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Edge enhancement through scattering media enabled by optical wavefront shaping

Photonics Research 2020年第6期8卷 954-962页

作者： ZIHAO LI ZHIPENG Yu HUI HUI HUANHAO LI TIANTING zhong honglin LU PUXIANG LA Deparment of Biomedical Engineering The Hong Kong Polytechnic UniversityHong Kong SARChina The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000China CAS Key Laboratory of Molecular Imaging Institute of AutomationChinese Academy of SciencesBeijing 100190China Key Laboratory for Quantum Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Currently at:Department of Bioengineeing University of PennsyIvaniaPhiladelphiaPennsylvania 19104USA

Edge enhancement is a fundamental and important topic in imaging and image processing,as perception of edge is one of the keys to identify and comprehend the contents of an *** enhancement can be performed in many ways,through hardware or *** methods,however,have been limited in free space or clear media for optical applications;in scattering media such as biological tissue,light is multiple scattered,and information is scrambled to a form of seemingly random *** desired,it is challenging to accom-plish edge enhancement in the presence of multiple *** this work,we introduce an implementation of optical wavefront shaping to achieve efficient edge enhancement through scattering media by a two-step *** first step is to acquire a hologram after the scattering medium,where information of the edge region is accurately encoded,while that of the nonedge region is intentionally encoded with inadequate *** second step is to decode the edge information by time reversing the scattered *** capability is demonstrated experimentally,and,further,the performance,as measured by the edge enhancement index(EI)and enhancement-to-noise ratio(ENR),can be controlled easily through tuning the beam *** and ENR can be reinforced by^8.5 and^263 folds,*** the best of our knowledge,this is the first demonstration that edge information of a spatial pattern can be extracted through strong turbidity,which can potentially enrich the comprehension of actual images obtained from a complex environment.

关键词： scattering tuning media

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Multi-valent mRNA vaccines against monkeypox enveloped or mature viron surface antigens demonstrate robust immune response and neutralizing activity

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中国科学:生命科学英文版 2023年第10期66卷 2329-2341页

作者： Niubing Zhang Xiang Cheng Yilong Zhu Ouyang Mo Huiqing Yu Liqi Zhu Juan Zhang Linlin Kuang Ying Gao Ruiyuan Cao Xiaozhen Liang Haikun Wang honglin Li Song Li Wu zhong Xuan Li Xiao Li Pei Hao Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchun 130122China Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China National Engineering Research Center for the Emergency Drug Beijing Institute of Pharmacology and ToxicologyBeijing 100850China Academicians Workstation of Jilin Province Changchun University of Chinese MedicineChangchun 130117China East China University of Science and Technology Shanghai 200237China Lingang Laboratory Shanghai 200031China University of Chinese Academy of Sciences Beijing 100049China

Monkeypox was declared a global health emergency by the World Health Organization,and as of March 2023,86,000 confirmed cases and 111 deaths across 110 countries have been *** causal agent,monkeypox virus(MPV)belongs to a large family of double-stranded DNA viruses,Orthopoxviridae,that also includes vaccinia virus(VACV)and *** produces two distinct forms of viral particles during its replication cycles:the enveloped viron(EV)that is released via exocytosis,and the mature viron(MV)that is discharged through lysis of host *** study was designed to develop multi-valent m RNA vaccines against monkeypox EV and MV surface proteins,and examine their efficacy and mechanism of *** m RNA vaccines were produced with different combinations of surface proteins from EV(A35R and B6R),MV(A29L,E8L,H3L and M1R),or EV and MV,and were administered in Balb/c mice to assess their immunogenicity potentials.A dynamic immune response was observed as soon as seven days after initial immunization,while a strong Ig G response to all immunogens was detected with ELISA after two *** higher number of immunogens contributed to a more robust total Ig G response and correlating neutralizing activity against VACV,indicating the additive potential of each immunogen in generating immune response and nullifying VACV ***,the m RNA vaccines elicited an antigen-specific CD4^(+)T cell response that is biased towards *** m RNA vaccines with different combinations of EVand MV surface antigens protected a mouse model from a lethal dose VACV challenge,with the EV and MV antigens-combined vaccine offering the strongest *** findings provide insight into the protective mechanism of multi-valent m RNAvaccines against MPV,and also the foundation for further development of effective and safe m RNA vaccines for enhanced protection against monkeypox virus outbreak.

