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Energy and Built Environment 2024年第4期5卷 592-606页

作者： Tianyi Zhao Zhe Li Xiuming Li honglian peng Institute of Building Energy School of Civil EngineeringFaculty of Infrastructure EngineeringDalian University of TechnologyDalian 116024China Anhui Province Key Laboratory of Intelligent Building&Building Energy Saving Anhui Jianzhu UniversityHefei 230022China School of Metallurgy Northeastern UniversityShenyang 110819China School of Architecture Harbin Institute of TechnologyHarbin150006China

Variable air volume air-conditioning system(VAV system)has multiple control loops that interfered with each other,which has serious impacts on its actual operation *** solve this problem,the index of global hydraulic stability,which takes the physical quantity of the pipe network pressure and the air flow rate as reference,is proposed based on Graph theory,and a pipe network model for the hydraulic calculation is ***,the simulation study based on the actual operation data is carried out in *** distribution of the pressure and the air flow in the pipe network is obtained,and the action interferences among adjacent terminal boxes are analyzed based on global hydraulic stability under damper position regulation strategy(DP strategy)and fan frequency regulation strategy(FF strategy).Results indicate that the FF strategy can decrease the total change distance of the damper position compared with the DP strategy,and then the fluctuation of the pressure and the air flow can be *** contribution of this study is to provide an evaluation index of global hydraulic stability,which can also be used in other air-conditioning systems with multiple terminals and multiple control loops.

关键词： VAV system Global hydraulic stability Adjustment strategy VAV box damper position

Research on the identification of the production origin of Angelica dahurica using LIBS technology combined with machine learning algorithms

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Optoelectronics Letters 2024年第3期20卷 171-176页

作者： SUN Jiaxing LI honglian YAO Yuhang YAN Qiongyan DONG Fang College of Quality and Technology Supervising Hebei UniversityBaoding 071000China National and Local Joint Engineering Center of Measuring Instruments and Metrology Systems Baoding 071000China Key Laboratory of Energy Measurement and Safety Detection Technology in Hebei Province Baoding 071000China

The origin of Angelica dahurica medicinal herbs varies, and their pharmacological effects also differ. In order to achieve rapid and accurate identification of the origin of Angelica dahurica medicinal herbs, this study utilizes laser induced breakdown spectroscopy(LIBS) technology combined with machine learning algorithms to identify the original source of Angelica dahurica. Sliced samples of Angelica dahurica were taken from four regions: Hebei, Henan, Zhejiang, and Sichuan. The spectral data from the sliced samples were used as features, and different algorithms including support vector machine(SVM), back propagation(BP) neural network, genetic algorithm-back propagation(GA-BP) neural network, particle swarm optimization-back propagation(PSO-BP) neural network, convolutional neural network(CNN), and CNN-SVM were employed to classify the origin of Angelica dahurica samples.

关键词： neural origin network

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Bioactive citrate-based polyurethane tissue adhesive for fast sealing and promoted wound healing

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Regenerative Biomaterials 2024年第1期3卷 69-81页

作者： Yan Li Jiawei Liu Chenxi Lian He Yang Mingjiang Zhang Youfa Wang honglian Dai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan University of TechnologyWuhan 430070China Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory Chaozhou 521000China Shenzhen Research Institute of Wuhan University of Technology Shenzhen 518000China

As a superior alternative to sutures,tissue adhesives have been developed significantly in recent ***,existing tissue adhesives struggle to form fast and stable adhesion between tissue interfaces,bond weakly in wet environments and lack *** this study,a degradable and bioactive citrate-based polyurethane adhesive is constructed to achieve rapid and strong tissue *** hydrophobic layer was created with polycaprolactone to overcome the bonding failure between tissue and adhesion layer in wet environments,which can effectively improve the wet bonding *** citrate-based polyurethane adhesive provides rapid,non-invasive,liquid-tight and seamless closure of skin incisions,overcoming the limitations of sutures and commercial tissue *** addition,it exhibits biocompatibility,biodegradability and hemostatic *** degradation product citrate could promote the process of angiogenesis and accelerate wound *** study provides a novel approach to the development of a fast-adhering wet tissue adhesive and provides a valuable contribution to the development of polyurethane-based tissue adhesives.

