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Polo-like kinase 1 as a biomarker predicts the prognosis and immunotherapy of breast invasive carcinoma patients

Oncology Research 2024年第2期32卷 339-351页

作者： JUAN SHEN WEIYU ZHANG QINQIN JIN FUYU GONG HEPING ZHANG hongliang xu JIEJIE LI HUI YAO XIYA JIANG YINTING YANG LIN HONG JIE MEI YANG SONG SHUGUANG ZHOU School of Big Data and Artificial Intelligence Anhui Xinhua UniversityHefei230088China Department of Gynecology and Obstetrics Maternity and Child Healthcare Hospital Affiliated to Anhui Medical UniversityAnhui Province Maternity and Child Healthcare HospitalHefei230001China Department of Gynecology and Obstetrics The Fifth Clinical College of Anhui Medical UniversityHefei230032China Departments of Breast Surgery Fuyang Women and Children’s HospitalFuyang236000China Departments of Pathology Anhui Province Maternity and Child Health HospitalHefei230001China Department of Pain The First Affiliated Hospital of Anhui Medical UniversityHefei230032China Department of Gynecology and Obstetrics Linquan Maternity and Child Healthcare HospitalFuyang236400China

Invasive breast carcinoma(BRCA)is associated with poor prognosis and high risk of mortality.Therefore,it is critical to identify novel biomarkers for the prognostic assessment of BRCA.Methods:The expression data of polo-like kinase 1(PLK1)in BRCA and the corresponding clinical information were extracted from TCGA and GEO databases.PLK1 expression was validated in diverse breast cancer cell lines by quantitative real-time polymerase chain reaction(qRT-PCR)and western blotting.Single sample gene set enrichment analysis(ssGSEA)was performed to evaluate immune infiltration in the BRCA microenvironment,and the random forest(RF)and support vector machine(SVM)algorithms were used to screen for the hub infiltrating cells and calculate the immunophenoscore(IPS).The RF algorithm and COX regression model were applied to calculate survival risk scores based on the PLK1 expression and immune cell infiltration.Finally,a prognostic nomogram was constructed with the risk score and pathological stage,and its clinical potential was evaluated by plotting calibration charts and DCA curves.The application of the nomogram was further validated in an immunotherapy cohort.Results:PLK1 expression was significantly higher in the tumor samples in TCGA-BRCA cohort.Furthermore,PLK1 expression level,age and stage were identified as independent prognostic factors of BRCA.While the IPS was unaffected by PLK1 expression,the TMB and MATH scores were higher in the PLK1-high group,and the TIDE scores were higher for the PLK1-low patients.We also identified 6 immune cell types with high infiltration,along with 11 immune cell types with low infiltration in the PLK1-high tumors.A risk score was devised using PLK1 expression and hub immune cells,which predicted the prognosis of BRCA patients.In addition,a nomogram was constructed based on the risk score and pathological staging,and showed good predictive performance.Conclusions:PLK1 expression and immune cell infiltration can predict post-immunotherapy prognosis of BRCA patients.

关键词： Breast invasive carcinoma(BRCA) Polo-like kinase 1(PLK 1) Random forest(RF) Support vector machine(SVM) Immune infiltration

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Sintering behavior of alumina whisker reinforced zirconia ceramics in hot oscillatory pressing

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Journal of Advanced Ceramics 2022年第6期11卷 893-900页

作者： Hongtian HE Rui ZHAO Hongyi TIAN Gang SHAO Hailong WANG Bingbing FAN Hongxia LU hongliang xu Rui ZHANG Li-nan AN School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China School of Materials Science and Engineering Luoyang Institute of Science and TechnologyLuoyang 471023China School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808China

Alumina whisker reinforced zirconia ceramic composite was prepared by both hot oscillatory pressing(HOP)and conventional hot pressing(HP).The results show that compared with HP,HOP can significantly increase the final density and densification rate of the material.Analysis of densification kinetics reveals that the predominant densification mechanism transits from grain boundary sliding in the beginning to the diffusion in the later stage.The main effect of the oscillating pressure is to increase the densification rate in the process of grain boundary sliding.The current study suggests that HOP is a promising technique for densifying whisker reinforced ceramics.

