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Millimeter waves in medical applications:status and prospects

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Intelligent Medicine 2024年第1期4卷 16-21页

作者： honglin wang Lin Lu Pengran Liu Jiayao Zhang Songxiang Liu Yi Xie Tongtong Huo Hong Zhou Mingdi Xue Ying Fang Jiaming Yang Zhewei Ye Department of Orthopedics Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Departments of Orthopedics Renmin Hospital of Wuhan UniversityWuhanHubei 430060China

Millimeter waves are electromagnetic waves with wavelengths of 1–10 mm,which have characteristics of high frequency and short wavelength.They have gradually and widely been used in engineering and medical fields.We have identified studies related to millimeter waves in the biomedical field and summarized the biological effects of millimeter waves and their current status in medical applications.Finally,the shortcomings of existing studies and future developments were analyzed and discussed,with the aim of providing a reference for further research and development of millimeter waves in the medical field.

关键词： Millimeter wave Biological effects Medical applications Vital signs monitoring

Analysis of CLARANS Algorithm for Weather Data Based on Spark

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Computers, Materials & Continua 2023年第8期76卷 2427-2441页

作者： Jiahao Zhang honglin wang College of Artificial Intelligence Nanjing University of Information Science and TechnologyNanjing210044China

With the rapid development of technology,processing the explosive growth of meteorological data on traditional standalone computing has become increasingly time-consuming,which cannot meet the demands of scientific research and business.Therefore,this paper proposes the implementation of the parallel Clustering Large Application based upon RANdomized Search(CLARANS)clustering algorithm on the Spark cloud computing platformto cluster China’s climate regions usingmeteorological data from1988 to 2018.The aim is to address the challenge of applying clustering algorithms to large datasets.In this paper,the morphological similarity distance is adopted as the similarity measurement standard instead of Euclidean distance,which improves clustering accuracy.Furthermore,the issue of local optima caused by an improper selection of initial clustering centers is addressed by utilizing the max-distance criterion.Compared to the k-means clustering algorithm already implemented in the Spark platform,the proposed algorithm has strong robustness,can reduce the interference of outliers in the dataset on clustering results,and has higher parallel performance than the frequently used serial algorithms,thus improving the efficiency of big data analysis.This experiment compares the clustered centroid data with the annual average meteorological data of representative cities in the five typical meteorological regions that exist in China,and the results show that the clustering results are in good agreement with the meteorological data obtained from the National Meteorological Science Data Center.This algorithm has a positive effect on the clustering analysis of massive meteorological data and deserves attention in scientific research activities.

关键词： Clustering analysis cloud computing platform parallel algorithm

Parameter optimization of control system design for uncertain wireless power transfer systems using modified genetic algorithm

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CAAI Transactions on Intelligence Technology 2022年第4期7卷 582-593页

作者： Xudong Gao Wenjie Cao Qiang Yang honglin wang Xiaolei wang Guang Jin Jun Zhang School of Artificial Intelligence/School of Future Technology Nanjing University of Information Science and TechnologyNanjingChina School of Electronic and Information Zhongyuan University of TechnologyZhengzhouChina Graduate School of Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyoJapan

The closed-loop wireless power transfer(WPT)system can realize constant voltage output in the presence of perturbation.However,the parameter design of the controller is a difficult problem.The traditional trial-and-error method is time-consuming and difficult to find optimal parameters.A parameter optimization strategy of control systems for uncertain WPT systems using the modified genetic algorithm(MGA)is proposed.Firstly,because the system has different characteristics at different periods,the simulation process is divided into three stages.The first one is the start-up stage,in which we mainly consider the overshoot and the rate of the voltage rise.The second one is the tracking stage,in which the tracking time and switching loss are mainly considered.The third one is the stabilisation stage,in which the steady-state error and switching loss are mainly considered.Secondly,three cost functions are designed according to the characteristics of the three stages,and then the optimal controller parameters of each stage are obtained by using MGA.Finally,the effectiveness of the proposed method is verified by simulation.The optimization results show that compared with the previous parameter optimization method,the optimal controller parameters obtained by the proposed method make the WPT system achieve better performance.

关键词： power optimization system

Immunoregulatory polysaccharides from Apocynum venetum L.flowers stimulate phagocytosis and cytokine expression via activating the NF-κB/MAPK signaling pathways in RAW264.7 cells

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Food Science and Human Wellness 2022年第4期11卷 806-814页

作者： honglin wang Changyang Ma Dongxiao Sun-Waterhouse Jinmei wang Geoffrey Ivan Neil Waterhouse Wenyi Kang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Functional Food Engineering Technology Research Center Kaifeng 475004China School of Chemical Sciences University of AucklandAuckland 1142New Zealand Joint International Research Laboratory of Food&Medicine Resource Function Kaifeng 475004China

Two immunomodulatory polysaccharides(Vp2a-Ⅱ and Vp3) were isolated and identified from Apocynum venetum L. flowers, and their innate immune-stimulating functions and working mechanisms were evaluated in RAW264.7 cells. Both the level of released nitric oxide(NO) and expression of inducible nitric oxide synthase(iNOS) m RNA were significantly enhanced in the RAW264.7 macrophages cells treated by Vp2a-Ⅱ and Vp3. Vp2a-Ⅱ(100–800 μg/m L) and Vp3(400 μg/mL) could significantly increase the phagocytic activity of RAW264.7 cells and the secretion and m RNA expression of TNF-α and IL-6 in a concentrationdependent manner through affecting mitogen-activated protein kinase(MAPK) activity and nuclear factor κB(NF-κB) nuclear translocation. Vp2a-Ⅱ might activate the MAPK signaling pathways and induce the nuclear translocation of NF-κB p65, whilst Vp3 likely activated the NF-κB and MAPK signaling pathways without influencing the p38 MAPK route.