关键词： tissue adhesive polyurethane citrate wet adhesion

A double-network porous hydrogel based on high internal phase emulsions as a vehicle for potassium sucrose octasulfate delivery accelerates diabetic wound healing

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Regenerative Biomaterials 2024年第4期3卷 82-97页

作者： Zhiwei Wang Lingshun Sun Weixing Wang Zheng Wang Ge Shi honglian Dai Aixi Yu Department of Orthopedics Trauma and Microsurgery Zhongnan Hospital of Wuhan UniversityWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan University of TechnologyWuhan 430070China

Diabetic wounds are a difficult medical *** secretion of matrix metalloproteinase-9(MMP-9)in diabetic wounds further degrades the extracellular matrix and growth factors and causes severe vascular damage,which seriously hinders diabetic wound *** solve these issues,a double-network porous hydrogel composed of poly(methyl methacrylate-co-acrylamide)(p(MMA-co-AM))and polyvinyl alcohol(PVA)was constructed by the high internal phase emulsion(HIPE)technique for the delivery of potassium sucrose octasulfate(PSO),a drug that can inhibit MMPs,increase angiogenesis and improve *** hydrogel possessed a typical polyHIPE hierarchical microstructure with interconnected porous morphologies,high porosity,high specific surface area,excellent mechanical properties and suitable swelling ***,the p(MMA-co-AM)/PVA@PSO hydrogel showed high drug-loading performance and effective PSO *** addition,both in vitro and in vivo studies showed that the p(MMA-co-AM)/PVA@PSO hydrogel had good biocompatibility and significantly accelerated diabetic wound healing by inhibiting excessive MMP-9 in diabetic wounds,increasing growth factor secretion,improving vascularization,increasing collagen deposition and promoting ***,this study provided a reliable therapeutic strategy for diabetic wound healing,some theoretical basis and new insights for the rational design and preparation of wound hydrogel dressings with high porosity,high drug-loading performance and excellent mechanical properties.

关键词： high internal phase emulsions double-network porous hydrogel drug delivery diabetic wound healing sucrose octasulfate

Activation of MAPK-mediated immunity by phosphatidic acid in response to positive-strand RNA viruses

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Plant Communications 2024年第1期5卷 84-100页

作者： Jiayu Lin Jinpeng Zhao Linlin Du pengkun Wang Bingjian Sun Chao Zhang Yan Shi honglian Li Hangjun Sun The Engineering Research Center for Plant Health Protection Technology in Henan Province College of Plant ProtectionHenan Agricultural UniversityZhengzhouHenan 450046China

Increasing evidence suggests that mitogen-activated protein kinase(MAPK)cascades play a crucial role in plant defense against ***,the mechanisms that underlie the activation of MAPK cascades in response to viral infection remain *** this study,we discovered that phosphatidic acid(PA)repre-sents a major class of lipids that respond to Potato virus Y(PVY)at an early stage of *** identified NbPLDa1(Nicotiana benthamiana phospholipase Da1)as the key enzyme responsible for increased PA levels during PVY infection and found that it plays an antiviral role.6K2 of PVY interacts with NbPLDa1,lead-ing to elevated PA *** addition,NbPLDa1 and PA are recruited by 6K2 to membrane-bound viral repli-cation *** the other hand,6K2 also induces activation of the MAPK pathway,dependent on its interaction with NbPLDa1 and the derived *** binds to WIPK/SIPK/NTF4,prompting their phosphoryla-tion of ***,spraying with exogenous PA is sufficient to activate the MAPK ***-down of the MEK2-WIPK/SIPK-WRKY8 cascade resulted in enhanced accumulation of PVY genomic RNA.6K2 of Turnip mosaic virus and p33 of Tomato bushy stunt virus also interacted with NbPLDa1 and induced the activation of MAPK-mediated *** of function of NbPLDa1 inhibited virus-induced activation of MAPK cascades and promoted viral RNA ***,activation of MAPK-mediated immunity by NbPLDa1-derived PA is a common strategy employed by hosts to counteract positive-strand RNA virus infection.