关键词： hot oscillatory pressing(HOP) densification behavior grain boundary sliding whisker reinforced ceramic composite

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Thruster direction controlling of assembled spacecraft based on gimbal suspension

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Journal of Systems Engineering and Electronics 2016年第2期27卷 442-448页

作者： hongliang xu Hai Huang School of Astronautics Beihang University

The attitude control system design and its control effect are affected considerably by the mass-property parameters of the spacecraft. In the mission of on-orbit servicing, as fuel is expended, or the payloads are added or removed, the center of mass will be changed in certain axe; consequently, some thrusters＇ directions are deviated from the center of mass（CM） in certain plane. The CM of assembled spacecraft estimation and thruster direction control are studied. Firstly, the attitude dynamics of the assembled spacecraft is established based on the Newton-Euler method. Secondly, the estimation can be identified by the least recursive squares algorithm. Then, a scheme to control the thrusters＇ directions is proposed. By using the gimbal installed at the end of the boom, the angle of the thruster is controlled by driving the gimbal; therefore, thrusters can be directed to the CM again. Finally, numerical simulations are used to verify this scheme. Results of the numerical simulations clearly show that this control scheme is rational and feasible.

关键词： on-orbit servicing thruster＇s direction control assembled spacecraft center of mass（CM） identification

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Oscillatory pressure-assisted sinter forging for preparation of high-performance SiC whisker reinforced Al_(2)O_(3) composites

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Journal of Advanced Ceramics 2023年第2期12卷 321-328页

作者： Hongtian HE Gang SHAO Rui ZHAO Hongyi TIAN Hailong WANG Bingbing FAN Hongxia LU hongliang xu Rui ZHANG Li-nan AN School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China School of Materials Science and Engineering Luoyang Institute of Science and TechnologyLuoyang 471023China School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808China

In this work,a novel process,oscillatory pressure-assisted sinter forging(OPSF),for the preparation of high-performance ceramic composites was reported.Compared with the samples made by conventional sinter forging(SF)and hot oscillatory pressing(HOP),the SiC whisker reinforced Al_(2)O_(3) composites(SiCw–Al_(2)O_(3))prepared by OPSF at the same temperature exhibited a higher density and significantly improved the mechanical properties.The improvements in densification and performance are attributed to simultaneous enhanced shear deformation at both macro-and micro-scales,resulting from the combination of die-free configuration and oscillatory pressure of OPSF.And the strength of grain boundary is greatly increased when the temperature reaches 1600℃ of OPSF,due to that the grain-boundary sliding became pronounced at higher temperatures.The current results shed light on a powerful technique for preparing ceramic composites,which is likely applicable to other systems.

关键词： sintering oscillatory pressure-assisted sinter forging(OPSF) densification mechanical property ceramic composites

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Can floor-area-ratio incentive promote low impact development in a highly urbanized area？ A case study in Changzhou City, China

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Frontiers of Environmental Science & Engineering 2018年第2期12卷 79-87页

作者： Ming Cheng Huapeng Qin Kangmao He hongliang xu Key Laboratory for Urban Habitat Environmental Science and Technology School of Environment and Energy Peking University Shenzhen Graduate School Shenzhen 518055 China

As an environmental friendly measure Jbr surface runoff reduction, low impact development （LID） has been applied successfully in urban areas. However, due to high price of land and additional expense for LID construction in highly urbanized areas, the developers of real estate would not like to proceed LID exploitation. Floor area ratio （FAR） refers to ＂the ratio ofa building＇s total floor area to the size of the piece of land upon which it is built.＇＂ Increasing FAR indicates that the developers can construct higher buildings and earn more money. By means of awarding FAR, the developers may be willing to practice LID construction. In this study, a new residential district is selected as a case study to analyze the trade- offbetween the runoffreduction goal achieving by LID practices and the incentive of awarding FAR to promote LID construction. The System for Urban Stormwater Treatment and Analysis IntegratioN （SUSTAIN） model is applied to simulate the runoff reduction under various LID designs and then derive the Pareto-optimal solutions to achieve urban runoff reduction goals based on cost efficiency. The results indicates that the maximum surface runoff reduction is 20.5%. Under the extremity scenarios, the government has options to award FAR of 0.028, 0.038 and 0.047 and the net benefits developers gain are 0 CNY, one million CNY and two million CNY, respectively. The results provide a LID construction guideline related to awarding FAR, which supports incentive policy making for promoting LID practices in the highly urbanized areas.