关键词： monkeypox virus enveloped and mature viron multi-valent mRNA vaccines immune response neutralizing antibody

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Construction of an integrated map and location of a bruchid resistance gene in mung bean

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The Crop Journal 2016年第5期4卷 360-366页

作者： Lixia Wang Chuanshu Wu Min zhong Dan Zhao Li Mei honglin Chen Suhua Wang Chunji Liu Xuzhen Cheng Institute of Crop Science Chinese Academy of Agricultural Sciences CSIRO Agriculture and Food

Bruchid beetle(Callosobruchus chinensis) poses a serious threat to the production and storage of mung bean(Vigna radiata). Mapping bruchid resistance(Br) will provide an important basis for cloning the responsible gene(s) and elucidating its functional mechanism, and will also facilitate marker-assisted selection in mung bean breeding. Here, we report the construction of the genetic linkage groups of mung bean and mapping of the Br1 locus using an RIL population derived from a cross between Berken, a bruchid-susceptible line, and ACC41, a bruchid-resistant line. A total of 560 markers were mapped onto 11 linkage groups,with 38.0% of the markers showing distorted segregation. The lengths of the linkage groups ranged from 45.2 to 117.0 c M with a total coverage of 732.9 c M and an average interval of1.3 c M between loci. Br1 was located on LG9 between BM202(0.7 c M) and Vr2-627(1.7 c M).Based on 270 shared SSR markers, most of the linkage groups were assigned to specific chromosomes. These results should further accelerate the genetic study of this crop.

关键词： Vigna radiata Callosobruchus chinensis Linkage map Resistance Gene mapping

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Triazole and Benzotriazole Derivatives as Novel Inhibitors for p90 Ribosomal S6 Protein Kinase 2： Synthesis, Molecular Docking and SAR Analysis

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Chinese Journal of Chemistry 2013年第9期31卷 1192-1198页

作者： Jun Yuan Ye zhong Shiliang Li Xue Zhao Guoqin Luan Zhenjiang Zhao Jin Huang honglin Li Yufang Xu Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor Engineering School of Pharmacy East China University of Science & Technology Shanghai 200237 China

A series of triazole and benzotriazole derivatives as novel p90 ribosomal S6 protein kinase 2 （RSK2） inhibitors were designed and synthesized. The in vitro activities against RSK2 were evaluated, and among 14 compounds, compounds 5, 6, 11, 12, 13 and 14 exhibited enzyme IC50 values of 8.91, 2.86, 3.19, 3.05, 4.49 and 2.09 μmol/L re- spectively. The proposed binding modes were simulated using molecular docking method, and the docking results coupled with the stmcture-activi1：y relationship （SAR） analysis indicated that all these active compounds bound to the RSK2 ATP binding site at NTKD, and the electron-donating groups on the 4-position of phenyl were the deter- minant point for the inhibitory activity.

关键词： RSK2 structure-activity relationships molecular docking

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添加大麦若叶粉对粳米粉面包的影响

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现代面粉工业 2023年第4期37卷 11-16页

作者：仲虹霖薛雯雯巩瀚钰周航吴隆坤胡盛安沈阳师范大学粮食学院沈阳110034

采用质构仪、拉伸仪、色差仪等设备,研究粳米粉面包原料的合适配比及添加大麦若叶粉的影响。通过对米面混合粉面团品质分析,发现东北粳米粉持水性略低于高筋小麦粉,混合粉中粳米粉占比越多,面团持水性越弱;粳米粉面团拉伸特性指标与米... 详细信息