关键词： Potato virus Y PVY positive-strand RNA virus +RNA virus phosphatidic acid PA NbPLDa1 MAPK WIPK/SIPK

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四针床电脑横机的全成形工艺

纺织学报 2017年第4期38卷 61-67页

作者：王敏丛洪莲蒋高明彭佳佳江南大学教育部针织技术工程研究中心江苏无锡214122

针对目前毛衫生产无法一体成形,下机后需再进行套口和缝合等不足,研究了四针床电脑横机的全成形工艺。从机器的针床、机头三角系统、拉力装置、送纱和导纱装置的工作原理出发,对平针组织、罗纹组织以及开口的成形编织原理进行分析,并以... 详细信息

针对目前毛衫生产无法一体成形,下机后需再进行套口和缝合等不足,研究了四针床电脑横机的全成形工艺。从机器的针床、机头三角系统、拉力装置、送纱和导纱装置的工作原理出发,对平针组织、罗纹组织以及开口的成形编织原理进行分析,并以典型的毛衫为例,用四针床电脑横机,探讨其结构成形方法。结果发现:基于4个针床配置的电脑横机使得毛衫能够进行满针筒状编织;四针床电脑横机全成形编织的基础是圆筒编织,具体包括筒状平针结构编织、筒状罗纹结构编织以及开口编织;通过选择编织方向和配置纱嘴,能完成典型款式毛衫,如高领长袖套衫、长袖开衫、无袖套衫,在四针床电脑横机上的一体成形。

关键词：四针床电脑横机全成形数字式送纱圆筒 C形编织

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汉防己甲素通过抑制Mincle/Syk信号介导的巨噬细胞炎性活化减轻小鼠缺血再灌注诱导的急性肾损伤

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中国病理生理杂志 2024年第4期40卷 670-678页

作者：彭泽王洪连粟宏伟王丽成都市双流区九江社区卫生服务中心四川成都610000 西南医科大学附属中医医院中西医结合研究中心四川泸州646000 西南医科大学附属中医医院泌尿外科四川泸州646000

目的:探讨汉防己甲素(Tet)对小鼠缺血再灌注诱导的急性肾损伤(IRI-AKI)的作用及其机制。方法:8周龄雄性C57BL/6小鼠随机分为假手术组、IRI-AKI组、低剂量(20 mg/kg)Tet组、高剂量(40 mg/kg)Tet组和槲皮素(50 mg/kg)阳性对照组,每组6只... 详细信息

目的:探讨汉防己甲素(Tet)对小鼠缺血再灌注诱导的急性肾损伤(IRI-AKI)的作用及其机制。方法:8周龄雄性C57BL/6小鼠随机分为假手术组、IRI-AKI组、低剂量(20 mg/kg)Tet组、高剂量(40 mg/kg)Tet组和槲皮素(50 mg/kg)阳性对照组,每组6只。采用双侧肾动静脉夹闭45 min后恢复血供的方法建立IRI-AKI模型,Tet和槲皮素组的IRI-AKI小鼠于术前1 h及术后连续3 d给予相应剂量药物腹腔注射,假手术和IRI-AKI组小鼠给予同等体积溶剂注射。实验终点处死动物,收集血清及肾脏组织样本,进行肾功能、病理、mRNA及蛋白等指标检测。在体外,采用脂多糖(LPS;300μg/L)刺激的原代小鼠骨髓来源巨噬细胞(BMDM)进行Tet(1、2和4 mg/L)的抗炎活性研究。结果:(1)与IRI-AKI组相比,低和高剂量Tet干预均能显著降低血清肌酐和血尿素氮水平(P<0.05),并减轻肾小管病理损伤(P<0.05)。(2)Tet干预可以显著抑制IRI-AKI小鼠肾组织中白细胞介素1β(IL-1β)和IL-6的mRNA和蛋白表达及NF-κB信号的活化,减少肾组织巨噬细胞浸润(P<0.05)。(3)在LPS刺激的BMDM中,Tet同样抑制IL-1β和IL-6的mRNA和蛋白表达及NF-κB信号的活化(P<0.05)。(4)进一步实验显示,Tet可以显著降低LPS刺激的BMDM和IRI-AKI小鼠肾组织中Mincle、Syk和p-Syk的表达水平(P<0.05)。结论:Tet可以显著减轻IRI-AKI小鼠肾损伤,减轻肾组织炎症反应,其可能的机制为抑制巨噬细胞Mincle/Syk/NF-κB促炎信号通路。

关键词：汉防己甲素急性肾损伤缺血再灌注巨噬细胞 Mincle/Syk/NF-κB信号通路

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Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

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Oncology Research 2024年第7期32卷 1185-1195页

作者： XIAOBI HUANG CHUNYUAN CHEN YONGYANG CHEN honglian ZHOU YONGHUA CHEN ZHONG HUANG YULIU XIE BAIYANG LIU YUDONG GUO ZHIXIONG YANG GUANGHUA CHEN WENMEI SU Department of Pulmonary Oncology Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Thoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Orthopedics Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China