关键词： Low impact development Runoff reductionIncentiveFloor area ratio SUSTAIN（System for Urban StormwaterTreatment and Analysis IntegratioN）

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Polymer-derived SiBCN ceramic pressure sensor with excellent sensing performance

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Journal of Advanced Ceramics 2020年第3期9卷 374-379页

作者： Gang SHAO Junpeng JIANG Mingjie JIANG Jie SU Wen LIU Hailong WANG hongliang xu Hongxia LU Rui ZHANG School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Provincial Key Laboratory of Aviation Materials and Application Technology Zhengzhou University of AeronauticsZhengzhou 450046China

Pressure measurement with excellent stability and long time durability is highly desired,especially at high temperature and harsh environments.A polymer-derived silicoboron carbonitride(SiBCN)ceramic pressure sensor with excellent stability,accuracy,and repeatability is designed based on the giant piezoresistivity of SiBCN ceramics.The SiBCN ceramic sensor was packaged in a stainless steel case and tested using half Wheatstone bridge with the uniaxial pressure up to 10 MPa.The SiBCN ceramic showed a remarkable piezoresistive effect with the gauge factor(K)as high as 5500.The output voltage of packed SiBCN ceramic sensor changes monotonically and smoothly versus external pressure.The as received SiBCN pressure sensor possesses features of short response time,excellent repeatability,stability,sensitivity,and accuracy.Taking the excellent high temperature thermo-mechanical properties of polymer-derived SiBCN ceramics(e.g.,high temperature stability,oxidation/corrosion resistance)into account,SiBCN ceramic sensor has significant potential for pressure measurement at high temperature and harsh environments.

关键词： polymer-derived ceramics(PDCs) silicoboron carbonitride(SiBCN)ceramic pressure sensor,piezoresistivity high termperature and harsh environment sensor

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角膜移植术后并发干眼的影响因素分析及列线图预测模型构建

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国际眼科杂志 2024年第6期24卷 970-974页

作者：徐宏亮康黔马志英成都爱迪眼科医院四川省成都市610031

目的:分析角膜移植术后并发干眼的影响因素,并构建预测角膜移植术后并发干眼的列线图预测模型。方法:收集2021-03/2023-02于我院行角膜移植术的患者117例的临床资料。根据术后是否并发干眼分为干眼组(n=96)和非干眼组(n=21),分析角膜移... 详细信息

目的:分析角膜移植术后并发干眼的影响因素,并构建预测角膜移植术后并发干眼的列线图预测模型。方法:收集2021-03/2023-02于我院行角膜移植术的患者117例的临床资料。根据术后是否并发干眼分为干眼组(n=96)和非干眼组(n=21),分析角膜移植术后并发干眼的危险因素,构建预测角膜移植术后并发干眼的列线图预测模型,模型的内部验证和预测效能分别用校正曲线、决策曲线评估。结果:合并糖尿病、合并睡眠障碍、合并睑板腺功能障碍、长期滥用滴眼液、长期配戴角膜接触镜、泪液中白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平是角膜移植术后并发干眼的危险因素(P0.07,列线图预测模型提供的临床净收益均高于单一指标。结论:基于角膜移植术后并发干眼的影响因素所构建的列线图预测模型对角膜移植术后并发干眼的预测价值较好。

关键词：角膜移植术干眼影响因素列线图预测模型构建

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立足公微运营创新化学学科教科研生态

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化学教学 2024年第4期 32-37页

作者：周玉枝郑新华徐宏亮华东师范大学上海200062 上海市浦东教育发展研究院上海200127

立足区域特点,根据师生需求,以“浦东化学在线”微信公众号为任务驱动载体,运用公众号建设在线资源、开展在线“教-学-研”实践,在解决问题的实践研究过程中,提升化学教师教科研能力,推动区域化学学科教科研方式的创新,建设学科教科研... 详细信息