采用质构仪、拉伸仪、色差仪等设备,研究粳米粉面包原料的合适配比及添加大麦若叶粉的影响。通过对米面混合粉面团品质分析,发现东北粳米粉持水性略低于高筋小麦粉,混合粉中粳米粉占比越多,面团持水性越弱;粳米粉面团拉伸特性指标与米面混合粉面团相比较差,粳米粉占比大会导致面包组织粗糙、口感不佳。结果表明:粳米粉与高筋小麦粉质量配比为4∶8时,混合粉面团延伸性较好;在120 g米面混合粉中添加大麦若叶粉2.5 g,膳食纤维含量更高,脂肪和麸质蛋白含量较低,面包具有独特的大麦若叶风味,感官评价较好,更加适合减肥人群和麸质敏感人群食用。

关键词：粳米粉面包大麦若叶粉质构特性感官评定

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海南荔枝养分投入限量标准及减量潜力分析

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热带作物学报 2024年第2期45卷 304-314页

作者：吴小巧朱镕钟于秀王鸿霖李伟芳洪秀杨李菊阮云泽李婷玉海南大学三亚南繁研究院海南三亚572000 海南大学热带作物学院海南海口570228 唐河县中等职业学校河南南阳473400

海南是我国荔枝最南端的生产区,但生产中养分过量投入和土壤退化的问题较为严重,缺乏合理的养分投入标准。本研究根据作物产量水平及当下优化管理获得氮素盈余关键阈值,解析不同类型农户养分管理水平的差异以及对土壤肥力的影响。通过... 详细信息

海南是我国荔枝最南端的生产区,但生产中养分过量投入和土壤退化的问题较为严重,缺乏合理的养分投入标准。本研究根据作物产量水平及当下优化管理获得氮素盈余关键阈值,解析不同类型农户养分管理水平的差异以及对土壤肥力的影响。通过对海南主产区荔枝产量、养分管理和土壤肥力现状进行剖析,基于养分平衡原理,通过定量作物养分需求规律及优化条件下的合理氮素盈余水平,明确荔枝养分用量上限,提出海南荔枝氮、磷、钾养分投入减量目标,对不同经营规模的农户养分收支平衡和土壤肥力差异开展评价。结果表明:(1)不同产量水平下荔枝氮、磷、钾用量上限分别为200、100、260 kg/hm^(2)(产量<10 t/hm^(2));273、136、355 kg/hm^(2)(产量为10~20 t/hm^(2));439、220、571 kg/hm^(2)(产量为20~42 t/hm^(2))。农户施肥过量投入现象较为突出,且随着经营规模的增加,养分过量投入加剧。小农户、中等经营主体、规模化经营主体氮素投入分别高于氮肥投入上限的60%、97%、131%;磷素投入量分别高于磷肥投入上限的204%、236%、258%;钾素投入量分别高于钾肥投入上限的70%、101%、119%。同时海南荔枝氮、磷、钾养分投入均显著高于全国荔枝施肥平均水平的70.8%、189.9%、123.4%。(2)海南荔枝园氮、磷、钾养分盈余分别为365、377、542 kg/hm^(2),养分利用效率(NUE)分别为34%、21%、27%,大量磷素在土壤中固定或损失。不同类型农户养分管理存在较大差异,只有1.2%的小农户处于高氮产出和低氮盈余区间,而中高经营主体均处于高氮素盈余水平区间。(3)荔枝果园土壤磷素过量积累和土壤酸化问题突出,46%的果园土壤全磷含量超过0.96 g/kg,处于较丰富水平。94%的果园为酸性土(pH4.5~5.5),77%的果园土壤质量指数(IFI)综合评级较低。针对目前海南荔枝养分投入不合理及土壤退化问题,应尽快采取和推广肥料定额制度,同时提高有机肥和化肥利用效率,推动荔枝产业的绿色发展。