Background:Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as *** dysregulation has been closely associated with ***00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this ***,the mechanism underlying its function in cancer progression remains poorly ***:Here,the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines,clinical samples,and ***:We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients,whereas knockdown of LINC00265 inhibited proliferation of cancer cell lines and tumor growth in *** blot andﬂow cytometry analyses indicated that silencing of LINC00265 induced autophagy and ***,we showed that LINC00265 interacted with and stabilized the transcriptional co-repressor Switch-independent 3a(SIN3A),which is a scaffold protein functioning either as a tumor repressor or as an oncogene in a context-dependent *** of SIN3A also reduced proliferation of lung cancer cells,which was correlated with the induction of *** observations raise the possibility that LINC00265 functions to promote the oncogenic activity of SIN3A in lung ***:Ourﬁndings thus identify SIN3A as a LINC00265-associated protein and should help to understand the mechanism underlying LINC00265-mediated oncogenesis.

关键词： LINC00265 Autophagy Lung adenocarcinoma(LUAD) Cancer progression Switch-independent 3a(SIN3A)

Label-free in-vivo classi-cation and tracking of red blood cells and platelets using Dynamic-YOLOv4 network

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 89-103页

作者： Caizhong Guan Bin He Hongting Zhang Shangpan Yang Yang Xu honglian Xiong Yaguang Zeng Mingyi Wang Xunbin Wei Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology School of Physics and Optoelectronic Engineering Foshan University Foshan 528225P.R.China Shenzhen International Graduate School Tsinghua University Shenzhen 518055P.R.China The Second Affliated Hospital of Heilongjiang University of Chinese Medicine Harbin 150001 P.R.China Peking University Cancer Hospital&Institute Beijing 100142 P.R.China Biomedical Engineering Department Peking University Beijing 100081P.R.China Institute of Medical Technology Peking University Health Science Center Beijing 100191P.R.China International Cancer Institute Peking University Beijing 100191P.R.China

In-vivo flow cytometry is a noninvasive real-time diagnostic technique that facilitates continuous monitoring of cells without perturbing their natural biological environment,which renders it a valuable tool for both scienti¯c research and clinical ***,the conventional approach for improving classi¯cation accuracy often involves labeling cells with fluorescence,which can lead to potential *** study proposes a label-free in-vivo flow cytometry technique,called dynamic YOLOv4(D-YOLOv4),which improves classi¯cation accuracy by integrating absorption intensity°uctuation modulation(AIFM)into YOLOv4 to demodulate the temporal features of moving red blood cells(RBCs)and *** zebra¯sh as an experimental model,the D-YOLOv4 method achieved average precisions(APs)of 0.90 for RBCs and 0.64 for thrombocytes(similar to platelets in mammals),resulting in an overall AP of *** scores notably surpass those attained by alternative network models,thereby demonstrating that the combination of physical models with neural networks provides an innovative approach toward developing label-free in-vivoflow cytometry,which holds promise for diverse in-vivo cell classi¯cation applications.

关键词： Label-free in-vivoflow cytometry cell classi¯cation and tracking D-YOLOv4

纬编双面移圈织物多层弹簧-质点结构模型构建与实现

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纺织学报 2024年第1期45卷 106-111页

作者：张静丛洪莲蒋高明江南大学针织技术教育部工程研究中心江苏无锡214122

纬编双面移圈织物工艺结构复杂多变,现有系统在进行设计开发时难以直观地展示出织物的组织结构特点。为实现纬编双面移圈织物的组织结构模拟,本文提出了一种纬编双面移圈织物多层弹簧-质点结构模型。首先建立了成圈、集圈、移圈线圈几... 详细信息

纬编双面移圈织物工艺结构复杂多变,现有系统在进行设计开发时难以直观地展示出织物的组织结构特点。为实现纬编双面移圈织物的组织结构模拟,本文提出了一种纬编双面移圈织物多层弹簧-质点结构模型。首先建立了成圈、集圈、移圈线圈几何结构模型,接着分析了纬编双面移圈织物结构特征,并在传统弹簧-质点模型的基础上构建了多层弹簧-质点模型,然后采用牛顿第二定律和Velocity-Verlet数值积分法求解了多层弹簧-质点模型的最终位置,最终提出了一种纬编双面移圈织物结构模拟的算法流程。本文建立的多层弹簧-质点结构模型能够反映纬编双面移圈织物的组织结构,具有较好的结构模拟效果。

关键词：纬编双面移圈弹簧-质点模型结构模拟线圈几何结构模型

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