立足区域特点,根据师生需求,以“浦东化学在线”微信公众号为任务驱动载体,运用公众号建设在线资源、开展在线“教-学-研”实践,在解决问题的实践研究过程中,提升化学教师教科研能力,推动区域化学学科教科研方式的创新,建设学科教科研新生态。

关键词：教科研生态在线学习资源在线“教-学-研” 数字化转型

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20年来学术论文英文标题研究

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阜阳师范大学学报（社会科学版） 2024年第1期 65-71页

作者：徐宏亮洪沛沛阜阳师范大学外国语学院安徽阜阳236037

标题对提高论文的检索率、阅读量和引用率起着重要作用。本文以滚雪球的方式收集了20年来127篇学术论文英文标题研究成果,重点分析了构成标题信息性和经济性的形式特征、内容特征、功能特征和语用特征,发现学界集中关注标题的形式特征... 详细信息

标题对提高论文的检索率、阅读量和引用率起着重要作用。本文以滚雪球的方式收集了20年来127篇学术论文英文标题研究成果,重点分析了构成标题信息性和经济性的形式特征、内容特征、功能特征和语用特征,发现学界集中关注标题的形式特征和内容特征,忽略了对标题功能特征和语用特征的研究;标题的句法结构和功能特征分类具有混淆性,且中文文献基本缺乏对标题信息内容的考察。最后,本文对未来学术论文的标题写作与研究提出了有针对性的意见和建议。

关键词：标题英文标题学术论文学术写作历时研究

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太空诱变膜荚黄芪种质资源表型特征变异分析

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干旱地区农业研究 2024年第3期42卷 1-12页

作者：李红玲陈垣郭凤霞许宏亮李瑞霞甘肃农业大学农学院/甘肃农业大学生命科学技术学院/甘肃省干旱生境作物学国家重点实验室甘肃兰州730070 天津市现代中药资源研究企业重点实验室/天津天士力现代中药资源有限公司天津300410

以膜荚黄芪太空搭载种子建立的33D、22H群体及未搭载原种(CK)群体的SP2代成药株为研究对象,对19个表型性状进行特征变异及多样性分析,以筛选具有优异性状的膜荚黄芪种质资源。结果表明:诱变后代群体的19个性状变异幅度、遗传多样性存在... 详细信息

以膜荚黄芪太空搭载种子建立的33D、22H群体及未搭载原种(CK)群体的SP2代成药株为研究对象,对19个表型性状进行特征变异及多样性分析,以筛选具有优异性状的膜荚黄芪种质资源。结果表明:诱变后代群体的19个性状变异幅度、遗传多样性存在不同程度差异,33D、22H群体及CK群体地上部分的4个质量性状的变异系数CV范围分别为0.35~0.78、0.38~0.84、0.41~0.64,即变异幅度表现为22H>33D>CK,遗传多样性指数H′范围分别为1.67~2.13、1.66~2.02、1.44~2.21,即变化幅度为CK>33D>22H;7个数量性状的CV范围分别为0.17~0.62、0.17~0.67、0.20~0.83,H′范围分别为1.47~2.01、1.72~2.04、1.59~2.11,即变异幅度表现均为CK>22H>33D;8个产量构成性状的CV范围分别为0.09~0.53、0.15~0.55、0.09~0.97,即变化幅度为CK>22H>33D,H′范围分别为1.81~2.09、1.73~2.06、1.59~2.03,即变化幅度为33D>22H>CK。通过主成分因子分析将诱变后代群体植株的12个数量性状指标简化为4个主因子,33D和22H群体数量性状累计贡献率均大于CK,分别达68.669%和70.414%,并筛选出二级分枝数、单根干质量、有效根长、侧根数、根长、折干率可作为膜荚黄芪评价代表性指标;诱变后SP2代地上部性状隶属函数值小于CK,产量构成性状隶属函数值大于CK。通过隶属函数和聚类分析将诱变后SP2代的2个群体分别归为3类不同类型植株(即Ⅰ、Ⅱ和Ⅲ型),第Ⅰ类群为良好类、第Ⅱ类群为优势类、第Ⅲ类群为后备类,综合评价筛选出性状优异种质39份、产量构成性状优异种质16份、矮株型高产种质3份。

关键词：膜荚黄芪太空诱变表型特征变异分析种质筛选

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