关键词：荔枝养分投入养分平衡化肥减量

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轻量级分组密码算法综述

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计算机科学 2023年第9期50卷 3-15页

作者：钟悦谷杰铭曹洪林中国政法大学证据科学研究院北京100088 国家计算机网络应急技术处理协调中心北京100029 哈尔滨工业大学网络空间安全学院哈尔滨150001

随着信息技术的快速发展,人类将进入万物互联时代,数以亿计的物联网设备接入网络,针对用户隐私、网络环境等的网络攻击持续增长。因此,保障物联网设备的信息安全至关重要。由于物联网设备的计算能力、电池容量和内存等资源十分受限,传... 详细信息

随着信息技术的快速发展,人类将进入万物互联时代,数以亿计的物联网设备接入网络,针对用户隐私、网络环境等的网络攻击持续增长。因此,保障物联网设备的信息安全至关重要。由于物联网设备的计算能力、电池容量和内存等资源十分受限,传统的分组密码算法不适用于具有低时延、低功耗等要求的物联网设备,轻量级分组密码算法应运而生。文中概述了轻量级分组密码算法的研究现状及进展,并根据算法结构将其分成6类进行详细阐述;依据多维度评价指标分别对轻量级分组密码算法的软硬件实现进行综合对比与分析,并从安全性、资源开销和性能3方面进行深入探讨;最后展望了轻量级分组密码算法的未来研究方向。

关键词：轻量级分组密码物联网数据安全密码算法隐私保护

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石墨烯化学镀铜对放电等离子烧结石墨烯增强铝基复合材料组织和性能的影响

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机械工程材料 2024年第7期48卷 55-62页

作者：周浪陈猛谭东灿苏玉琴钟钢邹爱华李志鹏华中科技大学无锡研究院无锡214174 中国航发贵州红林航空动力控制科技有限公司贵阳550009 南昌航空大学材料科学与工程学院南昌330063

通过化学镀方法得到镀铜石墨烯粉末,再通过静电自组装方法将镀铜石墨烯粉末与铝粉混合,然后经放电等离子烧结工艺制备镀铜石墨烯增强铝基复合材料,研究了不同质量分数(0.1%,0.2%,0.3%,0.4%,0.5%)镀铜石墨烯增强铝基复合材料的微观结构... 详细信息

通过化学镀方法得到镀铜石墨烯粉末,再通过静电自组装方法将镀铜石墨烯粉末与铝粉混合,然后经放电等离子烧结工艺制备镀铜石墨烯增强铝基复合材料,研究了不同质量分数(0.1%,0.2%,0.3%,0.4%,0.5%)镀铜石墨烯增强铝基复合材料的微观结构和性能,并与质量分数0.1%未镀铜石墨烯增强铝基复合材料进行对比。结果表明:镀铜石墨烯在复合材料中分散均匀,复合材料的相对密度均在99%以上;铝和铜发生反应生成了中间相Al_(2)Cu,但未有Al_(4)C_(3)界面相生成;镀铜石墨烯增强铝基复合材料的硬度和耐磨性能均优于未镀铜石墨烯增强铝基复合材料;随着镀铜石墨烯含量的增加,复合材料的硬度先升高后降低,磨损质量损失和摩擦因数均呈先减小后增加的趋势。当镀铜石墨烯的质量分数为0.2%时,复合材料具有优异的综合性能,其硬度为74.7 HV,磨损质量损失和摩擦因数均最小,分别为0.0023 g和0.259,磨损机制为氧化磨损。

关键词：铝基复合材料石墨烯化学镀铜放电等离子烧结 Al_(2)Cu 耐磨性能

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Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody

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Cellular & Molecular Immunology 2021年第3期18卷 675-685页

