant difference between the two groups of *** expressions of these cytokines were changed *** with cytokine methylation data,IL5 gene expression was down-regulated and hypomethylated;TNFαgene expression was up-regulated and ***:We provide a comprehensive analysis of autoantibodies,gene expression,methylation

关键词： Lupus nephritis systemic lupus erythematosus DNA methylation Gene expression

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A combined genome-wide DNA methylation and transcription ana...

第十届全国免疫学学术大会

作者： honglin Zhu Hui Luo tao Chen Shengxi Liu Quanzhen Li Xiaoxia Zuo Department of Rheumatology Xiangya Hospital Central South University Department of Immunology and Internal Medicine University of Texas Southwestern Medical Center 5323 Harry Hines BlvdDallas

Objectives:Systemic sclerosis(SSc)is an autoimmune disease with unknown *** have revealed epigenetic modification can contribute to susceptibility and pathogenic process in systemic autoimmune diseases by regulating gene activation or *** DNA methylation has been reported in dermal fibroblasts of SSc patients,but little is known about the DNA methylation changes in relation with gene expression on a genome-wide scale in ***:A genome-wide DNA methylation and transcription analysis were performed on PBMC from 19 SSc patients and 18 matched healthy controls(HC)using the Illumina Human Methy450 and Human HT-12 *** serum levels of proinflammatory cytokines were also analyzed by the Bio-plex human cytokine 27-plex *** methylated Cp G sites and genes between patients and controls were identified with Genomstudio,R and SAM *** association between DNA Methylation and gene expression were *** interaction pathways of the differentially expressed genes were analyzed by IPA ***:Out of 485,000 Cp G sites across the genome,4,848 hypomethylated and 216 hypermethylated Cp G sites were identified from SSc as compared with HC,representing 2,488 hypomethylated and 134 hypermethylated *** microarray analysis identified 1,023 significantly upregulated genes in SSc,of which 405 genes were hypomethylated,indicating a negative regulation of DNA methylation on gene *** hypomethylated genes in SSc include established autoimmune-related and novel genes,such as AIF1,ARID3A,IFI44L,PARP9,RSAD2,EPSTI1,EIF2AK2 and *** analysis revealed enrichment of genes involved in Wnt signaling pathway,leukocyte transendothelial migration,cell adhesion molecules and chemokine signaling *** Wnt signaling pathway was represented by hypomethylation of Wnt5b,Wnt7a,Smad2,and *** hypomethylated genes involved in chemokine signaling pathway were correlated with the increas

关键词： Systemic sclerosis DNA methylation gene expression

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约束阻尼板增材式拓扑渐进法减振动力学优化

机械科学与技术 2017年第6期36卷 971-977页

作者：贺红林陶结南昌航空大学航空制造工程学院南昌330063

研究阻尼结构的阻尼材料最优布局问题。基于虚功原理,构建约束阻尼板振动微分方程,从约束阻尼板若干基本假设出发并根据阻尼板自由振动微分方程,推导了结构模态阻尼比表达式。建立了以阻尼单元相对密度为拓扑设计变量,模态阻尼比最大为... 详细信息

研究阻尼结构的阻尼材料最优布局问题。基于虚功原理,构建约束阻尼板振动微分方程,从约束阻尼板若干基本假设出发并根据阻尼板自由振动微分方程,推导了结构模态阻尼比表达式。建立了以阻尼单元相对密度为拓扑设计变量,模态阻尼比最大为优化目标,阻尼材料用量为约束的阻尼结构拓扑优化数学模型。以阻尼单元模态阻尼比敏度为寻优方向的依据,采用增材式渐进法(AESO)求解优化模型,并依据拓扑优化准则在结构上不断敷设阻尼材料。编程实现了AESO算法,仿真计算表明:采用AESO优化时,阻尼材料主要敷设于结构的模态应变较大位置,且不会产生棋盘格现象,并且优化后的结构一阶模态阻尼比较优化前可增加83.6%,而常规渐进法带来的增幅仅72.13%。为进一步验证优化效果,还对结构进行了谐响应分析,结果表明采用增材式渐进法优化时,结构可获得更佳减振效果。

关键词：约束阻尼板虚功原理增材式渐进法(AESO) 谐响应

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食用豆生物育种研究进展

中国基础科学 2022年第4期24卷 53-64,68页

作者：吴磊杨涛陈红霖武晶中国农业科学院作物科学研究所北京100081

为了全面了解食用豆生物育种的研究进展和发展趋势,本文综述了食用豆在种质资源、遗传育种、基因组和育种技术等方面的研究现状。总体上看,食用豆生物育种研究也取得了一定的成绩,促进了食用豆的遗传研究,但是在生物育种技术的研发和应... 详细信息

为了全面了解食用豆生物育种的研究进展和发展趋势,本文综述了食用豆在种质资源、遗传育种、基因组和育种技术等方面的研究现状。总体上看,食用豆生物育种研究也取得了一定的成绩,促进了食用豆的遗传研究,但是在生物育种技术的研发和应用等方面与水稻、小麦、玉米和大豆相比还有较大的差距。针对食用豆研究中目前存在的诸如种质资源研究不足、育种可利用分子标记缺乏、转基因等技术应用不够等问题,提出了未来研究的重点方向和任务,为发展食用豆生物育种提供借鉴和参考。

关键词：食用豆种质资源生物育种

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CSMA/CD协议的形式化描述与验证

计算机应用 2013年第A2期33卷 235-237,268页

作者：张涛袁键田宏林 73610部队南京210018

模型检测是协议验证的技术之一。在CSMA/CD协议的验证过程中对该协议进行了简化,忽略了通道时延、退避算法等细节,运用Promela语言进行建模实现。最后,使用模型检测工具SPIN对协议实现的正确性、状态可达性以及可能存在的不可推进循环... 详细信息