关键词： Apocynum venetum L.flowers Immunomodulatory polysaccharide RAW264.7 cells NF-κB signaling pathway MAPK signaling pathway

A Fast Approach for Predicting Aerodynamic Noise Sources of High-Speed Train Running in Tunnel

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Computer Modeling in Engineering & Sciences 2022年第3期130卷 1371-1386页

作者： Deng Qin Tian Li honglin wang Jizhong Yang Yao Jiang Jiye Zhang Haiquan Bi State Key Laboratory of Traction Power Southwest Jiaotong UniversityChengdu610031China School of Mechanical Engineering Southwest Jiaotong UniversityChengdu610031China China Railway Eryuan Engineering Group Co. Ltd.Chengdu610031China

The aerodynamic noise of high-speed trains passing through a tunnel has gradually become an important issue.Numerical approaches for predicting the aerodynamic noise sources of high-speed trains running in tunnels are the key to alleviating aerodynamic noise issues.In this paper,two typical numerical methods are used to calculate the aerodynamic noise of high-speed trains.These are the static method combined with non-reflective boundary conditions and the dynamic mesh method combined with adaptive mesh.The fluctuating pressure,flow field and aerodynamic noise source are numerically simulated using the abovemethods.The results showthat the fluctuating pressure,flow field structure and noise source characteristics obtained using different methods,are basically consistent.Compared to the dynamic mesh method,the pressure,vortex size and noise source radiation intensity,obtained by the static method,are larger.The differences are in the tail car and its wake.The two calculation methods show that the spectral characteristics of the surface noise source are consistent.The maximum difference in the sound pressure level is 1.9 dBA.The static method is more efficient and more suitable for engineering applications.

关键词： High-speed train tunnel numerical calculation method aerodynamic noise source flow field

High faradic efficiency of CO_(2) conversion to formic acid catalyzed by Cu_(2)O hollow‑dices

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碳中和(英文)

碳中和(英文) 2022年第1期1卷 92-98页

作者： Jing Li Chen Meng Jingkun Gu honglin wang Ruoyun Dai Haozhi Sha Hongwei Zhu State Key Laboratory of Solid Waste Reuse for Building Materials Beijing Building Materials Academy of Sciences Research100041 BeijingChina State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua University100084 BeijingChina Department of Chemistry Tsinghua University100084 BeijingChina Key Lab of Advanced Materials of Ministry of Education of China National Center for Electron Microscopy in BeijingTsinghua University100084 BeijingChina.

Cu_(2)O has been intensively studied as an efficient catalyst for CO_(2) reduction reaction(CO_(2)RR).By various methods for fine-tuning the morphology and surface modification,high selectivity and activity of different products can be achieved.Here,we report a novel Cu_(2)O nanostructure design by facet-controlled etching,during which the catalyst structure switched from a cuboctahedron architecture to a hollow dice-like structure.The as-etched catalysts exhibit a high Faradic efficiency of formic acid,reaching 75.1% at a low potential of -1.0 V.Further characterizations indicate that the performance enhancement is attributed to the increased oxygen vacancies induced by the etching process.Our Cu_(2)O nanostructure design provides a new approach for high-efficiency catalysts for formic acid production at low potentials.

关键词： CO_(2)reduction Cu_(2)O Formic acid Facet-controlled etching Oxygen vacancy

Pollen self-elimination CRISPR–Cas genome editing prevents transgenic pollen dispersal in maize

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Plant Communications 2023年第6期4卷 212-215页

作者： honglin wang Xiantao Qi Jinjie Zhu Changlin Liu Hongwei Fan Xuecai Zhang Xinhai Li Qin Yang Chuanxiao Xie Institute of Crop Science Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China College of Agronomy Northwest A&F UniversityYangling 712100China International Maize and Wheat Improvement Center(CIMMYT) EI BatanMexico Hainan Yazhou Bay Seed Lab SanyaHainan Province 572024 China Henan Jinyuan Seed Industry Co. Ltd.ZhengzhouHenan ProvinceChina

Dear Editor,Genome editing with clustered regularly interspaced short palindromic repeats(CRISPR)–CRISPR-associated nuclease(Cas)-mediated technologies have revolutionized basic plant science and crop genetic improvement(Chen et al.,2019).Stable genetic transformation of CRISPR–Cas cassette(s)is the main approach to genome editing in planta.In many sexually reproducing plants,a major concern is the dispersal of genetically modified elements through pollen(Devos et al.,2005).Maize(Zea mays L.).

