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Science China Chemistry 2025年

作者： Yuanlong Pan Qiang Zhang Guangzheng Huang Yannan Luo honglin gao School of Materials and Energy National Center for International Research on Photoelectric and Energy MaterialsYunnan University

Modifying the microstructure of photocatalysts while simultaneously introducing vacancies has shown significant potential in enhancing their performance for hydrogen production. Herein, a novel tubular mesoporous carbon nitride（TMCN） with nitrogen vacancies was fabricated using a microwave-assisted synthesis strategy, employing melamine-cyanuric acid supramolecular（MC-S） as the precursor. The optimized TMCN exhibited an outstanding H2production rate, approximately 29 times higher than that of pristine g-C3N4. The N-vacancies serve as sites for reactant adsorption and activation, leading to enhanced delocalization of HOMO-LUMO. Furthermore, the porous structures of TMCN facilitate the reactant diffusion, while its tubular architectures promote the oriented transfer of charge carriers. Crucially, the markedly improved photocatalytic performance of TMCN can be predominantly attributed to the synergistic effects arising from its superior structure and N-vacancy defects. This work opens new possibilities for the simultaneous formation of surface defect states as photocatalytic reaction sites and distinctive structures conducive to charge carrier transport.

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Enzyme-activatable disk-shaped nanocarriers augment tumor permeability for breast cancer combination therapy

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Nano Research 2024年第7期17卷 6400-6410页

作者： Hanming Zhang honglin gao Yicong Zhang Yikun Han Qing Lin Tao Gong Xun Sun Zhirong Zhang Ling Zhang Shiqi Huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Unique physiopathological characteristics of tumor tissues impose obstacles to the sufficient penetration of traditional nanomedicines,resulting in undesirable drug delivery efficacy and therapeutic ***,we constructed TRAIL-[NDHCPT]^(GAC),a synergistic hydroxycamptothecin(HCPT)and tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)protein co-loaded disk-shaped nanocarrier withγ-glutamyl transpeptidase *** the novel nanodisks extravasated into the tumor interstitium,theγ-glutamyl transpeptidase overexpressed on the tumor cell membranes cleaved theγ-glutamyl portions of the nanodisk surface to produce positively charged amino *** a result,the cationic nanodisks possessed stronger tumor infiltration ability through transcytosis than anionic *** and TRAIL exerted synergistic antitumor effects with better overall therapeutic *** TRAIL-[ND-HCPT]^(GAC)system performed significantly better than free HCPT and remarkably prolonged the survival of breast tumor-bearing mice with no significant toxicity.

关键词： tumor penetration combination therapy charge reversal γ-glutamyl transpeptidase nanodisk

Influence of carbon and yttrium co-doping on the photocatalytic activity of mixed phase TiO_2

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Chinese Journal of Catalysis 2017年第10期38卷 1688-1696页

作者： honglin gao Jianmei Liu Jin Zhang Zhongqi Zhu Genlin Zhang Qingju Liu nano Materials & Technology Yunnan University Kunming 650091 Yunnan China School of Materials Science and Engineering Yunnan Key Laboratory for Micro Kunming 650091 Yunnan China

Mixed phase TiO2photocatalysts doped with C and Y were synthesized by a sol‐gel *** effects of C and Y doping and annealing temperatures on the structural and optical properties,and photocatalytic activity were *** found that both C and Y doping can broaden the absorption spectrum of TiO2to the visible light region and inhibit recombination of photogenerated electron/hole *** incorporation of Y into the TiO2lattice inhibited growth of crystalline grains,which increased the specific surface area and enhanced the photocatalytic *** photocatalytic performance of the samples was investigated in the photocatalytic degradation of methyl blue under visible light *** rate of methyl blue degradation over the(C,Y)‐co‐doped TiO2sample was much higher than those of undoped TiO2,C‐TiO2,and Y‐***,the apparent first‐order rate constant of the co‐doped sample was3.5times as large as that of undoped mix phase TiO2under the same experimental *** enhanced photocatalytic activity can be attributed to the synergic effect of(C,Y)‐co‐doping and the formation of an appropriate crystalline structure.