模型检测是协议验证的技术之一。在CSMA/CD协议的验证过程中对该协议进行了简化,忽略了通道时延、退避算法等细节,运用Promela语言进行建模实现。最后,使用模型检测工具SPIN对协议实现的正确性、状态可达性以及可能存在的不可推进循环进行了分析和检验,并从结果的有效性和正确性方面得出了相应验证输出图。

关键词： Promela SPIN 协议验证载波监听多路访问冲突检测机制形式化

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粘弹阻尼抗振结构双向渐进法拓扑动力学优化

农业机械学报 2016年第8期47卷 339-345,412页

作者：贺红林陶结刘尧弟夏自强南昌航空大学航空制造工程学院南昌330063

基于阻尼结构各层形变位移关系,推导了结构振动微分方程。构建了以阻尼比最大化为优化目标,阻尼材料用量为约束,阻尼单元状态为设计变量的拓扑优化数学模型。为寻找结构优化迭代方向,推导了模态阻尼比灵敏度。建立阻尼单元增删准则,利... 详细信息

基于阻尼结构各层形变位移关系,推导了结构振动微分方程。构建了以阻尼比最大化为优化目标,阻尼材料用量为约束,阻尼单元状态为设计变量的拓扑优化数学模型。为寻找结构优化迭代方向,推导了模态阻尼比灵敏度。建立阻尼单元增删准则,利用独立网格滤波技术进行滤波处理,采用双向渐进优化算法对阻尼结构进行了拓扑优化。按常规渐进法优化后,1阶、3阶阻尼比增幅分别为54.51%、36.21%,而按双向渐进优化所得相应阶次的模态阻尼比增幅则分别达76.69%、58.36%,且可有效改善阻尼结构优化后的棋盘格现象。为验证双向渐进优化算法拓扑优化结果,对阻尼结构进行谐响应分析与仿真,结果表明:采用双向渐进法优化时,结构特定阶次响应幅值更低,减振效果更佳。

关键词：阻尼抗振结构双向渐进法模态阻尼比拓扑动力学优化

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YB65型条盒包装机异型包装改进

烟草科技 2021年第4期54卷 100-106页

作者：卢洪林陈涛刘翔肖华宇红云红河烟草(集团)有限责任公司昆明卷烟厂昆明市650202

为解决异型卷烟人工包装生产成本高且效率低等问题,对YB65型条盒包装机进行了异型包装改进。通过改进条盒纸暂存和供料装置,设计条盒纸折叠成型装置,增加条盒封签自动贴标装置,满足了条盒纸拾取、释放、折叠及提升输送要求,实现了异型... 详细信息

为解决异型卷烟人工包装生产成本高且效率低等问题,对YB65型条盒包装机进行了异型包装改进。通过改进条盒纸暂存和供料装置,设计条盒纸折叠成型装置,增加条盒封签自动贴标装置,满足了条盒纸拾取、释放、折叠及提升输送要求,实现了异型条盒的立式包裹成型。以昆明卷烟厂生产的"云烟(百味人生)"为对象进行测试,结果表明:在生产速度25条/min条件下,改进后YB65包装机运行效率为78.0%,产量为34箱(每箱5万支卷烟)/班次,不合格产品剔除率为0.17%,累计停机时间为43.8 min/班次,条盒包装质量符合企业质检要求。该技术可为提高卷烟异型包装机械化生产水平提供支持。

关键词： YB65型条盒包装机条盒纸异型包装折叠成型

基于CAE的复杂薄壁防爆球冷流道注塑模具优化设计

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工程塑料应用 2023年第5期51卷 86-92页

作者：陶哲季宁么大锁于洋洋赵洪林姜金花李冬芳天津仁爱学院机械工程学院天津301636 天津市静海区统计局天津301600 天津大学内燃机燃烧学国家重点实验室天津300072 天津博世丰通科技有限公司天津301600

针对结构复杂且呈现薄壁特征的防爆球在注塑成型时极易造成困气和脱模时易变形的问题,基于CAE分析技术设计了一模八腔的点浇口三板式冷流道注塑模具。首先,基于CAE分析确定了防爆球的最佳浇口位置,在此基础上设计了其浇注系统和冷却系统... 详细信息

针对结构复杂且呈现薄壁特征的防爆球在注塑成型时极易造成困气和脱模时易变形的问题,基于CAE分析技术设计了一模八腔的点浇口三板式冷流道注塑模具。首先,基于CAE分析确定了防爆球的最佳浇口位置,在此基础上设计了其浇注系统和冷却系统,并应用CAE技术验证了其合理性;其次,为便于排气,解决薄壁防爆球在注塑时易产生困气导致欠注的问题,巧妙地设计了插拔式的动模型芯镶块和定模型芯镶块,利用镶块型芯固定板之间的配合间隙进行有效排气;由于产品壁薄且多隔板,在动模侧每颗防爆球上均匀布置4根圆顶针和4根扁口顶针,平稳顶出产品的同时减少了其变形量;而后,应用UG对复位机构和模具其他辅助机构进行了分析设计,完成了防爆球冷流道的注塑模具设计;最后,经试验验证,该模具结构合理,工作过程稳定可靠,可为具有薄壁特征的相似结构的产品冷流道注塑模具设计提供有益借鉴。

关键词： CAE技术薄壁防爆球冷流道注塑模具设计