关键词： CRISPR dispersal editing

Protein phosphatase 6 (Pp6) is crucial for regulatory T cell function and stability in autoimmunity

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Genes & Diseases 2022年第2期9卷 562-575页

作者： Wei Cai Junxun Zhang Hong Zhou Xiangxiao Li Fangzhou Lou Yang Sun Zhenyao Xu Jing Bai Qianqian Yin Zhikai wang Libo Sun Xiaojie Cai Sibei Tang Yue Wu Li Fan Hong wang honglin wang Qun Li Department of Immunology and Microbiology Shanghai Institute of ImmunologyKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationInstitute of Translational MedicineShanghai General HospitalShanghai Jiao Tong University School of Medicine(SJTU-SM)Shanghai 200025PR China The Department of Cardiovascular Medicine State Key Laboratory of Medical GenomicsShanghai Key Laboratory of HypertensionRuijin HospitalShanghai Institute of HypertensionShanghai Jiao Tong University School of MedicineShanghai 200025PR China

Regulatory T(T_(reg))cells constitute a dynamic population that is critical in autoimmunity.T_(reg) cell therapies for autoimmune diseases are mainly focused on enhancing their suppressive activities.However,recent studies demonstrated that certain inflammatory conditions induce T_(reg) cell instability with diminished FoxP3 expression and convert them into pathogenic effector cells.Therefore,the identification of novel targets crucial to both T_(reg) cell function and plasticity is of vital importance to the development of therapeutic approaches in autoimmunity.In this study,we found that conditional Pp6 knockout(cKO)in T_(reg) cells led to spontaneous autoinflammation,immune cell activation,and diminished levels of FoxP3 in CD4^(+)T cells in mice.Loss of Pp6 in T_(reg) cells exacerbated two classical mouse models of T_(reg)-related autoinflammation.Mechanistically,Pp6 deficiency increased CpG motif methylation of the FoxP3 locus by dephosphorylating Dnmt1 and enhancing Akt phosphorylation at Ser473/Thr308,leading to impaired FoxP3 expression in T_(reg) cells.In summary,our study proposes Pp6 as a critical positive regulator of FoxP3 that acts by decreasing DNA methylation of the FoxP3 gene enhancer and inhibiting Akt signaling,thus maintaining T_(reg) cell stability and preventing autoimmune diseases.

关键词： Akt DNA methyltransferase 1(Dnmt1) FoxP3 Protein phosphatase 6(Pp6)

Human umbilical cord mesenchymal stem cells for psoriasis:a phase 1/2a,single-arm study

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3512-3522页

作者： Lamei Cheng Siqi wang Cong Peng Xiao Zou Chao Yang Hua Mei Chuang Li Xian Su Na Xiao Qi Ouyang Mi Zhang Qiaolin wang Yan Luo Minxue Shen Qun Qin honglin wang Wu Zhu Guangxiu Lu Ge Lin Yehong Kuang Xiang Chen Institute of Reproductive and Stem Cell Engineering School of Basic Medical ScienceCentral South UniversityChangsha 410031China National Engineering Research Center of Human Stem Cell Changsha 410205China The Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Engineering Research Center of Skin Health and Disease Hunan Key Laboratory of Skin Cancer and PsoriasisNational Clinical Research Center for Geriatric Disorders(Xiangya Hospital)Changsha 410008China The Offce of Drug Clinical Trials Institution Xiangya HospitalCentral South UniversityChangsha 410031China precision Research Center for Refractory Diseases Shanghai General HospitalKey Laboratory of Cell Differentiation and Apoptosis of ChineseMinistry of EducationShanghai Jiao Tong University School of MedicineShanghai 200025China Reproductive and Genetic Hospital of CITIC-Xiangya Changsha 410221China

Psoriasis is a common,chronic immune-mediated systemic disease that had no effective and durable treatment.Mesenchymal stem cells(MSCs)have immunomodulatory properties.Therefore,we performed a phase 1/2a,single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs(UMSCs)in the treatment of psoriasis and to preliminarily explore the possible mechanisms.Seventeen patients with psoriasis were enrolled and received UMsC infusions.Adverse events,laboratory parameters,PASl,and PGA were analyzed.We did not observe obvious side effects during the treatment and 6-month follow-up.A total of 47.1%(8/17)of the psoriasis patients had at least 40%improvement in the PASl score,and 17.6%(3/17)had no sign of disease or minimal disease based on the PGA score.And the efficiency was 25%(2/8)for males and 66.7%(6/9)for females.After UMSC transplantation(UMSCT),the frequencies of Tregs and CD4^(+)memory T cells were significantly increased,and the frequencies of T helper(Th)17 and CD4^(+)naive T cells were significantly decreased in peripheral blood(PB)of psoriasis patients.And all responders showed significant increases in Tregs and CD4^(+)memory T cells,and significant decreases in Th17 cells and serum IL-17 level after UMsCT.And baseline level of Tregs in responders were significantly lower than those in nonresponders.In conclusion,allogeneic UMSCT is safe and partially effective in psoriasis patients,and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT.Trial registration Clinical Trials NCT03765957.

关键词： psoriasis infusion phase