关键词： Titanium dioxide Co‐doping Mixed phase Phase control Visible light photocatalysis

Tumor immune microenvironment-modulated nanostrategy for the treatment of lung cancer metastasis

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Chinese Medical Journal 2023年第23期136卷 2787-2801页

作者： Lingling Zhu Juan Wu honglin gao Ting Wang Guixiu Xiao Chenggong Hu Qing Lin Qinghua Zhou Lung Cancer Center Lung Cancer InstituteWest China Hospital of Sichuan UniversityChengduSichuan 610041China Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacyCollege of Polymer Science and EngineeringSichuan UniversityChengduSichuan 610041China Out-patient Department West China HospitalSichuan UniversityChengduSichuan 610041China Department of Critical Care Medicine West China Hospital of Sichuan UniversityChengduSichuan 610041China

As one of the most malignant tumors worldwide,lung cancer,fueled by metastasis,has shown rising mortality ***,effective clinical strategies aimed at preventing metastasis are lacking owing to its dynamic multi-step,complicated,and progressive *** has shown promise in treating cancer metastasis by reversing the immunosuppressive network of the tumor ***,drug resistance inevitably develops due to inadequate delivery of immunostimulants and an uncontrolled immune ***,adverse effects occur,such as autoimmunity,from the non-specific immune activation and non-specific inflammation in off-target *** that improve drug solubility,permeability,stability,bioavailability,as well as sustained,controlled,and targeted delivery can effectively overcome drug resistance and enhance the therapeutic effect while reducing adverse *** particular,nanomedicine-based immunotherapy can be utilized to target tumor metastasis,presenting a promising therapeutic strategy for lung *** strategies that boost the immunotherapy effect are classified based on the metastatic cascade related to the tumor immune microenvironment;the breaking away of primary tumors,circulating tumor cell dissemination,and premetastatic niche formation cause distant secondary site *** this review,we focus on the opportunities and challenges of integrating immunotherapy with nanoparticle formulation to establish nanotechnology-based immunotherapy by modulating the tumor microenvironment for preclinical and clinical applications in the management of patients with metastatic lung *** also discuss prospects for the emerging field and the clinical translation potential of these techniques.

关键词： Nanomedicine Lung cancer Metastasis Immunotherapy Tumor microenvironment

^(40)Ar/^(39)Ar测年法表观年龄计算中的误差分析

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第四纪研究 2012年第3期32卷 547-558页

作者：高洪林北京大学地球与空间科学学院造山带与地壳演化教育部重点实验室北京100871

除了样品因素外,第四纪地质样品^(40)Ar/^(39)Ar测年的关键在于测试和年龄计算中的误差控制。信号强度(随测量时刻)的拟合值可以采用最小二乘法进行直线或二次多项式拟合计算,但拟合值的误差不能通过拟合方程系数的误差进行计算,而应选... 详细信息