作者： Chunyan Yi Jing Xia Lan He Zhiyang Ling Xuesong Wang Yu Yan Jiangjun Wang Xinhao Zhao Weiguo Fan Xiaoyu Sun Ronghua Zhang Sheng Ye Rongguang Zhang Yongfen Xu Liyan Ma Yaguang Zhang honglin Zhou zhong Huang Junqi Niu Gang Long Junxia Lu Jin zhong Bing Sun State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of Sciences/University of Chinese Academy of SciencesShanghaiChina CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiChinese Academy of Sciences/University of Chinese Academy of SciencesShanghaiChina School of Life Science and Technology ShanghaiTech UniversityShanghaiChina CAS Key Laboratory of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghaiChina College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangshaChina National Laboratory of Biophysics Institute of BiophysicsChinese Academy of Sciences/University of Chinese Academy of Sciences BdjingBeijingChina Interdisciplinary Innovation Institute of Medicine&Engineering Beijing Advanced Innovation Center for Big Data-Based Precision MedicineSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Nanjing Galaxy Biopharma Co. LtdNanjingChina Hepatology Section First HospitalUniversity of JilinChangchunChina

Induction of broadly neutralizing monoclonal antibodies(bNAbs)that bind to the viral envelope glycoproteins is a major goal of hepatitis C virus(HCV)vaccine *** study of bNAbs arising in natural infection is essential in this *** generated a human antibody,8D6,recognizing the E2 protein of HCV isolated from a chronic hepatitis C *** antibody shows broadly neutralizing activity,which covers a pan-genotypic panel of cell culture-derived HCV virions(HCVcc).Functional and epitope analyses demonstrated that 8D6 can block the interaction between E2 and CD81 by targeting a highly conserved epitope on *** describe how the 8D6 lineage evolved via somatic hypermutation to achieve broad *** found that the V(D)J recombination-generated junctional and somatic hypermutation-induced disulfide bridge(C-C)motif in the CDRH3 is critical for the broad neutralization and binding activity of *** motif is conserved among a series of broadly neutralizing HCV antibodies,indicating a common binding ***,the 8D6 inferred germline(iGL)was reconstructed and tested for its binding affinity and neutralization ***,8D6 iGL-mediated relatively strong inhibition of the 1b genotype PR79L9 strain,suggesting that PR79L9 may serve as a potential natural viral strain that provides E2 sequences that induce ***,our detailed epitope mapping and genetic studies of the HCV E2-specific mAb 8D6 have allowed for further refinement of antigenic sites on E2 and reveal a new mechanism to generate a functional CDRH3,while its iGL can serve as a probe to identify potential HCV vaccine strains.

关键词： Hepatitis C virus neutralizing antibody inferred germline CDRH3 disulfide bridge motif

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基于近似动态规划的海上风电制氢微网实时能量管理策略

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电力建设 2022年第12期43卷 94-102页

作者：陈鸿琳刘新苗余浩钟治垚刘文昕艾小猛广东电网有限责任公司电网规划研究中心广州市510080 广东电网有限责任公司广州市510080 华中科技大学电气与电子工程学院武汉市430074

电解水制氢(power-to-hydrogen, PtH)装置耦合海上风电运行,在促进风电消纳的同时可以制备绿色氢能,推进工业领域的无碳化进程,因而备受关注。文章开展海上风电制氢微网的实时能量管理策略研究。首先,构建海上风电制氢微网的实时能量管... 详细信息

电解水制氢(power-to-hydrogen, PtH)装置耦合海上风电运行,在促进风电消纳的同时可以制备绿色氢能,推进工业领域的无碳化进程,因而备受关注。文章开展海上风电制氢微网的实时能量管理策略研究。首先,构建海上风电制氢微网的实时能量管理模型,包含海上风电、电制氢装置以及储氢罐等元件。然后,提出基于近似动态规划(approximate dynamic programming, ADP)的微网实时能量管理策略,采用分段线性函数近似状态值函数以应对不确定性因素。最后,通过算例验证所提策略的有效性和优越性。在所提策略下,海上风电通过电制氢装置就地消纳,实现氢气的提前制备和存储。以具备精准预测技术的理想算例为基准,所提策略在满足正态分布的实时测试场景下,优化准确率平均值大于99%。

关键词：近似动态规划(ADP) 电解水制氢(PtH) 海上风电实时优化微网

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