除了样品因素外,第四纪地质样品^(40)Ar/^(39)Ar测年的关键在于测试和年龄计算中的误差控制。信号强度(随测量时刻)的拟合值可以采用最小二乘法进行直线或二次多项式拟合计算,但拟合值的误差不能通过拟合方程系数的误差进行计算,而应选择合适的计算方法以便获得与实测值误差相协调的拟合值误差。减小质量歧视系数D的相对误差并控制^(36)Ar的原始误差,才能有效的降低质量歧视校正带给^(39)Ar的相对误差。^(40)Ar_(rad)的相对误差来源于^(40)Ar测量值的相对误差、^(36)Ar测量值的相对误差、^(36)Ar_(Ca)的相对误差、吸附大气氩^(36)Ar_(air)的相对误差以及样品经反应堆辐照后产生的^(39)Ar_K的相对误差等。当样品极年轻且含有较多吸附大气氩时,^(40)Ar_(rad)的相对误差就会变大;当样品极年轻且受到过度辐照时,^(39)Ar_K的相对误差对^(40)Ar_(rad)相对误差的贡献也会增大;当反应堆中热中子比例较高且样品辐照过程中没有Cd屏蔽时,校正系数α的相对误差对其贡献也不可忽略。当标样年龄小于100Ma时,J值相对误差等于标样测量值R_S的相对误差平方、衰变常数相对误差平方及标样年龄相对误差平方加和的平方根。当标样年龄大于100Ma时,衰变常数相对误差平方及标样年龄相对误差平方将被不同程度的放大(1倍多到几倍)后传递到J值相对误差中,从而增大了这两个来源的误差对J值相对误差的影响。

关键词： ^40Ar/^39Ar测年技术第四纪地质样品测年表观年龄计算误差分析

真空压铸技术对重型汽车变速箱后盖品质的影响

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特种铸造及有色合金 2016年第11期36卷 1158-1160页

作者：高红林陕西法士特汽车传动工程研究院

采用真空压铸生产了重型汽车变速箱后盖。通过对比分析真空压铸与普通压铸生产的铸件差异(质量、金相组织和热处理效果等),发现真空压铸件组织致密,内部气孔较少,废品率较低,提高了铸件品质,节约了成本。

关键词：真空压铸技术压铸模具真空压铸件普通压铸件

全自动^40Ar/^39Ar激光探针定年系统空白本底与微量样品定年

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地球学报 2005年第B9期26卷 39-43页

作者：高洪林北京大学地球与空间科学学院“造山带与地壳演化”教育部重点实验室北京100871

氩-氩定年法中系统的空白本底是实现微区微量定年的关键条件。在北京大学“造山带与地壳演化教育部重点实验室全自动^40Ar／^39Ar激光探针定年系统”上以ZBH-25黑云母标样为试验样品进行了1个颗粒、3个颗粒和5个颗粒的全熔法定年以及7... 详细信息

氩-氩定年法中系统的空白本底是实现微区微量定年的关键条件。在北京大学“造山带与地壳演化教育部重点实验室全自动^40Ar／^39Ar激光探针定年系统”上以ZBH-25黑云母标样为试验样品进行了1个颗粒、3个颗粒和5个颗粒的全熔法定年以及7个颗粒的4步、9步、14步、19步和24步的分步释氩年龄谱测试。获得的5个氩同位素空白本底水平表明，本系统已经完全具备对中生代或更老的地质样品进行单颗粒全熔法等时线定年的能力。矿物或岩石光片原位全熔法定年的空白本底条件也已经具备。在适当增加样品量情况下（如10个颗粒），几个百万年的年轻样品全熔等时线定年也可以实现。去除干扰分子对^36Ar空白本底的影响，以及系统长期稳定运行后^36Ar空白本底的逐渐降低，实现微量样品的分步释氩年龄谱定年是必然的。

关键词：北京大学 ^40Ar/^39Ar激光探针定年系统空白本底微量样品定年 ^40Ar/^39Ar 本底条件微量样品定年法激光探针全自动

改进的半空间频率均方声压法计算结构频带振动声辐射

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声学学报 2019年第1期44卷 106-115页

作者：高宏林黎胜孟春霞大连理工大学工业装备结构分析国家重点实验室运载工程与力学学部船舶工程学院大连116024 高新船舶与深海开发装备协同创新中心上海200240 水下测控技术重点实验室大连116013

为计算中高频半空间结构频带振动下声辐射问题,推导了基于能量源的半空间频率均方声压法(Frequency Averaged Quadratic Pressure, FAQP),并提出了改进的半空间FAQP法,克服了半空间FAQP法在失效频率下解不唯一的问题。频率带宽为4 Hz的... 详细信息

为计算中高频半空间结构频带振动下声辐射问题,推导了基于能量源的半空间频率均方声压法(Frequency Averaged Quadratic Pressure, FAQP),并提出了改进的半空间FAQP法,克服了半空间FAQP法在失效频率下解不唯一的问题。频率带宽为4 Hz的刚性壁面作用下的脉动球和与自由表面相接触的脉动半球的声辐射数值计算,验证了改进的半空间FAQP法对解决失效频率下解不唯一问题的有效性。同时,刚性壁面作用下的脉动球和与自由表面相接触的脉动半球声辐射数值计算结果均表明,在1/3倍频程下,改进的半空间FAQP法与常规边界元方法相比,具有更高的计算精度,更适用于中高频计算。

关键词：振动声辐射空间频率声压法计算结构频带数值计算刚性壁面边界元方法

结构频带振动声辐射的有限元结合频率均方声压法数值计算

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中国舰船研究 2017年第4期12卷 71-75,82页

作者：高宏林黎胜大连理工大学工业装备结构分析国家重点实验室辽宁大连116024 大连理工大学运载工程与力学学部船舶工程学院辽宁大连116024 高新船舶与深海开发装备协同创新中心上海200240

[目的]为了预报受频带激励的振动结构声辐射,[方法]利用有限元法(FEM)和频率均方声压法(FAQP),对受频带激励的结构振动声辐射问题进行数值计算研究。首先,通过有限元软件计算加筋圆柱壳在频带激励下表面质点速度的频率响应;然后,将结构... 详细信息

[目的]为了预报受频带激励的振动结构声辐射,[方法]利用有限元法(FEM)和频率均方声压法(FAQP),对受频带激励的结构振动声辐射问题进行数值计算研究。首先,通过有限元软件计算加筋圆柱壳在频带激励下表面质点速度的频率响应;然后,将结构表面质点速度转化为法向振动速度,再计算频带内的平均能量源(包括声强源、声压源和速度源);最后,通过FAQP法计算频带声压级,并与FEM和边界元法(BEM)计算的FAQP结果进行对比。[结果]结果表明,FEM和FAQP结合的方法可用于计算受频带激励结构的1/3倍频程的频带平均声辐射,且FEM和FAQP结合的方法具有较好的稳定性,计算频率更高,无需逐个频率计算再平均的过程。[结论]FEM和FAQP结合的方法可以作为一种适用于中、高频频带的内噪声预报方法。

关键词：声辐射有限元法频率均方声压法边界元法中高频

基于摩擦振动递归特性识别滑动轴承摩擦状态的试验研究

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振动与冲击 2022年第15期41卷 122-129页

作者：邢鹏飞李国宾高洪涛高宏林卢立讯大连海事大学轮机工程学院辽宁大连116026 大连海事大学船舶与海洋工程学院辽宁大连116026

为了有效监测滑动轴承摩擦状态,提出一种基于摩擦振动递归特性识别滑动轴承摩擦状态的方法。在滑动轴承试验台进行边界摩擦、混合摩擦和液体摩擦状态下的模拟试验,提取摩擦振动信号,并应用递归图及递归量化分析研究摩擦振动信号递归特... 详细信息

为了有效监测滑动轴承摩擦状态,提出一种基于摩擦振动递归特性识别滑动轴承摩擦状态的方法。在滑动轴承试验台进行边界摩擦、混合摩擦和液体摩擦状态下的模拟试验,提取摩擦振动信号,并应用递归图及递归量化分析研究摩擦振动信号递归特性的演变规律。结果表明:摩擦振动递归图与摩擦状态密切相关,能反映滑动轴承由边界摩擦到液体摩擦状态变化;递归量化参数中的确定度与聚类系数可用于预测与识别滑动轴承摩擦状态,为监测滑动轴承摩擦状态提供了一种新思路。

关键词：摩擦振动递归特性滑动轴承摩擦状态试验研究